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The map label for this gene is pyrP [H]

Identifier: 229918564

GI number: 229918564

Start: 2813906

End: 2815210

Strand: Direct

Name: pyrP [H]

Synonym: EAT1b_2851

Alternate gene names: 229918564

Gene position: 2813906-2815210 (Clockwise)

Preceding gene: 229918563

Following gene: 229918565

Centisome position: 93.8

GC content: 53.33

Gene sequence:

>1305_bases
ATGAAACAACCTGTTCTACACATCCACGAGCGTCCAGCTCACTTTCCACAATGGCTATTATTCAGCCTTCAACACGTCTT
CGCCATGTTCGGAGCGACGATTTTAGTCCCGATTTTGACAGGATTAAATACATCGGTCGCTCTCGTCGCTTCCGGCGTGG
CCACGCTCTCATTCTTAGCGATTACACGCTTCAAAGTCCCAACATACTTAGGTTCAAGTTTTGCCTACATCGCCCCAATC
ATAGCGGTCAGCCAGCAATGGGGTGTCGAAGCCGCACTCTTCGGCGGAATCGTCGCCGGGTCTGTATACGGGGTCGTTTC
CTTGATCATCTATAAGACGGGCGTCAACTGGTTGCTCCGATTGCTCCCACCGGTCGTCGTCGGACCGGTCATCATGGTCA
TCGGACTCTCGCTCGCACCGGTCGCCATCGACATGTCGATGAATCAAGATGGTGCCTATAACGGAACGTTCATGACGATT
GCCCTGCTTACACTTGGAATCACGATGCTCGCCATGACGAAGCTGAAAGGCGTTTGGGGTGCCGTCCCGATCCTCTTTGG
AATCGTTGGAGGATACGCAGTCGCAGCCGCATTTGGCATCATCGATTACTCGCCGATTCAACAAGCCAGCCTGTTCCAAC
TTCCTGACTTCACGATGGTGTTCGTCGACTACATGCCGATGTGGCAAGTCGGGGCCCTTCTCGCCATCGTTCCGGTCGCG
CTCGTCACGATGACGGAGCACATCGGAGATCAAATGGTCACGTCGAAAATCATCGGACGAGAGACGATGAAAGACCCAGG
TCTCCATCGCACGCTACTCGGAGACGGAGTAGGAAAAGCCGTTGCCTCTGCACTCGGTGGACCACCATGTACGACTTACG
GTGAGAACAACGGCGTCATGGCCATCACACGAGTCTACAGTGTCTACGTCATCGCTGGCGCAGCACTCATGGCCATCAGC
TTCGGATTCCTCGGTCACATTGAAGCGTTCATCTCGACCATCCCGAACCCGGTCAAAGGTGGAATCTCGATCCTCTTGTT
CGGTGTCATCGCGTCGAACGGATTACGGACGATGGTGGAGAGCAAAGTCGACTTGGCAGAAAAGCGCAACTTGATTATCT
CATCGGTCATCCTCGTCATCGGACTCGGTGGTGCGATGGTTCAAATCGGGAGCTTCCCGGTACAAGGCATGGCGCTTGCG
ACGGTCGTCGGTATTTTGTTGAACGCGATCTTACCGCATGAAGAAGACGATACAGCAGTCGAAGTCAACACAACTGAAGA
AACGAAACAAGCAAGTAACTTTTAA

Upstream 100 bases:

>100_bases
CCGACTCAGTGAAGTCGACACGGCGGATGAAGTCACGATCCATCAGCAATAAACGCATACCTTTAAGGTGGTCCAGAGAG
GCCAGGAAGGAGAATTCAAT

Downstream 100 bases:

>100_bases
TTCGATCCCGTGAGGTCGGCAAAGTGAAGGCTCGTTTATTTGGGTGTACCCTGCCCAGATAAAGGCGTCCCTTCACATCG
GTGAAGAGGCGCCTTTTCTC

Product: uracil-xanthine permease

Products: Proton [Cytoplasm]; uracil [Cytoplasm] [C]

Alternate protein names: Uracil transporter [H]

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MKQPVLHIHERPAHFPQWLLFSLQHVFAMFGATILVPILTGLNTSVALVASGVATLSFLAITRFKVPTYLGSSFAYIAPI
IAVSQQWGVEAALFGGIVAGSVYGVVSLIIYKTGVNWLLRLLPPVVVGPVIMVIGLSLAPVAIDMSMNQDGAYNGTFMTI
ALLTLGITMLAMTKLKGVWGAVPILFGIVGGYAVAAAFGIIDYSPIQQASLFQLPDFTMVFVDYMPMWQVGALLAIVPVA
LVTMTEHIGDQMVTSKIIGRETMKDPGLHRTLLGDGVGKAVASALGGPPCTTYGENNGVMAITRVYSVYVIAGAALMAIS
FGFLGHIEAFISTIPNPVKGGISILLFGVIASNGLRTMVESKVDLAEKRNLIISSVILVIGLGGAMVQIGSFPVQGMALA
TVVGILLNAILPHEEDDTAVEVNTTEETKQASNF

Sequences:

>Translated_434_residues
MKQPVLHIHERPAHFPQWLLFSLQHVFAMFGATILVPILTGLNTSVALVASGVATLSFLAITRFKVPTYLGSSFAYIAPI
IAVSQQWGVEAALFGGIVAGSVYGVVSLIIYKTGVNWLLRLLPPVVVGPVIMVIGLSLAPVAIDMSMNQDGAYNGTFMTI
ALLTLGITMLAMTKLKGVWGAVPILFGIVGGYAVAAAFGIIDYSPIQQASLFQLPDFTMVFVDYMPMWQVGALLAIVPVA
LVTMTEHIGDQMVTSKIIGRETMKDPGLHRTLLGDGVGKAVASALGGPPCTTYGENNGVMAITRVYSVYVIAGAALMAIS
FGFLGHIEAFISTIPNPVKGGISILLFGVIASNGLRTMVESKVDLAEKRNLIISSVILVIGLGGAMVQIGSFPVQGMALA
TVVGILLNAILPHEEDDTAVEVNTTEETKQASNF
>Mature_434_residues
MKQPVLHIHERPAHFPQWLLFSLQHVFAMFGATILVPILTGLNTSVALVASGVATLSFLAITRFKVPTYLGSSFAYIAPI
IAVSQQWGVEAALFGGIVAGSVYGVVSLIIYKTGVNWLLRLLPPVVVGPVIMVIGLSLAPVAIDMSMNQDGAYNGTFMTI
ALLTLGITMLAMTKLKGVWGAVPILFGIVGGYAVAAAFGIIDYSPIQQASLFQLPDFTMVFVDYMPMWQVGALLAIVPVA
LVTMTEHIGDQMVTSKIIGRETMKDPGLHRTLLGDGVGKAVASALGGPPCTTYGENNGVMAITRVYSVYVIAGAALMAIS
FGFLGHIEAFISTIPNPVKGGISILLFGVIASNGLRTMVESKVDLAEKRNLIISSVILVIGLGGAMVQIGSFPVQGMALA
TVVGILLNAILPHEEDDTAVEVNTTEETKQASNF

Specific function: Transport of uracil in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680145, Length=448, Percent_Identity=22.9910714285714, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI44680143, Length=452, Percent_Identity=22.787610619469, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1788843, Length=437, Percent_Identity=42.5629290617849, Blast_Score=326, Evalue=2e-90,
Organism=Escherichia coli, GI87081818, Length=419, Percent_Identity=36.9928400954654, Blast_Score=234, Evalue=1e-62,
Organism=Escherichia coli, GI87082181, Length=443, Percent_Identity=26.1851015801354, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI1790087, Length=460, Percent_Identity=27.6086956521739, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI87082178, Length=481, Percent_Identity=25.5717255717256, Blast_Score=87, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17541904, Length=164, Percent_Identity=30.4878048780488, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17542262, Length=158, Percent_Identity=30.379746835443, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17558856, Length=430, Percent_Identity=23.2558139534884, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI21356175, Length=420, Percent_Identity=24.5238095238095, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 45818; Mature: 45818

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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EEECCHHHHHCCCC
>Mature Secondary Structure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EEECCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; uracil [Periplasm] [C]

Specific reaction: Proton [Periplasm] + uracil [Periplasm] = Proton [Cytoplasm] + uracil [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8206848 [H]