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The map label for this gene is relA [H]

Identifier: 229918416

GI number: 229918416

Start: 2671550

End: 2673739

Strand: Direct

Name: relA [H]

Synonym: EAT1b_2702

Alternate gene names: 229918416

Gene position: 2671550-2673739 (Clockwise)

Preceding gene: 229918415

Following gene: 229918417

Centisome position: 89.05

GC content: 50.18

Gene sequence:

>2190_bases
ATGACCAAAAAACAAATCGTAAGTATTGAGGATCTTCTCGACGCGCTCGGGGAGTATATGGGTGACGACGATATAGCCGA
AGTGAAACGCGCTTACGAATACGCAAAACTTCATCATACCGGTCAGTTCCGACGTTCGGGCGAGCCCTATATCCTCCATC
CGGTCCAAGTGGCCGGCATTCTCGTTGATATCGGCTTAGATGCCACGACGATTATTGGAGCGCTCTTGCATGATGTTGTC
GAAGACACGGATATTTCGTTACAGCAATTGACGGACGATTTTGGTCCGGACGTGGCCATGCTTGTCGATGGGGTCACGAA
ACTTGGGAAGATCAAATATAAATCGAAAAAAGAAGAACTCGCCGAAAACCATCGGAAGATGATTATCGCCATGGCAGAAG
ACGTGCGCGTGATTTTGATCAAACTTGCGGACCGGCTCCACAATATGCGGACGCTTCAGCATATGCCGAAAGAAAAGCAA
GTTCAAAAGGCAGAAGAGACGCTCGAAATCTTTGCTCCGCTCGCGCACCGGATGGGGATCTCGACGATCAAGTGGGAGCT
CGAAGATATTTCATTACGTTATATCAACCCGCAGCAATACTATAAGATCGTCTCGATGATGAAACAAAAACGGACGGAAC
GAGAAGCACTCGTCACCTCTGTCATCACGGAAGTGAACGGGGTTCTAGAAGAAGTGCATATCGATGCAGACGTGAACGGC
CGACCGAAACATATCTATTCCATCTACAATAAGATGGTGAAGCATAAAAAAGAGTTCAATGAAATTTATGATTTGATGGC
GGTCCGCATTATCGTCGATTCGATTCGTGATTGTTATGCGGTGCTCGGGATCATCCATACGCAATACAAGCCGATGCCGG
GACGCTTCAAAGATTATATCGCCATGCCGAAACCGAACATGTATCAGTCGCTCCATACGACCGTGATCGGTCCGAAAGGT
GAACCGCTCGAAGTCCAAATTCGGACGAAGGACATGCACTTCATCGCCGAGTTCGGGATTGCGGCGCACTGGGCGTATAA
AGAAGGAAAAAATGTCTCGACGAACGGGTTCGACGAGAAGATCGCCCACCTTCGTGAGATTCTTGAGCTGCAAAAGGATA
CGACGGATGCCGAGGAATTCATGGAATCCCTCAAAGTTGATTTCTTTAGCGACATGCTTTACGTCTTCACACCGAAAGGG
GACGTCTTCGAATTGCCGAAGGGCTCAGTCCCGATCGACTATGCGTACCGAATTCATACAGAGATCGGCCATCGGATGAC
GGGCGCGAAAGTAAACGGTCGGATGGTGCCGCTCGACTACAAACTCGAGACGGGTGATATCATTGAAATCATTACGTCGA
AGCACAGTTACGGCCCGAGTAAGGACTGGTTGAAACTCGCGGTTTCGAGCCAGGCGAAGAACAAGATTCGTCAATGGTTC
AAACGTCAACAGCGTGAAGAGAACGTCGAGAAAGGGAAAGATCTCGTCGAGGCAGAAATCAAGAAACTTGGTTTTGAACC
GAAAGAGATTATCGATGAGCCGGCACTCAGTATCGTCGTCGAGAAGTTCAACTTCGGGAACGAGGAAGAGATGTATGCCG
CTGTCGGCTATCAAGGCATCACTGCCGCTCAAGTCGCGCATAAGTTGACGGAGAAGCAGCGCAAAGAGCCGAAACTCGAG
CTCTCTGAAGCGATCAGCGAATTGAAAGTCAGTCAGGCGCCGAAGAAGAAAACGGCAGAGGCGGGCGTGACGGTCAAAGG
AATCGACAACATGCTCGTGCGTATGAGCCGTTGCTGTAACCCGGTCCCGGGCGATGAGATTGTCGGATATATCACCCGTG
GCCGTGGGGTCTCGATTCACCGGAAAGACTGCTTGAACATTGTCAATGAGCAACACCCGGAGCGTCTCCTTGACGTCGAA
TGGGAAGTCGGACAGGCGAAAGAGAAGAACTATAACGTCGATATCGAGATCACGGGATATGATCGTTCTGGTCTCTTGAA
CGACGTCCTACAGGCGGTATCGGCGACGAATACGAATATCGTGGCCGTCAGTGGTCGGGGCGACCAAAACAAACAGGCCC
GCATCTCGATGACGATCTCGATTCCGAACGTGAATCACTTGCAGAAAGTCGTCGAGCGCATCAAACAAATCTCAGACGTG
TATTCGGTCAGCCGAGTCATGATGACGTGA

Upstream 100 bases:

>100_bases
ATAATGGTTATAAAAATCACAGAATCTTGAATACAAACTACTACCATGCTGCGACGAATCCGAGGCGATTGGAGCGGTTA
GAAAAAGGGTGTCGAATGTT

Downstream 100 bases:

>100_bases
CGAAAGGAAGAGGAACGTGCGTGTATTATTGCAACGAGTGAAAGAAGCATCGGTCACAGTCGAGGAAGAAGTCGTCGGGG
CAATCAACGCCGGATACTTG

Product: (p)ppGpp synthetase I, SpoT/RelA

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 729; Mature: 728

Protein sequence:

>729_residues
MTKKQIVSIEDLLDALGEYMGDDDIAEVKRAYEYAKLHHTGQFRRSGEPYILHPVQVAGILVDIGLDATTIIGALLHDVV
EDTDISLQQLTDDFGPDVAMLVDGVTKLGKIKYKSKKEELAENHRKMIIAMAEDVRVILIKLADRLHNMRTLQHMPKEKQ
VQKAEETLEIFAPLAHRMGISTIKWELEDISLRYINPQQYYKIVSMMKQKRTEREALVTSVITEVNGVLEEVHIDADVNG
RPKHIYSIYNKMVKHKKEFNEIYDLMAVRIIVDSIRDCYAVLGIIHTQYKPMPGRFKDYIAMPKPNMYQSLHTTVIGPKG
EPLEVQIRTKDMHFIAEFGIAAHWAYKEGKNVSTNGFDEKIAHLREILELQKDTTDAEEFMESLKVDFFSDMLYVFTPKG
DVFELPKGSVPIDYAYRIHTEIGHRMTGAKVNGRMVPLDYKLETGDIIEIITSKHSYGPSKDWLKLAVSSQAKNKIRQWF
KRQQREENVEKGKDLVEAEIKKLGFEPKEIIDEPALSIVVEKFNFGNEEEMYAAVGYQGITAAQVAHKLTEKQRKEPKLE
LSEAISELKVSQAPKKKTAEAGVTVKGIDNMLVRMSRCCNPVPGDEIVGYITRGRGVSIHRKDCLNIVNEQHPERLLDVE
WEVGQAKEKNYNVDIEITGYDRSGLLNDVLQAVSATNTNIVAVSGRGDQNKQARISMTISIPNVNHLQKVVERIKQISDV
YSVSRVMMT

Sequences:

>Translated_729_residues
MTKKQIVSIEDLLDALGEYMGDDDIAEVKRAYEYAKLHHTGQFRRSGEPYILHPVQVAGILVDIGLDATTIIGALLHDVV
EDTDISLQQLTDDFGPDVAMLVDGVTKLGKIKYKSKKEELAENHRKMIIAMAEDVRVILIKLADRLHNMRTLQHMPKEKQ
VQKAEETLEIFAPLAHRMGISTIKWELEDISLRYINPQQYYKIVSMMKQKRTEREALVTSVITEVNGVLEEVHIDADVNG
RPKHIYSIYNKMVKHKKEFNEIYDLMAVRIIVDSIRDCYAVLGIIHTQYKPMPGRFKDYIAMPKPNMYQSLHTTVIGPKG
EPLEVQIRTKDMHFIAEFGIAAHWAYKEGKNVSTNGFDEKIAHLREILELQKDTTDAEEFMESLKVDFFSDMLYVFTPKG
DVFELPKGSVPIDYAYRIHTEIGHRMTGAKVNGRMVPLDYKLETGDIIEIITSKHSYGPSKDWLKLAVSSQAKNKIRQWF
KRQQREENVEKGKDLVEAEIKKLGFEPKEIIDEPALSIVVEKFNFGNEEEMYAAVGYQGITAAQVAHKLTEKQRKEPKLE
LSEAISELKVSQAPKKKTAEAGVTVKGIDNMLVRMSRCCNPVPGDEIVGYITRGRGVSIHRKDCLNIVNEQHPERLLDVE
WEVGQAKEKNYNVDIEITGYDRSGLLNDVLQAVSATNTNIVAVSGRGDQNKQARISMTISIPNVNHLQKVVERIKQISDV
YSVSRVMMT
>Mature_728_residues
TKKQIVSIEDLLDALGEYMGDDDIAEVKRAYEYAKLHHTGQFRRSGEPYILHPVQVAGILVDIGLDATTIIGALLHDVVE
DTDISLQQLTDDFGPDVAMLVDGVTKLGKIKYKSKKEELAENHRKMIIAMAEDVRVILIKLADRLHNMRTLQHMPKEKQV
QKAEETLEIFAPLAHRMGISTIKWELEDISLRYINPQQYYKIVSMMKQKRTEREALVTSVITEVNGVLEEVHIDADVNGR
PKHIYSIYNKMVKHKKEFNEIYDLMAVRIIVDSIRDCYAVLGIIHTQYKPMPGRFKDYIAMPKPNMYQSLHTTVIGPKGE
PLEVQIRTKDMHFIAEFGIAAHWAYKEGKNVSTNGFDEKIAHLREILELQKDTTDAEEFMESLKVDFFSDMLYVFTPKGD
VFELPKGSVPIDYAYRIHTEIGHRMTGAKVNGRMVPLDYKLETGDIIEIITSKHSYGPSKDWLKLAVSSQAKNKIRQWFK
RQQREENVEKGKDLVEAEIKKLGFEPKEIIDEPALSIVVEKFNFGNEEEMYAAVGYQGITAAQVAHKLTEKQRKEPKLEL
SEAISELKVSQAPKKKTAEAGVTVKGIDNMLVRMSRCCNPVPGDEIVGYITRGRGVSIHRKDCLNIVNEQHPERLLDVEW
EVGQAKEKNYNVDIEITGYDRSGLLNDVLQAVSATNTNIVAVSGRGDQNKQARISMTISIPNVNHLQKVVERIKQISDVY
SVSRVMMT

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Escherichia coli, GI1790082, Length=721, Percent_Identity=40.0832177531207, Blast_Score=553, Evalue=1e-158,
Organism=Escherichia coli, GI1789147, Length=691, Percent_Identity=38.7843704775687, Blast_Score=536, Evalue=1e-153,
Organism=Drosophila melanogaster, GI24650996, Length=132, Percent_Identity=38.6363636363636, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 82906; Mature: 82774

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKKQIVSIEDLLDALGEYMGDDDIAEVKRAYEYAKLHHTGQFRRSGEPYILHPVQVAGI
CCCHHEECHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHCCCCCEEEEHHHEEEE
LVDIGLDATTIIGALLHDVVEDTDISLQQLTDDFGPDVAMLVDGVTKLGKIKYKSKKEEL
EEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
AENHRKMIIAMAEDVRVILIKLADRLHNMRTLQHMPKEKQVQKAEETLEIFAPLAHRMGI
HHHHHEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCC
STIKWELEDISLRYINPQQYYKIVSMMKQKRTEREALVTSVITEVNGVLEEVHIDADVNG
HHEEEEEEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCC
RPKHIYSIYNKMVKHKKEFNEIYDLMAVRIIVDSIRDCYAVLGIIHTQYKPMPGRFKDYI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCC
AMPKPNMYQSLHTTVIGPKGEPLEVQIRTKDMHFIAEFGIAAHWAYKEGKNVSTNGFDEK
CCCCCHHHHHHHHEEECCCCCCEEEEEEECCHHHHHHHCHHHEEECCCCCCCCCCCHHHH
IAHLREILELQKDTTDAEEFMESLKVDFFSDMLYVFTPKGDVFELPKGSVPIDYAYRIHT
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCEEEEECCCCCEEECCCCCCCCCHHEEEHH
EIGHRMTGAKVNGRMVPLDYKLETGDIIEIITSKHSYGPSKDWLKLAVSSQAKNKIRQWF
HHCCCCCCCEECCEEEEEEEEECCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
KRQQREENVEKGKDLVEAEIKKLGFEPKEIIDEPALSIVVEKFNFGNEEEMYAAVGYQGI
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHCCCCHHHHHHHHCCCCC
TAAQVAHKLTEKQRKEPKLELSEAISELKVSQAPKKKTAEAGVTVKGIDNMLVRMSRCCN
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHCCCEEECHHHHHHHHHHHCC
PVPGDEIVGYITRGRGVSIHRKDCLNIVNEQHPERLLDVEWEVGQAKEKNYNVDIEITGY
CCCCHHHHEEEECCCCCEEEHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCCEEEEEEECC
DRSGLLNDVLQAVSATNTNIVAVSGRGDQNKQARISMTISIPNVNHLQKVVERIKQISDV
CCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHH
YSVSRVMMT
HHHHHHHCC
>Mature Secondary Structure 
TKKQIVSIEDLLDALGEYMGDDDIAEVKRAYEYAKLHHTGQFRRSGEPYILHPVQVAGI
CCHHEECHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHCCCCCEEEEHHHEEEE
LVDIGLDATTIIGALLHDVVEDTDISLQQLTDDFGPDVAMLVDGVTKLGKIKYKSKKEEL
EEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
AENHRKMIIAMAEDVRVILIKLADRLHNMRTLQHMPKEKQVQKAEETLEIFAPLAHRMGI
HHHHHEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCC
STIKWELEDISLRYINPQQYYKIVSMMKQKRTEREALVTSVITEVNGVLEEVHIDADVNG
HHEEEEEEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCC
RPKHIYSIYNKMVKHKKEFNEIYDLMAVRIIVDSIRDCYAVLGIIHTQYKPMPGRFKDYI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCC
AMPKPNMYQSLHTTVIGPKGEPLEVQIRTKDMHFIAEFGIAAHWAYKEGKNVSTNGFDEK
CCCCCHHHHHHHHEEECCCCCCEEEEEEECCHHHHHHHCHHHEEECCCCCCCCCCCHHHH
IAHLREILELQKDTTDAEEFMESLKVDFFSDMLYVFTPKGDVFELPKGSVPIDYAYRIHT
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCEEEEECCCCCEEECCCCCCCCCHHEEEHH
EIGHRMTGAKVNGRMVPLDYKLETGDIIEIITSKHSYGPSKDWLKLAVSSQAKNKIRQWF
HHCCCCCCCEECCEEEEEEEEECCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
KRQQREENVEKGKDLVEAEIKKLGFEPKEIIDEPALSIVVEKFNFGNEEEMYAAVGYQGI
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHCCCCHHHHHHHHCCCCC
TAAQVAHKLTEKQRKEPKLELSEAISELKVSQAPKKKTAEAGVTVKGIDNMLVRMSRCCN
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHCCCEEECHHHHHHHHHHHCC
PVPGDEIVGYITRGRGVSIHRKDCLNIVNEQHPERLLDVEWEVGQAKEKNYNVDIEITGY
CCCCHHHHEEEECCCCCEEEHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCCEEEEEEECC
DRSGLLNDVLQAVSATNTNIVAVSGRGDQNKQARISMTISIPNVNHLQKVVERIKQISDV
CCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHH
YSVSRVMMT
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9383190; 9384377 [H]