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The map label for this gene is hssR [H]

Identifier: 229917890

GI number: 229917890

Start: 2105258

End: 2105932

Strand: Direct

Name: hssR [H]

Synonym: EAT1b_2168

Alternate gene names: 229917890

Gene position: 2105258-2105932 (Clockwise)

Preceding gene: 229917889

Following gene: 229917891

Centisome position: 70.18

GC content: 49.33

Gene sequence:

>675_bases
ATGGTCACCATTTTACTCGCAGAAGATGATGAGACGCTCGGCGGTTTATTAGTCGATTATTTGACGGTGGCCGGTTACCG
TGTCCTTCATGCAAAAGATGGAGAAGAAGCACTCGATTGGCTCGACCGTGAGCCAATCGATTTGCTCATTACCGACGTGA
TGATGCCACGATTGGATGGGCGTGAACTGACGGGACAATTACGTGACGCCGGGTATACGCTCCCAGTGCTCATGCTGACG
GTCCTCGATGCGATGAATGACAAAAAGCGCGGGTTTCATGCCGGAGCAGATGACTATGTCGTGAAACCGATCGATCTTGA
AGAACTTGAATTACGAATTGAGGCATTGTTACGACGAGCGCGCATTCATCACAGTCATCAGATTCAGTTGAACGACTGCG
TACTCGATGAGACGACGATGACGTTAGAAACGACTTCTGAGACGATCGAACTCCCTCGCAAAGAGTTTGAACTCCTCTAT
TTTTTGGCGACGCATTTGAATCAAGTCTTCACCCGGCAACAACTGTTAGACCGGATTTGGGGATATGAGACGGAGAGTGA
GACCCGAACGGTCGACGTCCATATTAATCGACTGCGTGCGCGTCTTAAGCCGATTGATGCATTTCAGATCAGTACGGTGT
GGGGACTCGGTTATCGATTGGAGCTGAAAAGATGA

Upstream 100 bases:

>100_bases
CGGGGTCGTGTTCGGCTATATTCCAGCTCGGAAAGCCTCGAACTTGCAACCGATTGAAGCGTTGCGAAACGTATAAGCCA
TTAGAAAGAAGGGAAACAAC

Downstream 100 bases:

>100_bases
AACGATTTATTAGTACCATCTACGGACGATTTTTAATGATTTTCTTCGGGCTCTTGTTGATTCCAATCCTCTTGACGTTC
ACGATTTTTTTGACCTTTCA

Product: two component transcriptional regulator, winged helix family

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MVTILLAEDDETLGGLLVDYLTVAGYRVLHAKDGEEALDWLDREPIDLLITDVMMPRLDGRELTGQLRDAGYTLPVLMLT
VLDAMNDKKRGFHAGADDYVVKPIDLEELELRIEALLRRARIHHSHQIQLNDCVLDETTMTLETTSETIELPRKEFELLY
FLATHLNQVFTRQQLLDRIWGYETESETRTVDVHINRLRARLKPIDAFQISTVWGLGYRLELKR

Sequences:

>Translated_224_residues
MVTILLAEDDETLGGLLVDYLTVAGYRVLHAKDGEEALDWLDREPIDLLITDVMMPRLDGRELTGQLRDAGYTLPVLMLT
VLDAMNDKKRGFHAGADDYVVKPIDLEELELRIEALLRRARIHHSHQIQLNDCVLDETTMTLETTSETIELPRKEFELLY
FLATHLNQVFTRQQLLDRIWGYETESETRTVDVHINRLRARLKPIDAFQISTVWGLGYRLELKR
>Mature_224_residues
MVTILLAEDDETLGGLLVDYLTVAGYRVLHAKDGEEALDWLDREPIDLLITDVMMPRLDGRELTGQLRDAGYTLPVLMLT
VLDAMNDKKRGFHAGADDYVVKPIDLEELELRIEALLRRARIHHSHQIQLNDCVLDETTMTLETTSETIELPRKEFELLY
FLATHLNQVFTRQQLLDRIWGYETESETRTVDVHINRLRARLKPIDAFQISTVWGLGYRLELKR

Specific function: Member of the two-component regulatory system hssS/hssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. Phosphorylated hssR binds to a direct repeat sequence within hrtAB promoter and activates the expression of hrtAB

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786599, Length=224, Percent_Identity=35.2678571428571, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI87082012, Length=220, Percent_Identity=35.4545454545455, Blast_Score=131, Evalue=3e-32,
Organism=Escherichia coli, GI1786784, Length=221, Percent_Identity=33.9366515837104, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1788394, Length=222, Percent_Identity=34.2342342342342, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1789402, Length=217, Percent_Identity=33.1797235023041, Blast_Score=118, Evalue=4e-28,
Organism=Escherichia coli, GI1789809, Length=224, Percent_Identity=33.4821428571429, Blast_Score=114, Evalue=7e-27,
Organism=Escherichia coli, GI1790860, Length=222, Percent_Identity=36.036036036036, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI2367329, Length=212, Percent_Identity=41.5094339622642, Blast_Score=107, Evalue=5e-25,
Organism=Escherichia coli, GI1790552, Length=219, Percent_Identity=33.7899543378995, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1787375, Length=223, Percent_Identity=32.2869955156951, Blast_Score=100, Evalue=8e-23,
Organism=Escherichia coli, GI1786911, Length=227, Percent_Identity=30.3964757709251, Blast_Score=95, Evalue=4e-21,
Organism=Escherichia coli, GI1787229, Length=225, Percent_Identity=32.4444444444444, Blast_Score=93, Evalue=1e-20,
Organism=Escherichia coli, GI1790863, Length=228, Percent_Identity=31.140350877193, Blast_Score=92, Evalue=2e-20,
Organism=Escherichia coli, GI145693140, Length=232, Percent_Identity=28.448275862069, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI145693157, Length=118, Percent_Identity=34.7457627118644, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1788713, Length=121, Percent_Identity=38.0165289256198, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1787487, Length=115, Percent_Identity=33.0434782608696, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1790299, Length=136, Percent_Identity=29.4117647058824, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI1790437, Length=127, Percent_Identity=29.1338582677165, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1788550, Length=129, Percent_Identity=29.4573643410853, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1788905, Length=106, Percent_Identity=34.9056603773585, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25914; Mature: 25914

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTILLAEDDETLGGLLVDYLTVAGYRVLHAKDGEEALDWLDREPIDLLITDVMMPRLDG
CEEEEEECCCCHHHHHHHHHHHHHCEEEEECCCCHHHHHHCCCCCHHHHHHHHHHCCCCC
RELTGQLRDAGYTLPVLMLTVLDAMNDKKRGFHAGADDYVVKPIDLEELELRIEALLRRA
HHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHH
RIHHSHQIQLNDCVLDETTMTLETTSETIELPRKEFELLYFLATHLNQVFTRQQLLDRIW
HHCCCCEEEECCEEECCCEEEEEECHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GYETESETRTVDVHINRLRARLKPIDAFQISTVWGLGYRLELKR
CCCCCCCCEEEEEEHHHHHHHCCCCCCEEEEEEECCCEEEEECC
>Mature Secondary Structure
MVTILLAEDDETLGGLLVDYLTVAGYRVLHAKDGEEALDWLDREPIDLLITDVMMPRLDG
CEEEEEECCCCHHHHHHHHHHHHHCEEEEECCCCHHHHHHCCCCCHHHHHHHHHHCCCCC
RELTGQLRDAGYTLPVLMLTVLDAMNDKKRGFHAGADDYVVKPIDLEELELRIEALLRRA
HHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHH
RIHHSHQIQLNDCVLDETTMTLETTSETIELPRKEFELLYFLATHLNQVFTRQQLLDRIW
HHCCCCEEEECCEEECCCEEEEEECHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GYETESETRTVDVHINRLRARLKPIDAFQISTVWGLGYRLELKR
CCCCCCCCEEEEEEHHHHHHHCCCCCCEEEEEEECCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA