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The map label for this gene is adh [H]

Identifier: 229918422

GI number: 229918422

Start: 2680154

End: 2681194

Strand: Direct

Name: adh [H]

Synonym: EAT1b_2709

Alternate gene names: 229918422

Gene position: 2680154-2681194 (Clockwise)

Preceding gene: 229918421

Following gene: 229918425

Centisome position: 89.34

GC content: 52.45

Gene sequence:

>1041_bases
ATGAAAGCTGTACAAGTTGTAGGATACGGGGACGTCGACCAACTTCAAGTGGTCGATATCCCGAAACCGACTCCGAAAGC
GGGAGAGGTTCTAATCAAGGTACGCGCCTGCGCGATTAACAATACGGAAATATGGATGCGAGAAGGGGCATATGGGACTA
GTGAGAAGTCAGGGTGGCGCCCGGAAGGCGTCCAGTTCCCACGCATTCCCGGTTCAGACATCACAGGTGAAGTCGTCGAG
CTCGGGGATGGGGTCAATCAAGCTTTGATGGGTCGACACGTCGTTTTATTCCCATTCACCTCGAGCGGACCTGAGCGGAA
AGAACATTTATCGGACGATATGTCCTTTATTGGATCAGAGTATGACGGAGGCTATGCAGAATATGTCGCCTGGCCGGCCG
ACCTTTGTTTTGATATGCCACTTGATGACTTCGTCGAGAGTGCAGTCTTTTCCGTGAGCGGACTCACGGCGTGGCATATG
AACGAGCAGTTACACATTCGTTCCGGTGAAACGATTGTCGTCACGGGTGCGAGCGGTGGGGTCGGTTCGCTCAACGTTCA
AATTGCGGCGAATGTATTCGGGGCGAAGGTGTTCGCCATCGTCGGTGATTTGAAAAACGAGCAAGAGTTAAAAGCGTTCG
GGGCGACTGAAGTCTTTTCTTATCGTTCTGAGACGCTCGCCGAGGACATCATCGCGGCGAACGGTGGTCCGGTCGATGCC
GTGCTTGACGTCGTCGGGGATGCGTTATTTGATGTGTCTCTTCAAGTATTGAAGAAGGGTGGGAAGTTCTGTATATCCGG
TTCTGCTGGCGGACAGACGACCCATCTCGATTTTCGGACACTCTACTTGAAACATATCGCCATGTACGGGTCTGTGCTCG
GGACACGGCATGAGTTCGCAGAGATGTTGCGCTCGATCGCTGAAGGGAAACTAAAACCGGTCATTGACCGAACGTTCCCG
CTCGAAGAGGCACGTGAGGCGCAGACGTATTTTAAACAATCCGGCAAGTTCGGAAAGATTGTCCTCATTCCGAACACATA
A

Upstream 100 bases:

>100_bases
CGAGGGCTGCCTGGTAGAGGGTGGCCCTTTTTGGCGTGATAACAGCATTTCGTGGGTAAATACATATGGATGAACGAAAG
AGAAGGAGGGAAGATCCACC

Downstream 100 bases:

>100_bases
AAAGAGAGGGGAGCAATCCCTCTCTTTTTCATGCGAATTTTACTTTGAGACGATCGACGTAGGCGATAAACAGACTGAAT
CGCTCTAACCAGAACTGGAA

Product: alcohol dehydrogenase zinc-binding domain protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MKAVQVVGYGDVDQLQVVDIPKPTPKAGEVLIKVRACAINNTEIWMREGAYGTSEKSGWRPEGVQFPRIPGSDITGEVVE
LGDGVNQALMGRHVVLFPFTSSGPERKEHLSDDMSFIGSEYDGGYAEYVAWPADLCFDMPLDDFVESAVFSVSGLTAWHM
NEQLHIRSGETIVVTGASGGVGSLNVQIAANVFGAKVFAIVGDLKNEQELKAFGATEVFSYRSETLAEDIIAANGGPVDA
VLDVVGDALFDVSLQVLKKGGKFCISGSAGGQTTHLDFRTLYLKHIAMYGSVLGTRHEFAEMLRSIAEGKLKPVIDRTFP
LEEAREAQTYFKQSGKFGKIVLIPNT

Sequences:

>Translated_346_residues
MKAVQVVGYGDVDQLQVVDIPKPTPKAGEVLIKVRACAINNTEIWMREGAYGTSEKSGWRPEGVQFPRIPGSDITGEVVE
LGDGVNQALMGRHVVLFPFTSSGPERKEHLSDDMSFIGSEYDGGYAEYVAWPADLCFDMPLDDFVESAVFSVSGLTAWHM
NEQLHIRSGETIVVTGASGGVGSLNVQIAANVFGAKVFAIVGDLKNEQELKAFGATEVFSYRSETLAEDIIAANGGPVDA
VLDVVGDALFDVSLQVLKKGGKFCISGSAGGQTTHLDFRTLYLKHIAMYGSVLGTRHEFAEMLRSIAEGKLKPVIDRTFP
LEEAREAQTYFKQSGKFGKIVLIPNT
>Mature_346_residues
MKAVQVVGYGDVDQLQVVDIPKPTPKAGEVLIKVRACAINNTEIWMREGAYGTSEKSGWRPEGVQFPRIPGSDITGEVVE
LGDGVNQALMGRHVVLFPFTSSGPERKEHLSDDMSFIGSEYDGGYAEYVAWPADLCFDMPLDDFVESAVFSVSGLTAWHM
NEQLHIRSGETIVVTGASGGVGSLNVQIAANVFGAKVFAIVGDLKNEQELKAFGATEVFSYRSETLAEDIIAANGGPVDA
VLDVVGDALFDVSLQVLKKGGKFCISGSAGGQTTHLDFRTLYLKHIAMYGSVLGTRHEFAEMLRSIAEGKLKPVIDRTFP
LEEAREAQTYFKQSGKFGKIVLIPNT

Specific function: Unknown

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI194239674, Length=354, Percent_Identity=29.3785310734463, Blast_Score=128, Evalue=6e-30,
Organism=Homo sapiens, GI13236495, Length=354, Percent_Identity=29.3785310734463, Blast_Score=128, Evalue=6e-30,
Organism=Homo sapiens, GI194239676, Length=353, Percent_Identity=27.7620396600567, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI22538446, Length=359, Percent_Identity=26.4623955431755, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI22538444, Length=359, Percent_Identity=26.4623955431755, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI24308257, Length=372, Percent_Identity=26.8817204301075, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI197927207, Length=193, Percent_Identity=29.5336787564767, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI1790485, Length=355, Percent_Identity=25.0704225352113, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI87081918, Length=327, Percent_Identity=29.0519877675841, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI1787863, Length=340, Percent_Identity=22.9411764705882, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1790045, Length=345, Percent_Identity=26.3768115942029, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI226510992, Length=320, Percent_Identity=25.625, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17507255, Length=334, Percent_Identity=25.748502994012, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17562876, Length=346, Percent_Identity=24.2774566473988, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6324486, Length=322, Percent_Identity=24.8447204968944, Blast_Score=86, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6323961, Length=322, Percent_Identity=24.5341614906832, Blast_Score=86, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6323729, Length=323, Percent_Identity=25.3869969040248, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6319520, Length=352, Percent_Identity=25, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319621, Length=326, Percent_Identity=23.9263803680982, Blast_Score=77, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6322619, Length=329, Percent_Identity=26.4437689969605, Blast_Score=74, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6319955, Length=329, Percent_Identity=26.4437689969605, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24581341, Length=272, Percent_Identity=30.8823529411765, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24581339, Length=272, Percent_Identity=30.8823529411765, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 37417; Mature: 37417

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVQVVGYGDVDQLQVVDIPKPTPKAGEVLIKVRACAINNTEIWMREGAYGTSEKSGWR
CCEEEEEECCCCCCEEEEECCCCCCCCCEEEEEEEEEEECCCEEEEECCCCCCCCCCCCC
PEGVQFPRIPGSDITGEVVELGDGVNQALMGRHVVLFPFTSSGPERKEHLSDDMSFIGSE
CCCCCCCCCCCCCCCCHHHHHCCCCCHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHCCC
YDGGYAEYVAWPADLCFDMPLDDFVESAVFSVSGLTAWHMNEQLHIRSGETIVVTGASGG
CCCCCHHEEECHHHHHCCCCHHHHHHHHHHHHCCEEEEECCCEEEEECCCEEEEECCCCC
VGSLNVQIAANVFGAKVFAIVGDLKNEQELKAFGATEVFSYRSETLAEDIIAANGGPVDA
CCEEEEEEEEHHHHHHHEEHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCHHH
VLDVVGDALFDVSLQVLKKGGKFCISGSAGGQTTHLDFRTLYLKHIAMYGSVLGTRHEFA
HHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEEHHHHHHHHHHHHHHHHHCCHHHHH
EMLRSIAEGKLKPVIDRTFPLEEAREAQTYFKQSGKFGKIVLIPNT
HHHHHHHCCCCCCHHCCCCCHHHHHHHHHHHHHCCCCEEEEEECCC
>Mature Secondary Structure
MKAVQVVGYGDVDQLQVVDIPKPTPKAGEVLIKVRACAINNTEIWMREGAYGTSEKSGWR
CCEEEEEECCCCCCEEEEECCCCCCCCCEEEEEEEEEEECCCEEEEECCCCCCCCCCCCC
PEGVQFPRIPGSDITGEVVELGDGVNQALMGRHVVLFPFTSSGPERKEHLSDDMSFIGSE
CCCCCCCCCCCCCCCCHHHHHCCCCCHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHCCC
YDGGYAEYVAWPADLCFDMPLDDFVESAVFSVSGLTAWHMNEQLHIRSGETIVVTGASGG
CCCCCHHEEECHHHHHCCCCHHHHHHHHHHHHCCEEEEECCCEEEEECCCEEEEECCCCC
VGSLNVQIAANVFGAKVFAIVGDLKNEQELKAFGATEVFSYRSETLAEDIIAANGGPVDA
CCEEEEEEEEHHHHHHHEEHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCHHH
VLDVVGDALFDVSLQVLKKGGKFCISGSAGGQTTHLDFRTLYLKHIAMYGSVLGTRHEFA
HHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEEHHHHHHHHHHHHHHHHHCCHHHHH
EMLRSIAEGKLKPVIDRTFPLEEAREAQTYFKQSGKFGKIVLIPNT
HHHHHHHCCCCCCHHCCCCCHHHHHHHHHHHHHCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479 [H]