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The map label for this gene is rotA [H]

Identifier: 237812908

GI number: 237812908

Start: 2612571

End: 2613146

Strand: Direct

Name: rotA [H]

Synonym: GBP346_A2668

Alternate gene names: 237812908

Gene position: 2612571-2613146 (Clockwise)

Preceding gene: 237812907

Following gene: 237812909

Centisome position: 63.74

GC content: 64.58

Gene sequence:

>576_bases
ATGAAACGTCTGTTGCTGGCGCTCGGCAGCGCCGCCCTCCTCGCGACCGCCCCCGCGTTCGCGCAATCGGCCGCGACGCA
CCCCGTCGTGCAGCTGAAGACCACGCAGGGCGACATCCGCGTCGAGCTGTATCCGGAGAAGGCGCCGAAGACCGTCGCCA
ACTTCCTTGATTACGTGAAGGCGGGCCAGTACAACGGCACGATCTTCCATCGCGTGATCAAGGGCTTCATGATCCAGGGC
GGCGGCTACAAGACGAACTTCGACGAGAAGCCGACCCGCGCGCCGATCCCGCTCGAGAGCAAGAACGGGCTGAAGAACGC
GACGGGCACGATCGCGATGGCGCGCACGAGCGATCCGAACTCGGCCACCGCGCAATTCTTCATCAACACCGTCGACAACG
CGGGCCTCGACTATCCGAACCCGGACGGCAACGGCTACGCGGTGTTCGGCAAGGTCGTGTCGGGCCTGGACGTCGTGAAG
AAGATCGAGGCTACCCCGACGACGGTGCGCGGCCCGATGCGCGACGTGCCGGAAAAGCCGATCGTGATCGAATCGGCGAC
GATCGTCTCGAAATAA

Upstream 100 bases:

>100_bases
GCGGCATGCTCGCGATGCCGCCTTACGCCGCGCCGTCACAATGACGCAATGACGCGCGGCTGCCGCCGCGCCTTTCCTTC
CACCCACCCAGAGGACCGTT

Downstream 100 bases:

>100_bases
GCCGGCCCGAGCCTCTCGCGCGGCCGCGCCGTCCCGAGCGGCCGCGCGCCGTTTAAACCCCATCCATCGAAGGAACCATC
ATGGTCGAACTGCATACGAA

Product: peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase A; Cyclophilin A; Rotamase A [H]

Number of amino acids: Translated: 191; Mature: 191

Protein sequence:

>191_residues
MKRLLLALGSAALLATAPAFAQSAATHPVVQLKTTQGDIRVELYPEKAPKTVANFLDYVKAGQYNGTIFHRVIKGFMIQG
GGYKTNFDEKPTRAPIPLESKNGLKNATGTIAMARTSDPNSATAQFFINTVDNAGLDYPNPDGNGYAVFGKVVSGLDVVK
KIEATPTTVRGPMRDVPEKPIVIESATIVSK

Sequences:

>Translated_191_residues
MKRLLLALGSAALLATAPAFAQSAATHPVVQLKTTQGDIRVELYPEKAPKTVANFLDYVKAGQYNGTIFHRVIKGFMIQG
GGYKTNFDEKPTRAPIPLESKNGLKNATGTIAMARTSDPNSATAQFFINTVDNAGLDYPNPDGNGYAVFGKVVSGLDVVK
KIEATPTTVRGPMRDVPEKPIVIESATIVSK
>Mature_191_residues
MKRLLLALGSAALLATAPAFAQSAATHPVVQLKTTQGDIRVELYPEKAPKTVANFLDYVKAGQYNGTIFHRVIKGFMIQG
GGYKTNFDEKPTRAPIPLESKNGLKNATGTIAMARTSDPNSATAQFFINTVDNAGLDYPNPDGNGYAVFGKVVSGLDVVK
KIEATPTTVRGPMRDVPEKPIVIESATIVSK

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI19557636, Length=166, Percent_Identity=36.7469879518072, Blast_Score=90, Evalue=1e-18,
Organism=Homo sapiens, GI22547212, Length=162, Percent_Identity=34.5679012345679, Blast_Score=85, Evalue=3e-17,
Organism=Homo sapiens, GI7657473, Length=162, Percent_Identity=34.5679012345679, Blast_Score=85, Evalue=3e-17,
Organism=Homo sapiens, GI22547215, Length=162, Percent_Identity=34.5679012345679, Blast_Score=85, Evalue=4e-17,
Organism=Homo sapiens, GI5454154, Length=185, Percent_Identity=35.1351351351351, Blast_Score=80, Evalue=8e-16,
Organism=Homo sapiens, GI24308049, Length=189, Percent_Identity=32.8042328042328, Blast_Score=80, Evalue=8e-16,
Organism=Homo sapiens, GI7706339, Length=162, Percent_Identity=33.9506172839506, Blast_Score=78, Evalue=5e-15,
Organism=Homo sapiens, GI4758950, Length=194, Percent_Identity=33.5051546391753, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI64276486, Length=181, Percent_Identity=30.3867403314917, Blast_Score=71, Evalue=6e-13,
Organism=Homo sapiens, GI10863927, Length=140, Percent_Identity=35, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1789763, Length=190, Percent_Identity=53.1578947368421, Blast_Score=182, Evalue=1e-47,
Organism=Escherichia coli, GI1786736, Length=162, Percent_Identity=53.0864197530864, Blast_Score=177, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI71980594, Length=137, Percent_Identity=40.1459854014599, Blast_Score=93, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI71980590, Length=137, Percent_Identity=40.1459854014599, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17539496, Length=142, Percent_Identity=35.2112676056338, Blast_Score=77, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17552780, Length=207, Percent_Identity=31.4009661835749, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17559074, Length=158, Percent_Identity=34.1772151898734, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17532641, Length=167, Percent_Identity=32.9341317365269, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17566266, Length=158, Percent_Identity=33.5443037974684, Blast_Score=70, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17506311, Length=142, Percent_Identity=34.5070422535211, Blast_Score=70, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17565860, Length=167, Percent_Identity=31.7365269461078, Blast_Score=68, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17506307, Length=140, Percent_Identity=35, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17532643, Length=175, Percent_Identity=34.8571428571429, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6323562, Length=160, Percent_Identity=36.25, Blast_Score=69, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6320359, Length=139, Percent_Identity=35.9712230215827, Blast_Score=64, Evalue=1e-11,
Organism=Drosophila melanogaster, GI19922912, Length=166, Percent_Identity=36.7469879518072, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17986117, Length=170, Percent_Identity=31.7647058823529, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI19922376, Length=170, Percent_Identity=32.3529411764706, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI45549139, Length=135, Percent_Identity=40.7407407407407, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI20130249, Length=157, Percent_Identity=36.3057324840764, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24652460, Length=149, Percent_Identity=30.8724832214765, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24664125, Length=157, Percent_Identity=34.3949044585987, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI21357783, Length=157, Percent_Identity=34.3949044585987, Blast_Score=68, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 20393; Mature: 20393

Theoretical pI: Translated: 10.04; Mature: 10.04

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRLLLALGSAALLATAPAFAQSAATHPVVQLKTTQGDIRVELYPEKAPKTVANFLDYVK
CCCEEEHHCCHHHHHHCCHHHHHCCCCCEEEEEECCCCEEEEEECCCCHHHHHHHHHHHH
AGQYNGTIFHRVIKGFMIQGGGYKTNFDEKPTRAPIPLESKNGLKNATGTIAMARTSDPN
CCCCCCHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCC
SATAQFFINTVDNAGLDYPNPDGNGYAVFGKVVSGLDVVKKIEATPTTVRGPMRDVPEKP
CCEEEEEEECCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCC
IVIESATIVSK
EEEECCEECCC
>Mature Secondary Structure
MKRLLLALGSAALLATAPAFAQSAATHPVVQLKTTQGDIRVELYPEKAPKTVANFLDYVK
CCCEEEHHCCHHHHHHCCHHHHHCCCCCEEEEEECCCCEEEEEECCCCHHHHHHHHHHHH
AGQYNGTIFHRVIKGFMIQGGGYKTNFDEKPTRAPIPLESKNGLKNATGTIAMARTSDPN
CCCCCCHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCC
SATAQFFINTVDNAGLDYPNPDGNGYAVFGKVVSGLDVVKKIEATPTTVRGPMRDVPEKP
CCEEEEEEECCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCC
IVIESATIVSK
EEEECCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9418240 [H]