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The map label for this gene is rnc [H]

Identifier: 237813195

GI number: 237813195

Start: 2883033

End: 2884436

Strand: Reverse

Name: rnc [H]

Synonym: GBP346_A2960

Alternate gene names: 237813195

Gene position: 2884436-2883033 (Counterclockwise)

Preceding gene: 237813196

Following gene: 237813194

Centisome position: 70.38

GC content: 67.31

Gene sequence:

>1404_bases
ATGCCCCTATCCCAGTTGGAAAGCCGGCTGCGCTATGAATTTCGCAATGCGGAATTATTGCGCCAGGCTTTGACCCATCG
CAGTCACAGTGCCACGCATAACGAACGGCTCGAGTTTCTCGGCGATTCCGTTCTGAATTGCGCGGTGGCCGCCCTTTTGT
TTCAGCGCTTCGGCAAGCTGGACGAAGGCGATTTGTCGCGCGTACGGGCGAACCTCGTCAAGCAGCAGTCGCTGTACGAA
ATTGCTCAGGCCCTCAATATCTCGGACGGCTTGCGGCTCGGCGAAGGCGAACTGCGCAGCGGCGGATTCCGAAGACCGTC
GATCCTCGCGGACGCATTCGAAGCCATCATCGGGGCGGTGTTCCTCGATGGCGGCTTCGAAGCCGCCCAAGGGGTGATCA
AGCGGCTGTACGTGCCGATTCTCGACCATATCGATCCGCGCACGCTCGGCAAGGACGCGAAAACGCTGCTGCAGGAGTAT
CTGCAAGGCCACAAGATCGCGCTGCCGACCTACACCGTCGTCGCGACGCATGGTGCGGCGCACAATCAACAGTTCGAAGT
CGAGTGCACGGTGCCGAAGCTGGACATCAAGGTGTCCGGCTCGGGCGCGAGCCGCCGCGCGGCCGAGCAGGCCGCGGCGA
AGAAGGCGCTCGACGAGGTGACGGCGGTGGCGCCGATGCTCGCGGCGAAGCCGAAGCGCTCGAAGAGCGCGCGTGGCGCC
AAGCATGTGGAGCCGGAGATCGTGCCGGGCGTGAAGGGTGTGCAGGAGGCGCTCGATCTGCGCTCGCCTGAGCGCAAGGA
GCGCGGCGCGAACCGTGTGGCGGGCGGCGAGGCGAAGGGCGTCGAATCGAAGGCGGTCGACGCGAAGCACGGGGAATCGA
GGGCCGCGCAGTTGCGCGCGGACGACGCGAAGGCAGGCGAGACGAAGGCGGGCGAGGCAAGGGCTTCGGCGGACGCGAAA
GCCGGCGCGCACACCCACGCGGCCGCTATGCCCGCCGTGCCTGAGCAAGCCGATGATGCCGCCCGGTCGCCCGCGACGAC
GCCCGTTGCGGTGATCCGCGCGGCGCACGTCGAGCACGGCCTCGACAAGGGCGAGCCGCGCGCGTCGAAGCCGGCGGAAA
AACCCGCTGCGGCGACGGACAAGCCGCCGGAGAAGGCGAGCGACAAGCCGTCGCCGGAAAAAACGTCGGAAAAAACGCCG
GACAAGAGTCACGAGAAGCAGCTGGACAAGTCTTCCGAGCCGGTGGCGGAAAAGGCGCTCGACAAGACGGCGGACAAGCC
GGATGCCGCCGCGCGTCTCCCTGCCGAAACGGCCGACCGGCCGCCGCGCGCTCGCGACGCGTCGTCGTCCGCCGAGCCGG
ATCTGGCCGCCGCGCCCGTGCGCGTCGCCGATGCAGGTCATTGA

Upstream 100 bases:

>100_bases
CGAACTACTTTAAGAACCGGCGGCAACACCGCCTCGTCACGCCTTTTCGCGCCTGGTCGCGTTTCCCGACCGAAGCGGCG
CCCGCGTTATACTCCTGTCC

Downstream 100 bases:

>100_bases
CATCGTCCCAATCGACATCGCGGTCGCGCACGGTTGCGCGGCCGCTTCAGAACCCAGCAGCAGCCTGATATGAACGCACC
CGCTCCCACCGGTTTCCGTT

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 467; Mature: 466

Protein sequence:

>467_residues
MPLSQLESRLRYEFRNAELLRQALTHRSHSATHNERLEFLGDSVLNCAVAALLFQRFGKLDEGDLSRVRANLVKQQSLYE
IAQALNISDGLRLGEGELRSGGFRRPSILADAFEAIIGAVFLDGGFEAAQGVIKRLYVPILDHIDPRTLGKDAKTLLQEY
LQGHKIALPTYTVVATHGAAHNQQFEVECTVPKLDIKVSGSGASRRAAEQAAAKKALDEVTAVAPMLAAKPKRSKSARGA
KHVEPEIVPGVKGVQEALDLRSPERKERGANRVAGGEAKGVESKAVDAKHGESRAAQLRADDAKAGETKAGEARASADAK
AGAHTHAAAMPAVPEQADDAARSPATTPVAVIRAAHVEHGLDKGEPRASKPAEKPAAATDKPPEKASDKPSPEKTSEKTP
DKSHEKQLDKSSEPVAEKALDKTADKPDAAARLPAETADRPPRARDASSSAEPDLAAAPVRVADAGH

Sequences:

>Translated_467_residues
MPLSQLESRLRYEFRNAELLRQALTHRSHSATHNERLEFLGDSVLNCAVAALLFQRFGKLDEGDLSRVRANLVKQQSLYE
IAQALNISDGLRLGEGELRSGGFRRPSILADAFEAIIGAVFLDGGFEAAQGVIKRLYVPILDHIDPRTLGKDAKTLLQEY
LQGHKIALPTYTVVATHGAAHNQQFEVECTVPKLDIKVSGSGASRRAAEQAAAKKALDEVTAVAPMLAAKPKRSKSARGA
KHVEPEIVPGVKGVQEALDLRSPERKERGANRVAGGEAKGVESKAVDAKHGESRAAQLRADDAKAGETKAGEARASADAK
AGAHTHAAAMPAVPEQADDAARSPATTPVAVIRAAHVEHGLDKGEPRASKPAEKPAAATDKPPEKASDKPSPEKTSEKTP
DKSHEKQLDKSSEPVAEKALDKTADKPDAAARLPAETADRPPRARDASSSAEPDLAAAPVRVADAGH
>Mature_466_residues
PLSQLESRLRYEFRNAELLRQALTHRSHSATHNERLEFLGDSVLNCAVAALLFQRFGKLDEGDLSRVRANLVKQQSLYEI
AQALNISDGLRLGEGELRSGGFRRPSILADAFEAIIGAVFLDGGFEAAQGVIKRLYVPILDHIDPRTLGKDAKTLLQEYL
QGHKIALPTYTVVATHGAAHNQQFEVECTVPKLDIKVSGSGASRRAAEQAAAKKALDEVTAVAPMLAAKPKRSKSARGAK
HVEPEIVPGVKGVQEALDLRSPERKERGANRVAGGEAKGVESKAVDAKHGESRAAQLRADDAKAGETKAGEARASADAKA
GAHTHAAAMPAVPEQADDAARSPATTPVAVIRAAHVEHGLDKGEPRASKPAEKPAAATDKPPEKASDKPSPEKTSEKTPD
KSHEKQLDKSSEPVAEKALDKTADKPDAAARLPAETADRPPRARDASSSAEPDLAAAPVRVADAGH

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030234, Length=229, Percent_Identity=27.0742358078603, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI155030236, Length=229, Percent_Identity=27.0742358078603, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1788920, Length=206, Percent_Identity=51.9417475728155, Blast_Score=214, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI193202651, Length=197, Percent_Identity=32.48730964467, Blast_Score=97, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17506883, Length=197, Percent_Identity=32.48730964467, Blast_Score=96, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6323895, Length=97, Percent_Identity=38.1443298969072, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17137682, Length=242, Percent_Identity=28.9256198347107, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 49580; Mature: 49449

Theoretical pI: Translated: 8.64; Mature: 8.64

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLSQLESRLRYEFRNAELLRQALTHRSHSATHNERLEFLGDSVLNCAVAALLFQRFGKL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DEGDLSRVRANLVKQQSLYEIAQALNISDGLRLGEGELRSGGFRRPSILADAFEAIIGAV
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
FLDGGFEAAQGVIKRLYVPILDHIDPRTLGKDAKTLLQEYLQGHKIALPTYTVVATHGAA
HHCCCHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHCCCEEECCEEEEEEECCCC
HNQQFEVECTVPKLDIKVSGSGASRRAAEQAAAKKALDEVTAVAPMLAAKPKRSKSARGA
CCCEEEEEEECCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCC
KHVEPEIVPGVKGVQEALDLRSPERKERGANRVAGGEAKGVESKAVDAKHGESRAAQLRA
CCCCCCCCCCHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCCHHHCCCCCCCHHHHHHCC
DDAKAGETKAGEARASADAKAGAHTHAAAMPAVPEQADDAARSPATTPVAVIRAAHVEHG
CCCCCCCCCCCHHHHCCCHHCCCCHHHHHCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHC
LDKGEPRASKPAEKPAAATDKPPEKASDKPSPEKTSEKTPDKSHEKQLDKSSEPVAEKAL
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHH
DKTADKPDAAARLPAETADRPPRARDASSSAEPDLAAAPVRVADAGH
HHCCCCCCHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCEECCCCCC
>Mature Secondary Structure 
PLSQLESRLRYEFRNAELLRQALTHRSHSATHNERLEFLGDSVLNCAVAALLFQRFGKL
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DEGDLSRVRANLVKQQSLYEIAQALNISDGLRLGEGELRSGGFRRPSILADAFEAIIGAV
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
FLDGGFEAAQGVIKRLYVPILDHIDPRTLGKDAKTLLQEYLQGHKIALPTYTVVATHGAA
HHCCCHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHCCCEEECCEEEEEEECCCC
HNQQFEVECTVPKLDIKVSGSGASRRAAEQAAAKKALDEVTAVAPMLAAKPKRSKSARGA
CCCEEEEEEECCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCC
KHVEPEIVPGVKGVQEALDLRSPERKERGANRVAGGEAKGVESKAVDAKHGESRAAQLRA
CCCCCCCCCCHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCCHHHCCCCCCCHHHHHHCC
DDAKAGETKAGEARASADAKAGAHTHAAAMPAVPEQADDAARSPATTPVAVIRAAHVEHG
CCCCCCCCCCCHHHHCCCHHCCCCHHHHHCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHC
LDKGEPRASKPAEKPAAATDKPPEKASDKPSPEKTSEKTPDKSHEKQLDKSSEPVAEKAL
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHH
DKTADKPDAAARLPAETADRPPRARDASSSAEPDLAAAPVRVADAGH
HHCCCCCCHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]