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The map label for this gene is pdhA [H]

Identifier: 229918498

GI number: 229918498

Start: 2752393

End: 2753478

Strand: Direct

Name: pdhA [H]

Synonym: EAT1b_2785

Alternate gene names: 229918498

Gene position: 2752393-2753478 (Clockwise)

Preceding gene: 229918495

Following gene: 229918499

Centisome position: 91.75

GC content: 48.07

Gene sequence:

>1086_bases
ATGAACAACGTTCAGGTACTTCAAAACGTGGAAGAAAACTTCCAAACGTTCCGTATTCTCGACGAGAAGGGTGAGGTCGT
CAACCAAGACGCAATGCCTGACCTAACGGACGAGCAACTTCAGGAACTCATGCGCCGCATGGTCTATACTCGAATCTGGG
ACCAACGCGCCATCTCACTTAACCGTCAAGGTCGCTTAGGATTCTACGCGCCAGTGGCAGGTCAAGAAGCGACGATGATC
GGGACGCAATACGCGCTCGACAAAGAGGACTGGATTCTTCCAGGATACCGTGATATCCCGCAACTCGTATTCCACGGACT
TCCGCTTTATCAAGCGTTCTTGTTCTCACGTGGACACGTGGCAGGAAACCGCATCCCTGAAGGTGTCAACGTATTGATGC
CACAAATCATCATCGGTGCACAAATCATTCAAACTGCGGGTGTGGCAATGGGCCTCAAACGCAACGGCAACAAAAATGTC
GCTATTACTTACACAGGTGACGGTGGCTCATCACAAGGTGACTTCTACGAAGGATTGAACTTTGCAGGTGCATTCAAATC
ACCAGCAATCTTCGTCGTTCAAAACAACCGTTTCGCTATCTCGACTCCTGTTGAAAAGCAAACAGCAGCTAAAACGATCG
CGCAAAAAGCTGTTGCAGCTGGAATCAACGGAATTCAAGTAGACGGAATGGACGTTCTTGCAGTGCTCGCAGCGACTCAA
CAAGCTCGTGTCGATGCACTCGAAGGAACACCGACACTCATCGAGTCACTCACTTACCGTTACGGACCACATACGCTCGC
TGGGGATGACCCAACACGTTACCGTACAAAAGAACTCGACACAGAGTATCAAGAAAAAGATCCACTCGTACGTTTCCGTC
TCTTCCTTGAGAACAAGAAACTCTGGAACGAAGACATGGAGAACGAAGTGATCGAGCAAGCGAAAGCTGACGTGAAAGAA
GCAATCAGCCAAGCAGACAAAGAACCAAAACAAAAAGTTTCGGACTTCATCAACAACATGTTCGAAGAACTTCCTTCAAA
CTTGAAAGAACAGCTTGAAGAATATACTGCAAAGGAGTCGAAGTAA

Upstream 100 bases:

>100_bases
ATACAGATTGCTTTTTTGGACAGATACACGTAAGATTTGAGATAGTGTTTGATCACAAAAAAGACAATTGTCTCATAGTT
GAAAGGATGAGGTGAAACGA

Downstream 100 bases:

>100_bases
GTTATGGCTCAAATGACAATGATCCAAGCGATTACTGATGCGATGCGCGTTGAAATGAAACGCGACGAGAAAGTACTTCT
TTTCGGAGAAGACGTTGGTA

Product: pyruvate dehydrogenase (acetyl-transferring) E1 component, subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 361; Mature: 361

Protein sequence:

>361_residues
MNNVQVLQNVEENFQTFRILDEKGEVVNQDAMPDLTDEQLQELMRRMVYTRIWDQRAISLNRQGRLGFYAPVAGQEATMI
GTQYALDKEDWILPGYRDIPQLVFHGLPLYQAFLFSRGHVAGNRIPEGVNVLMPQIIIGAQIIQTAGVAMGLKRNGNKNV
AITYTGDGGSSQGDFYEGLNFAGAFKSPAIFVVQNNRFAISTPVEKQTAAKTIAQKAVAAGINGIQVDGMDVLAVLAATQ
QARVDALEGTPTLIESLTYRYGPHTLAGDDPTRYRTKELDTEYQEKDPLVRFRLFLENKKLWNEDMENEVIEQAKADVKE
AISQADKEPKQKVSDFINNMFEELPSNLKEQLEEYTAKESK

Sequences:

>Translated_361_residues
MNNVQVLQNVEENFQTFRILDEKGEVVNQDAMPDLTDEQLQELMRRMVYTRIWDQRAISLNRQGRLGFYAPVAGQEATMI
GTQYALDKEDWILPGYRDIPQLVFHGLPLYQAFLFSRGHVAGNRIPEGVNVLMPQIIIGAQIIQTAGVAMGLKRNGNKNV
AITYTGDGGSSQGDFYEGLNFAGAFKSPAIFVVQNNRFAISTPVEKQTAAKTIAQKAVAAGINGIQVDGMDVLAVLAATQ
QARVDALEGTPTLIESLTYRYGPHTLAGDDPTRYRTKELDTEYQEKDPLVRFRLFLENKKLWNEDMENEVIEQAKADVKE
AISQADKEPKQKVSDFINNMFEELPSNLKEQLEEYTAKESK
>Mature_361_residues
MNNVQVLQNVEENFQTFRILDEKGEVVNQDAMPDLTDEQLQELMRRMVYTRIWDQRAISLNRQGRLGFYAPVAGQEATMI
GTQYALDKEDWILPGYRDIPQLVFHGLPLYQAFLFSRGHVAGNRIPEGVNVLMPQIIIGAQIIQTAGVAMGLKRNGNKNV
AITYTGDGGSSQGDFYEGLNFAGAFKSPAIFVVQNNRFAISTPVEKQTAAKTIAQKAVAAGINGIQVDGMDVLAVLAATQ
QARVDALEGTPTLIESLTYRYGPHTLAGDDPTRYRTKELDTEYQEKDPLVRFRLFLENKKLWNEDMENEVIEQAKADVKE
AISQADKEPKQKVSDFINNMFEELPSNLKEQLEEYTAKESK

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI11386135, Length=356, Percent_Identity=32.5842696629214, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI258645172, Length=356, Percent_Identity=32.5842696629214, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI4505685, Length=333, Percent_Identity=28.5285285285285, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI291084742, Length=333, Percent_Identity=28.5285285285285, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI4885543, Length=317, Percent_Identity=28.0757097791798, Blast_Score=121, Evalue=8e-28,
Organism=Homo sapiens, GI291084744, Length=299, Percent_Identity=28.4280936454849, Blast_Score=118, Evalue=7e-27,
Organism=Homo sapiens, GI291084757, Length=316, Percent_Identity=26.8987341772152, Blast_Score=95, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI86563357, Length=356, Percent_Identity=32.3033707865169, Blast_Score=191, Evalue=6e-49,
Organism=Caenorhabditis elegans, GI86563355, Length=356, Percent_Identity=32.3033707865169, Blast_Score=191, Evalue=7e-49,
Organism=Caenorhabditis elegans, GI32564172, Length=326, Percent_Identity=30.3680981595092, Blast_Score=127, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI17536047, Length=320, Percent_Identity=30.3125, Blast_Score=127, Evalue=7e-30,
Organism=Saccharomyces cerevisiae, GI6321026, Length=326, Percent_Identity=27.6073619631902, Blast_Score=113, Evalue=4e-26,
Organism=Drosophila melanogaster, GI21355903, Length=351, Percent_Identity=31.0541310541311, Blast_Score=168, Evalue=4e-42,
Organism=Drosophila melanogaster, GI24639744, Length=327, Percent_Identity=29.3577981651376, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI28571106, Length=327, Percent_Identity=29.3577981651376, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24639746, Length=294, Percent_Identity=30.2721088435374, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24639740, Length=327, Percent_Identity=29.3577981651376, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24639748, Length=337, Percent_Identity=29.9703264094956, Blast_Score=113, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017596 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 40486; Mature: 40486

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNVQVLQNVEENFQTFRILDEKGEVVNQDAMPDLTDEQLQELMRRMVYTRIWDQRAISL
CCCHHHHHHHHHHHHHEEHCCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
NRQGRLGFYAPVAGQEATMIGTQYALDKEDWILPGYRDIPQLVFHGLPLYQAFLFSRGHV
CCCCCCEEECCCCCCCEEEECHHHCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCC
AGNRIPEGVNVLMPQIIIGAQIIQTAGVAMGLKRNGNKNVAITYTGDGGSSQGDFYEGLN
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCHHHCCC
FAGAFKSPAIFVVQNNRFAISTPVEKQTAAKTIAQKAVAAGINGIQVDGMDVLAVLAATQ
CCCCCCCCEEEEEECCEEEEECCCHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHH
QARVDALEGTPTLIESLTYRYGPHTLAGDDPTRYRTKELDTEYQEKDPLVRFRLFLENKK
HHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCHHHHCCCCEEHHHHHHHHH
LWNEDMENEVIEQAKADVKEAISQADKEPKQKVSDFINNMFEELPSNLKEQLEEYTAKES
HHCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
K
C
>Mature Secondary Structure
MNNVQVLQNVEENFQTFRILDEKGEVVNQDAMPDLTDEQLQELMRRMVYTRIWDQRAISL
CCCHHHHHHHHHHHHHEEHCCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
NRQGRLGFYAPVAGQEATMIGTQYALDKEDWILPGYRDIPQLVFHGLPLYQAFLFSRGHV
CCCCCCEEECCCCCCCEEEECHHHCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCC
AGNRIPEGVNVLMPQIIIGAQIIQTAGVAMGLKRNGNKNVAITYTGDGGSSQGDFYEGLN
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCHHHCCC
FAGAFKSPAIFVVQNNRFAISTPVEKQTAAKTIAQKAVAAGINGIQVDGMDVLAVLAATQ
CCCCCCCCEEEEEECCEEEEECCCHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHH
QARVDALEGTPTLIESLTYRYGPHTLAGDDPTRYRTKELDTEYQEKDPLVRFRLFLENKK
HHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCHHHHCCCCEEHHHHHHHHH
LWNEDMENEVIEQAKADVKEAISQADKEPKQKVSDFINNMFEELPSNLKEQLEEYTAKES
HHCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
K
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2200674 [H]