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The map label for this gene is moeA [H]

Identifier: 237812587

GI number: 237812587

Start: 2300595

End: 2301887

Strand: Reverse

Name: moeA [H]

Synonym: GBP346_A2337

Alternate gene names: 237812587

Gene position: 2301887-2300595 (Counterclockwise)

Preceding gene: 237812588

Following gene: 237812586

Centisome position: 56.16

GC content: 71.54

Gene sequence:

>1293_bases
ATGCTGTCGACGGCCGATGCGCTGACGGCGCTGCTCGCGGCGGCGCGTCCGCTCGCCGAGATTGAAACCGTGCCGACGCT
CGAGGCGCTCAACCGCGTGCTCGCGGCCGACGTCGCGTCCGGGCTCGACGTGCCGCCGATGAACACGAGCGCGATGGACG
GCTACGCGGTGCGCATCGCCGACCTGACGCGCGGCGAGCGGCGCTTGCCGGTGTCGCAGCGAATTGCCGCCGGCCATCCG
GCGGCGCCGCTCGCGCCGGGGACGGCCGCGCGCATCTTCACGGGCGCGTCCGTGCCGGCCGGCGCGGACGCGGTCGTGAT
GCAGGAGCAAACGGAGGCGGCGGGCGACCAGGTCGACATCCTGCATACGCCGACGGTGGGCGAATGGATCACCGCGCAGG
GCGCGGACATTCGCCGCGGTTCGGTGATCCTGCCCGCCGGCACGCGGATGACGCCGCAGGCGATGGGGCTCGCGGCATCG
GTCGGCTGCGCGTCGCTCGCGGTCACGCGGCGCGTGAAGGTGGCGGTATTCTTTACGGGCGACGAACTGACGATGCCGGG
CGAGCCGCTCAAGCCCGGCGCGATCTACAACTCGAACCGCTTCACGCTGCGCGGGCTGCTCGAGCGGCTCGGCTGCGACG
TGACCGACTACGGCATCGTGCCGGATCGGCTCGACGCGACGCGCGCGGCGTTACGCGAGGCGGCGCGCGAGCACGATGTG
ATCGTGACGAGCGGCGGCGTGTCGGTGGGCGACGAGGATCACGTGAAGCCCGCGGTCGAGGCGGAAGGCCGGCTCGCGTT
GTGGCAGATCGCGATGAAGCCGGGCAAGCCGCTCGCGTTCGGCGCGATCAGGCGAGACGGCGCGGCGAGCGGCGCGGCTG
CCGTTGAGGCGAACGCGCACGGCGCGAGCGATGCGAGCGACACGCGCGCCATGCACGCGACGTCCGGCGGCGAAGCGTAT
TTCATCGGCCTGCCGGGCAACCCGGTGTCGAGCTTCGTCACGTTCCTGCTGTTCGTGCGGCCGTTCCTGTTGCGCGTCGC
GGGGGCGGCGCAGGTCGCGCCGCGCGCGGTGTCGCTGCGCGCGGATTTCACGCAGAACAAGGCGGATCGCCGCAACGAAT
TCCTGCGCGCGCGCGTGAACGCGGCGGGCGGGCTCGACCTGTTTCCGAACCAGAGCTCGGCCGTGCTGACATCGACGGTA
TGGGGCGACGGCCTGATCGACAATCCGCCCAACCACGCGATCAGCGCGGGCGAGACGGTGCGTTTCATTCCTTTTTCCGA
ATTGCTCGGTTGA

Upstream 100 bases:

>100_bases
GTCGCTCACATCCGCGCGAAGGCGTCGCTACAATGTCGCCATCCGGTCAACATTTCAATCGACGATGTCCCACCCCACTC
CCCAGACGCCGCGCGCGCCG

Downstream 100 bases:

>100_bases
AAGCCGGGCGGCGTAGCGACGATGAAGATTGAACTGAAGTTTTTCGCGAGCGTGCGCGAAGCGCTCGGCGTGGCGAGCGA
GACGGTGACGGTGCCGGACG

Product: molybdenum cofactor biosynthesis protein MoeA

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MLSTADALTALLAAARPLAEIETVPTLEALNRVLAADVASGLDVPPMNTSAMDGYAVRIADLTRGERRLPVSQRIAAGHP
AAPLAPGTAARIFTGASVPAGADAVVMQEQTEAAGDQVDILHTPTVGEWITAQGADIRRGSVILPAGTRMTPQAMGLAAS
VGCASLAVTRRVKVAVFFTGDELTMPGEPLKPGAIYNSNRFTLRGLLERLGCDVTDYGIVPDRLDATRAALREAAREHDV
IVTSGGVSVGDEDHVKPAVEAEGRLALWQIAMKPGKPLAFGAIRRDGAASGAAAVEANAHGASDASDTRAMHATSGGEAY
FIGLPGNPVSSFVTFLLFVRPFLLRVAGAAQVAPRAVSLRADFTQNKADRRNEFLRARVNAAGGLDLFPNQSSAVLTSTV
WGDGLIDNPPNHAISAGETVRFIPFSELLG

Sequences:

>Translated_430_residues
MLSTADALTALLAAARPLAEIETVPTLEALNRVLAADVASGLDVPPMNTSAMDGYAVRIADLTRGERRLPVSQRIAAGHP
AAPLAPGTAARIFTGASVPAGADAVVMQEQTEAAGDQVDILHTPTVGEWITAQGADIRRGSVILPAGTRMTPQAMGLAAS
VGCASLAVTRRVKVAVFFTGDELTMPGEPLKPGAIYNSNRFTLRGLLERLGCDVTDYGIVPDRLDATRAALREAAREHDV
IVTSGGVSVGDEDHVKPAVEAEGRLALWQIAMKPGKPLAFGAIRRDGAASGAAAVEANAHGASDASDTRAMHATSGGEAY
FIGLPGNPVSSFVTFLLFVRPFLLRVAGAAQVAPRAVSLRADFTQNKADRRNEFLRARVNAAGGLDLFPNQSSAVLTSTV
WGDGLIDNPPNHAISAGETVRFIPFSELLG
>Mature_430_residues
MLSTADALTALLAAARPLAEIETVPTLEALNRVLAADVASGLDVPPMNTSAMDGYAVRIADLTRGERRLPVSQRIAAGHP
AAPLAPGTAARIFTGASVPAGADAVVMQEQTEAAGDQVDILHTPTVGEWITAQGADIRRGSVILPAGTRMTPQAMGLAAS
VGCASLAVTRRVKVAVFFTGDELTMPGEPLKPGAIYNSNRFTLRGLLERLGCDVTDYGIVPDRLDATRAALREAAREHDV
IVTSGGVSVGDEDHVKPAVEAEGRLALWQIAMKPGKPLAFGAIRRDGAASGAAAVEANAHGASDASDTRAMHATSGGEAY
FIGLPGNPVSSFVTFLLFVRPFLLRVAGAAQVAPRAVSLRADFTQNKADRRNEFLRARVNAAGGLDLFPNQSSAVLTSTV
WGDGLIDNPPNHAISAGETVRFIPFSELLG

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=427, Percent_Identity=33.0210772833724, Blast_Score=181, Evalue=8e-46,
Organism=Homo sapiens, GI10880983, Length=427, Percent_Identity=33.0210772833724, Blast_Score=181, Evalue=8e-46,
Organism=Escherichia coli, GI1787049, Length=412, Percent_Identity=40.0485436893204, Blast_Score=273, Evalue=2e-74,
Organism=Caenorhabditis elegans, GI25147659, Length=368, Percent_Identity=30.9782608695652, Blast_Score=138, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI17562606, Length=221, Percent_Identity=27.6018099547511, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17136978, Length=407, Percent_Identity=32.9238329238329, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI24638841, Length=407, Percent_Identity=32.9238329238329, Blast_Score=156, Evalue=3e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 44763; Mature: 44763

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSTADALTALLAAARPLAEIETVPTLEALNRVLAADVASGLDVPPMNTSAMDGYAVRIA
CCCHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEE
DLTRGERRLPVSQRIAAGHPAAPLAPGTAARIFTGASVPAGADAVVMQEQTEAAGDQVDI
ECCCCCCCCCHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCEEEEECHHHHCCCEEEE
LHTPTVGEWITAQGADIRRGSVILPAGTRMTPQAMGLAASVGCASLAVTRRVKVAVFFTG
EECCCCCCEEECCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHEEEEEEEEEEEEC
DELTMPGEPLKPGAIYNSNRFTLRGLLERLGCDVTDYGIVPDRLDATRAALREAAREHDV
CEEECCCCCCCCCEEECCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCE
IVTSGGVSVGDEDHVKPAVEAEGRLALWQIAMKPGKPLAFGAIRRDGAASGAAAVEANAH
EEECCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCEEEEEEECCCCCCCCEEEECCCC
GASDASDTRAMHATSGGEAYFIGLPGNPVSSFVTFLLFVRPFLLRVAGAAQVAPRAVSLR
CCCCCCCCCEEEECCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCHHHHCCCEEEEE
ADFTQNKADRRNEFLRARVNAAGGLDLFPNQSSAVLTSTVWGDGLIDNPPNHAISAGETV
CCCCCCHHHHHHHHHHHHHCCCCCCEECCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEE
RFIPFSELLG
EEECHHHHCC
>Mature Secondary Structure
MLSTADALTALLAAARPLAEIETVPTLEALNRVLAADVASGLDVPPMNTSAMDGYAVRIA
CCCHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEE
DLTRGERRLPVSQRIAAGHPAAPLAPGTAARIFTGASVPAGADAVVMQEQTEAAGDQVDI
ECCCCCCCCCHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCEEEEECHHHHCCCEEEE
LHTPTVGEWITAQGADIRRGSVILPAGTRMTPQAMGLAASVGCASLAVTRRVKVAVFFTG
EECCCCCCEEECCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHEEEEEEEEEEEEC
DELTMPGEPLKPGAIYNSNRFTLRGLLERLGCDVTDYGIVPDRLDATRAALREAAREHDV
CEEECCCCCCCCCEEECCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCE
IVTSGGVSVGDEDHVKPAVEAEGRLALWQIAMKPGKPLAFGAIRRDGAASGAAAVEANAH
EEECCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCEEEEEEECCCCCCCCEEEECCCC
GASDASDTRAMHATSGGEAYFIGLPGNPVSSFVTFLLFVRPFLLRVAGAAQVAPRAVSLR
CCCCCCCCCEEEECCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCHHHHCCCEEEEE
ADFTQNKADRRNEFLRARVNAAGGLDLFPNQSSAVLTSTVWGDGLIDNPPNHAISAGETV
CCCCCCHHHHHHHHHHHHHCCCCCCEECCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEE
RFIPFSELLG
EEECHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]