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The map label for this gene is era [H]

Identifier: 237813194

GI number: 237813194

Start: 2882064

End: 2882963

Strand: Reverse

Name: era [H]

Synonym: GBP346_A2959

Alternate gene names: 237813194

Gene position: 2882963-2882064 (Counterclockwise)

Preceding gene: 237813195

Following gene: 237813193

Centisome position: 70.34

GC content: 64.11

Gene sequence:

>900_bases
ATGAACGCACCCGCTCCCACCGGTTTCCGTTGCGGCATGATCGCGATCGTCGGTCGTCCGAACGTCGGCAAGTCGACGCT
GATGAACGCACTCGTCGGCCAGAAGATCAGCATCACGTCGCGCAAGGCGCAGACGACCCGCCACCGGATCACCGGCATTC
ATACGCTCGACGATGCCCAGTACATCTTCGTCGACACGCCCGGTTTTCAGACCCGCCACAGCACCGCGCTCAACCGGTCG
CTGAACCGCGCGGTGACATCGACGCTCACGTCGGTCGACGCGATCCTGTTCGTGATCGAGGCGGGCCGCTTCGGCCCCGA
CGACCAGAAGGTGCTCGACCTGATTCCGCCCGGTACGCCGACGCTGCTCGTCGCGAACAAGCTCGACCGCGTGTCCGACA
AGGACACGCTGTACCCGTTCTTCCAGAAGATGGGCGGGCTGCGCGAGTTCGCGGAGATCGTGCCGCTGTCGGCGAAGCAT
CCGGAAGACATCCAGCGGCTGATGAACACGATCAAGCCGTATTTGCCGGAAGGCGACGCGATCTACGGCGAAGACGACCT
GACCGACCGCAGCTCGCGCTTCCTCGCGGCCGAGATCCTGCGCGAGAAGGTGTTCCGCTGGACGGGCGACGAGCTGCCCT
ACACGAGCACCGTCGTCATCGACAAGTTCGAGGAGGAGGGGCGGCTCACGCGCGTGTTCGCGACGATCCTCGTCGAGCGC
GATTCGCACAAGGCAATGGTGATCGGCAAGAAGGGCGCGAAGCTCAAGCAGATCAGCACCGAGGCGCGGCAGGACATGGA
GAAGCTGTTCGACGGCCCCGTCTATCTCGAAACTTTCGTCAAGGTGAGGAGCGGCTGGGCGGACAACGAAGCGGGGCTGC
GCGCCTATGGGTACGAATGA

Upstream 100 bases:

>100_bases
GCCCGTGCGCGTCGCCGATGCAGGTCATTGACATCGTCCCAATCGACATCGCGGTCGCGCACGGTTGCGCGGCCGCTTCA
GAACCCAGCAGCAGCCTGAT

Downstream 100 bases:

>100_bases
CGGGACGTCCGATGTCGGGATGACCGACGAGGCCGACGCCGACCCTCAACCCTTCGCCGCGCCGCCCGCAACCGGCGCGC
CGGCTGCCGACAAGCCGGCG

Product: GTP-binding protein Era

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MNAPAPTGFRCGMIAIVGRPNVGKSTLMNALVGQKISITSRKAQTTRHRITGIHTLDDAQYIFVDTPGFQTRHSTALNRS
LNRAVTSTLTSVDAILFVIEAGRFGPDDQKVLDLIPPGTPTLLVANKLDRVSDKDTLYPFFQKMGGLREFAEIVPLSAKH
PEDIQRLMNTIKPYLPEGDAIYGEDDLTDRSSRFLAAEILREKVFRWTGDELPYTSTVVIDKFEEEGRLTRVFATILVER
DSHKAMVIGKKGAKLKQISTEARQDMEKLFDGPVYLETFVKVRSGWADNEAGLRAYGYE

Sequences:

>Translated_299_residues
MNAPAPTGFRCGMIAIVGRPNVGKSTLMNALVGQKISITSRKAQTTRHRITGIHTLDDAQYIFVDTPGFQTRHSTALNRS
LNRAVTSTLTSVDAILFVIEAGRFGPDDQKVLDLIPPGTPTLLVANKLDRVSDKDTLYPFFQKMGGLREFAEIVPLSAKH
PEDIQRLMNTIKPYLPEGDAIYGEDDLTDRSSRFLAAEILREKVFRWTGDELPYTSTVVIDKFEEEGRLTRVFATILVER
DSHKAMVIGKKGAKLKQISTEARQDMEKLFDGPVYLETFVKVRSGWADNEAGLRAYGYE
>Mature_299_residues
MNAPAPTGFRCGMIAIVGRPNVGKSTLMNALVGQKISITSRKAQTTRHRITGIHTLDDAQYIFVDTPGFQTRHSTALNRS
LNRAVTSTLTSVDAILFVIEAGRFGPDDQKVLDLIPPGTPTLLVANKLDRVSDKDTLYPFFQKMGGLREFAEIVPLSAKH
PEDIQRLMNTIKPYLPEGDAIYGEDDLTDRSSRFLAAEILREKVFRWTGDELPYTSTVVIDKFEEEGRLTRVFATILVER
DSHKAMVIGKKGAKLKQISTEARQDMEKLFDGPVYLETFVKVRSGWADNEAGLRAYGYE

Specific function: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism [H]

COG id: COG1159

COG function: function code R; GTPase

Gene ontology:

Cell location: Cytoplasm. Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH type-2 domain [H]

Homologues:

Organism=Homo sapiens, GI24307899, Length=331, Percent_Identity=26.5861027190332, Blast_Score=91, Evalue=2e-18,
Organism=Escherichia coli, GI1788919, Length=290, Percent_Identity=50.6896551724138, Blast_Score=297, Evalue=6e-82,
Organism=Escherichia coli, GI87082120, Length=168, Percent_Identity=29.1666666666667, Blast_Score=64, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24646434, Length=305, Percent_Identity=26.2295081967213, Blast_Score=93, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005662
- InterPro:   IPR006073
- InterPro:   IPR015946
- InterPro:   IPR009019
- InterPro:   IPR004044
- InterPro:   IPR002917
- InterPro:   IPR005225 [H]

Pfam domain/function: PF07650 KH_2; PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 33383; Mature: 33383

Theoretical pI: Translated: 8.40; Mature: 8.40

Prosite motif: PS50823 KH_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAPAPTGFRCGMIAIVGRPNVGKSTLMNALVGQKISITSRKAQTTRHRITGIHTLDDAQ
CCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCEEECCHHHHHHHHHHCEEEEECCCE
YIFVDTPGFQTRHSTALNRSLNRAVTSTLTSVDAILFVIEAGRFGPDDQKVLDLIPPGTP
EEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCHHHEEECCCCCC
TLLVANKLDRVSDKDTLYPFFQKMGGLREFAEIVPLSAKHPEDIQRLMNTIKPYLPEGDA
EEEEEHHHHCCCCCCHHHHHHHHHCCHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCE
IYGEDDLTDRSSRFLAAEILREKVFRWTGDELPYTSTVVIDKFEEEGRLTRVFATILVER
EECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECHHHCCHHHHHHHHHHHCC
DSHKAMVIGKKGAKLKQISTEARQDMEKLFDGPVYLETFVKVRSGWADNEAGLRAYGYE
CCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCEECCCC
>Mature Secondary Structure
MNAPAPTGFRCGMIAIVGRPNVGKSTLMNALVGQKISITSRKAQTTRHRITGIHTLDDAQ
CCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCEEECCHHHHHHHHHHCEEEEECCCE
YIFVDTPGFQTRHSTALNRSLNRAVTSTLTSVDAILFVIEAGRFGPDDQKVLDLIPPGTP
EEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCHHHEEECCCCCC
TLLVANKLDRVSDKDTLYPFFQKMGGLREFAEIVPLSAKHPEDIQRLMNTIKPYLPEGDA
EEEEEHHHHCCCCCCHHHHHHHHHCCHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCE
IYGEDDLTDRSSRFLAAEILREKVFRWTGDELPYTSTVVIDKFEEEGRLTRVFATILVER
EECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECHHHCCHHHHHHHHHHHCC
DSHKAMVIGKKGAKLKQISTEARQDMEKLFDGPVYLETFVKVRSGWADNEAGLRAYGYE
CCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]