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The map label for this gene is cyp18 [H]

Identifier: 237812909

GI number: 237812909

Start: 2613227

End: 2613718

Strand: Direct

Name: cyp18 [H]

Synonym: GBP346_A2669

Alternate gene names: 237812909

Gene position: 2613227-2613718 (Clockwise)

Preceding gene: 237812908

Following gene: 237812910

Centisome position: 63.76

GC content: 59.96

Gene sequence:

>492_bases
ATGGTCGAACTGCATACGAACCACGGCGTCATCAAGCTCGAACTCGACGAAGCGAAGGCGCCGAAGACGGTCGAGAACTT
CCTGAACTACGTGAAGAAGGGCCACTACGACGGCACGATCTTCCATCGCGTGATCAACGGTTTCATGATCCAGGGCGGCG
GCTTCGAGCCGGGCCTGAAGCAAAAGCCGACCGACGCGCCGATCGCGAACGAAGCGAACAACGGCCTGAAGAACGATACG
TATACGATCGCGATGGCGCGCACGAACGATCCGCACTCGGCGACCGCGCAGTTCTTCATCAACGTGAACGACAACGAATT
CCTGAACCACTCGTCGCCGACCCCGCAGGGCTGGGGCTATGCGGTGTTCGGCAAGGTCGTCGAAGGCCAGGACATCGTCG
ACAAGATCAAGGCCGTCAAGACGGGCAGCAAGGGCTTCCATCAGGACGTGCCGAACGACGACGTCGTGATCGAGAAGGCC
GTCGTGGTCTGA

Upstream 100 bases:

>100_bases
CGACGATCGTCTCGAAATAAGCCGGCCCGAGCCTCTCGCGCGGCCGCGCCGTCCCGAGCGGCCGCGCGCCGTTTAAACCC
CATCCATCGAAGGAACCATC

Downstream 100 bases:

>100_bases
AGCCGGCGCGACGGGGGCAGCGGGATGTTGCAGGAGACACCGCCACGAAGCGTGTTTGCGGGCGTGCCCGGCGAGCGCGG
GCTCGCGCATGCGGCGCGCC

Product: peptidyl-prolyl cis-trans isomerase B

Products: NA

Alternate protein names: PPIase cyp18; SanCyp18; Rotamase cyp18 [H]

Number of amino acids: Translated: 163; Mature: 163

Protein sequence:

>163_residues
MVELHTNHGVIKLELDEAKAPKTVENFLNYVKKGHYDGTIFHRVINGFMIQGGGFEPGLKQKPTDAPIANEANNGLKNDT
YTIAMARTNDPHSATAQFFINVNDNEFLNHSSPTPQGWGYAVFGKVVEGQDIVDKIKAVKTGSKGFHQDVPNDDVVIEKA
VVV

Sequences:

>Translated_163_residues
MVELHTNHGVIKLELDEAKAPKTVENFLNYVKKGHYDGTIFHRVINGFMIQGGGFEPGLKQKPTDAPIANEANNGLKNDT
YTIAMARTNDPHSATAQFFINVNDNEFLNHSSPTPQGWGYAVFGKVVEGQDIVDKIKAVKTGSKGFHQDVPNDDVVIEKA
VVV
>Mature_163_residues
MVELHTNHGVIKLELDEAKAPKTVENFLNYVKKGHYDGTIFHRVINGFMIQGGGFEPGLKQKPTDAPIANEANNGLKNDT
YTIAMARTNDPHSATAQFFINVNDNEFLNHSSPTPQGWGYAVFGKVVEGQDIVDKIKAVKTGSKGFHQDVPNDDVVIEKA
VVV

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI7706339, Length=164, Percent_Identity=34.1463414634146, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI22547212, Length=163, Percent_Identity=33.1288343558282, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI7657473, Length=163, Percent_Identity=33.1288343558282, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI22547215, Length=163, Percent_Identity=33.1288343558282, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI24308049, Length=165, Percent_Identity=33.3333333333333, Blast_Score=77, Evalue=7e-15,
Organism=Homo sapiens, GI19557636, Length=165, Percent_Identity=30.9090909090909, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI310110104, Length=134, Percent_Identity=36.5671641791045, Blast_Score=65, Evalue=3e-11,
Organism=Escherichia coli, GI1786736, Length=162, Percent_Identity=66.6666666666667, Blast_Score=226, Evalue=4e-61,
Organism=Escherichia coli, GI1789763, Length=162, Percent_Identity=56.7901234567901, Blast_Score=173, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI71980590, Length=147, Percent_Identity=35.3741496598639, Blast_Score=82, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71980594, Length=147, Percent_Identity=35.3741496598639, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17532641, Length=172, Percent_Identity=31.3953488372093, Blast_Score=79, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17506311, Length=143, Percent_Identity=32.1678321678322, Blast_Score=70, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17539496, Length=162, Percent_Identity=32.0987654320988, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI19922912, Length=162, Percent_Identity=37.6543209876543, Blast_Score=77, Evalue=5e-15,
Organism=Drosophila melanogaster, GI17986117, Length=163, Percent_Identity=30.0613496932515, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19922376, Length=172, Percent_Identity=29.6511627906977, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 17890; Mature: 17890

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVELHTNHGVIKLELDEAKAPKTVENFLNYVKKGHYDGTIFHRVINGFMIQGGGFEPGLK
CEEEECCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCHHHHHHHCCEEEECCCCCCCCC
QKPTDAPIANEANNGLKNDTYTIAMARTNDPHSATAQFFINVNDNEFLNHSSPTPQGWGY
CCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCE
AVFGKVVEGQDIVDKIKAVKTGSKGFHQDVPNDDVVIEKAVVV
EEEEEEECCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECC
>Mature Secondary Structure
MVELHTNHGVIKLELDEAKAPKTVENFLNYVKKGHYDGTIFHRVINGFMIQGGGFEPGLK
CEEEECCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCHHHHHHHCCEEEECCCCCCCCC
QKPTDAPIANEANNGLKNDTYTIAMARTNDPHSATAQFFINVNDNEFLNHSSPTPQGWGY
CCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCE
AVFGKVVEGQDIVDKIKAVKTGSKGFHQDVPNDDVVIEKAVVV
EEEEEEECCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10400660 [H]