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The map label for this gene is adk

Identifier: 229917337

GI number: 229917337

Start: 1564609

End: 1565259

Strand: Reverse

Name: adk

Synonym: EAT1b_1612

Alternate gene names: 229917337

Gene position: 1565259-1564609 (Counterclockwise)

Preceding gene: 229917338

Following gene: 229917336

Centisome position: 52.18

GC content: 48.23

Gene sequence:

>651_bases
ATGAATCTAGTACTCATGGGCTTACCGGGTGCTGGGAAAGGGACTCAAGCGGCTAAAATCGTAGAAGAGTACCAAATCCC
TCACATTTCGACAGGCGACATGTTTCGTGCGGCAATCAAAGGCGGAACGCCACTCGGTAAAGAAGCCAAGTCATTCATGG
ATAAAGGTGAACTCGTACCGGACGAGGTAACAATCGGAATCGTACGTGAACGCCTTAGCCAAGATGACACAGAAAAAGGT
TTCTTACTCGATGGATTCCCGCGTACTGTTGCTCAAGCAGAGGCACTCGAAAGTTTGCTTAAAGATTTGGGGAAACAGAT
TGACCACGTCGTCAACATCGATGTGGATGCGGAAATTCTCGTTCCACGCTTGACAGGTCGTTGGATCTGCCCAACGTGTG
GTGCGACATATCACGTGATCTTCAACCCACCAAAAGTGGAAGGCATCTGTGATGTGGATGGGTCGGCACTCATGCAACGT
GAAGACGATAAAGAGGAAACGGTTCGCCGTCGCCTTGACGTCAACATCGAGCAATCGAAACCACTCATTGACTTTTACGC
TGAAAAAGGGTATCTTCGTACATTGGATGGAGATCGTCCAATCGATGTCGTATATGCCGATGTCAAAGCATTACTCGGTG
ATACTGAATGA

Upstream 100 bases:

>100_bases
TATAAAGGCTTTATCCGTTAAAGCGGAAGGAAGGGTTGACCCTTCCTTCCTGTCGTGTTTACAAGCCCTTCGTGAAAATC
AAAACTGGAGGCTAACCGAG

Downstream 100 bases:

>100_bases
TCATCACGAAGACGCCTCGTGAAATTGCGATTATGCGTGAGGCTGGGCAAATTGTTGCTCGAACGCACCAGGTGCTCAAA
CAGCACATTAAACCAGGAAT

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 216; Mature: 216

Protein sequence:

>216_residues
MNLVLMGLPGAGKGTQAAKIVEEYQIPHISTGDMFRAAIKGGTPLGKEAKSFMDKGELVPDEVTIGIVRERLSQDDTEKG
FLLDGFPRTVAQAEALESLLKDLGKQIDHVVNIDVDAEILVPRLTGRWICPTCGATYHVIFNPPKVEGICDVDGSALMQR
EDDKEETVRRRLDVNIEQSKPLIDFYAEKGYLRTLDGDRPIDVVYADVKALLGDTE

Sequences:

>Translated_216_residues
MNLVLMGLPGAGKGTQAAKIVEEYQIPHISTGDMFRAAIKGGTPLGKEAKSFMDKGELVPDEVTIGIVRERLSQDDTEKG
FLLDGFPRTVAQAEALESLLKDLGKQIDHVVNIDVDAEILVPRLTGRWICPTCGATYHVIFNPPKVEGICDVDGSALMQR
EDDKEETVRRRLDVNIEQSKPLIDFYAEKGYLRTLDGDRPIDVVYADVKALLGDTE
>Mature_216_residues
MNLVLMGLPGAGKGTQAAKIVEEYQIPHISTGDMFRAAIKGGTPLGKEAKSFMDKGELVPDEVTIGIVRERLSQDDTEKG
FLLDGFPRTVAQAEALESLLKDLGKQIDHVVNIDVDAEILVPRLTGRWICPTCGATYHVIFNPPKVEGICDVDGSALMQR
EDDKEETVRRRLDVNIEQSKPLIDFYAEKGYLRTLDGDRPIDVVYADVKALLGDTE

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI19923437, Length=212, Percent_Identity=43.3962264150943, Blast_Score=181, Evalue=4e-46,
Organism=Homo sapiens, GI7524346, Length=207, Percent_Identity=42.0289855072464, Blast_Score=179, Evalue=1e-45,
Organism=Homo sapiens, GI4502013, Length=207, Percent_Identity=42.0289855072464, Blast_Score=179, Evalue=1e-45,
Organism=Homo sapiens, GI310110345, Length=199, Percent_Identity=40.7035175879397, Blast_Score=152, Evalue=2e-37,
Organism=Homo sapiens, GI53832003, Length=199, Percent_Identity=40.7035175879397, Blast_Score=152, Evalue=2e-37,
Organism=Homo sapiens, GI8051579, Length=199, Percent_Identity=40.7035175879397, Blast_Score=152, Evalue=2e-37,
Organism=Homo sapiens, GI53832001, Length=199, Percent_Identity=40.7035175879397, Blast_Score=152, Evalue=2e-37,
Organism=Homo sapiens, GI4502011, Length=207, Percent_Identity=32.8502415458937, Blast_Score=117, Evalue=7e-27,
Organism=Homo sapiens, GI22749187, Length=209, Percent_Identity=30.622009569378, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI7706497, Length=211, Percent_Identity=27.9620853080569, Blast_Score=95, Evalue=5e-20,
Organism=Homo sapiens, GI28144899, Length=208, Percent_Identity=31.25, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI28144897, Length=208, Percent_Identity=31.25, Blast_Score=91, Evalue=1e-18,
Organism=Escherichia coli, GI1786680, Length=218, Percent_Identity=50.9174311926605, Blast_Score=212, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI17552384, Length=208, Percent_Identity=39.4230769230769, Blast_Score=166, Evalue=7e-42,
Organism=Caenorhabditis elegans, GI17567503, Length=212, Percent_Identity=33.4905660377358, Blast_Score=117, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI17537943, Length=199, Percent_Identity=31.6582914572864, Blast_Score=111, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17533833, Length=217, Percent_Identity=29.0322580645161, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6320432, Length=214, Percent_Identity=44.392523364486, Blast_Score=196, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6321018, Length=205, Percent_Identity=36.5853658536585, Blast_Score=143, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6322828, Length=216, Percent_Identity=29.1666666666667, Blast_Score=97, Evalue=1e-21,
Organism=Drosophila melanogaster, GI22026816, Length=212, Percent_Identity=40.5660377358491, Blast_Score=174, Evalue=3e-44,
Organism=Drosophila melanogaster, GI17737899, Length=196, Percent_Identity=40.8163265306122, Blast_Score=150, Evalue=7e-37,
Organism=Drosophila melanogaster, GI24645822, Length=196, Percent_Identity=40.8163265306122, Blast_Score=150, Evalue=7e-37,
Organism=Drosophila melanogaster, GI24663208, Length=205, Percent_Identity=25.8536585365854, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17647141, Length=205, Percent_Identity=25.8536585365854, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI221459597, Length=213, Percent_Identity=24.8826291079812, Blast_Score=84, Evalue=8e-17,
Organism=Drosophila melanogaster, GI21356893, Length=213, Percent_Identity=24.8826291079812, Blast_Score=84, Evalue=8e-17,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_EXISA (C4KZM5)

Other databases:

- EMBL:   CP001615
- RefSeq:   YP_002885983.1
- GeneID:   7868600
- GenomeReviews:   CP001615_GR
- KEGG:   eat:EAT1b_1612
- OMA:   RTYHVKY
- ProtClustDB:   PRK00279
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid

EC number: =2.7.4.3

Molecular weight: Translated: 23783; Mature: 23783

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLVLMGLPGAGKGTQAAKIVEEYQIPHISTGDMFRAAIKGGTPLGKEAKSFMDKGELVP
CCEEEEECCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHCCCCCC
DEVTIGIVRERLSQDDTEKGFLLDGFPRTVAQAEALESLLKDLGKQIDHVVNIDVDAEIL
CHHHHHHHHHHHCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCEEE
VPRLTGRWICPTCGATYHVIFNPPKVEGICDVDGSALMQREDDKEETVRRRLDVNIEQSK
EECCCCCEECCCCCCEEEEEECCCCCCEEECCCCHHHHCCCCCHHHHHHHHHCCCCCCCC
PLIDFYAEKGYLRTLDGDRPIDVVYADVKALLGDTE
CCEEHHHCCCEEEECCCCCCCEEHHHHHHHHCCCCC
>Mature Secondary Structure
MNLVLMGLPGAGKGTQAAKIVEEYQIPHISTGDMFRAAIKGGTPLGKEAKSFMDKGELVP
CCEEEEECCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHCCCCCC
DEVTIGIVRERLSQDDTEKGFLLDGFPRTVAQAEALESLLKDLGKQIDHVVNIDVDAEIL
CHHHHHHHHHHHCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCEEE
VPRLTGRWICPTCGATYHVIFNPPKVEGICDVDGSALMQREDDKEETVRRRLDVNIEQSK
EECCCCCEECCCCCCEEEEEECCCCCCEEECCCCHHHHCCCCCHHHHHHHHHCCCCCCCC
PLIDFYAEKGYLRTLDGDRPIDVVYADVKALLGDTE
CCEEHHHCCCEEEECCCCCCCEEHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA