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The map label for this gene is gltR [H]

Identifier: 237811945

GI number: 237811945

Start: 1624405

End: 1625430

Strand: Reverse

Name: gltR [H]

Synonym: GBP346_A1685

Alternate gene names: 237811945

Gene position: 1625430-1624405 (Counterclockwise)

Preceding gene: 237811948

Following gene: 237811943

Centisome position: 39.66

GC content: 72.51

Gene sequence:

>1026_bases
TTGACCGATCATTCTCGAAAAATGAATAATTCAGATTCGATCCATCCCACGGAGAGAATCATGGATCTGGCGGCTCTCGC
GATCTTTCGCGCGGTCGTGCGCGAGAACGGCGTGACGCGCGCGGCGGCAAAGCTCAACCGTGTGCAATCGAACGTCACGA
CGCGCATCAAGCAACTGGAGGAGCAGCTCGGCGCGCCGCTTTTCGTGCGCGACGGCCGCCGGCTCGTGCTCACCCCGCCC
GGCGAGACGCTGCTGCCGTATGCGGAGCGTCTGCTCGCGCTCGCCGACGAGGCGCGCCACGCGGTCACCGAAAACCGGCC
GCACGGCCGGTTGCGGCTCGGCGCGATGGAAAGCACCGCGGCGAGCCGCCTGCCCGCCTTGCTCGCCCGCTACCACCAGG
CGTGGCCCGACGTCACGCTCGAGCTCGTCACCGGCACGACGGGCAAGCTGATCGGTCTCGTGCGCGACTTCGAGCTCGAC
GCCGCGCTCGTCGCGACGCCGGCCGGCTCCGAGGCGCTCGGCGAGCCGTTCGAGACGGCGTCCGCGTTCACCGAAGAACT
GGTGCTGCTCACGCCGCGCGGCCATCCGCGCGTGCGCACGCCGCGCGACGTGCGGCTGCCGACGCTCGTCGCGTTCGAGC
GCGGCTGCGCGTACCGCGGCTGCGTCGAGCGCTGGTACGCGGCGGAGGGGCTGAAGCCCGAGCGCGTGCTCGAACTCGGC
TCGTATCACGCGATCGTCGCGTGCGTCGCGGCGGGCGCGGGCGTCGCGGTCGCGCCGCGCTCGGTGCTCGCCGTCCAGCG
CGAGCCGGACAGCCTCGGCGTGCACCCGATCGACGGCATGCCGCCGATCGATACGATGCTCGTCTGGCGCCAGGGGCATT
TCTCGGCGGCGCTCGCCGCGCTGCGCGACGCGTTGCGCGACGCCGCCGCCGCGGCGAACGCCACCGACGTCGCGGCGCAC
GAAGCGGCGAAGGTCGCGCCCCGGCGCACGCGGCGCGGCGCCGCGCGCGAAACGCTGCCGGCTTGA

Upstream 100 bases:

>100_bases
GGTAGAGAGTTCATCGTTTCGAGGGGCGAAGCGGCCACGCCATCGGGTCGGAAGCATCGCGGCCGGTCAAGATCATGGTC
GAAGTCGATTCGATGCTAGC

Downstream 100 bases:

>100_bases
TACGGGCAGGCGCGAATGCGTCCGGCGCGTCACGGTCACGGTCACGGTCCGGTCACGGTCGCGGTCGTCGTGACGTGACG
TAACGTGACGCGATGCGACG

Product: transcriptional regulator, LysR family

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 340

Protein sequence:

>341_residues
MTDHSRKMNNSDSIHPTERIMDLAALAIFRAVVRENGVTRAAAKLNRVQSNVTTRIKQLEEQLGAPLFVRDGRRLVLTPP
GETLLPYAERLLALADEARHAVTENRPHGRLRLGAMESTAASRLPALLARYHQAWPDVTLELVTGTTGKLIGLVRDFELD
AALVATPAGSEALGEPFETASAFTEELVLLTPRGHPRVRTPRDVRLPTLVAFERGCAYRGCVERWYAAEGLKPERVLELG
SYHAIVACVAAGAGVAVAPRSVLAVQREPDSLGVHPIDGMPPIDTMLVWRQGHFSAALAALRDALRDAAAAANATDVAAH
EAAKVAPRRTRRGAARETLPA

Sequences:

>Translated_341_residues
MTDHSRKMNNSDSIHPTERIMDLAALAIFRAVVRENGVTRAAAKLNRVQSNVTTRIKQLEEQLGAPLFVRDGRRLVLTPP
GETLLPYAERLLALADEARHAVTENRPHGRLRLGAMESTAASRLPALLARYHQAWPDVTLELVTGTTGKLIGLVRDFELD
AALVATPAGSEALGEPFETASAFTEELVLLTPRGHPRVRTPRDVRLPTLVAFERGCAYRGCVERWYAAEGLKPERVLELG
SYHAIVACVAAGAGVAVAPRSVLAVQREPDSLGVHPIDGMPPIDTMLVWRQGHFSAALAALRDALRDAAAAANATDVAAH
EAAKVAPRRTRRGAARETLPA
>Mature_340_residues
TDHSRKMNNSDSIHPTERIMDLAALAIFRAVVRENGVTRAAAKLNRVQSNVTTRIKQLEEQLGAPLFVRDGRRLVLTPPG
ETLLPYAERLLALADEARHAVTENRPHGRLRLGAMESTAASRLPALLARYHQAWPDVTLELVTGTTGKLIGLVRDFELDA
ALVATPAGSEALGEPFETASAFTEELVLLTPRGHPRVRTPRDVRLPTLVAFERGCAYRGCVERWYAAEGLKPERVLELGS
YHAIVACVAAGAGVAVAPRSVLAVQREPDSLGVHPIDGMPPIDTMLVWRQGHFSAALAALRDALRDAAAAANATDVAAHE
AAKVAPRRTRRGAARETLPA

Specific function: Positive regulator of glutamate biosynthesis (gltAB genes). Negatively regulates its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787806, Length=279, Percent_Identity=39.7849462365591, Blast_Score=206, Evalue=2e-54,
Organism=Escherichia coli, GI1788481, Length=295, Percent_Identity=30.8474576271186, Blast_Score=101, Evalue=9e-23,
Organism=Escherichia coli, GI87082132, Length=260, Percent_Identity=30.3846153846154, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1788887, Length=289, Percent_Identity=29.4117647058824, Blast_Score=94, Evalue=9e-21,
Organism=Escherichia coli, GI1790208, Length=260, Percent_Identity=31.5384615384615, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1788296, Length=246, Percent_Identity=28.4552845528455, Blast_Score=88, Evalue=7e-19,
Organism=Escherichia coli, GI157672245, Length=262, Percent_Identity=28.2442748091603, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1787879, Length=290, Percent_Identity=30, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI1788626, Length=266, Percent_Identity=28.9473684210526, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI48994962, Length=113, Percent_Identity=40.7079646017699, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1787601, Length=172, Percent_Identity=26.1627906976744, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI2367136, Length=294, Percent_Identity=28.5714285714286, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1790262, Length=248, Percent_Identity=25.4032258064516, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1789204, Length=247, Percent_Identity=27.9352226720648, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1788748, Length=302, Percent_Identity=26.8211920529801, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1786401, Length=131, Percent_Identity=35.1145038167939, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI145693105, Length=245, Percent_Identity=23.6734693877551, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI87081904, Length=224, Percent_Identity=26.7857142857143, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1790399, Length=279, Percent_Identity=24.0143369175627, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 36853; Mature: 36721

Theoretical pI: Translated: 9.20; Mature: 9.20

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDHSRKMNNSDSIHPTERIMDLAALAIFRAVVRENGVTRAAAKLNRVQSNVTTRIKQLE
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
EQLGAPLFVRDGRRLVLTPPGETLLPYAERLLALADEARHAVTENRPHGRLRLGAMESTA
HHHCCCEEEECCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCHHHHH
ASRLPALLARYHQAWPDVTLELVTGTTGKLIGLVRDFELDAALVATPAGSEALGEPFETA
HHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHCCCCEEEEECCCCCHHHCCCHHHH
SAFTEELVLLTPRGHPRVRTPRDVRLPTLVAFERGCAYRGCVERWYAAEGLKPERVLELG
HHHHHCEEEECCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHC
SYHAIVACVAAGAGVAVAPRSVLAVQREPDSLGVHPIDGMPPIDTMLVWRQGHFSAALAA
CHHHHHHHHHCCCCCEECCHHHEEEECCCCCCCCCCCCCCCCHHHHHEEECCHHHHHHHH
LRDALRDAAAAANATDVAAHEAAKVAPRRTRRGAARETLPA
HHHHHHHHHHHCCCHHHHHHHHHHHCHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TDHSRKMNNSDSIHPTERIMDLAALAIFRAVVRENGVTRAAAKLNRVQSNVTTRIKQLE
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
EQLGAPLFVRDGRRLVLTPPGETLLPYAERLLALADEARHAVTENRPHGRLRLGAMESTA
HHHCCCEEEECCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCHHHHH
ASRLPALLARYHQAWPDVTLELVTGTTGKLIGLVRDFELDAALVATPAGSEALGEPFETA
HHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHCCCCEEEEECCCCCHHHCCCHHHH
SAFTEELVLLTPRGHPRVRTPRDVRLPTLVAFERGCAYRGCVERWYAAEGLKPERVLELG
HHHHHCEEEECCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHC
SYHAIVACVAAGAGVAVAPRSVLAVQREPDSLGVHPIDGMPPIDTMLVWRQGHFSAALAA
CHHHHHHHHHCCCCCEECCHHHEEEECCCCCCCCCCCCCCCCHHHHHEEECCHHHHHHHH
LRDALRDAAAAANATDVAAHEAAKVAPRRTRRGAARETLPA
HHHHHHHHHHHCCCHHHHHHHHHHHCHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9023181; 9308178; 9384377 [H]