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The map label for this gene is cvrA [H]

Identifier: 229917174

GI number: 229917174

Start: 1413649

End: 1415139

Strand: Direct

Name: cvrA [H]

Synonym: EAT1b_1448

Alternate gene names: 229917174

Gene position: 1413649-1415139 (Clockwise)

Preceding gene: 229917172

Following gene: 229917180

Centisome position: 47.12

GC content: 50.1

Gene sequence:

>1491_bases
TTGCCCGTACCTGTTATAAGTACTGATGTACTCATTTTACTCTTCGGTCTACTTCTCGTAGCCGGTGTCATGGCGACACG
AATCTCGACTCGATTCGGCTTGCCCGCCTTGATTTTATTTATGGGAATCGGCATGATCATGGGAAGCGATATTACCGGTC
TCATTTTCTTTGACGACTCAAATCTGGCGCAGTTGATTGGAGTCGCTGCCTTGATTGTCATTTTGTTTGAAGGGGGTCTT
CAAACGAAATGGTCATCGATTCGGAGCGTCCTCGCCCCTTCTGCCTCGCTGGCGACGCTTGGGGTATTGATTACCACGAC
CGTGGTCGCCGTGGCCGTTCGTTTCGTATTTGGTTTCGATTGGATTGAATCTTTCTTGTTCGGTGCGATTATCGGTTCAA
CCGACGCAGCGGCCGTCTTTGCCGCATTTAAAGGAAAGAATATCTCACCGAAAGTCGGTGCGACTCTCGAAGCCGAGTCC
GGCACGAACGACCCGATGGCGATGTTTTTGACGATTCTCGCTCTCGACTTCATGATGAAGCCGGATACGACCATCTGGGA
CGGAATTTGGATGTTCGTCCTTCAAATCGTTGTCGGGGCATTAATCGGATTCATCCTTGGACAACTGTCTCGCCTCATGT
TGAATCACTTGAGACTTGATTCGAGCGGATTGCATGCCGTCCTCATGATTTCTATGGCGTTCCTCACGTATGGTGTCACA
GCTTACTTATTGGGAAGCGGATTACTCGCCGTCTATATCGCCGCCATGATTGTCGGAAATGCGGACACGGCGCATGAAGT
GACAATCGTCCAATTCTCAGAGGCGCTCGCATGGATCATGCAGATCATCATGTTCGTCATCCTTGGGTTACTCGTCTTCC
CTCGTCAACTCATCGAACCGGACTTGATTTGGAAGGGACTACTTATCTCATTCGTCCTTATGTTCCTGGCACGTCCGATC
GCCGTCTATTTATCGACACTTGGTATGGCATTTACGAGAAAAGAAAAGTTGTTCATCTCATGGGCTGGTCTAAAAGGTGC
CGTGCCGATTGTCCTTGCGACATTCCCGCTTATTGCCGGTACCGAAAATAGCCAACTGTTATTCAATGCCGTCTTTTTCG
TCGTCGTGACGAGCGCCCTGATTCAAGGGACGACGTTGACGCCACTTGCCGAGAAGTTAGGGTTGCTCGGTCCGGATAAA
ATCCGTTCCCCATACACAATCGCCCTCGTCTCAAGCAAACAGTCTCAACATAAGCTCGTTCCTTATGCGGTCACAGCCAG
CTCATCCATGATCGGAAAGACGCTTGCGGACATCACGCTCCCACCAAACACTGTCGTGAACGCCATCGTCCGAAACGAGT
ACTTGATTCCACCGAACGGTCAGACAGCCATCGAAGAAGGCGACCTCTTATACGTGCTTGCCTCGATGTATCGTCATGAT
CAACTCGACCAAACATTTGGTGAAGATGGGCTAGACCGAGTGGAATTATGA

Upstream 100 bases:

>100_bases
TCCAATGTGTATGGTTTGCCTAATCCTCAATTCTGAAATATCAGACGATTTCATGGTATAATGAACTTAAGAGTATTGTT
TCAGAAAGGAAGTGTTGTGT

Downstream 100 bases:

>100_bases
GTAAACGAATAACCGGCGCCTCATTTGAAGCGCCGGTTTTCTTATGCGTGTAAGTGTTTTGCTGATTGAATCAACGTCTC
AACATCTTCTGTCCGTCCTT

Product: potassium/proton antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 496; Mature: 495

Protein sequence:

>496_residues
MPVPVISTDVLILLFGLLLVAGVMATRISTRFGLPALILFMGIGMIMGSDITGLIFFDDSNLAQLIGVAALIVILFEGGL
QTKWSSIRSVLAPSASLATLGVLITTTVVAVAVRFVFGFDWIESFLFGAIIGSTDAAAVFAAFKGKNISPKVGATLEAES
GTNDPMAMFLTILALDFMMKPDTTIWDGIWMFVLQIVVGALIGFILGQLSRLMLNHLRLDSSGLHAVLMISMAFLTYGVT
AYLLGSGLLAVYIAAMIVGNADTAHEVTIVQFSEALAWIMQIIMFVILGLLVFPRQLIEPDLIWKGLLISFVLMFLARPI
AVYLSTLGMAFTRKEKLFISWAGLKGAVPIVLATFPLIAGTENSQLLFNAVFFVVVTSALIQGTTLTPLAEKLGLLGPDK
IRSPYTIALVSSKQSQHKLVPYAVTASSSMIGKTLADITLPPNTVVNAIVRNEYLIPPNGQTAIEEGDLLYVLASMYRHD
QLDQTFGEDGLDRVEL

Sequences:

>Translated_496_residues
MPVPVISTDVLILLFGLLLVAGVMATRISTRFGLPALILFMGIGMIMGSDITGLIFFDDSNLAQLIGVAALIVILFEGGL
QTKWSSIRSVLAPSASLATLGVLITTTVVAVAVRFVFGFDWIESFLFGAIIGSTDAAAVFAAFKGKNISPKVGATLEAES
GTNDPMAMFLTILALDFMMKPDTTIWDGIWMFVLQIVVGALIGFILGQLSRLMLNHLRLDSSGLHAVLMISMAFLTYGVT
AYLLGSGLLAVYIAAMIVGNADTAHEVTIVQFSEALAWIMQIIMFVILGLLVFPRQLIEPDLIWKGLLISFVLMFLARPI
AVYLSTLGMAFTRKEKLFISWAGLKGAVPIVLATFPLIAGTENSQLLFNAVFFVVVTSALIQGTTLTPLAEKLGLLGPDK
IRSPYTIALVSSKQSQHKLVPYAVTASSSMIGKTLADITLPPNTVVNAIVRNEYLIPPNGQTAIEEGDLLYVLASMYRHD
QLDQTFGEDGLDRVEL
>Mature_495_residues
PVPVISTDVLILLFGLLLVAGVMATRISTRFGLPALILFMGIGMIMGSDITGLIFFDDSNLAQLIGVAALIVILFEGGLQ
TKWSSIRSVLAPSASLATLGVLITTTVVAVAVRFVFGFDWIESFLFGAIIGSTDAAAVFAAFKGKNISPKVGATLEAESG
TNDPMAMFLTILALDFMMKPDTTIWDGIWMFVLQIVVGALIGFILGQLSRLMLNHLRLDSSGLHAVLMISMAFLTYGVTA
YLLGSGLLAVYIAAMIVGNADTAHEVTIVQFSEALAWIMQIIMFVILGLLVFPRQLIEPDLIWKGLLISFVLMFLARPIA
VYLSTLGMAFTRKEKLFISWAGLKGAVPIVLATFPLIAGTENSQLLFNAVFFVVVTSALIQGTTLTPLAEKLGLLGPDKI
RSPYTIALVSSKQSQHKLVPYAVTASSSMIGKTLADITLPPNTVVNAIVRNEYLIPPNGQTAIEEGDLLYVLASMYRHDQ
LDQTFGEDGLDRVEL

Specific function: Participates in control of cell volume in low-osmolarity conditions [H]

COG id: COG3263

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI41872703, Length=414, Percent_Identity=24.6376811594203, Blast_Score=82, Evalue=2e-15,
Organism=Escherichia coli, GI87081854, Length=461, Percent_Identity=40.3470715835141, Blast_Score=298, Evalue=5e-82,
Organism=Saccharomyces cerevisiae, GI6320663, Length=421, Percent_Identity=23.5154394299287, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI281360447, Length=354, Percent_Identity=22.8813559322034, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR016169
- InterPro:   IPR006037
- InterPro:   IPR005170 [H]

Pfam domain/function: PF03471 CorC_HlyC; PF00999 Na_H_Exchanger; PF02080 TrkA_C [H]

EC number: NA

Molecular weight: Translated: 53401; Mature: 53270

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVPVISTDVLILLFGLLLVAGVMATRISTRFGLPALILFMGIGMIMGSDITGLIFFDDS
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEECCC
NLAQLIGVAALIVILFEGGLQTKWSSIRSVLAPSASLATLGVLITTTVVAVAVRFVFGFD
CHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
WIESFLFGAIIGSTDAAAVFAAFKGKNISPKVGATLEAESGTNDPMAMFLTILALDFMMK
HHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHCC
PDTTIWDGIWMFVLQIVVGALIGFILGQLSRLMLNHLRLDSSGLHAVLMISMAFLTYGVT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
AYLLGSGLLAVYIAAMIVGNADTAHEVTIVQFSEALAWIMQIIMFVILGLLVFPRQLIEP
HHHHHCCHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
DLIWKGLLISFVLMFLARPIAVYLSTLGMAFTRKEKLFISWAGLKGAVPIVLATFPLIAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHCC
TENSQLLFNAVFFVVVTSALIQGTTLTPLAEKLGLLGPDKIRSPYTIALVSSKQSQHKLV
CCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCHHCCCCEEEEEEECCCCCCCCC
PYAVTASSSMIGKTLADITLPPNTVVNAIVRNEYLIPPNGQTAIEEGDLLYVLASMYRHD
CEEEECCCHHHHHHHHHCCCCCHHHHHHHHHCCEEECCCCCCCCCCCCHHHHHHHHHHHH
QLDQTFGEDGLDRVEL
HHHHHHCCCCCCCCCC
>Mature Secondary Structure 
PVPVISTDVLILLFGLLLVAGVMATRISTRFGLPALILFMGIGMIMGSDITGLIFFDDS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEECCC
NLAQLIGVAALIVILFEGGLQTKWSSIRSVLAPSASLATLGVLITTTVVAVAVRFVFGFD
CHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
WIESFLFGAIIGSTDAAAVFAAFKGKNISPKVGATLEAESGTNDPMAMFLTILALDFMMK
HHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHCC
PDTTIWDGIWMFVLQIVVGALIGFILGQLSRLMLNHLRLDSSGLHAVLMISMAFLTYGVT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
AYLLGSGLLAVYIAAMIVGNADTAHEVTIVQFSEALAWIMQIIMFVILGLLVFPRQLIEP
HHHHHCCHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
DLIWKGLLISFVLMFLARPIAVYLSTLGMAFTRKEKLFISWAGLKGAVPIVLATFPLIAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHCC
TENSQLLFNAVFFVVVTSALIQGTTLTPLAEKLGLLGPDKIRSPYTIALVSSKQSQHKLV
CCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCHHCCCCEEEEEEECCCCCCCCC
PYAVTASSSMIGKTLADITLPPNTVVNAIVRNEYLIPPNGQTAIEEGDLLYVLASMYRHD
CEEEECCCHHHHHHHHHCCCCCHHHHHHHHHCCEEECCCCCCCCCCCCHHHHHHHHHHHH
QLDQTFGEDGLDRVEL
HHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA