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The map label for this gene is lpxH [H]

Identifier: 237812910

GI number: 237812910

Start: 2613743

End: 2614543

Strand: Direct

Name: lpxH [H]

Synonym: GBP346_A2670

Alternate gene names: 237812910

Gene position: 2613743-2614543 (Clockwise)

Preceding gene: 237812909

Following gene: 237812911

Centisome position: 63.77

GC content: 68.54

Gene sequence:

>801_bases
ATGTTGCAGGAGACACCGCCACGAAGCGTGTTTGCGGGCGTGCCCGGCGAGCGCGGGCTCGCGCATGCGGCGCGCCCGTT
CCTGTTCGTCTCCGATCTGCACCTGAGCGACGCGATCCCGCATACGGTCGCCGCGTTCGAGCGCTTCGTACGCGTGACGG
CCGACAGCGCGGATTCGGTGTTCATCCTCGGCGATCTGTTCGAATACTGGATCGGCGACGATATCCTCGAGCACGATCCG
TTCGCCGCGCGGATGGCCGCGCTGCTGCACACGTTCTCCGAGCGCGGCATCGCGCTCTACGTAATGCACGGCAATCGCGA
CTTCCTGCTCGGCAAGCGCTTCATGAAAGCGGCGGGCGCGCTCCTCATTCCGGATCCGTCCGTCATCGTCGCGTTCGGCA
ACCGCATCGTGCTCGCGCATGGCGACGCGCAATGCACGGCCGATCGCGGCTACCAATGGTTTCGCCGCTTCGCGCGCAAC
GGCGTCGCGCAGCGGCTCTTTCTCGCGTGGCCGTTCGCGTGGCGCCGCGCGCTCGCGCAGCGGATGCGCGCGTCGAGCGA
AACCAGCCGGATGCGCCCCGCTTCGCCGCGCTACGACGTGACGCGCAAAGGCGTTGCCGCGCTCTTGCGGCGCAGCGGCG
CGCGCACGATCATCCACGGCCACACGCACAAGCCGGCGCGGCATGTCGAGGCAGACGGCGTGCGCTGGGTATTGCCCGAT
TGGGAGCTCGACCACGGCCTGCGACGCGGCGGTTATCTGCGCGTCGACGCGGAAGGAATACGCGCGCTGCCGCTCGATTG
A

Upstream 100 bases:

>100_bases
CAAGACGGGCAGCAAGGGCTTCCATCAGGACGTGCCGAACGACGACGTCGTGATCGAGAAGGCCGTCGTGGTCTGAAGCC
GGCGCGACGGGGGCAGCGGG

Downstream 100 bases:

>100_bases
GCGTCGCACCCGTTCGCGTCAAGCGGGCCGGGCGGTCAGGATGCGGTCTCGAAGCGGTCTCGAAGCGGTCTCGAAGCGAT
CAAGCAAGCCGCGCCACGAC

Product: UDP-2,3-diacylglucosamine hydrolase

Products: 2,3-bis(3-hydroxymyristoyl)-beta-D-glucosaminyl 1; UMP [C]

Alternate protein names: NA

Number of amino acids: Translated: 266; Mature: 266

Protein sequence:

>266_residues
MLQETPPRSVFAGVPGERGLAHAARPFLFVSDLHLSDAIPHTVAAFERFVRVTADSADSVFILGDLFEYWIGDDILEHDP
FAARMAALLHTFSERGIALYVMHGNRDFLLGKRFMKAAGALLIPDPSVIVAFGNRIVLAHGDAQCTADRGYQWFRRFARN
GVAQRLFLAWPFAWRRALAQRMRASSETSRMRPASPRYDVTRKGVAALLRRSGARTIIHGHTHKPARHVEADGVRWVLPD
WELDHGLRRGGYLRVDAEGIRALPLD

Sequences:

>Translated_266_residues
MLQETPPRSVFAGVPGERGLAHAARPFLFVSDLHLSDAIPHTVAAFERFVRVTADSADSVFILGDLFEYWIGDDILEHDP
FAARMAALLHTFSERGIALYVMHGNRDFLLGKRFMKAAGALLIPDPSVIVAFGNRIVLAHGDAQCTADRGYQWFRRFARN
GVAQRLFLAWPFAWRRALAQRMRASSETSRMRPASPRYDVTRKGVAALLRRSGARTIIHGHTHKPARHVEADGVRWVLPD
WELDHGLRRGGYLRVDAEGIRALPLD
>Mature_266_residues
MLQETPPRSVFAGVPGERGLAHAARPFLFVSDLHLSDAIPHTVAAFERFVRVTADSADSVFILGDLFEYWIGDDILEHDP
FAARMAALLHTFSERGIALYVMHGNRDFLLGKRFMKAAGALLIPDPSVIVAFGNRIVLAHGDAQCTADRGYQWFRRFARN
GVAQRLFLAWPFAWRRALAQRMRASSETSRMRPASPRYDVTRKGVAALLRRSGARTIIHGHTHKPARHVEADGVRWVLPD
WELDHGLRRGGYLRVDAEGIRALPLD

Specific function: Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP [H]

COG id: COG2908

COG function: function code S; Uncharacterized protein conserved in bacteria

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxH family [H]

Homologues:

Organism=Escherichia coli, GI1786735, Length=240, Percent_Identity=39.1666666666667, Blast_Score=173, Evalue=1e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004843
- InterPro:   IPR010138 [H]

Pfam domain/function: PF00149 Metallophos [H]

EC number: NA

Molecular weight: Translated: 29855; Mature: 29855

Theoretical pI: Translated: 10.65; Mature: 10.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQETPPRSVFAGVPGERGLAHAARPFLFVSDLHLSDAIPHTVAAFERFVRVTADSADSV
CCCCCCCCCEEECCCCCCCHHHHCCCEEEEECCCHHHCCHHHHHHHHHHHHHHCCCCCCE
FILGDLFEYWIGDDILEHDPFAARMAALLHTFSERGIALYVMHGNRDFLLGKRFMKAAGA
EEHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHCCE
LLIPDPSVIVAFGNRIVLAHGDAQCTADRGYQWFRRFARNGVAQRLFLAWPFAWRRALAQ
EECCCCCEEEEECCEEEEEECCCCCCHHCCHHHHHHHHHCCHHHHHHHHCCHHHHHHHHH
RMRASSETSRMRPASPRYDVTRKGVAALLRRSGARTIIHGHTHKPARHVEADGVRWVLPD
HHHCCCHHHHCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCEEEECCC
WELDHGLRRGGYLRVDAEGIRALPLD
CCHHHHHCCCCEEEEECCCCEECCCC
>Mature Secondary Structure
MLQETPPRSVFAGVPGERGLAHAARPFLFVSDLHLSDAIPHTVAAFERFVRVTADSADSV
CCCCCCCCCEEECCCCCCCHHHHCCCEEEEECCCHHHCCHHHHHHHHHHHHHHCCCCCCE
FILGDLFEYWIGDDILEHDPFAARMAALLHTFSERGIALYVMHGNRDFLLGKRFMKAAGA
EEHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHCCE
LLIPDPSVIVAFGNRIVLAHGDAQCTADRGYQWFRRFARNGVAQRLFLAWPFAWRRALAQ
EECCCCCEEEEECCEEEEEECCCCCCHHCCHHHHHHHHHCCHHHHHHHHCCHHHHHHHHH
RMRASSETSRMRPASPRYDVTRKGVAALLRRSGARTIIHGHTHKPARHVEADGVRWVLPD
HHHCCCHHHHCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCEEEECCC
WELDHGLRRGGYLRVDAEGIRALPLD
CCHHHHHCCCCEEEEECCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O; UDP-2,3-bis(3-hydroxymyristoyl)glucosamine [C]

Specific reaction: H2O + UDP-2,3-bis(3-hydroxymyristoyl)glucosamine = 2,3-bis(3-hydroxymyristoyl)-beta-D-glucosaminyl 1 + UMP [C]

General reaction: Lipid A biosynthesis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]