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The map label for this gene is purE [H]

Identifier: 229917944

GI number: 229917944

Start: 2170847

End: 2171335

Strand: Direct

Name: purE [H]

Synonym: EAT1b_2223

Alternate gene names: 229917944

Gene position: 2170847-2171335 (Clockwise)

Preceding gene: 229917942

Following gene: 229917945

Centisome position: 72.36

GC content: 50.31

Gene sequence:

>489_bases
ATGAACGTAGCAGTTGGAGTAATCATGGGAAGTTCATCTGATTGGGAGACGATGAAACATACGTGTGACGTGTTGGATGA
GTTGCAGATTCCATATGAAAAACAAGTCGTATCCGCTCACCGTACACCAGACCTTATGTTCGAATATGCTGAAGAGGCAC
GAGGCAGAGGCATCCAAGTGATCATTGCGGGTGCTGGTGGGGCAGCCCACCTTCCTGGAATGGTCGCTGCGAAAACGACA
CTTCCTGTCATCGGTGTCCCGGTTCAGTCGAAAGCACTCAATGGAATGGATTCGCTCCTCTCCATTGTTCAGATGCCTGC
AGGAGTTCCAGTAGCAACTGTTGCCATCGGAAAAGCGGGAGCAACGAATGCAGGATTATTGGCTGCTCAGATCCTCAGCA
TCCACTCCACAGACATAACACATCGACTGGATGCATTTCGTGAGAAGAAACAAGAGATGGCGATGCGAGGAACGGAGGAG
TTGGTCTGA

Upstream 100 bases:

>100_bases
CTGATCAGACTATGGGGTGTAGCGGACGTGTATTTGTCATGCCTATACCCTAAACTGATTGTCGGTTTAGGGATTTCTTT
TTGTAAGGGGGACATTGGGA

Downstream 100 bases:

>100_bases
TGAGAATCGGAATTTTAGGTGGAGGACAACTTGGACGGATGATGTCACTCAGTGCGAGTGCAATGGGATACACGACACTT
TGTCTTGACCCGAACCCCAA

Product: phosphoribosylaminoimidazole carboxylase, catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 162; Mature: 162

Protein sequence:

>162_residues
MNVAVGVIMGSSSDWETMKHTCDVLDELQIPYEKQVVSAHRTPDLMFEYAEEARGRGIQVIIAGAGGAAHLPGMVAAKTT
LPVIGVPVQSKALNGMDSLLSIVQMPAGVPVATVAIGKAGATNAGLLAAQILSIHSTDITHRLDAFREKKQEMAMRGTEE
LV

Sequences:

>Translated_162_residues
MNVAVGVIMGSSSDWETMKHTCDVLDELQIPYEKQVVSAHRTPDLMFEYAEEARGRGIQVIIAGAGGAAHLPGMVAAKTT
LPVIGVPVQSKALNGMDSLLSIVQMPAGVPVATVAIGKAGATNAGLLAAQILSIHSTDITHRLDAFREKKQEMAMRGTEE
LV
>Mature_162_residues
MNVAVGVIMGSSSDWETMKHTCDVLDELQIPYEKQVVSAHRTPDLMFEYAEEARGRGIQVIIAGAGGAAHLPGMVAAKTT
LPVIGVPVQSKALNGMDSLLSIVQMPAGVPVATVAIGKAGATNAGLLAAQILSIHSTDITHRLDAFREKKQEMAMRGTEE
LV

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=155, Percent_Identity=57.4193548387097, Blast_Score=155, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6324702, Length=157, Percent_Identity=54.7770700636943, Blast_Score=163, Evalue=9e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 17090; Mature: 17090

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
5.6 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVAVGVIMGSSSDWETMKHTCDVLDELQIPYEKQVVSAHRTPDLMFEYAEEARGRGIQV
CCEEEEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHCCCCEEE
IIAGAGGAAHLPGMVAAKTTLPVIGVPVQSKALNGMDSLLSIVQMPAGVPVATVAIGKAG
EEECCCCCCCCCCHHHHHCCCCEEECCCCHHHHCCHHHHHHHHHCCCCCCEEEEEECCCC
ATNAGLLAAQILSIHSTDITHRLDAFREKKQEMAMRGTEELV
CCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCHHHCC
>Mature Secondary Structure
MNVAVGVIMGSSSDWETMKHTCDVLDELQIPYEKQVVSAHRTPDLMFEYAEEARGRGIQV
CCEEEEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHCCCCEEE
IIAGAGGAAHLPGMVAAKTTLPVIGVPVQSKALNGMDSLLSIVQMPAGVPVATVAIGKAG
EEECCCCCCCCCCHHHHHCCCCEEECCCCHHHHCCHHHHHHHHHCCCCCCEEEEEECCCC
ATNAGLLAAQILSIHSTDITHRLDAFREKKQEMAMRGTEELV
CCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3036807; 9384377 [H]