Click here to switch to the map view.

The map label for this gene is tktA [C]

Identifier: 237812879

GI number: 237812879

Start: 2572753

End: 2573577

Strand: Reverse

Name: tktA [C]

Synonym: GBP346_A2638

Alternate gene names: 237812879

Gene position: 2573577-2572753 (Counterclockwise)

Preceding gene: 237812880

Following gene: 237812878

Centisome position: 62.79

GC content: 71.27

Gene sequence:

>825_bases
ATGGCGATGAATCTCGACAACCAGGTGCTGGAAAACCGCAAGCGGGTGCTGAAGATGCTGCACGGCGCCGACGGCGGGCA
TTTCGGCGGCGCGATGAGCGTGCTCGACACGCTCGTCGTGCTGTATCACCGCGTGCTGCGGCGCGATCCGGCGCGCCGGG
CCGACGGGCTCGCCGACCGGCTGATCCTCTCGAAGGGGCACGCCTCGGTCGCGCTGTACGCGGTGCTCGCGTCGATCGGC
GAGTTGCCGGAGGCGGAGCTCGCGACGTACGGCAAGGGCGGCGGGCGCTTGCCGTGCCATCCGGACATGACGCTGCTCGA
CGCGGTCGATTTTTCCACGGGCTCGCTCGGACAGGGGCTGTCGGTCGGCCTCGGCATGGCGTTCGCGTTGCGCGGCACCG
GCGCGCGCGTATGGGTCGTGCTCGGCGACGGCGAATGCCAGGAGGGGCAGGTGTGGGAGGCGGCGCAGTTCGCGTCGCGC
TACGGCGTCGACAACCTGCATGCGGTTGTCGACCTGAACGGTTTTCAGGAGATGGGCTGGCGCGGCATCGACGGCGTCGC
GCCCGAGCCGCTGCCCGACGCGGCGCGCAAGTGGGCGGCGTTCGGCTGGCACGTGCGCGAAGTGGCGGGGCACGATGCCG
CACGGCTCGAAGCCGCGATGCGCGCCATGACCGCGCAGCGAGGGCGGCCGAGCGTGCTGCTCGCGTCGACCGTGAAGGGG
CGCGGCATCCCCGCGTTCGAATTCGACCCCGGGCTGTCGCACTGCACGTCGCTCACCGACGATCAGTTCAGGCACGCGGT
GGCCGTCGCGGAGGGCGTCGCATGA

Upstream 100 bases:

>100_bases
CTCGCCGCGTTCGACGCGCGCTGGCGCGAGATCCGGCCGGAGGCGCTGTTGCGCGAGCACGGCTTGGCGCGCCTGCGCTG
AACCCTTGTTTCGAACAGGA

Downstream 100 bases:

>100_bases
GGCCCGCCGCGCATTGCGTGCAGGCGCTCGTCGAGCGCGCCGCGCACGATCGCCGGATCTGGCTGCTGGACGGCGATCTC
GCCGATTCGTACGGCGCAGA

Product: transketolase, N- subunit

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 274; Mature: 273

Protein sequence:

>274_residues
MAMNLDNQVLENRKRVLKMLHGADGGHFGGAMSVLDTLVVLYHRVLRRDPARRADGLADRLILSKGHASVALYAVLASIG
ELPEAELATYGKGGGRLPCHPDMTLLDAVDFSTGSLGQGLSVGLGMAFALRGTGARVWVVLGDGECQEGQVWEAAQFASR
YGVDNLHAVVDLNGFQEMGWRGIDGVAPEPLPDAARKWAAFGWHVREVAGHDAARLEAAMRAMTAQRGRPSVLLASTVKG
RGIPAFEFDPGLSHCTSLTDDQFRHAVAVAEGVA

Sequences:

>Translated_274_residues
MAMNLDNQVLENRKRVLKMLHGADGGHFGGAMSVLDTLVVLYHRVLRRDPARRADGLADRLILSKGHASVALYAVLASIG
ELPEAELATYGKGGGRLPCHPDMTLLDAVDFSTGSLGQGLSVGLGMAFALRGTGARVWVVLGDGECQEGQVWEAAQFASR
YGVDNLHAVVDLNGFQEMGWRGIDGVAPEPLPDAARKWAAFGWHVREVAGHDAARLEAAMRAMTAQRGRPSVLLASTVKG
RGIPAFEFDPGLSHCTSLTDDQFRHAVAVAEGVA
>Mature_273_residues
AMNLDNQVLENRKRVLKMLHGADGGHFGGAMSVLDTLVVLYHRVLRRDPARRADGLADRLILSKGHASVALYAVLASIGE
LPEAELATYGKGGGRLPCHPDMTLLDAVDFSTGSLGQGLSVGLGMAFALRGTGARVWVVLGDGECQEGQVWEAAQFASRY
GVDNLHAVVDLNGFQEMGWRGIDGVAPEPLPDAARKWAAFGWHVREVAGHDAARLEAAMRAMTAQRGRPSVLLASTVKGR
GIPAFEFDPGLSHCTSLTDDQFRHAVAVAEGVA

Specific function: Unknown

COG id: COG3959

COG function: function code G; Transketolase, N-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI133778974, Length=245, Percent_Identity=35.9183673469388, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI205277463, Length=245, Percent_Identity=36.734693877551, Blast_Score=131, Evalue=5e-31,
Organism=Homo sapiens, GI4507521, Length=245, Percent_Identity=36.734693877551, Blast_Score=131, Evalue=5e-31,
Organism=Homo sapiens, GI225637463, Length=147, Percent_Identity=38.0952380952381, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI225637459, Length=147, Percent_Identity=38.0952380952381, Blast_Score=91, Evalue=8e-19,
Organism=Homo sapiens, GI225637461, Length=147, Percent_Identity=38.0952380952381, Blast_Score=91, Evalue=8e-19,
Organism=Escherichia coli, GI48994911, Length=252, Percent_Identity=32.5396825396825, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1788808, Length=252, Percent_Identity=32.5396825396825, Blast_Score=112, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17539652, Length=241, Percent_Identity=36.5145228215768, Blast_Score=138, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6325331, Length=236, Percent_Identity=30.9322033898305, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6319593, Length=242, Percent_Identity=26.0330578512397, Blast_Score=77, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24666278, Length=257, Percent_Identity=35.408560311284, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI45551847, Length=239, Percent_Identity=34.3096234309623, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI45550715, Length=239, Percent_Identity=34.3096234309623, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24645119, Length=214, Percent_Identity=36.4485981308411, Blast_Score=126, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005474 [H]

Pfam domain/function: PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 29189; Mature: 29057

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00801 TRANSKETOLASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAMNLDNQVLENRKRVLKMLHGADGGHFGGAMSVLDTLVVLYHRVLRRDPARRADGLADR
CCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
LILSKGHASVALYAVLASIGELPEAELATYGKGGGRLPCHPDMTLLDAVDFSTGSLGQGL
HHHCCCCHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCH
SVGLGMAFALRGTGARVWVVLGDGECQEGQVWEAAQFASRYGVDNLHAVVDLNGFQEMGW
HHHHHHHHEEECCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCHHHCCC
RGIDGVAPEPLPDAARKWAAFGWHVREVAGHDAARLEAAMRAMTAQRGRPSVLLASTVKG
CCCCCCCCCCCHHHHHHHHHHCHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEEEECCCC
RGIPAFEFDPGLSHCTSLTDDQFRHAVAVAEGVA
CCCCCEECCCCHHHHHCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AMNLDNQVLENRKRVLKMLHGADGGHFGGAMSVLDTLVVLYHRVLRRDPARRADGLADR
CCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
LILSKGHASVALYAVLASIGELPEAELATYGKGGGRLPCHPDMTLLDAVDFSTGSLGQGL
HHHCCCCHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCH
SVGLGMAFALRGTGARVWVVLGDGECQEGQVWEAAQFASRYGVDNLHAVVDLNGFQEMGW
HHHHHHHHEEECCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCHHHCCC
RGIDGVAPEPLPDAARKWAAFGWHVREVAGHDAARLEAAMRAMTAQRGRPSVLLASTVKG
CCCCCCCCCCCHHHHHHHHHHCHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEEEECCCC
RGIPAFEFDPGLSHCTSLTDDQFRHAVAVAEGVA
CCCCCEECCCCHHHHHCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]