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The map label for this gene is cdr [H]

Identifier: 229917771

GI number: 229917771

Start: 2001240

End: 2003705

Strand: Direct

Name: cdr [H]

Synonym: EAT1b_2049

Alternate gene names: 229917771

Gene position: 2001240-2003705 (Clockwise)

Preceding gene: 229917770

Following gene: 229917772

Centisome position: 66.71

GC content: 51.01

Gene sequence:

>2466_bases
ATGAGTAAAAAAATCGTAATCGTCGGTGGGGTGGCAGGTGGTGCATCTGCAGCTGCACGACTCCGTCGTTTGAATGAAGA
GAATCACATCGTCATGTTCGACCGTGGAGAGTACATCTCGTTCGCGAACTGTGGTCTTCCATATTATATCGGGGACGTTA
TCCAAGACCGTCAAAAACTCCTCGTTCAAACCGTTGAAGGGATGAACAAGCGTTTCCAACTCGATATCCGCAATTTGACG
GAAGTCGTCAAAATCAACCGTGACGAGAAAACGGTGACGGTGAAACACGTCCAAACAGGCGAAACGTATGACGAGTCATA
CGACGTCCTCATCTTGTCACCGGGAGCAAAACCGATTCGTCCAAACATCCCTGGAATCGACGAGGCAGAAGATATCTTCA
CACTTCGCAACATTCCGGATACAGATAAAATCCGTGGCTACGTCGATGACAAGGCACCAAAGCATGCGACTGTAATCGGT
GGAGGTTTCATCGGGATCGAGATGGCAGAAAACTTACGTGAGCGTGGCGTTGAGGTGACGCTCGTTGAGATGGCAGACCA
AGTCATGACGCCACTTGACCGTGAGATGGTGGCGCCAATTCATGAACACATGCGCTTGCATGGCGTCGAGCTTCAATTGT
CTGATGGTGTTTCTTCATTCTCTGAAAAAGGGAAGAAGGTGCATTTGACGAGCGGTCGTGTCATCGATACAGATATGGTC
ATCATGTCGATTGGGGTTACACCAGAGTCGACGATTGCGCGTGAAGCAGGCCTTGAAACAGGTACGCGCGGGGCAATCCG
AGTAAACGAAAAAATGATGACATCTGACCCGTCGATTTACGCGATCGGGGACGCGGTCGAAGTACTCGACTATGTCTTCC
ATGAGCCAACTGTCGTCCCACTCGCATGGCCAGCGAACCGTCAAGGCCGTCTCGTTGCCGATATCATTAACGGTCGTGAC
GTGAAATATAACGGAACGATGGGAACGGGAATCGCCAAAGTGTTTGATATGACGGTCGCATCGACAGGCTGGAATGAAAA
ACGGTTGAAGGCGGCTGGTAAGACGTATGAAGCCGTCCACGTGCACCCCGGTTCACATGCCGGCTATTATCCAGGATCGA
CACCTGTGTCACTCAAACTCTTGTTCCACCCGACAACGGGTGAGATCTATGGTGCGCAAGGCGTTGGGATCAATGGAGTC
GACAAACGCATCGACGTCATTGCGACGGCGATGAAGGGCGGTTTGACAGTCCTCGATCTACCTGACCTTGAGCTCAGTTA
CGCACCACCGTTCAGCTCGGCGAAAGATCCGGTCAATATGATCGGGTACGTCGCGTCGAACGTCGTCCTCGGTGACAATG
AAGTCGTGCATTGGGATGAAATCGATGAGCTCGTGGAAAATGGAGCGACGTTATTAGACGTTCGCGATGAATCGGAGCAT
GAACTCGGAAAGATTCCAGGGTCGATCAATGTACCACTCAACTCATTACGAGAAAACTTGGACAACTACGACCGGAATGA
AACGATTTACGTGACGTGCCAAGTCGGTCTTCGTGGCTATCTCGCATCACGCATCTTACGTCAAAACGGCTTCAAGGTGA
AAAACTTGAGCGGTGGCTACAAGACGTGGTCGCAAATCAATCGTGATTTCGAGGCGCTTGAAGAAGCGAACACATCAAAT
GAAACAGCGGCTACCGTTGTAGAAGAGGAGCCAACACAAATGACAAATGCACCAATCGGGGAAGCGGTCGTGTTAGACAC
ATGTGGTCTACAATGCCCGGGACCTATTTTAGAAGTGAATAAGAAAGTCGCAGAACTCGGAGAAGGCGAAACGCTCCGCG
TGCTCGCGAGTGACCCAGGATTCTTCGCAGACATCGAAGCATGGGCGAAGAAGACAGGAAACAAACTCGTCTCGAAACAA
TTCGTGAACGGACGCGTTGAAGCCATCCTTCAAAAAGGACAAGGTCCGGCTGTACCACAAGCGGGCGCGCCAGCAGGAGA
CGGTGCATCAATGGTCGTCTTCAGCGGAGACCTCGACCGCGCACTCGCATCCCTCATCATTGCGCAAGGTGCTGCCGCGA
TGGGGAAAGACGTGACGATGTTCTTTACATTCTGGGGACTCAACGTCATCCGCAAACCGGATGCGCCGGAAGTGAAGAAA
CAAGGCCTTGAGAAAATGTTCGGCATGATGATGCCAGGACATGCCGGCGAACTTCCACTTTCGAATATGAACTTTGGTGG
TGTCGGTCAAAAAATGATGAAGAAAGTCATGAGCGACAAGAATGTTCCTTCTGTCGAAGAAATGATCAAGTCGGCGCAAG
AGGCAGGCGTAAAAATGGTAGCTTGCACGATGTCAATGGACGTCATGGGTATCAAAGAAGAAGAGTTGATTGATGGGGTC
GACCTTGGTGGTGTGGCGGCGTATCTCGGCGCAGCAGAAGGCGGTAACTTAAACCTCTTTATCTAA

Upstream 100 bases:

>100_bases
AAGCGACTTGGCAAATGGAGGCGAAAGGCTATAAAGTGGTCAATATAGAAGATGGCTTGATGAGTTGGCCAGGAGAAGTC
GTCAGAGGAGGAAATGGACA

Downstream 100 bases:

>100_bases
ACGGAATAGAAAACGAGTCGGATTGCGATGCGCTCTCCGGCTCGTTTTTTTTGCTTTTAGAAAGAGTCGAGGTGATATTG
AAAAAACGAATTAATATTGC

Product: FAD-dependent pyridine nucleotide-disulphide oxidoreductase

Products: NA

Alternate protein names: CoA-disulfide reductase; CoADR [H]

Number of amino acids: Translated: 821; Mature: 820

Protein sequence:

>821_residues
MSKKIVIVGGVAGGASAAARLRRLNEENHIVMFDRGEYISFANCGLPYYIGDVIQDRQKLLVQTVEGMNKRFQLDIRNLT
EVVKINRDEKTVTVKHVQTGETYDESYDVLILSPGAKPIRPNIPGIDEAEDIFTLRNIPDTDKIRGYVDDKAPKHATVIG
GGFIGIEMAENLRERGVEVTLVEMADQVMTPLDREMVAPIHEHMRLHGVELQLSDGVSSFSEKGKKVHLTSGRVIDTDMV
IMSIGVTPESTIAREAGLETGTRGAIRVNEKMMTSDPSIYAIGDAVEVLDYVFHEPTVVPLAWPANRQGRLVADIINGRD
VKYNGTMGTGIAKVFDMTVASTGWNEKRLKAAGKTYEAVHVHPGSHAGYYPGSTPVSLKLLFHPTTGEIYGAQGVGINGV
DKRIDVIATAMKGGLTVLDLPDLELSYAPPFSSAKDPVNMIGYVASNVVLGDNEVVHWDEIDELVENGATLLDVRDESEH
ELGKIPGSINVPLNSLRENLDNYDRNETIYVTCQVGLRGYLASRILRQNGFKVKNLSGGYKTWSQINRDFEALEEANTSN
ETAATVVEEEPTQMTNAPIGEAVVLDTCGLQCPGPILEVNKKVAELGEGETLRVLASDPGFFADIEAWAKKTGNKLVSKQ
FVNGRVEAILQKGQGPAVPQAGAPAGDGASMVVFSGDLDRALASLIIAQGAAAMGKDVTMFFTFWGLNVIRKPDAPEVKK
QGLEKMFGMMMPGHAGELPLSNMNFGGVGQKMMKKVMSDKNVPSVEEMIKSAQEAGVKMVACTMSMDVMGIKEEELIDGV
DLGGVAAYLGAAEGGNLNLFI

Sequences:

>Translated_821_residues
MSKKIVIVGGVAGGASAAARLRRLNEENHIVMFDRGEYISFANCGLPYYIGDVIQDRQKLLVQTVEGMNKRFQLDIRNLT
EVVKINRDEKTVTVKHVQTGETYDESYDVLILSPGAKPIRPNIPGIDEAEDIFTLRNIPDTDKIRGYVDDKAPKHATVIG
GGFIGIEMAENLRERGVEVTLVEMADQVMTPLDREMVAPIHEHMRLHGVELQLSDGVSSFSEKGKKVHLTSGRVIDTDMV
IMSIGVTPESTIAREAGLETGTRGAIRVNEKMMTSDPSIYAIGDAVEVLDYVFHEPTVVPLAWPANRQGRLVADIINGRD
VKYNGTMGTGIAKVFDMTVASTGWNEKRLKAAGKTYEAVHVHPGSHAGYYPGSTPVSLKLLFHPTTGEIYGAQGVGINGV
DKRIDVIATAMKGGLTVLDLPDLELSYAPPFSSAKDPVNMIGYVASNVVLGDNEVVHWDEIDELVENGATLLDVRDESEH
ELGKIPGSINVPLNSLRENLDNYDRNETIYVTCQVGLRGYLASRILRQNGFKVKNLSGGYKTWSQINRDFEALEEANTSN
ETAATVVEEEPTQMTNAPIGEAVVLDTCGLQCPGPILEVNKKVAELGEGETLRVLASDPGFFADIEAWAKKTGNKLVSKQ
FVNGRVEAILQKGQGPAVPQAGAPAGDGASMVVFSGDLDRALASLIIAQGAAAMGKDVTMFFTFWGLNVIRKPDAPEVKK
QGLEKMFGMMMPGHAGELPLSNMNFGGVGQKMMKKVMSDKNVPSVEEMIKSAQEAGVKMVACTMSMDVMGIKEEELIDGV
DLGGVAAYLGAAEGGNLNLFI
>Mature_820_residues
SKKIVIVGGVAGGASAAARLRRLNEENHIVMFDRGEYISFANCGLPYYIGDVIQDRQKLLVQTVEGMNKRFQLDIRNLTE
VVKINRDEKTVTVKHVQTGETYDESYDVLILSPGAKPIRPNIPGIDEAEDIFTLRNIPDTDKIRGYVDDKAPKHATVIGG
GFIGIEMAENLRERGVEVTLVEMADQVMTPLDREMVAPIHEHMRLHGVELQLSDGVSSFSEKGKKVHLTSGRVIDTDMVI
MSIGVTPESTIAREAGLETGTRGAIRVNEKMMTSDPSIYAIGDAVEVLDYVFHEPTVVPLAWPANRQGRLVADIINGRDV
KYNGTMGTGIAKVFDMTVASTGWNEKRLKAAGKTYEAVHVHPGSHAGYYPGSTPVSLKLLFHPTTGEIYGAQGVGINGVD
KRIDVIATAMKGGLTVLDLPDLELSYAPPFSSAKDPVNMIGYVASNVVLGDNEVVHWDEIDELVENGATLLDVRDESEHE
LGKIPGSINVPLNSLRENLDNYDRNETIYVTCQVGLRGYLASRILRQNGFKVKNLSGGYKTWSQINRDFEALEEANTSNE
TAATVVEEEPTQMTNAPIGEAVVLDTCGLQCPGPILEVNKKVAELGEGETLRVLASDPGFFADIEAWAKKTGNKLVSKQF
VNGRVEAILQKGQGPAVPQAGAPAGDGASMVVFSGDLDRALASLIIAQGAAAMGKDVTMFFTFWGLNVIRKPDAPEVKKQ
GLEKMFGMMMPGHAGELPLSNMNFGGVGQKMMKKVMSDKNVPSVEEMIKSAQEAGVKMVACTMSMDVMGIKEEELIDGVD
LGGVAAYLGAAEGGNLNLFI

Specific function: Catalyzes specifically the NADPH-dependent reduction of coenzyme A disulfide [H]

COG id: COG0446

COG function: function code R; Uncharacterized NAD(FAD)-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI226437568, Length=317, Percent_Identity=26.4984227129338, Blast_Score=99, Evalue=2e-20,
Organism=Homo sapiens, GI65787454, Length=317, Percent_Identity=26.4984227129338, Blast_Score=99, Evalue=2e-20,
Organism=Homo sapiens, GI21389617, Length=317, Percent_Identity=26.4984227129338, Blast_Score=99, Evalue=2e-20,
Organism=Escherichia coli, GI87082354, Length=338, Percent_Identity=28.698224852071, Blast_Score=94, Evalue=4e-20,
Organism=Escherichia coli, GI1788892, Length=296, Percent_Identity=28.3783783783784, Blast_Score=88, Evalue=3e-18,
Organism=Escherichia coli, GI1789765, Length=283, Percent_Identity=27.9151943462898, Blast_Score=86, Evalue=9e-18,
Organism=Escherichia coli, GI1786307, Length=309, Percent_Identity=27.831715210356, Blast_Score=84, Evalue=5e-17,
Organism=Escherichia coli, GI1789065, Length=291, Percent_Identity=26.8041237113402, Blast_Score=83, Evalue=9e-17,
Organism=Escherichia coli, GI1789915, Length=344, Percent_Identity=23.8372093023256, Blast_Score=64, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17559934, Length=225, Percent_Identity=28.4444444444444, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21358499, Length=217, Percent_Identity=30.4147465437788, Blast_Score=70, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24585130, Length=293, Percent_Identity=22.8668941979522, Blast_Score=67, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017758
- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.14 [H]

Molecular weight: Translated: 88825; Mature: 88694

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS50206 RHODANESE_3 ; PS01148 UPF0033

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKKIVIVGGVAGGASAAARLRRLNEENHIVMFDRGEYISFANCGLPYYIGDVIQDRQKL
CCCEEEEEECCCCCHHHHHHHHHCCCCCCEEEEECCCEEEEECCCCCHHHHHHHHHHHHH
LVQTVEGMNKRFQLDIRNLTEVVKINRDEKTVTVKHVQTGETYDESYDVLILSPGAKPIR
HHHHHHCCCCEEEEEHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCEEEECCCCCCCC
PNIPGIDEAEDIFTLRNIPDTDKIRGYVDDKAPKHATVIGGGFIGIEMAENLRERGVEVT
CCCCCCCCHHHHHEECCCCCHHHHCEEECCCCCCCEEEEECCEEEHHHHHHHHHCCCEEE
LVEMADQVMTPLDREMVAPIHEHMRLHGVELQLSDGVSSFSEKGKKVHLTSGRVIDTDMV
EHHHHHHHHCCCCHHHHHHHHHHHHEECEEEEECCCHHHHHHCCCEEEEECCCEEECCEE
IMSIGVTPESTIAREAGLETGTRGAIRVNEKMMTSDPSIYAIGDAVEVLDYVFHEPTVVP
EEEECCCCCHHHHHHCCCCCCCCCEEEECCCCCCCCCCEEEECHHHHHHHHHHCCCEEEE
LAWPANRQGRLVADIINGRDVKYNGTMGTGIAKVFDMTVASTGWNEKRLKAAGKTYEAVH
EECCCCCCCCEEEEECCCCEEEECCCCCCHHHHHHHHHHHCCCCCHHHHHHCCCCEEEEE
VHPGSHAGYYPGSTPVSLKLLFHPTTGEIYGAQGVGINGVDKRIDVIATAMKGGLTVLDL
ECCCCCCCCCCCCCCEEEEEEEECCCCCEECCCCCCCCCHHHHHHHHHHHHHCCEEEEEC
PDLELSYAPPFSSAKDPVNMIGYVASNVVLGDNEVVHWDEIDELVENGATLLDVRDESEH
CCCCEECCCCCCCCCCHHHHHHHHHCCEEECCCCEEEHHHHHHHHHCCCEEEEECCCCCH
ELGKIPGSINVPLNSLRENLDNYDRNETIYVTCQVGLRGYLASRILRQNGFKVKNLSGGY
HHHCCCCCCCCCHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHCCCEEEECCCCH
KTWSQINRDFEALEEANTSNETAATVVEEEPTQMTNAPIGEAVVLDTCGLQCPGPILEVN
HHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHCCCCCCCEEEEECCCCCCCCCHHHHH
KKVAELGEGETLRVLASDPGFFADIEAWAKKTGNKLVSKQFVNGRVEAILQKGQGPAVPQ
HHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHCHHHHHHHHHCHHHHHHHHCCCCCCCCC
AGAPAGDGASMVVFSGDLDRALASLIIAQGAAAMGKDVTMFFTFWGLNVIRKPDAPEVKK
CCCCCCCCCEEEEECCCHHHHHHHHHHHCCCHHCCCCEEEEEEEECCCEEECCCCCHHHH
QGLEKMFGMMMPGHAGELPLSNMNFGGVGQKMMKKVMSDKNVPSVEEMIKSAQEAGVKMV
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEE
ACTMSMDVMGIKEEELIDGVDLGGVAAYLGAAEGGNLNLFI
EEEECCCCCCCCHHHHHCCCCCCHHHHHHCCCCCCCEEEEC
>Mature Secondary Structure 
SKKIVIVGGVAGGASAAARLRRLNEENHIVMFDRGEYISFANCGLPYYIGDVIQDRQKL
CCEEEEEECCCCCHHHHHHHHHCCCCCCEEEEECCCEEEEECCCCCHHHHHHHHHHHHH
LVQTVEGMNKRFQLDIRNLTEVVKINRDEKTVTVKHVQTGETYDESYDVLILSPGAKPIR
HHHHHHCCCCEEEEEHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCEEEECCCCCCCC
PNIPGIDEAEDIFTLRNIPDTDKIRGYVDDKAPKHATVIGGGFIGIEMAENLRERGVEVT
CCCCCCCCHHHHHEECCCCCHHHHCEEECCCCCCCEEEEECCEEEHHHHHHHHHCCCEEE
LVEMADQVMTPLDREMVAPIHEHMRLHGVELQLSDGVSSFSEKGKKVHLTSGRVIDTDMV
EHHHHHHHHCCCCHHHHHHHHHHHHEECEEEEECCCHHHHHHCCCEEEEECCCEEECCEE
IMSIGVTPESTIAREAGLETGTRGAIRVNEKMMTSDPSIYAIGDAVEVLDYVFHEPTVVP
EEEECCCCCHHHHHHCCCCCCCCCEEEECCCCCCCCCCEEEECHHHHHHHHHHCCCEEEE
LAWPANRQGRLVADIINGRDVKYNGTMGTGIAKVFDMTVASTGWNEKRLKAAGKTYEAVH
EECCCCCCCCEEEEECCCCEEEECCCCCCHHHHHHHHHHHCCCCCHHHHHHCCCCEEEEE
VHPGSHAGYYPGSTPVSLKLLFHPTTGEIYGAQGVGINGVDKRIDVIATAMKGGLTVLDL
ECCCCCCCCCCCCCCEEEEEEEECCCCCEECCCCCCCCCHHHHHHHHHHHHHCCEEEEEC
PDLELSYAPPFSSAKDPVNMIGYVASNVVLGDNEVVHWDEIDELVENGATLLDVRDESEH
CCCCEECCCCCCCCCCHHHHHHHHHCCEEECCCCEEEHHHHHHHHHCCCEEEEECCCCCH
ELGKIPGSINVPLNSLRENLDNYDRNETIYVTCQVGLRGYLASRILRQNGFKVKNLSGGY
HHHCCCCCCCCCHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHCCCEEEECCCCH
KTWSQINRDFEALEEANTSNETAATVVEEEPTQMTNAPIGEAVVLDTCGLQCPGPILEVN
HHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHCCCCCCCEEEEECCCCCCCCCHHHHH
KKVAELGEGETLRVLASDPGFFADIEAWAKKTGNKLVSKQFVNGRVEAILQKGQGPAVPQ
HHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHCHHHHHHHHHCHHHHHHHHCCCCCCCCC
AGAPAGDGASMVVFSGDLDRALASLIIAQGAAAMGKDVTMFFTFWGLNVIRKPDAPEVKK
CCCCCCCCCEEEEECCCHHHHHHHHHHHCCCHHCCCCEEEEEEEECCCEEECCCCCHHHH
QGLEKMFGMMMPGHAGELPLSNMNFGGVGQKMMKKVMSDKNVPSVEEMIKSAQEAGVKMV
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEE
ACTMSMDVMGIKEEELIDGVDLGGVAAYLGAAEGGNLNLFI
EEEECCCCCCCCHHHHHCCCCCCHHHHHHCCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA