Click here to switch to the map view.

The map label for this gene is atoC [H]

Identifier: 237813247

GI number: 237813247

Start: 2932230

End: 2933615

Strand: Reverse

Name: atoC [H]

Synonym: GBP346_A3014

Alternate gene names: 237813247

Gene position: 2933615-2932230 (Counterclockwise)

Preceding gene: 237813249

Following gene: 237813246

Centisome position: 71.58

GC content: 67.97

Gene sequence:

>1386_bases
ATGGATGTTGCGGCAAGGCATCTCATCTATTATTCCCATCGCCCCGATGCGGATCTGCAGCGTTGTTTCGATCAGCACGG
CTGGCAAGTCGACGTTGTCGATTCGCCACGCGAGATGCGGCGTTCCGCCGCACGCGACGTGATCGCGGGCGGACTGCTCG
ATTTTTCGTGCGGCATCGGGGCCGCCGAATTGCGCGAGCTCGAAGCGAGCCTGAAGACGCCGAACGTCGGCTGGATCGCG
ACGACGCGGCGAGGGCAAATGGAAGACGACGCGGTGCGCCGGCTCGTGCGCGATTATTGTTTCGATTACGTGACGGTGCC
GTACGAGTGCGACCGCATCGTCGAATCGGTCGGCCACGCGTACGGCATGGTCACGCTGTCGGAAGGGCTCGCCCCCGCGG
CCGCGACGGTGCGCAACGAAGGCGAGATGGTCGGCACCTGCGAGGCGATGCTCGCGCTCTTCAAGATGATCCGCAAGGTC
GCGTCGACCGACGCGCCCGTGTTCATCTCGGGCGAATCCGGCACCGGCAAGGAGCTGACCGCGGTCGCGATTCACGAGCG
CTCGTCGCGCGCGGGCGCGCCGTTCGTCGCGATCAATTGCGGCGCGATTCCGCCGACGCTGTTGCAGGCCGAGCTGTTCG
GCTATGAGCGCGGCGCGTTCACCGGCGCGAATCAGCGCAAGATCGGCCGCATCGAAGCGGCCAACGGCGGCACGCTGTTC
CTCGACGAAATCGGCGACCTGCCGTTCGAGAGCCAGGCGAGCCTGCTGCGCTTCCTGCAGGAGCACAAGGTCGAGCGCGT
CGGCGGGCATCAGTCGATTCCGGTCGACGTGCGGATCATTTCCGCGACGCACGTCGATATGCAGATCGCATTGCGCAACG
GGCGCTTTCGCGAGGACCTGTATCACCGGCTGTGCGTGCTGAAGCTCGAGGAGCCGCCGCTGCGCGAGCGCGGCAAGGAC
ATCGAGATCCTCGCGCGCCACATGCTCGAGCGCTTCAAGGGCGACGCGCACCGGCGGCTGCGCGGCTTCACGCCCGATGC
GATCGCGGCGCTTCACAACTACGCGTGGCCCGGCAACGTGCGCGAGCTGATCAACCGGGTGCGGCGCGCGATCGTGATGT
CGGAAGGACGGATGATCAGCGCGGCCGATCTCGAGCTGTCGGGCTACGCGGAAGTCGCGCCGATGTCGCTCGAGGAGGCG
CGCGAGAGCGCCGAGCGGCACGCGATCGAAGTCGCGCTGCTGCGGCACCGCGGGCGGCTCGCGGACGCGGCGCGCGAGCT
CGGCGTATCGCGCGTGACGCTCTATCGTCTGCTCTGCGCGTACGGGATGCGCGACGACGACGGCGCGCGCGCGAAGCGCG
ACGAGGGGCTGCGCCGGGCCTGCTAG

Upstream 100 bases:

>100_bases
TGAAAAATGACGAGCCGAGTCCTTCTCGCAGGCCCCGGCTCGGTTCCGTCGCGCGCCTGTGCCAGGCGGCGCGACGCCAA
TCGATTGACTGGGTGGCGTC

Downstream 100 bases:

>100_bases
CGCGGGCCTTGTTAAAATGGCGGGCACGGCCGCTTTTCGCGGCCGGAGGAACCCGCATGAAACAGTATCTCGATCTCGTT
CGCACCATTCTCGATACCGG

Product: sigma-54 dependent transcriptional regulator, Fis family

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:

>461_residues
MDVAARHLIYYSHRPDADLQRCFDQHGWQVDVVDSPREMRRSAARDVIAGGLLDFSCGIGAAELRELEASLKTPNVGWIA
TTRRGQMEDDAVRRLVRDYCFDYVTVPYECDRIVESVGHAYGMVTLSEGLAPAAATVRNEGEMVGTCEAMLALFKMIRKV
ASTDAPVFISGESGTGKELTAVAIHERSSRAGAPFVAINCGAIPPTLLQAELFGYERGAFTGANQRKIGRIEAANGGTLF
LDEIGDLPFESQASLLRFLQEHKVERVGGHQSIPVDVRIISATHVDMQIALRNGRFREDLYHRLCVLKLEEPPLRERGKD
IEILARHMLERFKGDAHRRLRGFTPDAIAALHNYAWPGNVRELINRVRRAIVMSEGRMISAADLELSGYAEVAPMSLEEA
RESAERHAIEVALLRHRGRLADAARELGVSRVTLYRLLCAYGMRDDDGARAKRDEGLRRAC

Sequences:

>Translated_461_residues
MDVAARHLIYYSHRPDADLQRCFDQHGWQVDVVDSPREMRRSAARDVIAGGLLDFSCGIGAAELRELEASLKTPNVGWIA
TTRRGQMEDDAVRRLVRDYCFDYVTVPYECDRIVESVGHAYGMVTLSEGLAPAAATVRNEGEMVGTCEAMLALFKMIRKV
ASTDAPVFISGESGTGKELTAVAIHERSSRAGAPFVAINCGAIPPTLLQAELFGYERGAFTGANQRKIGRIEAANGGTLF
LDEIGDLPFESQASLLRFLQEHKVERVGGHQSIPVDVRIISATHVDMQIALRNGRFREDLYHRLCVLKLEEPPLRERGKD
IEILARHMLERFKGDAHRRLRGFTPDAIAALHNYAWPGNVRELINRVRRAIVMSEGRMISAADLELSGYAEVAPMSLEEA
RESAERHAIEVALLRHRGRLADAARELGVSRVTLYRLLCAYGMRDDDGARAKRDEGLRRAC
>Mature_461_residues
MDVAARHLIYYSHRPDADLQRCFDQHGWQVDVVDSPREMRRSAARDVIAGGLLDFSCGIGAAELRELEASLKTPNVGWIA
TTRRGQMEDDAVRRLVRDYCFDYVTVPYECDRIVESVGHAYGMVTLSEGLAPAAATVRNEGEMVGTCEAMLALFKMIRKV
ASTDAPVFISGESGTGKELTAVAIHERSSRAGAPFVAINCGAIPPTLLQAELFGYERGAFTGANQRKIGRIEAANGGTLF
LDEIGDLPFESQASLLRFLQEHKVERVGGHQSIPVDVRIISATHVDMQIALRNGRFREDLYHRLCVLKLEEPPLRERGKD
IEILARHMLERFKGDAHRRLRGFTPDAIAALHNYAWPGNVRELINRVRRAIVMSEGRMISAADLELSGYAEVAPMSLEEA
RESAERHAIEVALLRHRGRLADAARELGVSRVTLYRLLCAYGMRDDDGARAKRDEGLRRAC

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=362, Percent_Identity=42.5414364640884, Blast_Score=279, Evalue=3e-76,
Organism=Escherichia coli, GI1790437, Length=421, Percent_Identity=39.9049881235154, Blast_Score=271, Evalue=9e-74,
Organism=Escherichia coli, GI1788905, Length=377, Percent_Identity=40.8488063660477, Blast_Score=254, Evalue=9e-69,
Organism=Escherichia coli, GI1790299, Length=383, Percent_Identity=40.4699738903394, Blast_Score=254, Evalue=1e-68,
Organism=Escherichia coli, GI87082117, Length=280, Percent_Identity=44.2857142857143, Blast_Score=240, Evalue=2e-64,
Organism=Escherichia coli, GI1789233, Length=318, Percent_Identity=42.7672955974843, Blast_Score=232, Evalue=3e-62,
Organism=Escherichia coli, GI1789087, Length=300, Percent_Identity=41.6666666666667, Blast_Score=229, Evalue=2e-61,
Organism=Escherichia coli, GI1786524, Length=317, Percent_Identity=44.1640378548896, Blast_Score=221, Evalue=6e-59,
Organism=Escherichia coli, GI87082152, Length=345, Percent_Identity=40.5797101449275, Blast_Score=218, Evalue=8e-58,
Organism=Escherichia coli, GI87081872, Length=234, Percent_Identity=44.4444444444444, Blast_Score=194, Evalue=1e-50,
Organism=Escherichia coli, GI1787583, Length=319, Percent_Identity=37.6175548589342, Blast_Score=189, Evalue=3e-49,
Organism=Escherichia coli, GI87081858, Length=303, Percent_Identity=32.3432343234323, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1789828, Length=241, Percent_Identity=36.0995850622407, Blast_Score=125, Evalue=5e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 51249; Mature: 51249

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVAARHLIYYSHRPDADLQRCFDQHGWQVDVVDSPREMRRSAARDVIAGGLLDFSCGIG
CCCCCCEEEEECCCCCHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHCCCHHHCCCCC
AAELRELEASLKTPNVGWIATTRRGQMEDDAVRRLVRDYCFDYVTVPYECDRIVESVGHA
HHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHH
YGMVTLSEGLAPAAATVRNEGEMVGTCEAMLALFKMIRKVASTDAPVFISGESGTGKELT
HEEEECCCCCCHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCEE
AVAIHERSSRAGAPFVAINCGAIPPTLLQAELFGYERGAFTGANQRKIGRIEAANGGTLF
EEEEECCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCEEE
LDEIGDLPFESQASLLRFLQEHKVERVGGHQSIPVDVRIISATHVDMQIALRNGRFREDL
EEHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEECCEEEEEECCCCHHHHH
YHRLCVLKLEEPPLRERGKDIEILARHMLERFKGDAHRRLRGFTPDAIAALHNYAWPGNV
HHHHEEEECCCCCHHHCCCCHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHCCCCCHH
RELINRVRRAIVMSEGRMISAADLELSGYAEVAPMSLEEARESAERHAIEVALLRHRGRL
HHHHHHHHHHHHHCCCCEEEEECCEECCCCHHCCCCHHHHHHHHHHHHHHHHHHHHCCHH
ADAARELGVSRVTLYRLLCAYGMRDDDGARAKRDEGLRRAC
HHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCHHHCCHHHCC
>Mature Secondary Structure
MDVAARHLIYYSHRPDADLQRCFDQHGWQVDVVDSPREMRRSAARDVIAGGLLDFSCGIG
CCCCCCEEEEECCCCCHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHCCCHHHCCCCC
AAELRELEASLKTPNVGWIATTRRGQMEDDAVRRLVRDYCFDYVTVPYECDRIVESVGHA
HHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHH
YGMVTLSEGLAPAAATVRNEGEMVGTCEAMLALFKMIRKVASTDAPVFISGESGTGKELT
HEEEECCCCCCHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCEE
AVAIHERSSRAGAPFVAINCGAIPPTLLQAELFGYERGAFTGANQRKIGRIEAANGGTLF
EEEEECCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCEEE
LDEIGDLPFESQASLLRFLQEHKVERVGGHQSIPVDVRIISATHVDMQIALRNGRFREDL
EEHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEECCEEEEEECCCCHHHHH
YHRLCVLKLEEPPLRERGKDIEILARHMLERFKGDAHRRLRGFTPDAIAALHNYAWPGNV
HHHHEEEECCCCCHHHCCCCHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHCCCCCHH
RELINRVRRAIVMSEGRMISAADLELSGYAEVAPMSLEEARESAERHAIEVALLRHRGRL
HHHHHHHHHHHHHCCCCEEEEECCEECCCCHHCCCCHHHHHHHHHHHHHHHHHHHHCCHH
ADAARELGVSRVTLYRLLCAYGMRDDDGARAKRDEGLRRAC
HHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCHHHCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]