| Definition | Exiguobacterium sp. AT1b, complete genome. |
|---|---|
| Accession | NC_012673 |
| Length | 2,999,895 |
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The map label for this gene is tilS/hprT [H]
Identifier: 229917402
GI number: 229917402
Start: 1625438
End: 1625983
Strand: Reverse
Name: tilS/hprT [H]
Synonym: EAT1b_1677
Alternate gene names: 229917402
Gene position: 1625983-1625438 (Counterclockwise)
Preceding gene: 229917403
Following gene: 229917401
Centisome position: 54.2
GC content: 42.67
Gene sequence:
>546_bases ATGTCATTAATGAACGATATGGAGAAAATTTTAATCTCACGTGAAGAGATTCAAGAAAAGGTGAAAGAACTCGCTGGAAC ATTGAGCGAAGACTATAAAGAAGAGTTCCCACTTCTCGTATGTGTATTGAAAGGCGCGATGCCGTTCATGTCGGACCTCG TCAAAGAAATGGACATCCATTTAGAGATGGACTTCATGGACGTGTCGACGTATCACGGAGGAACTTCTTCGACAGGTGAA GTGAAAATCGAGAAAGATTTAAATACATCTGTAGAAGGACGCGACATCTTGATTGTAGAAGATATTATTGATAGTGGATT GACGCTTGGTTATCTCGTCGATCTTCTTAAATACCGTAAAGCGAAGTCTGTGAAGATTGTCACGCTTCTGGATAAGCCGA CTGGCCGTAAAAATGGTTTATCAGCAGACTATAGCGGTTTCGTGATTCCACACGAATTCGTTGTCGGCTACGGTCTCGAT TATGAAGAGAAATATCGTAACCTTCCTTATGTCGGTGTGCTCAAGCCGAGCGTTTACGGGGGCTAA
Upstream 100 bases:
>100_bases GGGTAAGAGTTTCAGATTTTCTAGACAAGTCGGATGCGATTTGTCTACGATTAATGGTAAAATGATGATTGTGTCGAAAC AGAAAGAGGAGGATTTCAAG
Downstream 100 bases:
>100_bases CGTTTTTCTTTTGAAAATGTGACGTGGTAAGATAAAGGAAATCCCCAAAGTATAGGCATATACTGAATGGGCGAGAACAT CGTTTCTCGGAATAGGAGGC
Product: hypoxanthine phosphoribosyltransferase
Products: NA
Alternate protein names: tRNA(Ile)-lysidine synthase; tRNA(Ile)-2-lysyl-cytidine synthase; tRNA(Ile)-lysidine synthetase; Hypoxanthine-guanine phosphoribosyltransferase; HGPRT; HGPRTase [H]
Number of amino acids: Translated: 181; Mature: 180
Protein sequence:
>181_residues MSLMNDMEKILISREEIQEKVKELAGTLSEDYKEEFPLLVCVLKGAMPFMSDLVKEMDIHLEMDFMDVSTYHGGTSSTGE VKIEKDLNTSVEGRDILIVEDIIDSGLTLGYLVDLLKYRKAKSVKIVTLLDKPTGRKNGLSADYSGFVIPHEFVVGYGLD YEEKYRNLPYVGVLKPSVYGG
Sequences:
>Translated_181_residues MSLMNDMEKILISREEIQEKVKELAGTLSEDYKEEFPLLVCVLKGAMPFMSDLVKEMDIHLEMDFMDVSTYHGGTSSTGE VKIEKDLNTSVEGRDILIVEDIIDSGLTLGYLVDLLKYRKAKSVKIVTLLDKPTGRKNGLSADYSGFVIPHEFVVGYGLD YEEKYRNLPYVGVLKPSVYGG >Mature_180_residues SLMNDMEKILISREEIQEKVKELAGTLSEDYKEEFPLLVCVLKGAMPFMSDLVKEMDIHLEMDFMDVSTYHGGTSSTGEV KIEKDLNTSVEGRDILIVEDIIDSGLTLGYLVDLLKYRKAKSVKIVTLLDKPTGRKNGLSADYSGFVIPHEFVVGYGLDY EEKYRNLPYVGVLKPSVYGG
Specific function: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionin
COG id: COG0634
COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase
Gene ontology:
Cell location: Cytoplasm (Probable) [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family [H]
Homologues:
Organism=Homo sapiens, GI4504483, Length=180, Percent_Identity=36.1111111111111, Blast_Score=105, Evalue=2e-23, Organism=Homo sapiens, GI9910262, Length=181, Percent_Identity=34.2541436464088, Blast_Score=104, Evalue=5e-23, Organism=Escherichia coli, GI87081689, Length=171, Percent_Identity=45.6140350877193, Blast_Score=157, Evalue=5e-40, Organism=Caenorhabditis elegans, GI17510817, Length=180, Percent_Identity=31.1111111111111, Blast_Score=91, Evalue=4e-19,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR005904 - InterPro: IPR012094 - InterPro: IPR012796 - InterPro: IPR012795 - InterPro: IPR020825 - InterPro: IPR000836 - InterPro: IPR014729 - InterPro: IPR011063 [H]
Pfam domain/function: PF01171 ATP_bind_3; PF00156 Pribosyltran; PF11734 TilS_C [H]
EC number: =2.4.2.8 [H]
Molecular weight: Translated: 20313; Mature: 20182
Theoretical pI: Translated: 4.56; Mature: 4.56
Prosite motif: PS00103 PUR_PYR_PR_TRANSFER
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.6 %Cys (Translated Protein) 4.4 %Met (Translated Protein) 5.0 %Cys+Met (Translated Protein) 0.6 %Cys (Mature Protein) 3.9 %Met (Mature Protein) 4.4 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSLMNDMEKILISREEIQEKVKELAGTLSEDYKEEFPLLVCVLKGAMPFMSDLVKEMDIH CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHCE LEMDFMDVSTYHGGTSSTGEVKIEKDLNTSVEGRDILIVEDIIDSGLTLGYLVDLLKYRK EEEEEEEEEEECCCCCCCCCEEEECCCCCCCCCCEEEEEHHHHHCCCHHHHHHHHHHHHC AKSVKIVTLLDKPTGRKNGLSADYSGFVIPHEFVVGYGLDYEEKYRNLPYVGVLKPSVYG CCCEEEEEEECCCCCCCCCCCCCCCCEEECHHHHEECCCCHHHHHCCCCEEEEECCCCCC G C >Mature Secondary Structure SLMNDMEKILISREEIQEKVKELAGTLSEDYKEEFPLLVCVLKGAMPFMSDLVKEMDIH CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHCE LEMDFMDVSTYHGGTSSTGEVKIEKDLNTSVEGRDILIVEDIIDSGLTLGYLVDLLKYRK EEEEEEEEEEECCCCCCCCCEEEECCCCCCCCCCEEEEEHHHHHCCCHHHHHHHHHHHHC AKSVKIVTLLDKPTGRKNGLSADYSGFVIPHEFVVGYGLDYEEKYRNLPYVGVLKPSVYG CCCEEEEEEECCCCCCCCCCCCCCCCEEECHHHHEECCCCHHHHHCCCCEEEEECCCCCC G C
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 11679669 [H]