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The map label for this gene is argH_2 [H]

Identifier: 237812295

GI number: 237812295

Start: 1991671

End: 1993071

Strand: Direct

Name: argH_2 [H]

Synonym: GBP346_A2043

Alternate gene names: 237812295

Gene position: 1991671-1993071 (Clockwise)

Preceding gene: 237812294

Following gene: 237812296

Centisome position: 48.59

GC content: 68.24

Gene sequence:

>1401_bases
ATGAGCAATCCGATGGCGAATCCGTGGGCCGGGCGCTTCAGCCAGACGATGACCGACAGCCTGGTGGCGTTCAACACGAG
CCTGCCGCTCGAAACGCGGCTCTTCGAGGCCGACATCGACGGCACGGCCGCGCACGTCGAGATGCTGCATGCGACGGGCC
TGCTGGAGACGGCGGAGCACGAGGCGCTCGCGCGCGCGCTCGACGAGATCCGCGCCGCGTGGCGCGCGGGCGAGATTCGG
CTGTCGCCCGCGCTCGAGGACATCCACATGAACCTCGAGACGCTGCTGGTCGACAAGCTCGGCGAGCTCGGCAAGAAAAC
GCATACCGCGCGCAGCCGCAACGATCAGCAGGCGAGCGCGCAGCGCCTCTATTTCATGCGCTCGACGCGCGAGCTGGTGG
ACGCGATCGACGCGCTGCAGCGCGCGATCCTCGAGCACGGCGAGCGCCACGACGCGCTCGTGATGCCATCGTACACGCAC
CTGCAGCGCGCCGAATTCACGTATTACGCGCACTGGCTCGCGACTTACGTGGTGATGCTCGAGCGCGACCGCAGCCGCTT
CGTCGACGCGCTCGCGCGCGCCGACCAGTGCCCGCTCGGCGCCTGTGCGTCGACCGGCACGAGCCTGCCGATCGACCGCC
GGCGCTCGGCGTCGCGGCTGGGCTTCAGGGAGCCCACGCTGCACAGCATCGATTCGGTGTCCGACCGCGACTACCTCGTC
GAATTCTGCTCGCACGCGGCGAATCTGATGATCCATCTGTCGCGGCTGTCGGAGGAGCTCATTTCGTTCACGAGCCAGGA
ATTCGGCTTCATCGCGCTCGCGGACGGCTACTGCACCGGCAGCTCGATCATGCCGCAGAAGAAGAACCCCGACGTGCCGG
AGCTCGTGCGCGGCAAGGCGGCATCGGTGATCGGCAACGCGATGAGCCTGATGGCGCTCCTGAAGGCGCTGCCGCTCGGC
TACAACAAGGATCTGCAGGAGGACAAGACCGCGTGGTTCGCCGCGCTCGACAACTGCATGTCGTCGCTCGCGATCCTGAC
CGAGCTGGTTCGCACGATGGCGCCCGTGCCCGACAGGATGCGCCAGGCGACGCTCGGCGGGCACATCATCGCCACCGAGT
ACGCGAACTACCTGGTCCGCAAGGGCATGCCGTTTCGCGAAGCGCATCGGGTCGTCGGCGAGCTGGTGAAGACGGCGGAC
GCACGCGGCGTCGACGTGTCGGCGCTGCCCCAGGCGGCATTCGCCGAGGCGAGCCCGCTGTTCGGCGACGACATCGGCCG
CGTCACCGTCGAGGACATGGTGTCGCGCAAGAACTCGTACGGCTCGTGCGGCGACCAGGCGCTCGGCGAGCTGCTCGCGC
AGCTTCGCTCGATGCTGGACGCGCATCGTCCCGGCCGATGA

Upstream 100 bases:

>100_bases
GCCGCGCGATCAGCGGCGAGGATGCGACGGGCTTCCTGAACACGCTCGGCCTGCGTATCGGCATCGAAGCCGCGCGCGCC
GGCAACACGGGAGCCGGCGC

Downstream 100 bases:

>100_bases
CCGCTCGAGCACTGGCCATGTCGGAGCCCATGCGTTCACTCATCCCGGCCGCGCGAACGGCGTCGGGCATCTCGTACTGC
TCGTTCGGCGAACTGCTGCA

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 466; Mature: 465

Protein sequence:

>466_residues
MSNPMANPWAGRFSQTMTDSLVAFNTSLPLETRLFEADIDGTAAHVEMLHATGLLETAEHEALARALDEIRAAWRAGEIR
LSPALEDIHMNLETLLVDKLGELGKKTHTARSRNDQQASAQRLYFMRSTRELVDAIDALQRAILEHGERHDALVMPSYTH
LQRAEFTYYAHWLATYVVMLERDRSRFVDALARADQCPLGACASTGTSLPIDRRRSASRLGFREPTLHSIDSVSDRDYLV
EFCSHAANLMIHLSRLSEELISFTSQEFGFIALADGYCTGSSIMPQKKNPDVPELVRGKAASVIGNAMSLMALLKALPLG
YNKDLQEDKTAWFAALDNCMSSLAILTELVRTMAPVPDRMRQATLGGHIIATEYANYLVRKGMPFREAHRVVGELVKTAD
ARGVDVSALPQAAFAEASPLFGDDIGRVTVEDMVSRKNSYGSCGDQALGELLAQLRSMLDAHRPGR

Sequences:

>Translated_466_residues
MSNPMANPWAGRFSQTMTDSLVAFNTSLPLETRLFEADIDGTAAHVEMLHATGLLETAEHEALARALDEIRAAWRAGEIR
LSPALEDIHMNLETLLVDKLGELGKKTHTARSRNDQQASAQRLYFMRSTRELVDAIDALQRAILEHGERHDALVMPSYTH
LQRAEFTYYAHWLATYVVMLERDRSRFVDALARADQCPLGACASTGTSLPIDRRRSASRLGFREPTLHSIDSVSDRDYLV
EFCSHAANLMIHLSRLSEELISFTSQEFGFIALADGYCTGSSIMPQKKNPDVPELVRGKAASVIGNAMSLMALLKALPLG
YNKDLQEDKTAWFAALDNCMSSLAILTELVRTMAPVPDRMRQATLGGHIIATEYANYLVRKGMPFREAHRVVGELVKTAD
ARGVDVSALPQAAFAEASPLFGDDIGRVTVEDMVSRKNSYGSCGDQALGELLAQLRSMLDAHRPGR
>Mature_465_residues
SNPMANPWAGRFSQTMTDSLVAFNTSLPLETRLFEADIDGTAAHVEMLHATGLLETAEHEALARALDEIRAAWRAGEIRL
SPALEDIHMNLETLLVDKLGELGKKTHTARSRNDQQASAQRLYFMRSTRELVDAIDALQRAILEHGERHDALVMPSYTHL
QRAEFTYYAHWLATYVVMLERDRSRFVDALARADQCPLGACASTGTSLPIDRRRSASRLGFREPTLHSIDSVSDRDYLVE
FCSHAANLMIHLSRLSEELISFTSQEFGFIALADGYCTGSSIMPQKKNPDVPELVRGKAASVIGNAMSLMALLKALPLGY
NKDLQEDKTAWFAALDNCMSSLAILTELVRTMAPVPDRMRQATLGGHIIATEYANYLVRKGMPFREAHRVVGELVKTADA
RGVDVSALPQAAFAEASPLFGDDIGRVTVEDMVSRKNSYGSCGDQALGELLAQLRSMLDAHRPGR

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=466, Percent_Identity=37.5536480686695, Blast_Score=313, Evalue=2e-85,
Organism=Homo sapiens, GI68303542, Length=466, Percent_Identity=37.5536480686695, Blast_Score=313, Evalue=2e-85,
Organism=Homo sapiens, GI68303549, Length=466, Percent_Identity=36.0515021459227, Blast_Score=283, Evalue=2e-76,
Organism=Homo sapiens, GI68303547, Length=466, Percent_Identity=35.1931330472103, Blast_Score=281, Evalue=1e-75,
Organism=Escherichia coli, GI1790398, Length=453, Percent_Identity=43.2671081677704, Blast_Score=338, Evalue=5e-94,
Organism=Saccharomyces cerevisiae, GI6321806, Length=468, Percent_Identity=36.7521367521368, Blast_Score=296, Evalue=3e-81,
Organism=Drosophila melanogaster, GI221473854, Length=448, Percent_Identity=39.7321428571429, Blast_Score=353, Evalue=1e-97,
Organism=Drosophila melanogaster, GI78706858, Length=448, Percent_Identity=39.7321428571429, Blast_Score=353, Evalue=1e-97,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 51477; Mature: 51346

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNPMANPWAGRFSQTMTDSLVAFNTSLPLETRLFEADIDGTAAHVEMLHATGLLETAEH
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHEECCCCCHHHHHHHHHHHHHHHHHHH
EALARALDEIRAAWRAGEIRLSPALEDIHMNLETLLVDKLGELGKKTHTARSRNDQQASA
HHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
QRLYFMRSTRELVDAIDALQRAILEHGERHDALVMPSYTHLQRAEFTYYAHWLATYVVML
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHH
ERDRSRFVDALARADQCPLGACASTGTSLPIDRRRSASRLGFREPTLHSIDSVSDRDYLV
HHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCHHHHHHHHCCCCCCCHHHHHCCCCHHHHH
EFCSHAANLMIHLSRLSEELISFTSQEFGFIALADGYCTGSSIMPQKKNPDVPELVRGKA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHCHH
ASVIGNAMSLMALLKALPLGYNKDLQEDKTAWFAALDNCMSSLAILTELVRTMAPVPDRM
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
RQATLGGHIIATEYANYLVRKGMPFREAHRVVGELVKTADARGVDVSALPQAAFAEASPL
HHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCHHHCCHHHHHCCCCC
FGDDIGRVTVEDMVSRKNSYGSCGDQALGELLAQLRSMLDAHRPGR
CCCCCCCEEHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SNPMANPWAGRFSQTMTDSLVAFNTSLPLETRLFEADIDGTAAHVEMLHATGLLETAEH
CCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHEECCCCCHHHHHHHHHHHHHHHHHHH
EALARALDEIRAAWRAGEIRLSPALEDIHMNLETLLVDKLGELGKKTHTARSRNDQQASA
HHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
QRLYFMRSTRELVDAIDALQRAILEHGERHDALVMPSYTHLQRAEFTYYAHWLATYVVML
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHH
ERDRSRFVDALARADQCPLGACASTGTSLPIDRRRSASRLGFREPTLHSIDSVSDRDYLV
HHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCHHHHHHHHCCCCCCCHHHHHCCCCHHHHH
EFCSHAANLMIHLSRLSEELISFTSQEFGFIALADGYCTGSSIMPQKKNPDVPELVRGKA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHCHH
ASVIGNAMSLMALLKALPLGYNKDLQEDKTAWFAALDNCMSSLAILTELVRTMAPVPDRM
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
RQATLGGHIIATEYANYLVRKGMPFREAHRVVGELVKTADARGVDVSALPQAAFAEASPL
HHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCHHHCCHHHHHCCCCC
FGDDIGRVTVEDMVSRKNSYGSCGDQALGELLAQLRSMLDAHRPGR
CCCCCCCEEHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA