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The map label for this gene is napA [H]

Identifier: 237812427

GI number: 237812427

Start: 2143763

End: 2145097

Strand: Direct

Name: napA [H]

Synonym: GBP346_A2175

Alternate gene names: 237812427

Gene position: 2143763-2145097 (Clockwise)

Preceding gene: 237812426

Following gene: 237812428

Centisome position: 52.31

GC content: 71.84

Gene sequence:

>1335_bases
ATGGCTGACTGGATACTGCAACTGTGCGTCGTGGTGGTCGTCGCATTCACGCTCGGCGCGCTCGCGCAACGGCTCGGGCA
AGGCCGGGTCGTCGGCGAGCTGCTCGCCGGGCTGCTGCTCGGCCCGTCGGCGTTCGGCGCGCTCACCGTGGCGGGGCACG
GCGCGCTGATCGGCCCGCAGACGGCCGCGCTCCTCTCGCGGCTCGGCGAACTCGGTCTCGTGTTCCTGATGTTCCAGACG
GGCATGCACATCACCTGGACGACGGCGCACGGGCGCTCGTCCGGGCTCGTCGCGACCGTCGTCGCGGGGTTCGGCATGGC
GCTGCCGTTCGCGACAGGCTGCGCGATCGCCGTCGCGGCGTCCGGATCGTTCCAGCCGCAGGCGTCGCATCTCGCCTATG
TGCTGTTCTGCGGGATCGCGCTGTCCGTGTCGGCGCTGCCCGTCATGATGCGCATCATCGCGGACGCGCGCATCGCCGGG
CGCGCGTGCGCGACGCTATCGATACTCGCGGCGACGTTGACCGATTCGCTCGGCTGGCTGATGCTCGCGGCCGTCGGCAC
GCTCGCGACCTCGGGCCTGTCGCCCGCCTCGACGGTGCACGCGATGGGCGTGCTCGTCGCGTTCGTCGTCGTGTCGATCT
CGCTCGTGCGCCCCATCGTGCTCGGCGTGCTCGATCGAACGCGCCGGGCCGGCAGCGGCTCCGCCATGTTGATCTGCGCG
CTCTGCTACGTGCTGCTGTCGTCGTGGGCCGCGGCGCGGCTCGGCTTTCACGGCGCGTTCGGCGCGCTCGTCGCGGCCGC
CAACCTCGCGGGGCGCCACGACCTGCGCCAGCTGTGGGACGCGCGCTTCGCCGGCCTCGCCGATCTCGTGCTGATTCCGC
TCTTCTTCGTCAGCATGGGCTTTCAGGCATCGTTCTCCGCGCTCGACACGGGCGCGGCCTGGGGCTGGCTCGCCGCGTTT
CTCGTCGGCGGCGTGGCGACGAAATTCGCCGGCTGCTACGCGGGCGCGCGACTGTGCGGCATCGACCGCGCGGAGGCGAC
GCTCGTGGGCGTGCTGATGAACTGCCGCGGCACGGTCGAGCTGATGGTGCTCGCGATCGGCCTGCAGTTGCGGATCATTC
CCGCTTCGCTGTACACGGTCCTGCTGATCGCGACGCTGACGATGACGTGGTTGAGCGCGATGTCGACCCATCGGCTCGCG
AAGCGCCGCCCGCTGCGCTCGCCGCCGGCGGGCGCGGGCGACGCGCCGGCGGGATTTCGCGCGACGCAGGCTCAGGCGGC
AGGCGGCGATGCCCGTCTGCCAGGATTGCCGGAGGCATCGCGCCCGTCGCGATGA

Upstream 100 bases:

>100_bases
GTCGCCGCGATGTAACCCGCGGCGGGCGCGCCGACGCGCGGGCGCGCGGGCGCGCATGCCCCCGGCGCGCCCGCGCACCG
AACGCGAGGAGCCAACGAAG

Downstream 100 bases:

>100_bases
ATACCCATGGATACCATCGTTCCGTTTCTTTCCGATTCCACCGCACGCTGGCTGCCGCTCGCGCTGTCCGAACAGGTGAG
CGGCAAGGCCCCGCTCGCCG

Product: sodium/hydrogen exchanger

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 444; Mature: 443

Protein sequence:

>444_residues
MADWILQLCVVVVVAFTLGALAQRLGQGRVVGELLAGLLLGPSAFGALTVAGHGALIGPQTAALLSRLGELGLVFLMFQT
GMHITWTTAHGRSSGLVATVVAGFGMALPFATGCAIAVAASGSFQPQASHLAYVLFCGIALSVSALPVMMRIIADARIAG
RACATLSILAATLTDSLGWLMLAAVGTLATSGLSPASTVHAMGVLVAFVVVSISLVRPIVLGVLDRTRRAGSGSAMLICA
LCYVLLSSWAAARLGFHGAFGALVAAANLAGRHDLRQLWDARFAGLADLVLIPLFFVSMGFQASFSALDTGAAWGWLAAF
LVGGVATKFAGCYAGARLCGIDRAEATLVGVLMNCRGTVELMVLAIGLQLRIIPASLYTVLLIATLTMTWLSAMSTHRLA
KRRPLRSPPAGAGDAPAGFRATQAQAAGGDARLPGLPEASRPSR

Sequences:

>Translated_444_residues
MADWILQLCVVVVVAFTLGALAQRLGQGRVVGELLAGLLLGPSAFGALTVAGHGALIGPQTAALLSRLGELGLVFLMFQT
GMHITWTTAHGRSSGLVATVVAGFGMALPFATGCAIAVAASGSFQPQASHLAYVLFCGIALSVSALPVMMRIIADARIAG
RACATLSILAATLTDSLGWLMLAAVGTLATSGLSPASTVHAMGVLVAFVVVSISLVRPIVLGVLDRTRRAGSGSAMLICA
LCYVLLSSWAAARLGFHGAFGALVAAANLAGRHDLRQLWDARFAGLADLVLIPLFFVSMGFQASFSALDTGAAWGWLAAF
LVGGVATKFAGCYAGARLCGIDRAEATLVGVLMNCRGTVELMVLAIGLQLRIIPASLYTVLLIATLTMTWLSAMSTHRLA
KRRPLRSPPAGAGDAPAGFRATQAQAAGGDARLPGLPEASRPSR
>Mature_443_residues
ADWILQLCVVVVVAFTLGALAQRLGQGRVVGELLAGLLLGPSAFGALTVAGHGALIGPQTAALLSRLGELGLVFLMFQTG
MHITWTTAHGRSSGLVATVVAGFGMALPFATGCAIAVAASGSFQPQASHLAYVLFCGIALSVSALPVMMRIIADARIAGR
ACATLSILAATLTDSLGWLMLAAVGTLATSGLSPASTVHAMGVLVAFVVVSISLVRPIVLGVLDRTRRAGSGSAMLICAL
CYVLLSSWAAARLGFHGAFGALVAAANLAGRHDLRQLWDARFAGLADLVLIPLFFVSMGFQASFSALDTGAAWGWLAAFL
VGGVATKFAGCYAGARLCGIDRAEATLVGVLMNCRGTVELMVLAIGLQLRIIPASLYTVLLIATLTMTWLSAMSTHRLAK
RRPLRSPPAGAGDAPAGFRATQAQAAGGDARLPGLPEASRPSR

Specific function: This is a Na(+)/H(+) antiporter. It can mediate sodium uptake when a transmembrane pH gradient is applied [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6322367, Length=458, Percent_Identity=24.8908296943231, Blast_Score=153, Evalue=4e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 45545; Mature: 45414

Theoretical pI: Translated: 10.32; Mature: 10.32

Prosite motif: PS00436 PEROXIDASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADWILQLCVVVVVAFTLGALAQRLGQGRVVGELLAGLLLGPSAFGALTVAGHGALIGPQ
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHCEEEEECCCCEECCH
TAALLSRLGELGLVFLMFQTGMHITWTTAHGRSSGLVATVVAGFGMALPFATGCAIAVAA
HHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEC
SGSFQPQASHLAYVLFCGIALSVSALPVMMRIIADARIAGRACATLSILAATLTDSLGWL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLAAVGTLATSGLSPASTVHAMGVLVAFVVVSISLVRPIVLGVLDRTRRAGSGSAMLICA
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
LCYVLLSSWAAARLGFHGAFGALVAAANLAGRHDLRQLWDARFAGLADLVLIPLFFVSMG
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
FQASFSALDTGAAWGWLAAFLVGGVATKFAGCYAGARLCGIDRAEATLVGVLMNCRGTVE
CCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHCCCHHH
LMVLAIGLQLRIIPASLYTVLLIATLTMTWLSAMSTHRLAKRRPLRSPPAGAGDAPAGFR
HHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
ATQAQAAGGDARLPGLPEASRPSR
HHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
ADWILQLCVVVVVAFTLGALAQRLGQGRVVGELLAGLLLGPSAFGALTVAGHGALIGPQ
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHCEEEEECCCCEECCH
TAALLSRLGELGLVFLMFQTGMHITWTTAHGRSSGLVATVVAGFGMALPFATGCAIAVAA
HHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEC
SGSFQPQASHLAYVLFCGIALSVSALPVMMRIIADARIAGRACATLSILAATLTDSLGWL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLAAVGTLATSGLSPASTVHAMGVLVAFVVVSISLVRPIVLGVLDRTRRAGSGSAMLICA
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
LCYVLLSSWAAARLGFHGAFGALVAAANLAGRHDLRQLWDARFAGLADLVLIPLFFVSMG
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
FQASFSALDTGAAWGWLAAFLVGGVATKFAGCYAGARLCGIDRAEATLVGVLMNCRGTVE
CCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHCCCHHH
LMVLAIGLQLRIIPASLYTVLLIATLTMTWLSAMSTHRLAKRRPLRSPPAGAGDAPAGFR
HHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
ATQAQAAGGDARLPGLPEASRPSR
HHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1312090; 1325937 [H]