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The map label for this gene is cysNC [H]

Identifier: 237812890

GI number: 237812890

Start: 2592004

End: 2593515

Strand: Reverse

Name: cysNC [H]

Synonym: GBP346_A2649

Alternate gene names: 237812890

Gene position: 2593515-2592004 (Counterclockwise)

Preceding gene: 237812892

Following gene: 237812889

Centisome position: 63.28

GC content: 72.49

Gene sequence:

>1512_bases
ATGACGACGTCCATGAGAGAGCGTAGACGGGGTATTGCCTTTATGCGGTCCTGCGATGACTTTCTACGGACATCGGAATT
GTCCATCGCGGCGGTCAACAGCCTGCGGCGCACCATCGCGCCGTCGCATCGGGTGCTGGACGCGTGCGGATCGGGCGCCG
CCTGCCTGCTGGCGTCGCGCTACGGCGCGAAGCAGGTGGTGGCGCTCGCGGCCGCAGAGGCGACGCTCGTGGGGGCGCGA
GCCGGCGCGAACGGTCCCGGCGAACGGATATCGTTCGTCGACGCCGAGCAGGCCGCGGCGCTCGTCGCGCGGCAAGGGCG
GTTCGACGTCGTGCTCGGGCTCGCAGGCGGCGGGCGCGACGGGCTCGATCCGCATTACGGCGCTCGGCTCGACGCGTTCG
CACGGCGCTTCGGCACGGCGAACGTTGCCGTCGTGCCCAACGGTGTGCGCTACGACGCGCAACTCGTCGAATGGCGCGAG
GCCGAGCGGCTCGAGGCGGACGTCGCGGCCAGGCAGCGCGCCCTCGAAGCGCGCTACGACCTCACGCTTGGCCCGGTGCT
CGACCAGGTGGCCGCCGGGGCCGCGCCGCGTGGCCGCGTGCGCGCCGACGCGCTGCGCGCGCTCTGCGCGCGGCTGCCGT
TTCTGTCGTGCCGGCCGGGCGATGGCGGTGATGCCGGTACAAGCGGCACAAGCGGCACGGCGGCGCCCGAGCATGTCGAG
TTGACCGCCGCGCACGGCGGCCGTGCCGACGGCGTGCTGTGGACGCAGGAGCTGATACACGACGGCATCGTCATCGAACG
GATTCAGGGGTGCAGCTGGCTCGACGAACGCGTCGATCTCGAGGCGGGCGACGCGATCGCGGTGCCCGTCGCCGACATGG
CGCGGGCCGCGCCGCTCGACGGCGGCGAAGCGCCGCCGCAGCTCGCGCCCACGCCGCGCGCATCCGGCGCGCCCGCGCCG
CTCGTCTTCTGGCTGACCGGTATCTCGGGGGCCGGCAAGACGACGATCGCGACACGTTTCAAGCAGCGGGCGGACGCCGA
CGCGTGGCCCACCGTCGTGCTCGACGGCGACACGCTGCGCGGCGGCCTCAACGCGGATCTCGGCTTCTGCGACGCGGACC
GCGCGGAGAACGTGCGCCGCATCGCCGAGGTCGCGGCGCTGATGGCCGACACGGGGCTCGTCGTCGTCGTCTCGTGCATT
TCGCCCAGGCGGTCGTTTCGCGAAACGGCGCGCGAAATCGTCGGCGCCGAGCGCTTCGTCGAGGTGTTCGTCGATACGCC
GCCCGCGGTCGCGCAGGCGCGCGATCCGAAAGGGCTGTATCGGCGCGCACGCGCGGGGTTGATCGCGTCGTTCACCGGCA
TCGATTCGGACTACGAGCCACCGCCGGATCCGCAATTGCGCATCGATACGACGACGCACGACGTCGAGGACGCGACGCAG
ATGCTGCGCCGCTACTACGTCGACGCGCGCCTGTCCGGCGCGCGTGCGGGCACCGCCGAGTGCGCGGCGTGA

Upstream 100 bases:

>100_bases
CGATTCATAAATCGGTTGCCTTTCCGTAGCGCCGCAGAAGATCAAATACGACATTCCGAGGGCGCGTGCCTGTATTGCAC
GCGCATGTCAAAACGATTAA

Downstream 100 bases:

>100_bases
CGCCGCCGCTCCGTTCCTTCCTTCGCCGATGGCCAATAGCGAGACAAACGATGAGCGTTCACGACATGACTCACCCGGGC
GAGCTCGCACCGGTGCGAGC

Product: sulfate adenylate transferase, subunit 1/adenylylsulfate kinase

Products: NA

Alternate protein names: Sulfate adenylyltransferase subunit 1; ATP-sulfurylase large subunit; Sulfate adenylate transferase; SAT; Adenylyl-sulfate kinase; APS kinase; ATP adenosine-5'-phosphosulfate 3'-phosphotransferase [H]

Number of amino acids: Translated: 503; Mature: 502

Protein sequence:

>503_residues
MTTSMRERRRGIAFMRSCDDFLRTSELSIAAVNSLRRTIAPSHRVLDACGSGAACLLASRYGAKQVVALAAAEATLVGAR
AGANGPGERISFVDAEQAAALVARQGRFDVVLGLAGGGRDGLDPHYGARLDAFARRFGTANVAVVPNGVRYDAQLVEWRE
AERLEADVAARQRALEARYDLTLGPVLDQVAAGAAPRGRVRADALRALCARLPFLSCRPGDGGDAGTSGTSGTAAPEHVE
LTAAHGGRADGVLWTQELIHDGIVIERIQGCSWLDERVDLEAGDAIAVPVADMARAAPLDGGEAPPQLAPTPRASGAPAP
LVFWLTGISGAGKTTIATRFKQRADADAWPTVVLDGDTLRGGLNADLGFCDADRAENVRRIAEVAALMADTGLVVVVSCI
SPRRSFRETAREIVGAERFVEVFVDTPPAVAQARDPKGLYRRARAGLIASFTGIDSDYEPPPDPQLRIDTTTHDVEDATQ
MLRRYYVDARLSGARAGTAECAA

Sequences:

>Translated_503_residues
MTTSMRERRRGIAFMRSCDDFLRTSELSIAAVNSLRRTIAPSHRVLDACGSGAACLLASRYGAKQVVALAAAEATLVGAR
AGANGPGERISFVDAEQAAALVARQGRFDVVLGLAGGGRDGLDPHYGARLDAFARRFGTANVAVVPNGVRYDAQLVEWRE
AERLEADVAARQRALEARYDLTLGPVLDQVAAGAAPRGRVRADALRALCARLPFLSCRPGDGGDAGTSGTSGTAAPEHVE
LTAAHGGRADGVLWTQELIHDGIVIERIQGCSWLDERVDLEAGDAIAVPVADMARAAPLDGGEAPPQLAPTPRASGAPAP
LVFWLTGISGAGKTTIATRFKQRADADAWPTVVLDGDTLRGGLNADLGFCDADRAENVRRIAEVAALMADTGLVVVVSCI
SPRRSFRETAREIVGAERFVEVFVDTPPAVAQARDPKGLYRRARAGLIASFTGIDSDYEPPPDPQLRIDTTTHDVEDATQ
MLRRYYVDARLSGARAGTAECAA
>Mature_502_residues
TTSMRERRRGIAFMRSCDDFLRTSELSIAAVNSLRRTIAPSHRVLDACGSGAACLLASRYGAKQVVALAAAEATLVGARA
GANGPGERISFVDAEQAAALVARQGRFDVVLGLAGGGRDGLDPHYGARLDAFARRFGTANVAVVPNGVRYDAQLVEWREA
ERLEADVAARQRALEARYDLTLGPVLDQVAAGAAPRGRVRADALRALCARLPFLSCRPGDGGDAGTSGTSGTAAPEHVEL
TAAHGGRADGVLWTQELIHDGIVIERIQGCSWLDERVDLEAGDAIAVPVADMARAAPLDGGEAPPQLAPTPRASGAPAPL
VFWLTGISGAGKTTIATRFKQRADADAWPTVVLDGDTLRGGLNADLGFCDADRAENVRRIAEVAALMADTGLVVVVSCIS
PRRSFRETAREIVGAERFVEVFVDTPPAVAQARDPKGLYRRARAGLIASFTGIDSDYEPPPDPQLRIDTTTHDVEDATQM
LRRYYVDARLSGARAGTAECAA

Specific function: APS kinase catalyzes the synthesis of activated sulfate [H]

COG id: COG0529

COG function: function code P; Adenylylsulfate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the APS kinase family [H]

Homologues:

Organism=Homo sapiens, GI46094058, Length=161, Percent_Identity=53.416149068323, Blast_Score=161, Evalue=2e-39,
Organism=Homo sapiens, GI34447231, Length=161, Percent_Identity=51.5527950310559, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI62912492, Length=161, Percent_Identity=51.5527950310559, Blast_Score=157, Evalue=2e-38,
Organism=Escherichia coli, GI1789107, Length=167, Percent_Identity=49.7005988023952, Blast_Score=171, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17542422, Length=160, Percent_Identity=46.25, Blast_Score=143, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6322852, Length=171, Percent_Identity=44.4444444444444, Blast_Score=155, Evalue=1e-38,
Organism=Drosophila melanogaster, GI24667032, Length=161, Percent_Identity=49.0683229813665, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24667028, Length=161, Percent_Identity=49.0683229813665, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24667036, Length=161, Percent_Identity=49.0683229813665, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24667040, Length=161, Percent_Identity=49.0683229813665, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI116007838, Length=161, Percent_Identity=49.0683229813665, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24667044, Length=161, Percent_Identity=49.0683229813665, Blast_Score=154, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002891
- InterPro:   IPR000795
- InterPro:   IPR011779
- InterPro:   IPR009001
- InterPro:   IPR004161
- InterPro:   IPR009000 [H]

Pfam domain/function: PF01583 APS_kinase; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: =2.7.7.4; =2.7.1.25 [H]

Molecular weight: Translated: 53142; Mature: 53011

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTSMRERRRGIAFMRSCDDFLRTSELSIAAVNSLRRTIAPSHRVLDACGSGAACLLASR
CCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHH
YGAKQVVALAAAEATLVGARAGANGPGERISFVDAEQAAALVARQGRFDVVLGLAGGGRD
CCHHHHHHHHHHHHHEEECCCCCCCCCCCEEEECHHHHHHHHHCCCCEEEEEEECCCCCC
GLDPHYGARLDAFARRFGTANVAVVPNGVRYDAQLVEWREAERLEADVAARQRALEARYD
CCCCCCCCHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LTLGPVLDQVAAGAAPRGRVRADALRALCARLPFLSCRPGDGGDAGTSGTSGTAAPEHVE
CCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEE
LTAAHGGRADGVLWTQELIHDGIVIERIQGCSWLDERVDLEAGDAIAVPVADMARAAPLD
EEECCCCCCCCHHHHHHHHHCCHHHHHHCCCCHHHHHCCCCCCCEEEECHHHHHHHCCCC
GGEAPPQLAPTPRASGAPAPLVFWLTGISGAGKTTIATRFKQRADADAWPTVVLDGDTLR
CCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCCEEEECCCCCC
GGLNADLGFCDADRAENVRRIAEVAALMADTGLVVVVSCISPRRSFRETAREIVGAERFV
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEHHCCHHHHHHHHHHHHHHHHHH
EVFVDTPPAVAQARDPKGLYRRARAGLIASFTGIDSDYEPPPDPQLRIDTTTHDVEDATQ
HHHCCCCCHHHCCCCCHHHHHHHHCCCEEEECCCCCCCCCCCCCCEEEECCCCCHHHHHH
MLRRYYVDARLSGARAGTAECAA
HHHHHHHHHHCCCCCCCCHHCCC
>Mature Secondary Structure 
TTSMRERRRGIAFMRSCDDFLRTSELSIAAVNSLRRTIAPSHRVLDACGSGAACLLASR
CCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHH
YGAKQVVALAAAEATLVGARAGANGPGERISFVDAEQAAALVARQGRFDVVLGLAGGGRD
CCHHHHHHHHHHHHHEEECCCCCCCCCCCEEEECHHHHHHHHHCCCCEEEEEEECCCCCC
GLDPHYGARLDAFARRFGTANVAVVPNGVRYDAQLVEWREAERLEADVAARQRALEARYD
CCCCCCCCHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LTLGPVLDQVAAGAAPRGRVRADALRALCARLPFLSCRPGDGGDAGTSGTSGTAAPEHVE
CCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEE
LTAAHGGRADGVLWTQELIHDGIVIERIQGCSWLDERVDLEAGDAIAVPVADMARAAPLD
EEECCCCCCCCHHHHHHHHHCCHHHHHHCCCCHHHHHCCCCCCCEEEECHHHHHHHCCCC
GGEAPPQLAPTPRASGAPAPLVFWLTGISGAGKTTIATRFKQRADADAWPTVVLDGDTLR
CCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCCEEEECCCCCC
GGLNADLGFCDADRAENVRRIAEVAALMADTGLVVVVSCISPRRSFRETAREIVGAERFV
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEHHCCHHHHHHHHHHHHHHHHHH
EVFVDTPPAVAQARDPKGLYRRARAGLIASFTGIDSDYEPPPDPQLRIDTTTHDVEDATQ
HHHCCCCCHHHCCCCCHHHHHHHHCCCEEEECCCCCCCCCCCCCCEEEECCCCCHHHHHH
MLRRYYVDARLSGARAGTAECAA
HHHHHHHHHHCCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]