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The map label for this gene is norM [H]

Identifier: 229917974

GI number: 229917974

Start: 2206793

End: 2208151

Strand: Direct

Name: norM [H]

Synonym: EAT1b_2253

Alternate gene names: 229917974

Gene position: 2206793-2208151 (Clockwise)

Preceding gene: 229917972

Following gene: 229917975

Centisome position: 73.56

GC content: 51.07

Gene sequence:

>1359_bases
ATGTACCAAACACATTCATTAAACGAAAAAATCAAACTGTTCTTCACGATTTTCTTTCCAATTCTAGTCACGCAAGTGTC
TTTTTATTTGATTAGCTTTTTCGATACCGTCATGTCCGGACGTGCAGGTGCCGTCGATTTGGCTGGTGTCGGAGTCGGTT
CAAGCTTGTGGATGCCGGTGTATACCGGACTGAGTGGAATCTTGTTGGCGGTGGCCCCAATCGTGTCGCAAGCGCTTGGT
GCGAGAGACCGTCAACAGATTCAACGTACCTTGTTTCAAGGTATCTATTTAGCCATCATGCTGAGCGTAATCACGTTGAC
GTTGGGATCATTCCTTGTGCCGATGGCAATCGAGAGCATGGGGCTCAGTGTAGAAGGGAAACGAATCGCGACGCAATACT
TGCTTGCCCTTGGATTCGGCGTCTTGCCGATGTTCCTGTTCAATGTGCTACGCACGCTCATGGATGCCCTTGGCAAGACG
AGAGTCTCGATGATCCTCATACTATTAGGGTTACCCATTAATGTCGGATTAAATTACATCTTCATCTTCGGAAAACTGGG
TGTGCCGGCGTACGGCGGGGTTGGAGCGGGAATCGCCTCGAGCATCACTTACTGGCTACTCTTCTTCATGGCCTTCTTCT
TCGTGAGAAACGGGAAGCCGTTCCGCGAATACAAGTTTTTACGGACGACCGAACGGATGGTCTGGCTCCGACAAAAAGAG
TTGTTACAACTTGGGACCCCAATCGGGCTCGCCATTTTCGCCGAAGTCAGCATCTTTGCGGCGGTCACGGTATTGCTCAG
TTCATACGGTGACCAAATCGTCGCGGCTCACCAAGCGGCGATTAACTTTGCCTCATTCGTGTACATGTTGCCACTCTCGG
CATCGAGCGCGTTGACGATTGTCGTGGGGTATGAGCTCGGCGCGAAACGACTGCAGGATGCCGTCCGCTATGCAAAAATC
GGGCTCGCGCTCTGTCTCGGTGTCTCTATCTTTTCGGGTGCTTTTTTGTTTTGGCAAAACGAGCGGGTCGCGGCCATTTA
TACGAATGACCCGACGGTCGTGGACCTTGCAGCGCACTTTATGATCTTCGCTGTATTCTTCCAATTGTCAGATGCCGTCG
CGGCACCGATCCAAGGGATATTACGTGGCTTTAAAGACGTCAACATCACGCTCGTCCTTTCACTCGTCGCTTATTGGGTC
ATCGGTTTACCTCTCGGGTATGTTTTGGCAGAGCACGCCGGGTTTGGACCAGACGGCTATTGGATTGGCTTGATTGCTGG
ACTTGCAGCCGGAGCGGTCTTGTTATTCCTCCGGTTAGTATGGATTGTCCGACGCTATGGCACGATTCAATCGACATAA

Upstream 100 bases:

>100_bases
GAACGTGTTCCACGTTTCCAACAGTTCAAATTTAAGTTTTTCTGCATGCCGTTGATTCATGATTATAAGTTCCTTTCTGA
AAAAGAGATGAGGGTTGTCC

Downstream 100 bases:

>100_bases
AGAGGAGAAGATTGTTCGCAAATGTGAACAATCTTTTATTTATTTAAAATTGGTCTATACAACTATACTTTTATCCGATA
TGATAACATGGAGGAAAACA

Product: multidrug efflux protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 452; Mature: 452

Protein sequence:

>452_residues
MYQTHSLNEKIKLFFTIFFPILVTQVSFYLISFFDTVMSGRAGAVDLAGVGVGSSLWMPVYTGLSGILLAVAPIVSQALG
ARDRQQIQRTLFQGIYLAIMLSVITLTLGSFLVPMAIESMGLSVEGKRIATQYLLALGFGVLPMFLFNVLRTLMDALGKT
RVSMILILLGLPINVGLNYIFIFGKLGVPAYGGVGAGIASSITYWLLFFMAFFFVRNGKPFREYKFLRTTERMVWLRQKE
LLQLGTPIGLAIFAEVSIFAAVTVLLSSYGDQIVAAHQAAINFASFVYMLPLSASSALTIVVGYELGAKRLQDAVRYAKI
GLALCLGVSIFSGAFLFWQNERVAAIYTNDPTVVDLAAHFMIFAVFFQLSDAVAAPIQGILRGFKDVNITLVLSLVAYWV
IGLPLGYVLAEHAGFGPDGYWIGLIAGLAAGAVLLFLRLVWIVRRYGTIQST

Sequences:

>Translated_452_residues
MYQTHSLNEKIKLFFTIFFPILVTQVSFYLISFFDTVMSGRAGAVDLAGVGVGSSLWMPVYTGLSGILLAVAPIVSQALG
ARDRQQIQRTLFQGIYLAIMLSVITLTLGSFLVPMAIESMGLSVEGKRIATQYLLALGFGVLPMFLFNVLRTLMDALGKT
RVSMILILLGLPINVGLNYIFIFGKLGVPAYGGVGAGIASSITYWLLFFMAFFFVRNGKPFREYKFLRTTERMVWLRQKE
LLQLGTPIGLAIFAEVSIFAAVTVLLSSYGDQIVAAHQAAINFASFVYMLPLSASSALTIVVGYELGAKRLQDAVRYAKI
GLALCLGVSIFSGAFLFWQNERVAAIYTNDPTVVDLAAHFMIFAVFFQLSDAVAAPIQGILRGFKDVNITLVLSLVAYWV
IGLPLGYVLAEHAGFGPDGYWIGLIAGLAAGAVLLFLRLVWIVRRYGTIQST
>Mature_452_residues
MYQTHSLNEKIKLFFTIFFPILVTQVSFYLISFFDTVMSGRAGAVDLAGVGVGSSLWMPVYTGLSGILLAVAPIVSQALG
ARDRQQIQRTLFQGIYLAIMLSVITLTLGSFLVPMAIESMGLSVEGKRIATQYLLALGFGVLPMFLFNVLRTLMDALGKT
RVSMILILLGLPINVGLNYIFIFGKLGVPAYGGVGAGIASSITYWLLFFMAFFFVRNGKPFREYKFLRTTERMVWLRQKE
LLQLGTPIGLAIFAEVSIFAAVTVLLSSYGDQIVAAHQAAINFASFVYMLPLSASSALTIVVGYELGAKRLQDAVRYAKI
GLALCLGVSIFSGAFLFWQNERVAAIYTNDPTVVDLAAHFMIFAVFFQLSDAVAAPIQGILRGFKDVNITLVLSLVAYWV
IGLPLGYVLAEHAGFGPDGYWIGLIAGLAAGAVLLFLRLVWIVRRYGTIQST

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Homo sapiens, GI153792564, Length=439, Percent_Identity=23.2346241457859, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI22907060, Length=452, Percent_Identity=23.2300884955752, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI48994890, Length=442, Percent_Identity=35.7466063348416, Blast_Score=274, Evalue=1e-74,
Organism=Escherichia coli, GI226510954, Length=456, Percent_Identity=21.9298245614035, Blast_Score=73, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6321821, Length=371, Percent_Identity=23.4501347708895, Blast_Score=76, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6320545, Length=436, Percent_Identity=22.4770642201835, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 49342; Mature: 49342

Theoretical pI: Translated: 9.80; Mature: 9.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MYQTHSLNEKIKLFFTIFFPILVTQVSFYLISFFDTVMSGRAGAVDLAGVGVGSSLWMPV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHH
YTGLSGILLAVAPIVSQALGARDRQQIQRTLFQGIYLAIMLSVITLTLGSFLVPMAIESM
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLSVEGKRIATQYLLALGFGVLPMFLFNVLRTLMDALGKTRVSMILILLGLPINVGLNYI
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCEE
FIFGKLGVPAYGGVGAGIASSITYWLLFFMAFFFVRNGKPFREYKFLRTTERMVWLRQKE
EEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
LLQLGTPIGLAIFAEVSIFAAVTVLLSSYGDQIVAAHQAAINFASFVYMLPLSASSALTI
HHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEE
VVGYELGAKRLQDAVRYAKIGLALCLGVSIFSGAFLFWQNERVAAIYTNDPTVVDLAAHF
EEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCEEEEEECCCCCHHHHHHHH
MIFAVFFQLSDAVAAPIQGILRGFKDVNITLVLSLVAYWVIGLPLGYVLAEHAGFGPDGY
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
WIGLIAGLAAGAVLLFLRLVWIVRRYGTIQST
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9734814; 9384377 [H]