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The map label for this gene is cry [H]

Identifier: 229918425

GI number: 229918425

Start: 2682213

End: 2683427

Strand: Direct

Name: cry [H]

Synonym: EAT1b_2712

Alternate gene names: 229918425

Gene position: 2682213-2683427 (Clockwise)

Preceding gene: 229918422

Following gene: 229918426

Centisome position: 89.41

GC content: 48.48

Gene sequence:

>1215_bases
ATGAAAACAATCATTTGGTACCAAAACGATTTACGTGTTGATGATCATTTGCCGCTCGAAGAAGCACTTCACCATGACGA
TCCGATTGAAGGTCATTTTTTCATCAGTCCGAATCAGTTCATTGAAAATCGTTATGGCGTCATTCCACTCGGGAACGAAC
GACTGCGTTTCCTGAAGGAGTCATTAGAGGATGTGTCCGGCTCACTCGATGCGCTTGGAATCCCATTTTACGTGCACGTC
GGTCATCCGCTCGAGACGCTCGATCCATCCGACCGTCTCTTGTTTCAACGGGCCGTCGGGTACAATGAGCGCCGACGTGA
AAATGAAGTGATGAAAAGATGGAAAGGGACGTACAAGACGTTCGAAGGATTTACTTTATTTGAAAAAGAAGATAACCCAT
TTGAGAAAATGCCGTTTCTCTTCACAGAGTTTCGAAAAGCGGTCGAATATGATGTACGGCCTCGCGAACTGATCTCCAGG
AAGGCAACTGCTGCCACACGCGAGGTGACGTTCCCATTTTCGATTCAAGAAGTAAAGCAAGACCCAAGGACGGCATTTCC
ATTCAAAGGTGGCGAATTGGCTGCGAAACGTCGGCTGAACGACTATTTGTCCGTGCCGATTCGAACGTATAAAGAAACGA
GAAACGGATTTGGGGTCGATGACTCGACGAAGCTATCAGCGTATTTAGCGAACGGGTCGTTATCCCCACGACGGGTGTTT
TTTGAACTCGAAGCGCATGAACGAACACATGGAGTAAATGAATCGACTTACTGGTTGTATTTTGAACTATTATGGCGTGA
ATTTTTCCAATGGGTCGCGCTCGATCAAGGGAAAAAATTGTTTCGGTCACAAGGCATTCGGTCGAAACGAAAAGACTGGC
GCGTCGATCCGGATGTCGTAGAAACATGGCGACGAGGAGAGACGGGCGTCGATTTCGTCGATGCGTTCATGCGCGAACTG
AATGCGACGGGATGGATGTCCAATCGGGGACGACAAATCGTGGCCAACTATTTCGCAAAGGAGTTGAAACAAGACTGGCG
CTACGGGGCTTCCTACTTTGAATCAAAATTGATCGATTACGACGTGGCGAGCAATTGGGGGAATTGGGCGTACCAAGCGG
GTGTCGGAAACGACTCAAGGGACCGCCGTTTCAACATCGAGCGTCAACAGTTCACGTATGATCCGGACCGTGCGTTTCGT
AACAAATGGTTGTGA

Upstream 100 bases:

>100_bases
TATTCCACACAATTTGATTTTGAAAACATATCTCAAGCACATTCCAGCCTCATGACGGAAATCATAACCCATCATACTAT
AGAGTGGAGGAGGTCTATTG

Downstream 100 bases:

>100_bases
CCAAACTGTCACGAGAAGTCGGCGTTTCTCATTGACTTCTTTTTACAGAAGCGCTATAGTTAAATCAACAGATGGGATAC
CTGAGGTGTACGAGAGCCGC

Product: cryptochrome, DASH family

Products: 2 pyrimidine residues (in DNA) [C]

Alternate protein names: NA

Number of amino acids: Translated: 404; Mature: 404

Protein sequence:

>404_residues
MKTIIWYQNDLRVDDHLPLEEALHHDDPIEGHFFISPNQFIENRYGVIPLGNERLRFLKESLEDVSGSLDALGIPFYVHV
GHPLETLDPSDRLLFQRAVGYNERRRENEVMKRWKGTYKTFEGFTLFEKEDNPFEKMPFLFTEFRKAVEYDVRPRELISR
KATAATREVTFPFSIQEVKQDPRTAFPFKGGELAAKRRLNDYLSVPIRTYKETRNGFGVDDSTKLSAYLANGSLSPRRVF
FELEAHERTHGVNESTYWLYFELLWREFFQWVALDQGKKLFRSQGIRSKRKDWRVDPDVVETWRRGETGVDFVDAFMREL
NATGWMSNRGRQIVANYFAKELKQDWRYGASYFESKLIDYDVASNWGNWAYQAGVGNDSRDRRFNIERQQFTYDPDRAFR
NKWL

Sequences:

>Translated_404_residues
MKTIIWYQNDLRVDDHLPLEEALHHDDPIEGHFFISPNQFIENRYGVIPLGNERLRFLKESLEDVSGSLDALGIPFYVHV
GHPLETLDPSDRLLFQRAVGYNERRRENEVMKRWKGTYKTFEGFTLFEKEDNPFEKMPFLFTEFRKAVEYDVRPRELISR
KATAATREVTFPFSIQEVKQDPRTAFPFKGGELAAKRRLNDYLSVPIRTYKETRNGFGVDDSTKLSAYLANGSLSPRRVF
FELEAHERTHGVNESTYWLYFELLWREFFQWVALDQGKKLFRSQGIRSKRKDWRVDPDVVETWRRGETGVDFVDAFMREL
NATGWMSNRGRQIVANYFAKELKQDWRYGASYFESKLIDYDVASNWGNWAYQAGVGNDSRDRRFNIERQQFTYDPDRAFR
NKWL
>Mature_404_residues
MKTIIWYQNDLRVDDHLPLEEALHHDDPIEGHFFISPNQFIENRYGVIPLGNERLRFLKESLEDVSGSLDALGIPFYVHV
GHPLETLDPSDRLLFQRAVGYNERRRENEVMKRWKGTYKTFEGFTLFEKEDNPFEKMPFLFTEFRKAVEYDVRPRELISR
KATAATREVTFPFSIQEVKQDPRTAFPFKGGELAAKRRLNDYLSVPIRTYKETRNGFGVDDSTKLSAYLANGSLSPRRVF
FELEAHERTHGVNESTYWLYFELLWREFFQWVALDQGKKLFRSQGIRSKRKDWRVDPDVVETWRRGETGVDFVDAFMREL
NATGWMSNRGRQIVANYFAKELKQDWRYGASYFESKLIDYDVASNWGNWAYQAGVGNDSRDRRFNIERQQFTYDPDRAFR
NKWL

Specific function: May have a photoreceptor function. Binds DNA; probably functions as a transcriptional repressor [H]

COG id: COG0415

COG function: function code L; Deoxyribodipyrimidine photolyase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DNA photolyase domain [H]

Homologues:

Organism=Homo sapiens, GI188536100, Length=407, Percent_Identity=24.8157248157248, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI4758072, Length=406, Percent_Identity=23.3990147783251, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI188536103, Length=360, Percent_Identity=25.8333333333333, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI1786926, Length=431, Percent_Identity=27.8422273781903, Blast_Score=140, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6324962, Length=228, Percent_Identity=31.140350877193, Blast_Score=112, Evalue=1e-25,
Organism=Drosophila melanogaster, GI17137248, Length=407, Percent_Identity=26.5356265356265, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24585455, Length=407, Percent_Identity=26.5356265356265, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24648152, Length=204, Percent_Identity=26.9607843137255, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002081
- InterPro:   IPR014133
- InterPro:   IPR018394
- InterPro:   IPR006050
- InterPro:   IPR005101
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00875 DNA_photolyase; PF03441 FAD_binding_7 [H]

EC number: 4.1.99.3 [C]

Molecular weight: Translated: 47928; Mature: 47928

Theoretical pI: Translated: 7.91; Mature: 7.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTIIWYQNDLRVDDHLPLEEALHHDDPIEGHFFISPNQFIENRYGVIPLGNERLRFLKE
CCEEEEECCCCCCCCCCCHHHHHCCCCCCCCEEEECCHHHHHCCCCEEECCHHHHHHHHH
SLEDVSGSLDALGIPFYVHVGHPLETLDPSDRLLFQRAVGYNERRRENEVMKRWKGTYKT
HHHHHCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHH
FEGFTLFEKEDNPFEKMPFLFTEFRKAVEYDVRPRELISRKATAATREVTFPFSIQEVKQ
CCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHEEECCCCHHHHHC
DPRTAFPFKGGELAAKRRLNDYLSVPIRTYKETRNGFGVDDSTKLSAYLANGSLSPRRVF
CCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCEEEEEEECCCCCCEEEE
FELEAHERTHGVNESTYWLYFELLWREFFQWVALDQGKKLFRSQGIRSKRKDWRVDPDVV
EEEECHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCHHHH
ETWRRGETGVDFVDAFMRELNATGWMSNRGRQIVANYFAKELKQDWRYGASYFESKLIDY
HHHHCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DVASNWGNWAYQAGVGNDSRDRRFNIERQQFTYDPDRAFRNKWL
HHHCCCCCEEEECCCCCCCCCCEECCCHHHCCCCHHHHHHCCCC
>Mature Secondary Structure
MKTIIWYQNDLRVDDHLPLEEALHHDDPIEGHFFISPNQFIENRYGVIPLGNERLRFLKE
CCEEEEECCCCCCCCCCCHHHHHCCCCCCCCEEEECCHHHHHCCCCEEECCHHHHHHHHH
SLEDVSGSLDALGIPFYVHVGHPLETLDPSDRLLFQRAVGYNERRRENEVMKRWKGTYKT
HHHHHCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHH
FEGFTLFEKEDNPFEKMPFLFTEFRKAVEYDVRPRELISRKATAATREVTFPFSIQEVKQ
CCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHEEECCCCHHHHHC
DPRTAFPFKGGELAAKRRLNDYLSVPIRTYKETRNGFGVDDSTKLSAYLANGSLSPRRVF
CCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCEEEEEEECCCCCCEEEE
FELEAHERTHGVNESTYWLYFELLWREFFQWVALDQGKKLFRSQGIRSKRKDWRVDPDVV
EEEECHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCHHHH
ETWRRGETGVDFVDAFMRELNATGWMSNRGRQIVANYFAKELKQDWRYGASYFESKLIDY
HHHHCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DVASNWGNWAYQAGVGNDSRDRRFNIERQQFTYDPDRAFRNKWL
HHHCCCCCEEEECCCCCCCCCCEECCCHHHCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: ATP; FADH2; Flavin; pterin [C]

Metal ions: NA

Kcat value (1/min): 2.4 [C]

Specific activity: NA

Km value (mM): NA

Substrates: cyclobutadipyrimidine (in DNA) [C]

Specific reaction: cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA) [C]

General reaction: C-C-bond cleavage [C]

Inhibitor: yeast DNA [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14621292 [H]