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The map label for this gene is trxA [H]

Identifier: 229918330

GI number: 229918330

Start: 2582178

End: 2582492

Strand: Direct

Name: trxA [H]

Synonym: EAT1b_2615

Alternate gene names: 229918330

Gene position: 2582178-2582492 (Clockwise)

Preceding gene: 229918329

Following gene: 229918331

Centisome position: 86.08

GC content: 46.67

Gene sequence:

>315_bases
ATGGCTATTAAACACGCAACGACTCAATCGTTTGAACAAGATGTAAAAGAGGGCGTCGTCCTCGTAGATTTCTGGGCAAC
TTGGTGTGGACCATGCCGCATGATCGCGCCAGTTCTCGAAGAACTCGATCAAGAAATGGGTGACCAAGTCCAAATCGTGA
AACTCGACGTCGACGAAAACCCTGAAGTCGCAGGTGCTTTCCAAATCCAAAGTATCCCGACACTCATGATGTTCAAAGAT
GGCGAGCCTGTTTCGAAAACAATGGGCTTCCAACCAAAAGAAGCATTGAAAGAGTTTATCGCGACAGCACAATAA

Upstream 100 bases:

>100_bases
AACGTTTTGGGGTTGTTACCCTCCGTGGTATACTCTGAACATGAATTGCATGAGAGTTCTTTATCAGGACTCTCTCATCT
TATTGGGGAGGTTTTTACAA

Downstream 100 bases:

>100_bases
TTGCGTAGCAGCCGACCTGAATCGGCTGCTTTTTTGTTTTGCGGAATAGAAAAGAAGGAAAAGGACAGGCAAGTAGGGAA
TAAGTTGAGTTGTTCCACGC

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 104; Mature: 103

Protein sequence:

>104_residues
MAIKHATTQSFEQDVKEGVVLVDFWATWCGPCRMIAPVLEELDQEMGDQVQIVKLDVDENPEVAGAFQIQSIPTLMMFKD
GEPVSKTMGFQPKEALKEFIATAQ

Sequences:

>Translated_104_residues
MAIKHATTQSFEQDVKEGVVLVDFWATWCGPCRMIAPVLEELDQEMGDQVQIVKLDVDENPEVAGAFQIQSIPTLMMFKD
GEPVSKTMGFQPKEALKEFIATAQ
>Mature_103_residues
AIKHATTQSFEQDVKEGVVLVDFWATWCGPCRMIAPVLEELDQEMGDQVQIVKLDVDENPEVAGAFQIQSIPTLMMFKDG
EPVSKTMGFQPKEALKEFIATAQ

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI42794771, Length=98, Percent_Identity=32.6530612244898, Blast_Score=69, Evalue=6e-13,
Organism=Homo sapiens, GI21361403, Length=84, Percent_Identity=33.3333333333333, Blast_Score=69, Evalue=7e-13,
Organism=Homo sapiens, GI224493972, Length=98, Percent_Identity=32.6530612244898, Blast_Score=65, Evalue=1e-11,
Organism=Homo sapiens, GI50592994, Length=71, Percent_Identity=39.4366197183099, Blast_Score=64, Evalue=4e-11,
Organism=Escherichia coli, GI87082331, Length=100, Percent_Identity=47, Blast_Score=105, Evalue=7e-25,
Organism=Escherichia coli, GI1788936, Length=97, Percent_Identity=38.1443298969072, Blast_Score=83, Evalue=3e-18,
Organism=Escherichia coli, GI87081747, Length=81, Percent_Identity=34.5679012345679, Blast_Score=62, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI212646193, Length=81, Percent_Identity=40.7407407407407, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17509965, Length=62, Percent_Identity=46.7741935483871, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71980565, Length=87, Percent_Identity=33.3333333333333, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71980562, Length=82, Percent_Identity=34.1463414634146, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=103, Percent_Identity=40.7766990291262, Blast_Score=84, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6321648, Length=84, Percent_Identity=45.2380952380952, Blast_Score=82, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6319925, Length=73, Percent_Identity=43.8356164383562, Blast_Score=75, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28573567, Length=99, Percent_Identity=35.3535353535354, Blast_Score=78, Evalue=9e-16,
Organism=Drosophila melanogaster, GI17648013, Length=76, Percent_Identity=43.421052631579, Blast_Score=77, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24583090, Length=76, Percent_Identity=43.421052631579, Blast_Score=77, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24639826, Length=82, Percent_Identity=36.5853658536585, Blast_Score=75, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24664269, Length=61, Percent_Identity=45.9016393442623, Blast_Score=71, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21358065, Length=102, Percent_Identity=30.3921568627451, Blast_Score=66, Evalue=4e-12,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11603; Mature: 11472

Theoretical pI: Translated: 4.09; Mature: 4.09

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
5.8 %Met     (Translated Protein)
7.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIKHATTQSFEQDVKEGVVLVDFWATWCGPCRMIAPVLEELDQEMGDQVQIVKLDVDEN
CCCCCCHHHHHHHHHHCCEEEEEHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCC
PEVAGAFQIQSIPTLMMFKDGEPVSKTMGFQPKEALKEFIATAQ
CCCCEEEEECCCCEEEEEECCCCHHHHCCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
AIKHATTQSFEQDVKEGVVLVDFWATWCGPCRMIAPVLEELDQEMGDQVQIVKLDVDEN
CCCCCHHHHHHHHHHCCEEEEEHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCC
PEVAGAFQIQSIPTLMMFKDGEPVSKTMGFQPKEALKEFIATAQ
CCCCEEEEECCCCEEEEEECCCCHHHHCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2559145; 8969504; 9384377; 8755892 [H]