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The map label for this gene is lepB [H]

Identifier: 237813196

GI number: 237813196

Start: 2884587

End: 2885480

Strand: Reverse

Name: lepB [H]

Synonym: GBP346_A2961

Alternate gene names: 237813196

Gene position: 2885480-2884587 (Counterclockwise)

Preceding gene: 237813197

Following gene: 237813195

Centisome position: 70.4

GC content: 61.97

Gene sequence:

>894_bases
ATGAATTTTGCGTTGATCCTTTTCGTGCTCGTCGTCGTGACGGGCATTGCGTGGGTGTTGGACAAGCTGGTTTTCCTGCC
GCGGCGGAAGAAGGCGGCGGATACGGCGGTCGCCGAGTTCGACCGCCAGCAGGAACGGGTCGGCGAGCGCTTCGCCGACG
AGAACGCGCCGCAGACGCGCGCGCGCCTGCGTGACGAGAAGCTGCGCCAGCCGTGGTGGCTCGAGTACACGGCGAGCTTC
TTTCCGGTGATTCTCGTCGTGTTCGTCGTGCGCTCGTTCGTGGTCGAGCCGTTCAAGATTCCGTCGGGCTCGATGGTGCC
GACGCTGCTCGTCGGCGATTTCATCCTTGTCAACAAGTTCGATTACGGCCTGCGCCTGCCGATCACGAATCAGAAGATCA
CCGCCGGCCGTCCGCTCGAGCGCGGCGACGTCGTCGTGTTCCGCTATCCGAAGGACGAATCGGTCGACTACATCAAGCGC
GTGATCGGCCTGCCGGGCGATACGGTCGCGTATCAGGACAAGAAGCTGACGATCAACGGCCAGCCCGTGCCCGAGGCGCC
GCTGCCCGATTACTTCGACGAAGAGCGGATGAACTATGCGAAGCAGTTCGAAGAAACGCTCGGCACGCGCAAGAACGCGA
TCCTGAACAATCCGTCGGTGCCGCCGTTCGTGATGGGGGCGGACGATTATCCCTATCGCAACAATTGCCAGTACGACAGC
CGCGGCGTCGTCTGCAAGGTGCCGCCCGGCCATTACTTCATGATGGGCGACAACCGCGACAACAGCGCGGACAGCCGTTA
CTGGGGCTTCGTGCCGGACAAGAACATCGTCGGCCGCGCGTTCTTCATCTGGATGAACTTCAGCGACCTCAAACGCATCG
GCTCGTTCAACTGA

Upstream 100 bases:

>100_bases
AGGCAAGAAACGAATGAAGCAGGTGGGTTCGGTCGAGATCCCGCAGGAGGCGTTCCTGGCGATCTTGCGAGTCGAAGACA
AATAACAGGACTGATCCTCT

Downstream 100 bases:

>100_bases
GCCGCGTCGAACGCTGCGACATGCCGCGCACGGGCTGCGCGGCGTGTTGCCGAACTACTTTAAGAACCGGCGGCAACACC
GCCTCGTCACGCCTTTTCGC

Product: signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MNFALILFVLVVVTGIAWVLDKLVFLPRRKKAADTAVAEFDRQQERVGERFADENAPQTRARLRDEKLRQPWWLEYTASF
FPVILVVFVVRSFVVEPFKIPSGSMVPTLLVGDFILVNKFDYGLRLPITNQKITAGRPLERGDVVVFRYPKDESVDYIKR
VIGLPGDTVAYQDKKLTINGQPVPEAPLPDYFDEERMNYAKQFEETLGTRKNAILNNPSVPPFVMGADDYPYRNNCQYDS
RGVVCKVPPGHYFMMGDNRDNSADSRYWGFVPDKNIVGRAFFIWMNFSDLKRIGSFN

Sequences:

>Translated_297_residues
MNFALILFVLVVVTGIAWVLDKLVFLPRRKKAADTAVAEFDRQQERVGERFADENAPQTRARLRDEKLRQPWWLEYTASF
FPVILVVFVVRSFVVEPFKIPSGSMVPTLLVGDFILVNKFDYGLRLPITNQKITAGRPLERGDVVVFRYPKDESVDYIKR
VIGLPGDTVAYQDKKLTINGQPVPEAPLPDYFDEERMNYAKQFEETLGTRKNAILNNPSVPPFVMGADDYPYRNNCQYDS
RGVVCKVPPGHYFMMGDNRDNSADSRYWGFVPDKNIVGRAFFIWMNFSDLKRIGSFN
>Mature_297_residues
MNFALILFVLVVVTGIAWVLDKLVFLPRRKKAADTAVAEFDRQQERVGERFADENAPQTRARLRDEKLRQPWWLEYTASF
FPVILVVFVVRSFVVEPFKIPSGSMVPTLLVGDFILVNKFDYGLRLPITNQKITAGRPLERGDVVVFRYPKDESVDYIKR
VIGLPGDTVAYQDKKLTINGQPVPEAPLPDYFDEERMNYAKQFEETLGTRKNAILNNPSVPPFVMGADDYPYRNNCQYDS
RGVVCKVPPGHYFMMGDNRDNSADSRYWGFVPDKNIVGRAFFIWMNFSDLKRIGSFN

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Escherichia coli, GI1788921, Length=323, Percent_Identity=42.4148606811146, Blast_Score=215, Evalue=2e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 34128; Mature: 34128

Theoretical pI: Translated: 8.90; Mature: 8.90

Prosite motif: PS00501 SPASE_I_1 ; PS00760 SPASE_I_2 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFALILFVLVVVTGIAWVLDKLVFLPRRKKAADTAVAEFDRQQERVGERFADENAPQTR
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
ARLRDEKLRQPWWLEYTASFFPVILVVFVVRSFVVEPFKIPSGSMVPTLLVGDFILVNKF
HHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCHHHHHCCEEEEEEC
DYGLRLPITNQKITAGRPLERGDVVVFRYPKDESVDYIKRVIGLPGDTVAYQDKKLTING
CCCEECCCCCCEECCCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCCCEEECCCEEEECC
QPVPEAPLPDYFDEERMNYAKQFEETLGTRKNAILNNPSVPPFVMGADDYPYRNNCQYDS
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHCCCCCCCCCEEECCCCCCCCCCCCCCC
RGVVCKVPPGHYFMMGDNRDNSADSRYWGFVPDKNIVGRAFFIWMNFSDLKRIGSFN
CCCEEEECCCCEEEEECCCCCCCCCCEECCCCCCCCCCEEEEEEECHHHHHHHCCCC
>Mature Secondary Structure
MNFALILFVLVVVTGIAWVLDKLVFLPRRKKAADTAVAEFDRQQERVGERFADENAPQTR
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
ARLRDEKLRQPWWLEYTASFFPVILVVFVVRSFVVEPFKIPSGSMVPTLLVGDFILVNKF
HHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCHHHHHCCEEEEEEC
DYGLRLPITNQKITAGRPLERGDVVVFRYPKDESVDYIKRVIGLPGDTVAYQDKKLTING
CCCEECCCCCCEECCCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCCCEEECCCEEEECC
QPVPEAPLPDYFDEERMNYAKQFEETLGTRKNAILNNPSVPPFVMGADDYPYRNNCQYDS
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHCCCCCCCCCEEECCCCCCCCCCCCCCC
RGVVCKVPPGHYFMMGDNRDNSADSRYWGFVPDKNIVGRAFFIWMNFSDLKRIGSFN
CCCEEEECCCCEEEEECCCCCCCCCCEECCCCCCCCCCEEEEEEECHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1546969 [H]