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The map label for this gene is cobW [H]

Identifier: 237812230

GI number: 237812230

Start: 1930005

End: 1931078

Strand: Direct

Name: cobW [H]

Synonym: GBP346_A1977

Alternate gene names: 237812230

Gene position: 1930005-1931078 (Clockwise)

Preceding gene: 237812229

Following gene: 237812231

Centisome position: 47.09

GC content: 70.2

Gene sequence:

>1074_bases
ATGCAGATGCGCAAAATTCCCGTGACGATCGTCACGGGCTTCCTCGGCAGCGGCAAGACGACGCTCTTGCGCCACATCCT
CCAGCACGCGGGCGGCCGCCGGATCGTCGTGATCGTCAACGAGTTCGGCGAACTCGGCATCGACGGCGAGATCCTGAAGG
GCTGCGGCGTCGGCTGCGACGAAGCCGGCCGCGAAGTCGACGGCCGGCTCTACGAGCTCGCGAACGGGTGCCTGTGCTGC
ACCGTGCAGGAAGAGTTCTATCCGGTGATGGAGCAACTCGTCGAGCGCCGCGCGCACATCGATCACGTGCTGATCGAGAC
CTCCGGCCTCGCGCTGCCCAAGCCGCTCGTGCAGGCGTTCAACTGGCCGTCGATCAAGAACGGCTTCACGGTCGACGCGG
TGCTGACCGTGGTCGACGCGCCCGCCACCGCGCGCGGCCAGTTCGCCGAGAACCCCGCCGCCGTCGACGCGCAGCGCCGC
GCGGACCCGAATCTCGATCACGAATCGCCGCTGCACGAGCTGTTCGCCGATCAGCTGTCGTCCGCCGATCTCGTGATCGT
CAACAAGACCGATCTGCTCGACGACGCGGCGCTCGCCGCCGTCGAGGCGACGATTCGCGACGAAGTCCCGCCGCAGGTGA
AGCTCGTGCGCGCGCGGCGCGGCGAGCTCGATCTCGCGACGCTGCTCGGGCTAAACGCCGCGTCCGAGGAGACGATCCAT
CTGCGGCACGATCATCACGGCTCGGCCGACGACGCCGATCACCATCACGACGAGTTCGACTCGGTCGTCGTCGAGGCGCG
GGTGAGCTCGCGCGAGGCCGCGCTCGGCGCGCTCGGGGCGCTCGTCGAGGCGCACGCGATCTATCGCGTGAAGGGCTTCG
CCGCGTTGCCGGGCGTGCCGATGCGGCTCGTCGTGCAGGGCGTCGGCCGGCGCTTCGACAGCTATTTCGACCGCCGCTGG
CGCGACGGCGAGGCGCCCGCGAGCCGCTTCGTGCTGATCGGCGAGGACCTCGACGCGGCCGCGCTGCAGCGCGCGTTCGA
CGCGGCGCTCGCCGCGCACGGGCAGGCCGCGTGA

Upstream 100 bases:

>100_bases
CATGAGCTCATGCGCCGCGCGCGTCGCACGCCGCCGCGGCACCGGCCCGAGGCCCGATTACCCCTTACTCCATGACCCGA
TACCGACCAACGGACCTCCC

Downstream 100 bases:

>100_bases
CGCGGCGGCGGGCGACGCGCGGCGCAGCCGGGCCGCGCCGGACGCGCTTGACGGGGGCGTAGCGCGATGCATCTGTTGCG
CACCACGCCGGGCGGCTTCG

Product: cobalamin biosynthesis protein CobW

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MQMRKIPVTIVTGFLGSGKTTLLRHILQHAGGRRIVVIVNEFGELGIDGEILKGCGVGCDEAGREVDGRLYELANGCLCC
TVQEEFYPVMEQLVERRAHIDHVLIETSGLALPKPLVQAFNWPSIKNGFTVDAVLTVVDAPATARGQFAENPAAVDAQRR
ADPNLDHESPLHELFADQLSSADLVIVNKTDLLDDAALAAVEATIRDEVPPQVKLVRARRGELDLATLLGLNAASEETIH
LRHDHHGSADDADHHHDEFDSVVVEARVSSREAALGALGALVEAHAIYRVKGFAALPGVPMRLVVQGVGRRFDSYFDRRW
RDGEAPASRFVLIGEDLDAAALQRAFDAALAAHGQAA

Sequences:

>Translated_357_residues
MQMRKIPVTIVTGFLGSGKTTLLRHILQHAGGRRIVVIVNEFGELGIDGEILKGCGVGCDEAGREVDGRLYELANGCLCC
TVQEEFYPVMEQLVERRAHIDHVLIETSGLALPKPLVQAFNWPSIKNGFTVDAVLTVVDAPATARGQFAENPAAVDAQRR
ADPNLDHESPLHELFADQLSSADLVIVNKTDLLDDAALAAVEATIRDEVPPQVKLVRARRGELDLATLLGLNAASEETIH
LRHDHHGSADDADHHHDEFDSVVVEARVSSREAALGALGALVEAHAIYRVKGFAALPGVPMRLVVQGVGRRFDSYFDRRW
RDGEAPASRFVLIGEDLDAAALQRAFDAALAAHGQAA
>Mature_357_residues
MQMRKIPVTIVTGFLGSGKTTLLRHILQHAGGRRIVVIVNEFGELGIDGEILKGCGVGCDEAGREVDGRLYELANGCLCC
TVQEEFYPVMEQLVERRAHIDHVLIETSGLALPKPLVQAFNWPSIKNGFTVDAVLTVVDAPATARGQFAENPAAVDAQRR
ADPNLDHESPLHELFADQLSSADLVIVNKTDLLDDAALAAVEATIRDEVPPQVKLVRARRGELDLATLLGLNAASEETIH
LRHDHHGSADDADHHHDEFDSVVVEARVSSREAALGALGALVEAHAIYRVKGFAALPGVPMRLVVQGVGRRFDSYFDRRW
RDGEAPASRFVLIGEDLDAAALQRAFDAALAAHGQAA

Specific function: Might be involved in cobalt reduction leading to cobalt(I) corrinoids [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI33469141, Length=365, Percent_Identity=29.5890410958904, Blast_Score=142, Evalue=7e-34,
Organism=Homo sapiens, GI126722884, Length=365, Percent_Identity=29.3150684931507, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI148727351, Length=365, Percent_Identity=29.3150684931507, Blast_Score=138, Evalue=6e-33,
Organism=Homo sapiens, GI146231952, Length=365, Percent_Identity=28.7671232876712, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI223941779, Length=356, Percent_Identity=28.6516853932584, Blast_Score=132, Evalue=4e-31,
Organism=Homo sapiens, GI223941776, Length=366, Percent_Identity=27.5956284153005, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI119120938, Length=151, Percent_Identity=39.0728476821192, Blast_Score=99, Evalue=5e-21,
Organism=Escherichia coli, GI87082430, Length=355, Percent_Identity=30.4225352112676, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI1788499, Length=185, Percent_Identity=32.4324324324324, Blast_Score=90, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6324356, Length=390, Percent_Identity=25.3846153846154, Blast_Score=110, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012824
- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 38622; Mature: 38622

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQMRKIPVTIVTGFLGSGKTTLLRHILQHAGGRRIVVIVNEFGELGIDGEILKGCGVGCD
CCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHCCCCCC
EAGREVDGRLYELANGCLCCTVQEEFYPVMEQLVERRAHIDHVLIETSGLALPKPLVQAF
HHCCHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHCEEEEECCCCCCCHHHHHHC
NWPSIKNGFTVDAVLTVVDAPATARGQFAENPAAVDAQRRADPNLDHESPLHELFADQLS
CCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHCC
SADLVIVNKTDLLDDAALAAVEATIRDEVPPQVKLVRARRGELDLATLLGLNAASEETIH
CCCEEEEECCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHCCCCCCCCEEE
LRHDHHGSADDADHHHDEFDSVVVEARVSSREAALGALGALVEAHAIYRVKGFAALPGVP
EEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCH
MRLVVQGVGRRFDSYFDRRWRDGEAPASRFVLIGEDLDAAALQRAFDAALAAHGQAA
HHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MQMRKIPVTIVTGFLGSGKTTLLRHILQHAGGRRIVVIVNEFGELGIDGEILKGCGVGCD
CCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHCCCCCC
EAGREVDGRLYELANGCLCCTVQEEFYPVMEQLVERRAHIDHVLIETSGLALPKPLVQAF
HHCCHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHCEEEEECCCCCCCHHHHHHC
NWPSIKNGFTVDAVLTVVDAPATARGQFAENPAAVDAQRRADPNLDHESPLHELFADQLS
CCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHCC
SADLVIVNKTDLLDDAALAAVEATIRDEVPPQVKLVRARRGELDLATLLGLNAASEETIH
CCCEEEEECCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHCCCCCCCCEEE
LRHDHHGSADDADHHHDEFDSVVVEARVSSREAALGALGALVEAHAIYRVKGFAALPGVP
EEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCH
MRLVVQGVGRRFDSYFDRRWRDGEAPASRFVLIGEDLDAAALQRAFDAALAAHGQAA
HHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]