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The map label for this gene is hflK [H]

Identifier: 237812541

GI number: 237812541

Start: 2258125

End: 2259489

Strand: Reverse

Name: hflK [H]

Synonym: GBP346_A2290

Alternate gene names: 237812541

Gene position: 2259489-2258125 (Counterclockwise)

Preceding gene: 237812542

Following gene: 237812540

Centisome position: 55.13

GC content: 70.18

Gene sequence:

>1365_bases
GTGAACGACTACAACGAGCGGAGTACCTGGCGGCGAATGCGCGCCTTGCTGTCGATCAACGATCCCCGCTGGGGACGCGG
CGGCAACGGCGACAAGCCGCGCGCGAACGAGTCGAAGCGCCCGAACGGGCGCGACGACGGCCCCCCGGATCTCGACGAAA
TGTGGCGGAACTTCAACCGTCGCCTGAGCGGCTGGTTCGGCGGCAAGGGCGGCGGCAACAACGGCTTTCGTCCCGACAAC
GGGCGCGCCGCGCGCGTCGGCGTCGGCATCGTCGCGGGCGTGCTGATCGCGATCTATCTCGGCAGCGGCATCTTCATCGT
CCAGGACGGCCAGACGGGCGTCGTGCTGCGCTTGGGCCAATACAAGGGCTCGGTCGGCGACGGCGTCCATTGGCGTCTGC
CGTATCCGTTCGAATCGCACGAGATCGTCGACACCGCGCAGGTGCGCTCGATCGAGATCGGCCGCAACAACGTGGTGCGG
CTCGCGAACGTGAAGGACGCGTCGATGCTCACGCGCGACGCCGATATCGTCGACGTGCGCTTCGCCGTTCAATATCGGGT
CGGGTCGCCCACCGACTATCTGTTTCACGCCGTCGATCCCGAGCGCAGCGTATCGCAGGCCGCGCAGGCGGTGGTGCGCG
AGATCGTCGGTGCGAGGCGCGCGGACGAGGTGCTCGCGCAGGATCGCGACGCATTGCGCGACGCGCTTTCGAAAGCGATC
CAGCGCGACCTCGACCGCTACCGCACGGGCCTCGTCGTGACGGGCGTGACCGTGCAAAGCGTTTCGCCGCCCGAGCAGGT
GCAGGCCGCCGTCGACGACATCGCGAAAGCGCGTCAGGACAGCGAGGCCGCGAAGAACGCCGCGCAGGCGTATGCAAGCG
AATTGCTGCCGCGCGCGCAGGGCGACGCGGCGAAGATGGTCGACGACGCGAAGTCGTACGCCGAGCGCGTCGTCGCGCAA
GCCGAGGGCGACGCGGAACGCTTCAAGCAGGTCTACGCGCAGTACTCGAAGGCGCCCGCGGTGATCCGCGAGCGGATGTA
TCTCGAGACGATGCAGGAGATCTATTCGAACACGACGAAGGTGTACGTCGGCAACAAGGCGGGCAACAGCGTGCTGTATC
TGCCGCTCGACAAGATCGTCGAGGCGGGCCGCCAGCGCGCCGCCGAGGCCGCGAGCGCCGGCGTCGCGCCGCCCGCGAGC
GGCGCGCAAGCGCCCGCGCCGGCGGTGTCCGCGCCGGCGTCGGCCGCAGCCGCCGCGAGCGCGCCGCGCGCGGCGGCGCC
CGCGGCGGCGAGCCCGGCGTCCGGCAGCGATTCGCGCTCGCGCGAGGCGTTGCGCAGCCGGTCGCGCACCGACGATCTGC
AGTAA

Upstream 100 bases:

>100_bases
CGGCGCGCCGGCGCTACCACACGAAGACCACCCGGTTTCCGAACACGGGCGCTGACGGCTGCGGCCGATCAAGTTGCGCC
AATCTGGTGAACAAACACAG

Downstream 100 bases:

>100_bases
CGAGGAGCGCATCAACATGAACCGAATCATTGCGCTCGTCGTAGCGATCGTCATCGTCGCGCTGGTGGCCTCGTCGACGG
TGCTCGTCGTCGATCCGCGC

Product: HflK protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MNDYNERSTWRRMRALLSINDPRWGRGGNGDKPRANESKRPNGRDDGPPDLDEMWRNFNRRLSGWFGGKGGGNNGFRPDN
GRAARVGVGIVAGVLIAIYLGSGIFIVQDGQTGVVLRLGQYKGSVGDGVHWRLPYPFESHEIVDTAQVRSIEIGRNNVVR
LANVKDASMLTRDADIVDVRFAVQYRVGSPTDYLFHAVDPERSVSQAAQAVVREIVGARRADEVLAQDRDALRDALSKAI
QRDLDRYRTGLVVTGVTVQSVSPPEQVQAAVDDIAKARQDSEAAKNAAQAYASELLPRAQGDAAKMVDDAKSYAERVVAQ
AEGDAERFKQVYAQYSKAPAVIRERMYLETMQEIYSNTTKVYVGNKAGNSVLYLPLDKIVEAGRQRAAEAASAGVAPPAS
GAQAPAPAVSAPASAAAAASAPRAAAPAAASPASGSDSRSREALRSRSRTDDLQ

Sequences:

>Translated_454_residues
MNDYNERSTWRRMRALLSINDPRWGRGGNGDKPRANESKRPNGRDDGPPDLDEMWRNFNRRLSGWFGGKGGGNNGFRPDN
GRAARVGVGIVAGVLIAIYLGSGIFIVQDGQTGVVLRLGQYKGSVGDGVHWRLPYPFESHEIVDTAQVRSIEIGRNNVVR
LANVKDASMLTRDADIVDVRFAVQYRVGSPTDYLFHAVDPERSVSQAAQAVVREIVGARRADEVLAQDRDALRDALSKAI
QRDLDRYRTGLVVTGVTVQSVSPPEQVQAAVDDIAKARQDSEAAKNAAQAYASELLPRAQGDAAKMVDDAKSYAERVVAQ
AEGDAERFKQVYAQYSKAPAVIRERMYLETMQEIYSNTTKVYVGNKAGNSVLYLPLDKIVEAGRQRAAEAASAGVAPPAS
GAQAPAPAVSAPASAAAAASAPRAAAPAAASPASGSDSRSREALRSRSRTDDLQ
>Mature_454_residues
MNDYNERSTWRRMRALLSINDPRWGRGGNGDKPRANESKRPNGRDDGPPDLDEMWRNFNRRLSGWFGGKGGGNNGFRPDN
GRAARVGVGIVAGVLIAIYLGSGIFIVQDGQTGVVLRLGQYKGSVGDGVHWRLPYPFESHEIVDTAQVRSIEIGRNNVVR
LANVKDASMLTRDADIVDVRFAVQYRVGSPTDYLFHAVDPERSVSQAAQAVVREIVGARRADEVLAQDRDALRDALSKAI
QRDLDRYRTGLVVTGVTVQSVSPPEQVQAAVDDIAKARQDSEAAKNAAQAYASELLPRAQGDAAKMVDDAKSYAERVVAQ
AEGDAERFKQVYAQYSKAPAVIRERMYLETMQEIYSNTTKVYVGNKAGNSVLYLPLDKIVEAGRQRAAEAASAGVAPPAS
GAQAPAPAVSAPASAAAAASAPRAAAPAAASPASGSDSRSREALRSRSRTDDLQ

Specific function: HflC and HflK could encode or regulate a protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflK subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790616, Length=373, Percent_Identity=32.9758713136729, Blast_Score=188, Evalue=6e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010201
- InterPro:   IPR020980
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7; PF12221 HflK_N [H]

EC number: NA

Molecular weight: Translated: 48847; Mature: 48847

Theoretical pI: Translated: 9.66; Mature: 9.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDYNERSTWRRMRALLSINDPRWGRGGNGDKPRANESKRPNGRDDGPPDLDEMWRNFNR
CCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
RLSGWFGGKGGGNNGFRPDNGRAARVGVGIVAGVLIAIYLGSGIFIVQDGQTGVVLRLGQ
HHCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEEEC
YKGSVGDGVHWRLPYPFESHEIVDTAQVRSIEIGRNNVVRLANVKDASMLTRDADIVDVR
CCCCCCCCEEEEECCCCCCCCHHHHHHHEEEEECCCCEEEEECCCHHHHHHCCCCEEEEE
FAVQYRVGSPTDYLFHAVDPERSVSQAAQAVVREIVGARRADEVLAQDRDALRDALSKAI
EEEEEECCCCCHHEEEECCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
QRDLDRYRTGLVVTGVTVQSVSPPEQVQAAVDDIAKARQDSEAAKNAAQAYASELLPRAQ
HHHHHHHHCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GDAAKMVDDAKSYAERVVAQAEGDAERFKQVYAQYSKAPAVIRERMYLETMQEIYSNTTK
CCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCEE
VYVGNKAGNSVLYLPLDKIVEAGRQRAAEAASAGVAPPASGAQAPAPAVSAPASAAAAAS
EEEECCCCCEEEEECHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHC
APRAAAPAAASPASGSDSRSREALRSRSRTDDLQ
CCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MNDYNERSTWRRMRALLSINDPRWGRGGNGDKPRANESKRPNGRDDGPPDLDEMWRNFNR
CCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
RLSGWFGGKGGGNNGFRPDNGRAARVGVGIVAGVLIAIYLGSGIFIVQDGQTGVVLRLGQ
HHCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEEEC
YKGSVGDGVHWRLPYPFESHEIVDTAQVRSIEIGRNNVVRLANVKDASMLTRDADIVDVR
CCCCCCCCEEEEECCCCCCCCHHHHHHHEEEEECCCCEEEEECCCHHHHHHCCCCEEEEE
FAVQYRVGSPTDYLFHAVDPERSVSQAAQAVVREIVGARRADEVLAQDRDALRDALSKAI
EEEEEECCCCCHHEEEECCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
QRDLDRYRTGLVVTGVTVQSVSPPEQVQAAVDDIAKARQDSEAAKNAAQAYASELLPRAQ
HHHHHHHHCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GDAAKMVDDAKSYAERVVAQAEGDAERFKQVYAQYSKAPAVIRERMYLETMQEIYSNTTK
CCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCEE
VYVGNKAGNSVLYLPLDKIVEAGRQRAAEAASAGVAPPASGAQAPAPAVSAPASAAAAAS
EEEECCCCCEEEEECHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHC
APRAAAPAAASPASGSDSRSREALRSRSRTDDLQ
CCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]