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The map label for this gene is purQ

Identifier: 229917949

GI number: 229917949

Start: 2174708

End: 2175388

Strand: Direct

Name: purQ

Synonym: EAT1b_2228

Alternate gene names: 229917949

Gene position: 2174708-2175388 (Clockwise)

Preceding gene: 229917948

Following gene: 229917950

Centisome position: 72.49

GC content: 52.72

Gene sequence:

>681_bases
ATGAAGTTTGCGGTCATCGTCTTTCCAGGATCAAACTGTGACCTCGACATGTACCACGCGGTAAAAGATGTGCTCGGGGA
AGAAGCGGAATACGTGTTCCATACGGAAACCTCACTTGAAGGATTCGATGGGGTCCTCTTACCAGGCGGTTTCTCATACG
GAGACTACTTGCGCTGCGGATCAATCGCCCAGTTTTCACCAATCATGGCTGAAGTGAAGCGTTTCGCGGAAGAAGGACGC
CCGGTACTCGGCGTATGTAACGGATTCCAAGTGCTCGTCGAAGCGGGACTCCTTCCAGGCGTATTGATGCGAAACCGCGA
TTTGAAATTCATGTGTAAGACCGTCGACCTCGTCGTCGAAAACAACGAAACGATGTTCACAAGTGAGTACGCGGCACAGG
AAACGATTCGCGTGCCAATCGCACACGGTGAGGGCAACTACTACTGTGACGATGCGACACTTGCGGCATTGAAGGCAAAT
GGCCAGATTGCGTTCACCTATAAAGAGAACCCGAACGGATCGGTCGAAAACATCGCCGGCATCACGAACGAGGCAGGGAA
CGTACTCGGCATGATGCCACACCCGGAGCGTGCGGTCGAAGCGTTGCTCGGTGGGGAAGACGGTAAACGGTTATTCACGT
CAATCGTAAAATGGGGGGCACGACATGTTACTTACAACTGA

Upstream 100 bases:

>100_bases
TAGCGGACGACACGACAGAAGACATGGTCAAAGAAATGTGTGAGAAGTTACTCGTCAATACGGTCATTGAGAATTATGAA
ATCGAGATGGGGGTACTCGC

Downstream 100 bases:

>100_bases
ACCGACAGCTACACAAATCCGTGATGAACGGATCTATGCCACGATGGGATTATCGGACGACGAATACGCGCTCGTCGTCT
CACTGCTTGGCCGGGAACCG

Product: phosphoribosylformylglycinamidine synthase I

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase I; FGAM synthase I

Number of amino acids: Translated: 226; Mature: 226

Protein sequence:

>226_residues
MKFAVIVFPGSNCDLDMYHAVKDVLGEEAEYVFHTETSLEGFDGVLLPGGFSYGDYLRCGSIAQFSPIMAEVKRFAEEGR
PVLGVCNGFQVLVEAGLLPGVLMRNRDLKFMCKTVDLVVENNETMFTSEYAAQETIRVPIAHGEGNYYCDDATLAALKAN
GQIAFTYKENPNGSVENIAGITNEAGNVLGMMPHPERAVEALLGGEDGKRLFTSIVKWGARHVTYN

Sequences:

>Translated_226_residues
MKFAVIVFPGSNCDLDMYHAVKDVLGEEAEYVFHTETSLEGFDGVLLPGGFSYGDYLRCGSIAQFSPIMAEVKRFAEEGR
PVLGVCNGFQVLVEAGLLPGVLMRNRDLKFMCKTVDLVVENNETMFTSEYAAQETIRVPIAHGEGNYYCDDATLAALKAN
GQIAFTYKENPNGSVENIAGITNEAGNVLGMMPHPERAVEALLGGEDGKRLFTSIVKWGARHVTYN
>Mature_226_residues
MKFAVIVFPGSNCDLDMYHAVKDVLGEEAEYVFHTETSLEGFDGVLLPGGFSYGDYLRCGSIAQFSPIMAEVKRFAEEGR
PVLGVCNGFQVLVEAGLLPGVLMRNRDLKFMCKTVDLVVENNETMFTSEYAAQETIRVPIAHGEGNYYCDDATLAALKAN
GQIAFTYKENPNGSVENIAGITNEAGNVLGMMPHPERAVEALLGGEDGKRLFTSIVKWGARHVTYN

Specific function: Unknown

COG id: COG0047

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Escherichia coli, GI48994899, Length=253, Percent_Identity=30.0395256916996, Blast_Score=82, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6321498, Length=270, Percent_Identity=28.1481481481481, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24582111, Length=214, Percent_Identity=26.1682242990654, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24582109, Length=214, Percent_Identity=26.1682242990654, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17137292, Length=214, Percent_Identity=26.1682242990654, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURQ_EXISA (C4L298)

Other databases:

- EMBL:   CP001615
- RefSeq:   YP_002886595.1
- ProteinModelPortal:   C4L298
- GeneID:   7870815
- GenomeReviews:   CP001615_GR
- KEGG:   eat:EAT1b_2228
- OMA:   FPGTNCD
- ProtClustDB:   PRK03619
- GO:   GO:0005737
- HAMAP:   MF_00421
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR010075
- PIRSF:   PIRSF001586
- TIGRFAMs:   TIGR01737

Pfam domain/function: PF00117 GATase

EC number: =6.3.5.3

Molecular weight: Translated: 24702; Mature: 24702

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 86-86 ACT_SITE 194-194 ACT_SITE 196-196

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFAVIVFPGSNCDLDMYHAVKDVLGEEAEYVFHTETSLEGFDGVLLPGGFSYGDYLRCG
CEEEEEEECCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEECCCCCCCCHHCCC
SIAQFSPIMAEVKRFAEEGRPVLGVCNGFQVLVEAGLLPGVLMRNRDLKFMCKTVDLVVE
CCHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHCCCCCHHHCCCCHHEEEEEEEEEEE
NNETMFTSEYAAQETIRVPIAHGEGNYYCDDATLAALKANGQIAFTYKENPNGSVENIAG
CCCEEEEHHHHCCCEEEEEEEECCCCEEECCCEEEEEECCCEEEEEEECCCCCCHHHHCC
ITNEAGNVLGMMPHPERAVEALLGGEDGKRLFTSIVKWGARHVTYN
CCCCCCCEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKFAVIVFPGSNCDLDMYHAVKDVLGEEAEYVFHTETSLEGFDGVLLPGGFSYGDYLRCG
CEEEEEEECCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEECCCCCCCCHHCCC
SIAQFSPIMAEVKRFAEEGRPVLGVCNGFQVLVEAGLLPGVLMRNRDLKFMCKTVDLVVE
CCHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHCCCCCHHHCCCCHHEEEEEEEEEEE
NNETMFTSEYAAQETIRVPIAHGEGNYYCDDATLAALKANGQIAFTYKENPNGSVENIAG
CCCEEEEHHHHCCCEEEEEEEECCCCEEECCCEEEEEECCCEEEEEEECCCCCCHHHHCC
ITNEAGNVLGMMPHPERAVEALLGGEDGKRLFTSIVKWGARHVTYN
CCCCCCCEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA