Click here to switch to the map view.

The map label for this gene is map [H]

Identifier: 229917336

GI number: 229917336

Start: 1563854

End: 1564612

Strand: Reverse

Name: map [H]

Synonym: EAT1b_1611

Alternate gene names: 229917336

Gene position: 1564612-1563854 (Counterclockwise)

Preceding gene: 229917337

Following gene: 229917335

Centisome position: 52.16

GC content: 48.62

Gene sequence:

>759_bases
ATGATCATCACGAAGACGCCTCGTGAAATTGCGATTATGCGTGAGGCTGGGCAAATTGTTGCTCGAACGCACCAGGTGCT
CAAACAGCACATTAAACCAGGAATCACGACGCTTGAGCTCGACCGGATTGCGGAAGATTACATTCGCAGCCAAGGTGCGA
CGCCATCGTTCAAAGGCTATAACGGTTTTACCGGTAGTGTTTGCGCTTCGGTGAACGAAGAGCTTGTTCATGGCATTCCA
GGAAAACGGGTATTGAAGGATGGAGATATTATCTCAATCGACATCGGTGCCTACTATAATGGATACCATGGAGATTCCGC
TTGGACTTATCCAGTGGGAACAATCTCAGAAGAGACACAGCGGCTACTTGACGTAACCGAAGAAAGTCTGTATAAAGGAT
TGGAGCACGCCAAGGCTGGAGGGCGATTGACAGATATTTCGCATGCGATTCAAGCATATGTTGAATCAAATGACTTTTCT
GTCGTCCGCGAATACGTCGGTCATGGTGTTGGACAAAATTTGCATGAAGAACCGCAAATTCCACACTATGGTCCACCGGG
GAAAGGGCCGCGCCTGAAGACTGGGATGACGTTAGCCATTGAACCAATGGTTAATGCTGGTCAACGCTATGTTCGAACAC
TGGCTGATAACTGGACAGTTGTCACCGTGGACGGTAGCATGTGCGCCCACTTTGAGCACACCATCGCCATCACAGACGAT
GGATACGAGATTTTAACGAAACTCGATTCCGGTGAATGA

Upstream 100 bases:

>100_bases
TTGACTTTTACGCTGAAAAAGGGTATCTTCGTACATTGGATGGAGATCGTCCAATCGATGTCGTATATGCCGATGTCAAA
GCATTACTCGGTGATACTGA

Downstream 100 bases:

>100_bases
GGCTCTATTGTTTCATACTGATCCGTTCTGGATCCTTCTCTCACAGTAGATGGCAATAGATCGTCTGTGCTCCTAAAGAT
TTTCATATAGAAAGGGGAAT

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
MIITKTPREIAIMREAGQIVARTHQVLKQHIKPGITTLELDRIAEDYIRSQGATPSFKGYNGFTGSVCASVNEELVHGIP
GKRVLKDGDIISIDIGAYYNGYHGDSAWTYPVGTISEETQRLLDVTEESLYKGLEHAKAGGRLTDISHAIQAYVESNDFS
VVREYVGHGVGQNLHEEPQIPHYGPPGKGPRLKTGMTLAIEPMVNAGQRYVRTLADNWTVVTVDGSMCAHFEHTIAITDD
GYEILTKLDSGE

Sequences:

>Translated_252_residues
MIITKTPREIAIMREAGQIVARTHQVLKQHIKPGITTLELDRIAEDYIRSQGATPSFKGYNGFTGSVCASVNEELVHGIP
GKRVLKDGDIISIDIGAYYNGYHGDSAWTYPVGTISEETQRLLDVTEESLYKGLEHAKAGGRLTDISHAIQAYVESNDFS
VVREYVGHGVGQNLHEEPQIPHYGPPGKGPRLKTGMTLAIEPMVNAGQRYVRTLADNWTVVTVDGSMCAHFEHTIAITDD
GYEILTKLDSGE
>Mature_252_residues
MIITKTPREIAIMREAGQIVARTHQVLKQHIKPGITTLELDRIAEDYIRSQGATPSFKGYNGFTGSVCASVNEELVHGIP
GKRVLKDGDIISIDIGAYYNGYHGDSAWTYPVGTISEETQRLLDVTEESLYKGLEHAKAGGRLTDISHAIQAYVESNDFS
VVREYVGHGVGQNLHEEPQIPHYGPPGKGPRLKTGMTLAIEPMVNAGQRYVRTLADNWTVVTVDGSMCAHFEHTIAITDD
GYEILTKLDSGE

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=244, Percent_Identity=39.7540983606557, Blast_Score=184, Evalue=7e-47,
Organism=Homo sapiens, GI40385867, Length=247, Percent_Identity=38.8663967611336, Blast_Score=179, Evalue=2e-45,
Organism=Escherichia coli, GI1786364, Length=247, Percent_Identity=48.582995951417, Blast_Score=238, Evalue=2e-64,
Organism=Escherichia coli, GI1789275, Length=221, Percent_Identity=27.6018099547511, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1788728, Length=204, Percent_Identity=26.9607843137255, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI71996291, Length=218, Percent_Identity=41.2844036697248, Blast_Score=181, Evalue=4e-46,
Organism=Saccharomyces cerevisiae, GI6323273, Length=239, Percent_Identity=41.0041841004184, Blast_Score=188, Evalue=8e-49,
Organism=Drosophila melanogaster, GI21355531, Length=239, Percent_Identity=40.5857740585774, Blast_Score=188, Evalue=4e-48,
Organism=Drosophila melanogaster, GI24583427, Length=245, Percent_Identity=37.5510204081633, Blast_Score=172, Evalue=2e-43,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 27665; Mature: 27665

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIITKTPREIAIMREAGQIVARTHQVLKQHIKPGITTLELDRIAEDYIRSQGATPSFKGY
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCCCCCCC
NGFTGSVCASVNEELVHGIPGKRVLKDGDIISIDIGAYYNGYHGDSAWTYPVGTISEETQ
CCCCHHHHHHHHHHHHHCCCCCCEECCCCEEEEEECCEECCCCCCCCEECCCCCCCHHHH
RLLDVTEESLYKGLEHAKAGGRLTDISHAIQAYVESNDFSVVREYVGHGVGQNLHEEPQI
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCC
PHYGPPGKGPRLKTGMTLAIEPMVNAGQRYVRTLADNWTVVTVDGSMCAHFEHTIAITDD
CCCCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHCCCEEEEECCCEEECEEEEEEEECC
GYEILTKLDSGE
CHHHHHCCCCCC
>Mature Secondary Structure
MIITKTPREIAIMREAGQIVARTHQVLKQHIKPGITTLELDRIAEDYIRSQGATPSFKGY
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCCCCCCC
NGFTGSVCASVNEELVHGIPGKRVLKDGDIISIDIGAYYNGYHGDSAWTYPVGTISEETQ
CCCCHHHHHHHHHHHHHCCCCCCEECCCCEEEEEECCEECCCCCCCCEECCCCCCCHHHH
RLLDVTEESLYKGLEHAKAGGRLTDISHAIQAYVESNDFSVVREYVGHGVGQNLHEEPQI
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCC
PHYGPPGKGPRLKTGMTLAIEPMVNAGQRYVRTLADNWTVVTVDGSMCAHFEHTIAITDD
CCCCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHCCCEEEEECCCEEECEEEEEEEECC
GYEILTKLDSGE
CHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192928; 11058132 [H]