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The map label for this gene is ffh [H]

Identifier: 229918605

GI number: 229918605

Start: 2858353

End: 2859693

Strand: Direct

Name: ffh [H]

Synonym: EAT1b_2892

Alternate gene names: 229918605

Gene position: 2858353-2859693 (Clockwise)

Preceding gene: 229918604

Following gene: 229918606

Centisome position: 95.28

GC content: 50.04

Gene sequence:

>1341_bases
ATGGCATTTGAAGGATTATCAGAACGATTGCAATCGACACTTTCAAAAATGCGCGGTAAAGGGAAAATCTCGGAGACCGA
TGTCAAAGAGATGATGCGTGAGGTACGCCTCGCCCTCCTCGAAGCCGACGTCAACTTTAAAGTCGTCAAGCAATTCGTCA
ATGACGTGAAGGAGCGCGCCGTTGGTCAGGATGTCATGAAATCATTGACGCCAGGTCAACAAGTCGTCAAAATCGTTCAC
GAAGAGTTGTCGAACTTGATGGGAAGCGATGTCGTCCCGATCACATTCAGTCAGAAACCACCGACAGTCGTCATGATGGT
CGGTCTGCAAGGGGCAGGGAAAACGACAACGACCGGGAAGCTAGCGAACTTGATTCGCAAAAAGCATAACCGAAGTCCTC
TTCTCGTCGCGGCGGACATTTACCGTCCGGCGGCAATCAAGCAGCTCGAGACACTCGGAAAACAACTCGATTTACCGGTC
TTCTCACTTGGTGATCAAGTGAAGCCGGAAGAGATTGTGACGAAGGCACTCGAGTACGCAAAAACAAATCATCACGATTT
CGTGTTGATCGATACGGCCGGTCGCCTTCATATCGATGAGACGCTTATGGGCGAGCTCGAAAATGTGAAGACGATTGCCA
AACCAAATGAGATCTTCCTCGTCGTCGATTCGATGACGGGTCAAGATGCGGTCAATGTGGCCGACAGTTTCAATGAGAAA
CTCGGAATCACCGGGGTCGTGCTCACAAAGCTCGACGGAGATACACGAGGCGGGGCAGCCCTTTCGATCAAGGCAGTCAC
GGGAGCGCCGATTAAATTCGTCGGTCTCGGAGAAAAGTTGGATGCCCTCGAACCATTCCACCCGGAACGCATGGCGTCAC
GGATCCTTGGAATGGGGGACGTGCTCTCGCTCATTGAAAAAGCCGAGACACAGATGGACCAAGACGCAGCGAAGGAGCTT
GAAAGCAAAATTCGTGACGCGTCATTCACGTTCGATGATTTCATTGAACAGTTGGCCCAAGTGAAAAACATGGGACCAAT
TGATGAATTACTTTCGATGTTACCTGGTGCAGGTAAGATGAAAGGGTTGAAGAACGTCCAAATCGACGAGAAACAACTCG
ATCACGTCGAAGCGATCATTCGCTCGATGACGAAACATGAGCGCGCCAATCCGGAAGTGCTCAACGCGAGTCGTCGTAAG
CGGATCGCAAAAGGGAGCGGTCGCTCGATTCAAGAAGTGAACCGTCTCATCAAACAGTTCGATGACATGAAGAAGATGAT
GAAACAAATGTCAGGACAAATGAAAGGGAAGAAAAAAGGCCTTGGCCTTCCATTCTTCTAA

Upstream 100 bases:

>100_bases
GCCAGCAACTTCTTCAGACCCTCAAACGTCAAGTCGAGCTCACCGATGACGTGAGCGCCACGATTTCTGCGCTTGAGAAT
TTAGAGTAGGGGGCTGAAGC

Downstream 100 bases:

>100_bases
CAAAACCTTTTGTCAGTCGAACGAAAAAGCTGTATACTATAAAAGTTGTCAATTCTTAAACACATGATGGAGGTATATTA
CCATGGCAGTTAAAATTCGT

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 446; Mature: 445

Protein sequence:

>446_residues
MAFEGLSERLQSTLSKMRGKGKISETDVKEMMREVRLALLEADVNFKVVKQFVNDVKERAVGQDVMKSLTPGQQVVKIVH
EELSNLMGSDVVPITFSQKPPTVVMMVGLQGAGKTTTTGKLANLIRKKHNRSPLLVAADIYRPAAIKQLETLGKQLDLPV
FSLGDQVKPEEIVTKALEYAKTNHHDFVLIDTAGRLHIDETLMGELENVKTIAKPNEIFLVVDSMTGQDAVNVADSFNEK
LGITGVVLTKLDGDTRGGAALSIKAVTGAPIKFVGLGEKLDALEPFHPERMASRILGMGDVLSLIEKAETQMDQDAAKEL
ESKIRDASFTFDDFIEQLAQVKNMGPIDELLSMLPGAGKMKGLKNVQIDEKQLDHVEAIIRSMTKHERANPEVLNASRRK
RIAKGSGRSIQEVNRLIKQFDDMKKMMKQMSGQMKGKKKGLGLPFF

Sequences:

>Translated_446_residues
MAFEGLSERLQSTLSKMRGKGKISETDVKEMMREVRLALLEADVNFKVVKQFVNDVKERAVGQDVMKSLTPGQQVVKIVH
EELSNLMGSDVVPITFSQKPPTVVMMVGLQGAGKTTTTGKLANLIRKKHNRSPLLVAADIYRPAAIKQLETLGKQLDLPV
FSLGDQVKPEEIVTKALEYAKTNHHDFVLIDTAGRLHIDETLMGELENVKTIAKPNEIFLVVDSMTGQDAVNVADSFNEK
LGITGVVLTKLDGDTRGGAALSIKAVTGAPIKFVGLGEKLDALEPFHPERMASRILGMGDVLSLIEKAETQMDQDAAKEL
ESKIRDASFTFDDFIEQLAQVKNMGPIDELLSMLPGAGKMKGLKNVQIDEKQLDHVEAIIRSMTKHERANPEVLNASRRK
RIAKGSGRSIQEVNRLIKQFDDMKKMMKQMSGQMKGKKKGLGLPFF
>Mature_445_residues
AFEGLSERLQSTLSKMRGKGKISETDVKEMMREVRLALLEADVNFKVVKQFVNDVKERAVGQDVMKSLTPGQQVVKIVHE
ELSNLMGSDVVPITFSQKPPTVVMMVGLQGAGKTTTTGKLANLIRKKHNRSPLLVAADIYRPAAIKQLETLGKQLDLPVF
SLGDQVKPEEIVTKALEYAKTNHHDFVLIDTAGRLHIDETLMGELENVKTIAKPNEIFLVVDSMTGQDAVNVADSFNEKL
GITGVVLTKLDGDTRGGAALSIKAVTGAPIKFVGLGEKLDALEPFHPERMASRILGMGDVLSLIEKAETQMDQDAAKELE
SKIRDASFTFDDFIEQLAQVKNMGPIDELLSMLPGAGKMKGLKNVQIDEKQLDHVEAIIRSMTKHERANPEVLNASRRKR
IAKGSGRSIQEVNRLIKQFDDMKKMMKQMSGQMKGKKKGLGLPFF

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=449, Percent_Identity=33.630289532294, Blast_Score=234, Evalue=2e-61,
Organism=Homo sapiens, GI226371618, Length=371, Percent_Identity=34.2318059299191, Blast_Score=202, Evalue=5e-52,
Organism=Homo sapiens, GI89061728, Length=153, Percent_Identity=35.9477124183007, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI295424842, Length=316, Percent_Identity=26.2658227848101, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI23308697, Length=316, Percent_Identity=26.2658227848101, Blast_Score=97, Evalue=3e-20,
Organism=Escherichia coli, GI1788963, Length=424, Percent_Identity=54.7169811320755, Blast_Score=466, Evalue=1e-132,
Organism=Escherichia coli, GI1789874, Length=251, Percent_Identity=34.2629482071713, Blast_Score=157, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17539958, Length=444, Percent_Identity=30.4054054054054, Blast_Score=221, Evalue=6e-58,
Organism=Caenorhabditis elegans, GI193206261, Length=297, Percent_Identity=29.2929292929293, Blast_Score=100, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6325345, Length=421, Percent_Identity=31.1163895486936, Blast_Score=214, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6320498, Length=211, Percent_Identity=32.7014218009479, Blast_Score=94, Evalue=3e-20,
Organism=Drosophila melanogaster, GI17647949, Length=440, Percent_Identity=31.1363636363636, Blast_Score=215, Evalue=6e-56,
Organism=Drosophila melanogaster, GI24641198, Length=301, Percent_Identity=26.2458471760797, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 49187; Mature: 49056

Theoretical pI: Translated: 9.72; Mature: 9.72

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFEGLSERLQSTLSKMRGKGKISETDVKEMMREVRLALLEADVNFKVVKQFVNDVKERA
CCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
VGQDVMKSLTPGQQVVKIVHEELSNLMGSDVVPITFSQKPPTVVMMVGLQGAGKTTTTGK
HHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEEECCCCCCCCCHHH
LANLIRKKHNRSPLLVAADIYRPAAIKQLETLGKQLDLPVFSLGDQVKPEEIVTKALEYA
HHHHHHHHCCCCCEEEEHHHHCHHHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHHH
KTNHHDFVLIDTAGRLHIDETLMGELENVKTIAKPNEIFLVVDSMTGQDAVNVADSFNEK
HCCCCCEEEEECCCCEEECHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHH
LGITGVVLTKLDGDTRGGAALSIKAVTGAPIKFVGLGEKLDALEPFHPERMASRILGMGD
CCCCEEEEEEECCCCCCCCEEEEEEECCCCEEEEECCCHHHCCCCCCHHHHHHHHHCHHH
VLSLIEKAETQMDQDAAKELESKIRDASFTFDDFIEQLAQVKNMGPIDELLSMLPGAGKM
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCCC
KGLKNVQIDEKQLDHVEAIIRSMTKHERANPEVLNASRRKRIAKGSGRSIQEVNRLIKQF
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHCHHHHHHHHCCCCCCHHHHHHHHHHH
DDMKKMMKQMSGQMKGKKKGLGLPFF
HHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
AFEGLSERLQSTLSKMRGKGKISETDVKEMMREVRLALLEADVNFKVVKQFVNDVKERA
CCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
VGQDVMKSLTPGQQVVKIVHEELSNLMGSDVVPITFSQKPPTVVMMVGLQGAGKTTTTGK
HHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEEECCCCCCCCCHHH
LANLIRKKHNRSPLLVAADIYRPAAIKQLETLGKQLDLPVFSLGDQVKPEEIVTKALEYA
HHHHHHHHCCCCCEEEEHHHHCHHHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHHH
KTNHHDFVLIDTAGRLHIDETLMGELENVKTIAKPNEIFLVVDSMTGQDAVNVADSFNEK
HCCCCCEEEEECCCCEEECHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHH
LGITGVVLTKLDGDTRGGAALSIKAVTGAPIKFVGLGEKLDALEPFHPERMASRILGMGD
CCCCEEEEEEECCCCCCCCEEEEEEECCCCEEEEECCCHHHCCCCCCHHHHHHHHHCHHH
VLSLIEKAETQMDQDAAKELESKIRDASFTFDDFIEQLAQVKNMGPIDELLSMLPGAGKM
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCCC
KGLKNVQIDEKQLDHVEAIIRSMTKHERANPEVLNASRRKRIAKGSGRSIQEVNRLIKQF
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHCHHHHHHHHCCCCCCHHHHHHHHHHH
DDMKKMMKQMSGQMKGKKKGLGLPFF
HHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8335643; 9384377; 7511896 [H]