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The map label for this gene is tycA [H]

Identifier: 237812889

GI number: 237812889

Start: 2590115

End: 2592016

Strand: Reverse

Name: tycA [H]

Synonym: GBP346_A2648

Alternate gene names: 237812889

Gene position: 2592016-2590115 (Counterclockwise)

Preceding gene: 237812890

Following gene: 237812888

Centisome position: 63.24

GC content: 72.92

Gene sequence:

>1902_bases
GTGCGCGGCGTGACGCCGCCGCTCCGTTCCTTCCTTCGCCGATGGCCAATAGCGAGACAAACGATGAGCGTTCACGACAT
GACTCACCCGGGCGAGCTCGCACCGGTGCGAGCGGACCGATTCGGCCGGCGGTTCGCGACGGCGGCCGCGGCCGAGATCG
CCGCCGCCGATTCGCTGACGGCGCGATTCGCCGACGTGGCCGCGCGCCGGGGCGATGCGCTCGCGGTGACGTGCGGCGAC
GAACGCTGGACGTACGGCGCGCTTGCGGCACGCGCGCGCCGCATCGCCGAAGCGGTTCGCGCGGCGGGCGAGGCGGGCGG
CGAACCGGTCGCGCTCCTCTATCCGCACGGCGCGCCGATGATCGCCGCGATGTTCGGCGTGCTCGGCGCCGGCAAGTTCT
ACGTCCCGCTGATCGCCGACCATCCGCTGCCGCACCTGCAATCGATCGTGCGCGAGTGCGGCTGCCGGCTCGTGCTCGCC
GCGCCCGAGCTCGCCGAGACGGCCGCGCGCCTCGGCGTCTCGGCGCGCGTCATCGACGACGCGCGCCTGCCGCCGGCGCA
CGGCCCGTTCGACGCGCGCGGCGGCGACGCGGTTTCGTATCTGCTGTTCACGTCGGGCACGACCGGCGTGCCGAAGGGCG
TGATGCAGTGCGACCGCAATGTGCTGCACCACGCCGCGTGCTACGCGGCGTCGATCGGCCTTGACGACGACGACCGGATG
ACGCTGCTGCCGTACTACGGCTTCGACGCGTCGGTGATGGACATCTTCGCCACGCTGCTGACGGGCGCGAGCCTGCATCT
GTGGGACGTGCGCGAGCGCGGCGTCGACGGCATCGGCGAATGGCTCGCGCGCGAGCGCATGACGATCTGGCATTCGACGC
CGAGCGTGCTGCGCGCCACGTTTGCCGCCTTCGCGCGGCCGGCCGCGCTGCGCTGGGTCGTGCTGGGCGGCGAGGCCGCG
ACGGGCGGCGACGTCGCGCTCGTCGCGCGGCACGGCGGCCCGCGATGCCGGCTGCTCAACGGCCTGGGGCCGACCGAATG
CACGACGGCGCTGCAATACGTCGCCGATCCCGCCGCCGATGCGAGTGTCGCGCGTCTGCCCGTCGGCCGGCCGGTGCCGG
GCGTCGAGGTCGAGCTCGCCGATGCGCGGGGCGAAGCCTGCGCGACCGAGGGCGAACTCGTGATCGTCAGCCCCTTCGTC
GCGCTCGGGTACTGGGGGCGCGCGGAGCTGAGCGCCGAGCGCTTTCGCCAGACGGCGCGCCCGGACGGCGCGCGGCGGTA
TCGCACGGGCGATCTGCTGCGGATCGACGCGCGCGGCTGCTACGAACATCTGACGCGGGTCGACGATCAGATCAAGATTC
GCGGCCTGCGCGTCGAACTCGGCGAAATCCAGGCGACGCTCGCCGCGCATGACGACGTGCTTCAGGCGGTCGTGCTGCCG
CGCCTTGACGAAGCCACGCAGCAGCAGACGATCGTCGCGTACGTCGTGCCGCGCGCGGCGTCGGCCGACGTCGCGGCGCT
GCGCGAATACGTCGCGAGCCGTTTGCCCGCGCACATGGTGCCGCGCGCGATCGTTCGCGTCGATGCGATGCCGTTGCTGC
CGAACGGCAAGCTGAATCGCCGCGCGCTGCCGGCGCCGCCGCGCGCGGAAGTGGCGGCGGGCGAGCGCAAGGCGCCGCGC
ACGCCGTTGCACCGGCTGCTCGCCGCATGCTGGGCCGACGTGCTGCGGCGCGACACGGTGGGCATCGACGAGAACTTCTT
CGAACTCGGCGGCGATTCGCTGCTCGGCGCGCAACTGCTGTCGCGCGTGAAGCGCGACCTCGAGCTCGACGCGCGGCTCG
GCGACCTGTTTCGCCATCCGACAGTCGAGTCGCTGGCCGAGCATCTGCTGGCTTGCCGATGA

Upstream 100 bases:

>100_bases
GCATCGATACGACGACGCACGACGTCGAGGACGCGACGCAGATGCTGCGCCGCTACTACGTCGACGCGCGCCTGTCCGGC
GCGCGTGCGGGCACCGCCGA

Downstream 100 bases:

>100_bases
TCGGCCTCGCGGCCGCGGACATGGCGATGCGAATTCCGATGCGATCAACCGATTCGGCGAGACGGACATGACCGACAGCA
TGCAGGATAGCCTCGACGAA

Product: amino acid adenylation domain protein

Products: NA

Alternate protein names: Tyrocidine synthase I; ATP-dependent D-phenylalanine adenylase; D-PheA; D-phenylalanine activase; Phenylalanine racemase [ATP-hydrolyzing] [H]

Number of amino acids: Translated: 633; Mature: 633

Protein sequence:

>633_residues
MRGVTPPLRSFLRRWPIARQTMSVHDMTHPGELAPVRADRFGRRFATAAAAEIAAADSLTARFADVAARRGDALAVTCGD
ERWTYGALAARARRIAEAVRAAGEAGGEPVALLYPHGAPMIAAMFGVLGAGKFYVPLIADHPLPHLQSIVRECGCRLVLA
APELAETAARLGVSARVIDDARLPPAHGPFDARGGDAVSYLLFTSGTTGVPKGVMQCDRNVLHHAACYAASIGLDDDDRM
TLLPYYGFDASVMDIFATLLTGASLHLWDVRERGVDGIGEWLARERMTIWHSTPSVLRATFAAFARPAALRWVVLGGEAA
TGGDVALVARHGGPRCRLLNGLGPTECTTALQYVADPAADASVARLPVGRPVPGVEVELADARGEACATEGELVIVSPFV
ALGYWGRAELSAERFRQTARPDGARRYRTGDLLRIDARGCYEHLTRVDDQIKIRGLRVELGEIQATLAAHDDVLQAVVLP
RLDEATQQQTIVAYVVPRAASADVAALREYVASRLPAHMVPRAIVRVDAMPLLPNGKLNRRALPAPPRAEVAAGERKAPR
TPLHRLLAACWADVLRRDTVGIDENFFELGGDSLLGAQLLSRVKRDLELDARLGDLFRHPTVESLAEHLLACR

Sequences:

>Translated_633_residues
MRGVTPPLRSFLRRWPIARQTMSVHDMTHPGELAPVRADRFGRRFATAAAAEIAAADSLTARFADVAARRGDALAVTCGD
ERWTYGALAARARRIAEAVRAAGEAGGEPVALLYPHGAPMIAAMFGVLGAGKFYVPLIADHPLPHLQSIVRECGCRLVLA
APELAETAARLGVSARVIDDARLPPAHGPFDARGGDAVSYLLFTSGTTGVPKGVMQCDRNVLHHAACYAASIGLDDDDRM
TLLPYYGFDASVMDIFATLLTGASLHLWDVRERGVDGIGEWLARERMTIWHSTPSVLRATFAAFARPAALRWVVLGGEAA
TGGDVALVARHGGPRCRLLNGLGPTECTTALQYVADPAADASVARLPVGRPVPGVEVELADARGEACATEGELVIVSPFV
ALGYWGRAELSAERFRQTARPDGARRYRTGDLLRIDARGCYEHLTRVDDQIKIRGLRVELGEIQATLAAHDDVLQAVVLP
RLDEATQQQTIVAYVVPRAASADVAALREYVASRLPAHMVPRAIVRVDAMPLLPNGKLNRRALPAPPRAEVAAGERKAPR
TPLHRLLAACWADVLRRDTVGIDENFFELGGDSLLGAQLLSRVKRDLELDARLGDLFRHPTVESLAEHLLACR
>Mature_633_residues
MRGVTPPLRSFLRRWPIARQTMSVHDMTHPGELAPVRADRFGRRFATAAAAEIAAADSLTARFADVAARRGDALAVTCGD
ERWTYGALAARARRIAEAVRAAGEAGGEPVALLYPHGAPMIAAMFGVLGAGKFYVPLIADHPLPHLQSIVRECGCRLVLA
APELAETAARLGVSARVIDDARLPPAHGPFDARGGDAVSYLLFTSGTTGVPKGVMQCDRNVLHHAACYAASIGLDDDDRM
TLLPYYGFDASVMDIFATLLTGASLHLWDVRERGVDGIGEWLARERMTIWHSTPSVLRATFAAFARPAALRWVVLGGEAA
TGGDVALVARHGGPRCRLLNGLGPTECTTALQYVADPAADASVARLPVGRPVPGVEVELADARGEACATEGELVIVSPFV
ALGYWGRAELSAERFRQTARPDGARRYRTGDLLRIDARGCYEHLTRVDDQIKIRGLRVELGEIQATLAAHDDVLQAVVLP
RLDEATQQQTIVAYVVPRAASADVAALREYVASRLPAHMVPRAIVRVDAMPLLPNGKLNRRALPAPPRAEVAAGERKAPR
TPLHRLLAACWADVLRRDTVGIDENFFELGGDSLLGAQLLSRVKRDLELDARLGDLFRHPTVESLAEHLLACR

Specific function: In the first step of peptide synthesis this enzyme activates phenylalanine and racemizes it to the D-isomer [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 acyl carrier domain [H]

Homologues:

Organism=Homo sapiens, GI45580730, Length=453, Percent_Identity=25.3863134657837, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI13325057, Length=523, Percent_Identity=26.5774378585086, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI156151445, Length=528, Percent_Identity=21.780303030303, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI1786801, Length=624, Percent_Identity=28.6858974358974, Blast_Score=180, Evalue=2e-46,
Organism=Escherichia coli, GI145693145, Length=502, Percent_Identity=25.8964143426295, Blast_Score=95, Evalue=2e-20,
Organism=Escherichia coli, GI1788107, Length=547, Percent_Identity=24.8628884826325, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1789201, Length=351, Percent_Identity=28.4900284900285, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1790505, Length=382, Percent_Identity=26.4397905759162, Blast_Score=78, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17531443, Length=442, Percent_Identity=23.5294117647059, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17556356, Length=301, Percent_Identity=25.5813953488372, Blast_Score=77, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6319591, Length=650, Percent_Identity=25.6923076923077, Blast_Score=173, Evalue=9e-44,
Organism=Drosophila melanogaster, GI18859661, Length=375, Percent_Identity=25.3333333333333, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24581924, Length=358, Percent_Identity=26.2569832402235, Blast_Score=77, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010071
- InterPro:   IPR009081
- InterPro:   IPR020459
- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR001242
- InterPro:   IPR010060
- InterPro:   IPR006163
- InterPro:   IPR006162 [H]

Pfam domain/function: PF00501 AMP-binding; PF00668 Condensation; PF00550 PP-binding [H]

EC number: =5.1.1.11 [H]

Molecular weight: Translated: 68206; Mature: 68206

Theoretical pI: Translated: 7.76; Mature: 7.76

Prosite motif: PS00012 PHOSPHOPANTETHEINE ; PS50075 ACP_DOMAIN ; PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGVTPPLRSFLRRWPIARQTMSVHDMTHPGELAPVRADRFGRRFATAAAAEIAAADSLT
CCCCCHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
ARFADVAARRGDALAVTCGDERWTYGALAARARRIAEAVRAAGEAGGEPVALLYPHGAPM
HHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHH
IAAMFGVLGAGKFYVPLIADHPLPHLQSIVRECGCRLVLAAPELAETAARLGVSARVIDD
HHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCCCEEEEECCHHHHHHHHHCCCEEEECC
ARLPPAHGPFDARGGDAVSYLLFTSGTTGVPKGVMQCDRNVLHHAACYAASIGLDDDDRM
CCCCCCCCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCE
TLLPYYGFDASVMDIFATLLTGASLHLWDVRERGVDGIGEWLARERMTIWHSTPSVLRAT
EEEEECCCCHHHHHHHHHHHCCCCEEEEECHHHCCCHHHHHHHHCCCEEECCCHHHHHHH
FAAFARPAALRWVVLGGEAATGGDVALVARHGGPRCRLLNGLGPTECTTALQYVADPAAD
HHHHHCCCEEEEEEECCCCCCCCCEEEEEECCCCCEEEECCCCCHHHHHHHHHHHCCCCC
ASVARLPVGRPVPGVEVELADARGEACATEGELVIVSPFVALGYWGRAELSAERFRQTAR
CCHHCCCCCCCCCCCEEEEECCCCCCCCCCCCEEEEEHHHHHCCCCCCHHHHHHHHHHCC
PDGARRYRTGDLLRIDARGCYEHLTRVDDQIKIRGLRVELGEIQATLAAHDDVLQAVVLP
CCCCCCCCCCCEEEECCHHHHHHHHCCCCCEEEEEEEEEHHHHHHHHHHHHHHHHHHHHC
RLDEATQQQTIVAYVVPRAASADVAALREYVASRLPAHMVPRAIVRVDAMPLLPNGKLNR
CCCHHHHHCEEEEEEECCCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCC
RALPAPPRAEVAAGERKAPRTPLHRLLAACWADVLRRDTVGIDENFFELGGDSLLGAQLL
CCCCCCCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCHHHHHHHH
SRVKRDLELDARLGDLFRHPTVESLAEHLLACR
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MRGVTPPLRSFLRRWPIARQTMSVHDMTHPGELAPVRADRFGRRFATAAAAEIAAADSLT
CCCCCHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
ARFADVAARRGDALAVTCGDERWTYGALAARARRIAEAVRAAGEAGGEPVALLYPHGAPM
HHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHH
IAAMFGVLGAGKFYVPLIADHPLPHLQSIVRECGCRLVLAAPELAETAARLGVSARVIDD
HHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCCCEEEEECCHHHHHHHHHCCCEEEECC
ARLPPAHGPFDARGGDAVSYLLFTSGTTGVPKGVMQCDRNVLHHAACYAASIGLDDDDRM
CCCCCCCCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCE
TLLPYYGFDASVMDIFATLLTGASLHLWDVRERGVDGIGEWLARERMTIWHSTPSVLRAT
EEEEECCCCHHHHHHHHHHHCCCCEEEEECHHHCCCHHHHHHHHCCCEEECCCHHHHHHH
FAAFARPAALRWVVLGGEAATGGDVALVARHGGPRCRLLNGLGPTECTTALQYVADPAAD
HHHHHCCCEEEEEEECCCCCCCCCEEEEEECCCCCEEEECCCCCHHHHHHHHHHHCCCCC
ASVARLPVGRPVPGVEVELADARGEACATEGELVIVSPFVALGYWGRAELSAERFRQTAR
CCHHCCCCCCCCCCCEEEEECCCCCCCCCCCCEEEEEHHHHHCCCCCCHHHHHHHHHHCC
PDGARRYRTGDLLRIDARGCYEHLTRVDDQIKIRGLRVELGEIQATLAAHDDVLQAVVLP
CCCCCCCCCCCEEEECCHHHHHHHHCCCCCEEEEEEEEEHHHHHHHHHHHHHHHHHHHHC
RLDEATQQQTIVAYVVPRAASADVAALREYVASRLPAHMVPRAIVRVDAMPLLPNGKLNR
CCCHHHHHCEEEEEEECCCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCC
RALPAPPRAEVAAGERKAPRTPLHRLLAACWADVLRRDTVGIDENFFELGGDSLLGAQLL
CCCCCCCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCHHHHHHHH
SRVKRDLELDARLGDLFRHPTVESLAEHLLACR
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3267240; 9352938; 3032912; 8193142 [H]