Click here to switch to the map view.

The map label for this gene is metR [H]

Identifier: 237813357

GI number: 237813357

Start: 3035473

End: 3036405

Strand: Direct

Name: metR [H]

Synonym: GBP346_A3127

Alternate gene names: 237813357

Gene position: 3035473-3036405 (Clockwise)

Preceding gene: 237813356

Following gene: 237813358

Centisome position: 74.06

GC content: 69.99

Gene sequence:

>933_bases
ATGATCCGCTCCCCGCTCGAATTCCGGCATCTGCAGACGCTCGTCGCGCTGCGCGATACCGGCAACCTGTCGCGCGCCGC
GCAGGTGCTGTGCCTCACGCAATCGGCGCTGTCGCATCAGTTGAAGGCGCTCGAAACGCATTTCGGGCTGCCGCTGTTCG
TGCGCAAATCCGCCCCGCTCACGTTCACCGCGGCCGGCAAGCGGCTGCTCGCGCTCGCCGAGCAGGTCGTGCCCGCGATC
GAGGAAGCCGAGCGCGACATCGCGCGCCTCGCGCTCGGCACGGGCGGCGCGTTGCGGATCGCGGTCGAGTGCCACACCTG
CTTCGATTGGCTGATGCCCGCGATGGACGCGTTCCGGCAGCGCTGGCCGGAAGTGGAACTCGACATCGTGTCGGGCTTTC
ACGCGGATCCGATCGGCCTGCTGCACCAGGATCGCGCGGATCTCGCGATCGTCGCCGAGGCCGATGCCGACGAGGCCGTC
GACTATCACCCGCTCTTTCGCTTCCAGATCGTCGGGCTCGTCGGCAACGACCACGCGCTCGCGCACCAGCCGTCGCTCAC
GGCCGCCGATTTCGCCGACGAGACGCTGATCACGTACCCGGTGCCCGACGAGATGCTCGACATCGTCCGGCAAGTGCTCA
AGCCCGCCGGCATCGAGCCGAAGCGGCGCACGTCGGAGCTGACGATCGCGATCCTGCAGCTCGTCGCGAGCCGGCGCGGC
GTGGCGGCGCTGCCGCTGTGGGCGGTGGCCACCTACCTCGACAAGCGCTACGTGAGCGCGCGCCCCGTGCTGCGCGCCGA
CGGCTCGACGCTGTCGGGCGAGCTCTACGCGGCGACGCTGCCGGCGTTCTCGACGCGCGCGTACGCGGCCGATTTCGTCG
CGACGATGCGCGAGACGAGCGCGGCGTCGCTGCCCGAGATCGAGCTGCTGTAA

Upstream 100 bases:

>100_bases
TGACCGGCAGTATCGGATTTGCCCTATCATTACTCAAACGAAAGTTTTTGCCGAACAACATGAATTTTTTTCAACATCAT
TCGCCGAGACGCACACTGCA

Downstream 100 bases:

>100_bases
GCGGCGCGCCGCACGCCGCTTGCCCCCGTTTTCGCCGAAAAACCGTCGGCCGCCGGTCGCCGCGGGTAAAATCGAGCCTA
TTCCTATCCCAACATCCCAT

Product: transcriptional activator MetR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MIRSPLEFRHLQTLVALRDTGNLSRAAQVLCLTQSALSHQLKALETHFGLPLFVRKSAPLTFTAAGKRLLALAEQVVPAI
EEAERDIARLALGTGGALRIAVECHTCFDWLMPAMDAFRQRWPEVELDIVSGFHADPIGLLHQDRADLAIVAEADADEAV
DYHPLFRFQIVGLVGNDHALAHQPSLTAADFADETLITYPVPDEMLDIVRQVLKPAGIEPKRRTSELTIAILQLVASRRG
VAALPLWAVATYLDKRYVSARPVLRADGSTLSGELYAATLPAFSTRAYAADFVATMRETSAASLPEIELL

Sequences:

>Translated_310_residues
MIRSPLEFRHLQTLVALRDTGNLSRAAQVLCLTQSALSHQLKALETHFGLPLFVRKSAPLTFTAAGKRLLALAEQVVPAI
EEAERDIARLALGTGGALRIAVECHTCFDWLMPAMDAFRQRWPEVELDIVSGFHADPIGLLHQDRADLAIVAEADADEAV
DYHPLFRFQIVGLVGNDHALAHQPSLTAADFADETLITYPVPDEMLDIVRQVLKPAGIEPKRRTSELTIAILQLVASRRG
VAALPLWAVATYLDKRYVSARPVLRADGSTLSGELYAATLPAFSTRAYAADFVATMRETSAASLPEIELL
>Mature_310_residues
MIRSPLEFRHLQTLVALRDTGNLSRAAQVLCLTQSALSHQLKALETHFGLPLFVRKSAPLTFTAAGKRLLALAEQVVPAI
EEAERDIARLALGTGGALRIAVECHTCFDWLMPAMDAFRQRWPEVELDIVSGFHADPIGLLHQDRADLAIVAEADADEAV
DYHPLFRFQIVGLVGNDHALAHQPSLTAADFADETLITYPVPDEMLDIVRQVLKPAGIEPKRRTSELTIAILQLVASRRG
VAALPLWAVATYLDKRYVSARPVLRADGSTLSGELYAATLPAFSTRAYAADFVATMRETSAASLPEIELL

Specific function: Control of the last step in methionine biosynthesis; metR is a positive activator of the metA, metE and metH genes [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790262, Length=303, Percent_Identity=38.9438943894389, Blast_Score=214, Evalue=6e-57,
Organism=Escherichia coli, GI1787879, Length=250, Percent_Identity=27.6, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1788296, Length=198, Percent_Identity=32.3232323232323, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1786401, Length=157, Percent_Identity=31.8471337579618, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI157672245, Length=247, Percent_Identity=26.7206477732794, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI87082132, Length=260, Percent_Identity=27.3076923076923, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1788887, Length=186, Percent_Identity=29.5698924731183, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1790208, Length=150, Percent_Identity=30, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI145693105, Length=241, Percent_Identity=23.6514522821577, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1789283, Length=112, Percent_Identity=41.0714285714286, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1787530, Length=181, Percent_Identity=27.6243093922652, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1789173, Length=108, Percent_Identity=31.4814814814815, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1788297, Length=167, Percent_Identity=28.1437125748503, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI1790399, Length=281, Percent_Identity=24.5551601423488, Blast_Score=61, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33894; Mature: 33894

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRSPLEFRHLQTLVALRDTGNLSRAAQVLCLTQSALSHQLKALETHFGLPLFVRKSAPL
CCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCE
TFTAAGKRLLALAEQVVPAIEEAERDIARLALGTGGALRIAVECHTCFDWLMPAMDAFRQ
EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHHHHHH
RWPEVELDIVSGFHADPIGLLHQDRADLAIVAEADADEAVDYHPLFRFQIVGLVGNDHAL
HCCCCEEEEECCCCCCCCHHHCCCCCCEEEEEECCCCCCCCCCCEEEEEEEEEECCCCCC
AHQPSLTAADFADETLITYPVPDEMLDIVRQVLKPAGIEPKRRTSELTIAILQLVASRRG
CCCCCCCHHHCCCCCEEEECCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCC
VAALPLWAVATYLDKRYVSARPVLRADGSTLSGELYAATLPAFSTRAYAADFVATMRETS
CCHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHC
AASLPEIELL
CCCCCCEECC
>Mature Secondary Structure
MIRSPLEFRHLQTLVALRDTGNLSRAAQVLCLTQSALSHQLKALETHFGLPLFVRKSAPL
CCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCE
TFTAAGKRLLALAEQVVPAIEEAERDIARLALGTGGALRIAVECHTCFDWLMPAMDAFRQ
EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHHHHHH
RWPEVELDIVSGFHADPIGLLHQDRADLAIVAEADADEAVDYHPLFRFQIVGLVGNDHAL
HCCCCEEEEECCCCCCCCHHHCCCCCCEEEEEECCCCCCCCCCCEEEEEEEEEECCCCCC
AHQPSLTAADFADETLITYPVPDEMLDIVRQVLKPAGIEPKRRTSELTIAILQLVASRRG
CCCCCCCHHHCCCCCEEEECCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCC
VAALPLWAVATYLDKRYVSARPVLRADGSTLSGELYAATLPAFSTRAYAADFVATMRETS
CCHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHC
AASLPEIELL
CCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]