Click here to switch to the map view.

The map label for this gene is argG_2 [H]

Identifier: 237812294

GI number: 237812294

Start: 1990460

End: 1991674

Strand: Direct

Name: argG_2 [H]

Synonym: GBP346_A2042

Alternate gene names: 237812294

Gene position: 1990460-1991674 (Clockwise)

Preceding gene: 237812293

Following gene: 237812295

Centisome position: 48.56

GC content: 66.17

Gene sequence:

>1215_bases
ATGAAACCCAAACACATTCTCCTCGCTTATTCCGGCGGCCTCGACACGTCCACCGCGCTGCACTTCCTGAAGCGGCATTT
CGATTGCCGCGTCACCGCCTATTGCGCGAACCTCGGGCAGAAGGAGGATTGGGAGCGGATGAAACGCCGCGCGGCGATCG
CCGGCGCGGACGAGCTGGTCATCGAGGATCTGCGCGAGACGTTCATCGGCGATTTCGTGTTTCCCGCGCTGAAGGCGAAC
GCGTCGTACGAGCGGGACTATCTGCTCGGCACGCCGCTCGCCCGCCCGGCGATCGTCAAGGGGCTCATCGAGTACGCGCG
CAAGCACGACGTCGATTGCCTGTCGCACGGCTGCACGCAGAAGGGCAACGATCAGGTGCGCTTCGAGATGGCCGCGAAGA
TCCTCGCGCCCGATCTGCCGACGGTCGCGCCGTGGCGCATCTGGTCGCTGCAGTCGCGCGAGGATCTGTTCGCGTATTGT
CAGCAGCACGGCATTCCGGTCGAAAGCCGTCCGGACAATCTGTTGAGCCACGACGAGAATCTCGTGCACATCACGACGGA
GGGCGACTATCTGGAGAGCGTCGCGAACGCGTTCGACTGGCGCGACGCGAACTGGATCACGCCGCCCATGCAAGCGCCGG
ATGCGATCGAGACGATCACGCTCGGGTTCCGCCGGGGCGTGCCCGTCAGCGTCGACGGCGCGGCGCTCGGGCCGGTCGAG
CTGGTCGAGCGGCTCAACGAAGCGGGCGCCCGCAACGGCGTCGGCTTCCAGGACATCATCGAGAACCGCATCAACGGCCT
GAAGGTGCGCGGCGTGTTCGAGAACCCCGCGCTGACGATCCTGCACGCCGCGCATCGCAAGCTCGAGAAGATCACGCTCG
GCCGCGACGTCGAGCGCCTGCGCAACCTCGTGTCGGACGACTACGGCGACATCGTCTACCGCGGCCTGTGGTTCAGCGAC
GAGCGGCTCTGCCTGCAGGCGCTCATCGACGAATCGCAGAAGTACGTGAGCGGCGACGTGAAGGTTCAGCTCTACAAGGG
TTCGTGCACGCCGTGCGCCGTCGAATCGGAGCAGTCGCTTTATTCGCGCGAGCTCGTGACGCTGCACGCGGGCCGCGCGA
TCAGCGGCGAGGATGCGACGGGCTTCCTGAACACGCTCGGCCTGCGTATCGGCATCGAAGCCGCGCGCGCCGGCAACACG
GGAGCCGGCGCATGA

Upstream 100 bases:

>100_bases
GAACTGGCCGACAACGTCAACCAGATTCGCGGCAAGCGCGACAACTACCTCGTCGGCTAGTCGGCGAGGCGGCGAACCCA
TCCATCACGGAAGATCGGAC

Downstream 100 bases:

>100_bases
GCAATCCGATGGCGAATCCGTGGGCCGGGCGCTTCAGCCAGACGATGACCGACAGCCTGGTGGCGTTCAACACGAGCCTG
CCGCTCGAAACGCGGCTCTT

Product: argininosuccinate synthase

Products: NA

Alternate protein names: Citrulline--aspartate ligase [H]

Number of amino acids: Translated: 404; Mature: 404

Protein sequence:

>404_residues
MKPKHILLAYSGGLDTSTALHFLKRHFDCRVTAYCANLGQKEDWERMKRRAAIAGADELVIEDLRETFIGDFVFPALKAN
ASYERDYLLGTPLARPAIVKGLIEYARKHDVDCLSHGCTQKGNDQVRFEMAAKILAPDLPTVAPWRIWSLQSREDLFAYC
QQHGIPVESRPDNLLSHDENLVHITTEGDYLESVANAFDWRDANWITPPMQAPDAIETITLGFRRGVPVSVDGAALGPVE
LVERLNEAGARNGVGFQDIIENRINGLKVRGVFENPALTILHAAHRKLEKITLGRDVERLRNLVSDDYGDIVYRGLWFSD
ERLCLQALIDESQKYVSGDVKVQLYKGSCTPCAVESEQSLYSRELVTLHAGRAISGEDATGFLNTLGLRIGIEAARAGNT
GAGA

Sequences:

>Translated_404_residues
MKPKHILLAYSGGLDTSTALHFLKRHFDCRVTAYCANLGQKEDWERMKRRAAIAGADELVIEDLRETFIGDFVFPALKAN
ASYERDYLLGTPLARPAIVKGLIEYARKHDVDCLSHGCTQKGNDQVRFEMAAKILAPDLPTVAPWRIWSLQSREDLFAYC
QQHGIPVESRPDNLLSHDENLVHITTEGDYLESVANAFDWRDANWITPPMQAPDAIETITLGFRRGVPVSVDGAALGPVE
LVERLNEAGARNGVGFQDIIENRINGLKVRGVFENPALTILHAAHRKLEKITLGRDVERLRNLVSDDYGDIVYRGLWFSD
ERLCLQALIDESQKYVSGDVKVQLYKGSCTPCAVESEQSLYSRELVTLHAGRAISGEDATGFLNTLGLRIGIEAARAGNT
GAGA
>Mature_404_residues
MKPKHILLAYSGGLDTSTALHFLKRHFDCRVTAYCANLGQKEDWERMKRRAAIAGADELVIEDLRETFIGDFVFPALKAN
ASYERDYLLGTPLARPAIVKGLIEYARKHDVDCLSHGCTQKGNDQVRFEMAAKILAPDLPTVAPWRIWSLQSREDLFAYC
QQHGIPVESRPDNLLSHDENLVHITTEGDYLESVANAFDWRDANWITPPMQAPDAIETITLGFRRGVPVSVDGAALGPVE
LVERLNEAGARNGVGFQDIIENRINGLKVRGVFENPALTILHAAHRKLEKITLGRDVERLRNLVSDDYGDIVYRGLWFSD
ERLCLQALIDESQKYVSGDVKVQLYKGSCTPCAVESEQSLYSRELVTLHAGRAISGEDATGFLNTLGLRIGIEAARAGNT
GAGA

Specific function: Arginine biosynthesis; seventh step. [C]

COG id: COG0137

COG function: function code E; Argininosuccinate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the argininosuccinate synthase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI53759107, Length=395, Percent_Identity=41.0126582278481, Blast_Score=288, Evalue=7e-78,
Organism=Homo sapiens, GI16950633, Length=395, Percent_Identity=41.0126582278481, Blast_Score=288, Evalue=7e-78,
Organism=Escherichia coli, GI1789563, Length=411, Percent_Identity=28.4671532846715, Blast_Score=133, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6324514, Length=405, Percent_Identity=37.2839506172839, Blast_Score=249, Evalue=4e-67,
Organism=Drosophila melanogaster, GI21358151, Length=409, Percent_Identity=39.6088019559902, Blast_Score=279, Evalue=2e-75,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001518
- InterPro:   IPR018223
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00764 Arginosuc_synth [H]

EC number: =6.3.4.5 [H]

Molecular weight: Translated: 44774; Mature: 44774

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: PS00564 ARGININOSUCCIN_SYN_1 ; PS00565 ARGININOSUCCIN_SYN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPKHILLAYSGGLDTSTALHFLKRHFDCRVTAYCANLGQKEDWERMKRRAAIAGADELV
CCCCEEEEEECCCCCHHHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHHHHHCCHHHHH
IEDLRETFIGDFVFPALKANASYERDYLLGTPLARPAIVKGLIEYARKHDVDCLSHGCTQ
HHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHHHCCHHHHHHCCCC
KGNDQVRFEMAAKILAPDLPTVAPWRIWSLQSREDLFAYCQQHGIPVESRPDNLLSHDEN
CCCCCCHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCCCHHHCCCCC
LVHITTEGDYLESVANAFDWRDANWITPPMQAPDAIETITLGFRRGVPVSVDGAALGPVE
EEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEECCCCCCHHH
LVERLNEAGARNGVGFQDIIENRINGLKVRGVFENPALTILHAAHRKLEKITLGRDVERL
HHHHHHHHCCCCCCCHHHHHHHHHCCEEEEEEECCCHHHHHHHHHHHHHHHHCCHHHHHH
RNLVSDDYGDIVYRGLWFSDERLCLQALIDESQKYVSGDVKVQLYKGSCTPCAVESEQSL
HHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHH
YSRELVTLHAGRAISGEDATGFLNTLGLRIGIEAARAGNTGAGA
HHHHHEEEECCCEECCCCCHHHHHHHHHHEEEHHHCCCCCCCCC
>Mature Secondary Structure
MKPKHILLAYSGGLDTSTALHFLKRHFDCRVTAYCANLGQKEDWERMKRRAAIAGADELV
CCCCEEEEEECCCCCHHHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHHHHHCCHHHHH
IEDLRETFIGDFVFPALKANASYERDYLLGTPLARPAIVKGLIEYARKHDVDCLSHGCTQ
HHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHHHCCHHHHHHCCCC
KGNDQVRFEMAAKILAPDLPTVAPWRIWSLQSREDLFAYCQQHGIPVESRPDNLLSHDEN
CCCCCCHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCCCHHHCCCCC
LVHITTEGDYLESVANAFDWRDANWITPPMQAPDAIETITLGFRRGVPVSVDGAALGPVE
EEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEECCCCCCHHH
LVERLNEAGARNGVGFQDIIENRINGLKVRGVFENPALTILHAAHRKLEKITLGRDVERL
HHHHHHHHCCCCCCCHHHHHHHHHCCEEEEEEECCCHHHHHHHHHHHHHHHHCCHHHHHH
RNLVSDDYGDIVYRGLWFSDERLCLQALIDESQKYVSGDVKVQLYKGSCTPCAVESEQSL
HHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHH
YSRELVTLHAGRAISGEDATGFLNTLGLRIGIEAARAGNTGAGA
HHHHHEEEECCCEECCCCCHHHHHHHHHHEEEHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA