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The map label for this gene is pbuX [H]

Identifier: 229917700

GI number: 229917700

Start: 1935071

End: 1936375

Strand: Direct

Name: pbuX [H]

Synonym: EAT1b_1977

Alternate gene names: 229917700

Gene position: 1935071-1936375 (Clockwise)

Preceding gene: 229917699

Following gene: 229917701

Centisome position: 64.5

GC content: 52.34

Gene sequence:

>1305_bases
ATGAATACATTTAAGACGGCAAGTCTCGGATTTCAGCATCTGCTCGCCATGTACACGGGAGCAGCCATCGTCCCGCTCAT
CGTCGGTGGTGCCATCGGGCTTGGTCCAACCGAGCTCGCCTATCTCGTCGCAATTGATTTATTCATGTGTGGGGTGGCGA
CGCTTTTACAAGTATGGACGACACGCTTTACGGGTGTTGGATTGCCGGTCGTCCTCGGATGTACGTTCACAGCGGTCGGT
CCGATGATCGCGATTGGAAGCGCAAATGGAATTACGGCTATTTATGGCGCTTTGATTGCCAGTGGGTTCATCGTCATCCT
CATTTCCGGATTTGTCGGGAAGCTCGCACGTTTCTTCCCGCCGGTCGTTCTCGGTTCGGTCGTGACAATCATTGGTCTCT
CACTGATTCCGGTCGCCATTAATGACATCGGTGGCGGGATGCCAGGTGAGCCTGGATTCGCATCGATGCAGAATCTCGGA
TTAGGTGGTTTGACGATTTTACTCATTCTCATCTTGAACCGTGTCGGTACTGTCTTCACACGCGCCGCTGCTGTCCTCTT
TGCCGTCCTCATCGGGACAGGGGTTGCTGCTTCGCTCGGTCTCGTGGACTTCAGTCCTGTCCGGGAAGCGGGTTGGTTCC
AAATGGTTCAACCGTTCTACTTTGGGATGCCGACATTTGATGTGTCCGCGATCCTCGTCATGACGCTCGTCGCCATTATC
TCGATGATTGAATCGACAGGTGTATTCTTGGCGCTCAGCGATATCACGAAAAGGCCGATTGGTTCGAACGAATTGACGAA
AGGGTATCGTGCGGAAGGTGTCGCAACGATTCTCGGAGGGATTTTCAACAGTTTCCCGTACACGACATTCAGTCAAAATG
TCGGACTTGTTCAATTGTCAGGTGTAAAATCGCGCCGTGTCATCTTCTGGACAGGTGGGTTACTCATCTTGCTCGGATTC
CTTCCGAAAGTCGCCACATTCACGACATTGATTCCAAAGCCTGTTTTAGGTGGAGCGATGCTCGTCATGTTCGGAACGGT
CGCTGCTTCCGGCATTCGAATTCTGAGTCAGGTCGATTTTTCGAAAAACGAGAATTTGATTACCATCGCACTCTCGATTG
GTGTCGGACTCGGCATCACCGCTAACCCGGCGATTGTCGCCAACATGCCGGAATGGCTTCAATTGTTCACAGATAGTGCC
ATCGTGGCAGGTTCGTTCACAGCGCTCCTGTTGAATGGGTTCTTCCGTATGATGGACCGATTCCGTCCCGGGACAATCAT
TGCCGAGGAACGGCAAGTCAGCTAG

Upstream 100 bases:

>100_bases
TAGGGCGCGATAAACTGATTGAGCGTGGTTATCGCGTCGAATCGCTAGCGCGCGTCGCGAAATTAGAGAAAGACCATATC
TCGTTCGTGGAGGTCGTTCG

Downstream 100 bases:

>100_bases
ACTGAAGGAAATAGTAGTCTAGGAGGAGTCACGAATGGGGAAAACTGCACTTGTCGTAGGCGCGACCGGCTTGATTGGCC
GCGAATTGGTGGAACAGTTG

Product: xanthine permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MNTFKTASLGFQHLLAMYTGAAIVPLIVGGAIGLGPTELAYLVAIDLFMCGVATLLQVWTTRFTGVGLPVVLGCTFTAVG
PMIAIGSANGITAIYGALIASGFIVILISGFVGKLARFFPPVVLGSVVTIIGLSLIPVAINDIGGGMPGEPGFASMQNLG
LGGLTILLILILNRVGTVFTRAAAVLFAVLIGTGVAASLGLVDFSPVREAGWFQMVQPFYFGMPTFDVSAILVMTLVAII
SMIESTGVFLALSDITKRPIGSNELTKGYRAEGVATILGGIFNSFPYTTFSQNVGLVQLSGVKSRRVIFWTGGLLILLGF
LPKVATFTTLIPKPVLGGAMLVMFGTVAASGIRILSQVDFSKNENLITIALSIGVGLGITANPAIVANMPEWLQLFTDSA
IVAGSFTALLLNGFFRMMDRFRPGTIIAEERQVS

Sequences:

>Translated_434_residues
MNTFKTASLGFQHLLAMYTGAAIVPLIVGGAIGLGPTELAYLVAIDLFMCGVATLLQVWTTRFTGVGLPVVLGCTFTAVG
PMIAIGSANGITAIYGALIASGFIVILISGFVGKLARFFPPVVLGSVVTIIGLSLIPVAINDIGGGMPGEPGFASMQNLG
LGGLTILLILILNRVGTVFTRAAAVLFAVLIGTGVAASLGLVDFSPVREAGWFQMVQPFYFGMPTFDVSAILVMTLVAII
SMIESTGVFLALSDITKRPIGSNELTKGYRAEGVATILGGIFNSFPYTTFSQNVGLVQLSGVKSRRVIFWTGGLLILLGF
LPKVATFTTLIPKPVLGGAMLVMFGTVAASGIRILSQVDFSKNENLITIALSIGVGLGITANPAIVANMPEWLQLFTDSA
IVAGSFTALLLNGFFRMMDRFRPGTIIAEERQVS
>Mature_434_residues
MNTFKTASLGFQHLLAMYTGAAIVPLIVGGAIGLGPTELAYLVAIDLFMCGVATLLQVWTTRFTGVGLPVVLGCTFTAVG
PMIAIGSANGITAIYGALIASGFIVILISGFVGKLARFFPPVVLGSVVTIIGLSLIPVAINDIGGGMPGEPGFASMQNLG
LGGLTILLILILNRVGTVFTRAAAVLFAVLIGTGVAASLGLVDFSPVREAGWFQMVQPFYFGMPTFDVSAILVMTLVAII
SMIESTGVFLALSDITKRPIGSNELTKGYRAEGVATILGGIFNSFPYTTFSQNVGLVQLSGVKSRRVIFWTGGLLILLGF
LPKVATFTTLIPKPVLGGAMLVMFGTVAASGIRILSQVDFSKNENLITIALSIGVGLGITANPAIVANMPEWLQLFTDSA
IVAGSFTALLLNGFFRMMDRFRPGTIIAEERQVS

Specific function: Transport of xanthine in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680148, Length=500, Percent_Identity=26, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI40316845, Length=500, Percent_Identity=26, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI44680145, Length=440, Percent_Identity=24.0909090909091, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI44680143, Length=444, Percent_Identity=23.6486486486486, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI87082181, Length=416, Percent_Identity=44.7115384615385, Blast_Score=317, Evalue=1e-87,
Organism=Escherichia coli, GI1790087, Length=420, Percent_Identity=36.9047619047619, Blast_Score=218, Evalue=6e-58,
Organism=Escherichia coli, GI87082178, Length=447, Percent_Identity=34.0044742729307, Blast_Score=191, Evalue=8e-50,
Organism=Escherichia coli, GI87081818, Length=451, Percent_Identity=30.5986696230599, Blast_Score=139, Evalue=5e-34,
Organism=Escherichia coli, GI1788843, Length=386, Percent_Identity=30.3108808290155, Blast_Score=132, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI17542262, Length=433, Percent_Identity=25.1732101616628, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17558856, Length=332, Percent_Identity=25.3012048192771, Blast_Score=88, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17542260, Length=173, Percent_Identity=28.3236994219653, Blast_Score=75, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI71993493, Length=173, Percent_Identity=27.1676300578035, Blast_Score=71, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17541904, Length=435, Percent_Identity=21.3793103448276, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21356175, Length=419, Percent_Identity=26.2529832935561, Blast_Score=92, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017588
- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 45384; Mature: 45384

Theoretical pI: Translated: 9.41; Mature: 9.41

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTFKTASLGFQHLLAMYTGAAIVPLIVGGAIGLGPTELAYLVAIDLFMCGVATLLQVWT
CCCCCCHHHHHHHHHHHHHCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
TRFTGVGLPVVLGCTFTAVGPMIAIGSANGITAIYGALIASGFIVILISGFVGKLARFFP
HHHCCCCCHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PVVLGSVVTIIGLSLIPVAINDIGGGMPGEPGFASMQNLGLGGLTILLILILNRVGTVFT
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHH
RAAAVLFAVLIGTGVAASLGLVDFSPVREAGWFQMVQPFYFGMPTFDVSAILVMTLVAII
HHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
SMIESTGVFLALSDITKRPIGSNELTKGYRAEGVATILGGIFNSFPYTTFSQNVGLVQLS
HHHHHCCCEEEEHHHHCCCCCCCHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEC
GVKSRRVIFWTGGLLILLGFLPKVATFTTLIPKPVLGGAMLVMFGTVAASGIRILSQVDF
CCCCCEEEEEECHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
SKNENLITIALSIGVGLGITANPAIVANMPEWLQLFTDSAIVAGSFTALLLNGFFRMMDR
CCCCCEEEEEEEECCCCCCCCCCEEEECCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
FRPGTIIAEERQVS
CCCCCEEECCCCCC
>Mature Secondary Structure
MNTFKTASLGFQHLLAMYTGAAIVPLIVGGAIGLGPTELAYLVAIDLFMCGVATLLQVWT
CCCCCCHHHHHHHHHHHHHCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
TRFTGVGLPVVLGCTFTAVGPMIAIGSANGITAIYGALIASGFIVILISGFVGKLARFFP
HHHCCCCCHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PVVLGSVVTIIGLSLIPVAINDIGGGMPGEPGFASMQNLGLGGLTILLILILNRVGTVFT
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHH
RAAAVLFAVLIGTGVAASLGLVDFSPVREAGWFQMVQPFYFGMPTFDVSAILVMTLVAII
HHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
SMIESTGVFLALSDITKRPIGSNELTKGYRAEGVATILGGIFNSFPYTTFSQNVGLVQLS
HHHHHCCCEEEEHHHHCCCCCCCHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEC
GVKSRRVIFWTGGLLILLGFLPKVATFTTLIPKPVLGGAMLVMFGTVAASGIRILSQVDF
CCCCCEEEEEECHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
SKNENLITIALSIGVGLGITANPAIVANMPEWLQLFTDSAIVAGSFTALLLNGFFRMMDR
CCCCCEEEEEEEECCCCCCCCCCEEEECCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
FRPGTIIAEERQVS
CCCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9098051; 9384377 [H]