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The map label for this gene is aceA [H]

Identifier: 229917621

GI number: 229917621

Start: 1861560

End: 1862837

Strand: Direct

Name: aceA [H]

Synonym: EAT1b_1896

Alternate gene names: 229917621

Gene position: 1861560-1862837 (Clockwise)

Preceding gene: 229917620

Following gene: 229917622

Centisome position: 62.05

GC content: 52.82

Gene sequence:

>1278_bases
ATGAAAAAACGCGAAGAATTGTTGAACAGCTGGAAGTCAGAACGATTTGAAGGGGTAGAACGTCCATACTCTGTAGAAGA
CGTCATGAAATTACGAGGGTCTATCGTAATTGAACATACACTTGCGACAAAGGGAGCGGAACGCCTGTGGCAATTGATGC
ACGAGCGTGACTACGTCCATGCACTAGGTGCGTTGACAGGGAACCAGGCGATTCAGCAAGTGAAGGCAGGACTCGAAGCC
ATCTATTTGAGTGGTTGGCAAGTAGCGGCGGATGCGAACCTGTCAGGTCACATGTATCCGGACCAGAGTCTATATCCGGC
CAACTCAGTGCCAAGTGTCGTCAAACGAATCAACCAAGCGCTTCAACGTGCTGACCAAATTCAAACGGCAGAAGGGAAAG
GCGACACGCATTGGTTCGCACCGATTGTCGCGGATATGGAAGCCGGTTTTGGTGGGGTGCTCAACGTATTCGAACTGACG
AAGGCGATGATTGAAGCGGGGGCTGCCGGCGTTCACCTCGAAGACCAGCTCTCGTCTGAGAAGAAATGTGGTCACCTCGG
TGGGAAGGTATTACTCCCGACGCAGACGGCTGTGAAAAACTTGATTTCGGCTCGACTCGCGGCAGACGTCATGGGTGTCC
CGACAATCATCGTAGCGCGGACAGATGCGCACGCGGCGAACTTGATCACGAGCGACATCGACCCAATCGATCATCCGTTC
ATCATTGGAGAGCGTACGCCGGAAGGCTTCTATCGTACGGAAGCTGGTATCGAGCAAGCAATCGCTCGTGGTCTCGCTTA
TGCACCGTATGCAGACCTCGTCTGGTGTGAGACGTCCGAACCAGATTTGGCAGAGGCACGTCAATTTGCCGAAGCGATTC
ATGCGAAGTATCCAGGCAAACTTCTCGCTTACAACTGCTCGCCATCGTTCAACTGGAAGAAGAAGCTGTCAGACGAAGAG
ATCGCCACGTTCCAACAAGAAATCGGCGCAATGGGCTACAAGTTCCAGTTCGTTACACTCGCTGGATTCCACGCGCTCAA
CTTCGGCATGTTCGAGCTCGCACGCGGTTACAAAGATCGTGGCATGGCGGCTTACTCGGAGTTACAGCAAGCAGAATTTG
CGGCTGAAGTACATGGTTACACGGCGACACGTCATCAGCGTGAAGTCGGAACGGGTTACTTCGATGAAGTCTCGCTCGTC
ATCTCAGGTGGACAATCATCAACGACAGCGCTCGCAGGTTCGACCGAGACTGAACAGTTTGAAACACCGTTGCATTGA

Upstream 100 bases:

>100_bases
GGAGTGCTGCGCTTACCTCGACTAAACCATTTCGTTTACACCATCTGTTATATAACAAATTTAATTTTGTGAAATTAATA
TAATACAGGAGGGTTTATTG

Downstream 100 bases:

>100_bases
GCGATGCCCCTCGACAAGAGGGGTTTTTTGTGTCCAAATTTGGAACACCTGCATCCTGTTCACTTAAATGTGACGTATTT
CACATTTTTGTTGTCGAACT

Product: isocitrate lyase

Products: NA

Alternate protein names: ICL; Isocitrase; Isocitratase [H]

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MKKREELLNSWKSERFEGVERPYSVEDVMKLRGSIVIEHTLATKGAERLWQLMHERDYVHALGALTGNQAIQQVKAGLEA
IYLSGWQVAADANLSGHMYPDQSLYPANSVPSVVKRINQALQRADQIQTAEGKGDTHWFAPIVADMEAGFGGVLNVFELT
KAMIEAGAAGVHLEDQLSSEKKCGHLGGKVLLPTQTAVKNLISARLAADVMGVPTIIVARTDAHAANLITSDIDPIDHPF
IIGERTPEGFYRTEAGIEQAIARGLAYAPYADLVWCETSEPDLAEARQFAEAIHAKYPGKLLAYNCSPSFNWKKKLSDEE
IATFQQEIGAMGYKFQFVTLAGFHALNFGMFELARGYKDRGMAAYSELQQAEFAAEVHGYTATRHQREVGTGYFDEVSLV
ISGGQSSTTALAGSTETEQFETPLH

Sequences:

>Translated_425_residues
MKKREELLNSWKSERFEGVERPYSVEDVMKLRGSIVIEHTLATKGAERLWQLMHERDYVHALGALTGNQAIQQVKAGLEA
IYLSGWQVAADANLSGHMYPDQSLYPANSVPSVVKRINQALQRADQIQTAEGKGDTHWFAPIVADMEAGFGGVLNVFELT
KAMIEAGAAGVHLEDQLSSEKKCGHLGGKVLLPTQTAVKNLISARLAADVMGVPTIIVARTDAHAANLITSDIDPIDHPF
IIGERTPEGFYRTEAGIEQAIARGLAYAPYADLVWCETSEPDLAEARQFAEAIHAKYPGKLLAYNCSPSFNWKKKLSDEE
IATFQQEIGAMGYKFQFVTLAGFHALNFGMFELARGYKDRGMAAYSELQQAEFAAEVHGYTATRHQREVGTGYFDEVSLV
ISGGQSSTTALAGSTETEQFETPLH
>Mature_425_residues
MKKREELLNSWKSERFEGVERPYSVEDVMKLRGSIVIEHTLATKGAERLWQLMHERDYVHALGALTGNQAIQQVKAGLEA
IYLSGWQVAADANLSGHMYPDQSLYPANSVPSVVKRINQALQRADQIQTAEGKGDTHWFAPIVADMEAGFGGVLNVFELT
KAMIEAGAAGVHLEDQLSSEKKCGHLGGKVLLPTQTAVKNLISARLAADVMGVPTIIVARTDAHAANLITSDIDPIDHPF
IIGERTPEGFYRTEAGIEQAIARGLAYAPYADLVWCETSEPDLAEARQFAEAIHAKYPGKLLAYNCSPSFNWKKKLSDEE
IATFQQEIGAMGYKFQFVTLAGFHALNFGMFELARGYKDRGMAAYSELQQAEFAAEVHGYTATRHQREVGTGYFDEVSLV
ISGGQSSTTALAGSTETEQFETPLH

Specific function: Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase- positive serine pathway [H]

COG id: COG2224

COG function: function code C; Isocitrate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family [H]

Homologues:

Organism=Escherichia coli, GI1790445, Length=434, Percent_Identity=67.0506912442396, Blast_Score=588, Evalue=1e-169,
Organism=Escherichia coli, GI1786525, Length=252, Percent_Identity=28.1746031746032, Blast_Score=82, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17561814, Length=424, Percent_Identity=64.3867924528302, Blast_Score=573, Evalue=1e-164,
Organism=Caenorhabditis elegans, GI71982926, Length=424, Percent_Identity=64.3867924528302, Blast_Score=573, Evalue=1e-164,
Organism=Saccharomyces cerevisiae, GI6320908, Length=291, Percent_Identity=36.426116838488, Blast_Score=171, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6325263, Length=247, Percent_Identity=38.8663967611336, Blast_Score=164, Evalue=3e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006254
- InterPro:   IPR000918
- InterPro:   IPR018523
- InterPro:   IPR015813 [H]

Pfam domain/function: PF00463 ICL [H]

EC number: =4.1.3.1 [H]

Molecular weight: Translated: 46615; Mature: 46615

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: PS00161 ISOCITRATE_LYASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKREELLNSWKSERFEGVERPYSVEDVMKLRGSIVIEHTLATKGAERLWQLMHERDYVH
CCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHH
ALGALTGNQAIQQVKAGLEAIYLSGWQVAADANLSGHMYPDQSLYPANSVPSVVKRINQA
HHHHHHHHHHHHHHHHHHHEEEECCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
LQRADQIQTAEGKGDTHWFAPIVADMEAGFGGVLNVFELTKAMIEAGAAGVHLEDQLSSE
HHHHHHHCCCCCCCCCEEHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEHHHHCCH
KKCGHLGGKVLLPTQTAVKNLISARLAADVMGVPTIIVARTDAHAANLITSDIDPIDHPF
HHHHHCCCEEEECCHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHCCCCCCCCCE
IIGERTPEGFYRTEAGIEQAIARGLAYAPYADLVWCETSEPDLAEARQFAEAIHAKYPGK
EEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCC
LLAYNCSPSFNWKKKLSDEEIATFQQEIGAMGYKFQFVTLAGFHALNFGMFELARGYKDR
EEEEECCCCCCHHHHCCHHHHHHHHHHHCCCCEEEEEEEEECHHHHHHHHHHHHCCHHHC
GMAAYSELQQAEFAAEVHGYTATRHQREVGTGYFDEVSLVISGGQSSTTALAGSTETEQF
CHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCEEEEEEECCCCCCEEECCCCCCCCC
ETPLH
CCCCC
>Mature Secondary Structure
MKKREELLNSWKSERFEGVERPYSVEDVMKLRGSIVIEHTLATKGAERLWQLMHERDYVH
CCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHH
ALGALTGNQAIQQVKAGLEAIYLSGWQVAADANLSGHMYPDQSLYPANSVPSVVKRINQA
HHHHHHHHHHHHHHHHHHHEEEECCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
LQRADQIQTAEGKGDTHWFAPIVADMEAGFGGVLNVFELTKAMIEAGAAGVHLEDQLSSE
HHHHHHHCCCCCCCCCEEHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEHHHHCCH
KKCGHLGGKVLLPTQTAVKNLISARLAADVMGVPTIIVARTDAHAANLITSDIDPIDHPF
HHHHHCCCEEEECCHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHCCCCCCCCCE
IIGERTPEGFYRTEAGIEQAIARGLAYAPYADLVWCETSEPDLAEARQFAEAIHAKYPGK
EEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCC
LLAYNCSPSFNWKKKLSDEEIATFQQEIGAMGYKFQFVTLAGFHALNFGMFELARGYKDR
EEEEECCCCCCHHHHCCHHHHHHHHHHHCCCCEEEEEEEEECHHHHHHHHHHHHCCHHHC
GMAAYSELQQAEFAAEVHGYTATRHQREVGTGYFDEVSLVISGGQSSTTALAGSTETEQF
CHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCEEEEEEECCCCCCEEECCCCCCCCC
ETPLH
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]