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The map label for this gene is sul [H]

Identifier: 229917394

GI number: 229917394

Start: 1616809

End: 1617594

Strand: Reverse

Name: sul [H]

Synonym: EAT1b_1669

Alternate gene names: 229917394

Gene position: 1617594-1616809 (Counterclockwise)

Preceding gene: 229917395

Following gene: 229917393

Centisome position: 53.92

GC content: 51.4

Gene sequence:

>786_bases
ATGACGAAAATCATGGGTATTTTAAACGTGACCCCGGACTCGTTTTCGGATGGGGGACGGTATACGGCAATCGAGGAAGC
TGTACGACATGCGAAACAACTCGTACAAGAAGGTGCCGATGCGATTGATATCGGTGGAGAATCGACAAGGCCGGGCGCAG
TACTTGTTTCCGAGGAAGAAGAGATTGAACGTGTCGTCCCAATCATCCGTCGACTGAAAAACGAAATCGATGTTCCGATT
TCGATTGATACGTATAAGCCGATGGTGGCGAGAGCGGCAATCGAGGCCGGTGCGACGATCATCAATGACGTATGGGGTTC
GAAATGGGGAGACCGCTCGATGGCACGTGTCGCTTTCGAATGTGAGGTTCCCATCATTCTCATGCACAACCGAACAGACC
GGGACTACCATCATTTCATTGAAGATGTGGTTAGCGATCTACAGGAATCAATTGAGATTGCACATGCGGCAGGCGTAAGG
GATGAGCACATTTGGTTAGATCCGGGCATCGGATTTGCGAAAGACGTGGCGCAAAACCTTGAACTCATGAATCATCTCGA
CGTGATCACACGTCTTGGGTATCCTGTTCTGCTCGGCACGTCGCGTAAGTCGTTTATCGGGCATACACTCGATTTACCGA
CAGAGGAACGGCTCGAAGGAACGATTGCGACGACGTGTCTTGGCATCATGAAAGGATGCGACTGGGTGCGTGTGCACGAC
GTCAAAGCGAACGCCCGTGCTGCGAAGATGATGGATGCGATGATTGGGGGGAACGGACATGGATAA

Upstream 100 bases:

>100_bases
TGACGCATTATGGAAATCTGAGATACCCCGGTAAAGACGGGGTACGATTTAACGAAGTGTGGGCGAAACTCGTTCGCTCA
CTTGGTTAGGAGGCGGAAAC

Downstream 100 bases:

>100_bases
AATATTTGTGAACGGGATGCGTTTTTACGGGTATCATGGGGTGTTTGAAGAAGAAAACCGTCTCGGTCAACGGTTTCACG
TGGATTTAATGTGTGAACTA

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 261; Mature: 260

Protein sequence:

>261_residues
MTKIMGILNVTPDSFSDGGRYTAIEEAVRHAKQLVQEGADAIDIGGESTRPGAVLVSEEEEIERVVPIIRRLKNEIDVPI
SIDTYKPMVARAAIEAGATIINDVWGSKWGDRSMARVAFECEVPIILMHNRTDRDYHHFIEDVVSDLQESIEIAHAAGVR
DEHIWLDPGIGFAKDVAQNLELMNHLDVITRLGYPVLLGTSRKSFIGHTLDLPTEERLEGTIATTCLGIMKGCDWVRVHD
VKANARAAKMMDAMIGGNGHG

Sequences:

>Translated_261_residues
MTKIMGILNVTPDSFSDGGRYTAIEEAVRHAKQLVQEGADAIDIGGESTRPGAVLVSEEEEIERVVPIIRRLKNEIDVPI
SIDTYKPMVARAAIEAGATIINDVWGSKWGDRSMARVAFECEVPIILMHNRTDRDYHHFIEDVVSDLQESIEIAHAAGVR
DEHIWLDPGIGFAKDVAQNLELMNHLDVITRLGYPVLLGTSRKSFIGHTLDLPTEERLEGTIATTCLGIMKGCDWVRVHD
VKANARAAKMMDAMIGGNGHG
>Mature_260_residues
TKIMGILNVTPDSFSDGGRYTAIEEAVRHAKQLVQEGADAIDIGGESTRPGAVLVSEEEEIERVVPIIRRLKNEIDVPIS
IDTYKPMVARAAIEAGATIINDVWGSKWGDRSMARVAFECEVPIILMHNRTDRDYHHFIEDVVSDLQESIEIAHAAGVRD
EHIWLDPGIGFAKDVAQNLELMNHLDVITRLGYPVLLGTSRKSFIGHTLDLPTEERLEGTIATTCLGIMKGCDWVRVHDV
KANARAAKMMDAMIGGNGHG

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=261, Percent_Identity=39.463601532567, Blast_Score=193, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6324073, Length=321, Percent_Identity=33.9563862928349, Blast_Score=161, Evalue=9e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 28733; Mature: 28602

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKIMGILNVTPDSFSDGGRYTAIEEAVRHAKQLVQEGADAIDIGGESTRPGAVLVSEEE
CCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCEEEECCHH
EIERVVPIIRRLKNEIDVPISIDTYKPMVARAAIEAGATIINDVWGSKWGDRSMARVAFE
HHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHCHHHHHHHHCCCCCCCHHHEEEEE
CEVPIILMHNRTDRDYHHFIEDVVSDLQESIEIAHAAGVRDEHIWLDPGIGFAKDVAQNL
CCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHH
ELMNHLDVITRLGYPVLLGTSRKSFIGHTLDLPTEERLEGTIATTCLGIMKGCDWVRVHD
HHHHHHHHHHHCCCCEEEECCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEE
VKANARAAKMMDAMIGGNGHG
CCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TKIMGILNVTPDSFSDGGRYTAIEEAVRHAKQLVQEGADAIDIGGESTRPGAVLVSEEE
CCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCEEEECCHH
EIERVVPIIRRLKNEIDVPISIDTYKPMVARAAIEAGATIINDVWGSKWGDRSMARVAFE
HHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHCHHHHHHHHCCCCCCCHHHEEEEE
CEVPIILMHNRTDRDYHHFIEDVVSDLQESIEIAHAAGVRDEHIWLDPGIGFAKDVAQNL
CCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHH
ELMNHLDVITRLGYPVLLGTSRKSFIGHTLDLPTEERLEGTIATTCLGIMKGCDWVRVHD
HHHHHHHHHHHCCCCEEEECCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEE
VKANARAAKMMDAMIGGNGHG
CCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2123867; 7584024; 9384377 [H]