Click here to switch to the map view.

The map label for this gene is hutM [H]

Identifier: 229917180

GI number: 229917180

Start: 1420161

End: 1421522

Strand: Direct

Name: hutM [H]

Synonym: EAT1b_1454

Alternate gene names: 229917180

Gene position: 1420161-1421522 (Clockwise)

Preceding gene: 229917174

Following gene: 229917184

Centisome position: 47.34

GC content: 52.79

Gene sequence:

>1362_bases
TTGGAAACAAATAAACTAAAGCGCGAGCTGTCCACCCGGCAACTTACGATGATTTCCCTCGGGAGCGCCATCGGAACCGG
GCTGTTCCTCGGAAGCGGTCTCGCGATTCAAACCGCTGGCCCGAGCGTGCTCGTCAGCTATGCCATCGGGGCGTTCATCG
TCCTCTTACTAATGGGTGCTCTCGCCGAAATGACGGTCGCCCATCCAACATCCGGATCATTCGGAACGATTGCCGAGCGA
TACGTTCATCCACTCGCCGGTTTTCTCGTCCGTTACTCTTACTGGGTCGCGAACGTACTGGCTGTAGGGGTTGAAGTCAG
TGCCATCGCCATCTACATGCGCTACTGGTTCCCAGATGTGAACGGGTTCGTTTGGGTCGCCCTCTTCGGTGGACTACTCA
TTTACGTCAACGCCCGTCACGTTCACACGTTCGGAACGACCGAATACTGGTTATCCTTCATCAAAGTAACTGCCATCATC
CTATTCATCGTCCTCGGTGCCGCCACATTGTTCGGCGAACCAGGATCACCGATTGAGTCAATCACGACAGGAAACGAAGG
CTTCTTCGCGTTCGGCTTTTACGGAATGTGGGTGACGATTTTCATCTCCCTCTTCAGTTTCCTTGGAACCGAACTCGTCG
CTGTGACAGCGGGAGAAGCGAAAGACCCGGACCAGGCCGTACCACGCGCTTTACGCGCGACCGTGTTCCGCTTGACGTTC
TTCTATGTCGTCACGCTCGCGATCATGCTCATGCTGATCCCATGGCAGCAAGCCGGGATCGACCAAAGTCCGTTCGTGCT
CGTCATGGAACAGTTTGATGTCCCGTTCGCGGCAGGCATCCTCAACTTTGTGATTTTGATCGCCGCCTTGTCTGCGATGA
ACGCGCAGCTTTACGCGTCGACACGTATGATGTACTCGCTCGCGGAAGCCGGCGATGCACCGAAAGCGTTCAAAAAAATC
AGCAAAAATGGGATCCCGATGTTCGCGCTACTCGTTTCAACAGGCGGGATCGTCCTCGCCGCTTTGCTACAAGTATTCAT
GGAGTCGTCGTATCCATTCTTGATGGGAATCTCGATGTTCGGAGCTATTTTTACTTGGTTCATGGTCTTCGTCTCCCACT
TGTTCTTCCGTAAGAAATGGACTGGGCGAAAACTCCCTGTCCGCATGATGGGATATCCATTTCTCCCATTGCTCGGGGCG
GTCTTACTGCTCAGCCTGATGATCACGACATGGTTCACGGATTTCAACATCTTGCTGAAATTCGGCGTACCTTGGTTGAT
CGGATTGACGATCATCTATTACGTGCGTGAACAAATGCGTAAAAAACAAGATCGTCCAAGCGATATTGAACAAGCCAACT
AA

Upstream 100 bases:

>100_bases
AAATGAGAAACCTTCATCGATTTTTCGAATTGACATTGTTTTTTTTCGTCTGCTATAGTCGTCCACAACAACATTTCACT
CAGCTAAAGGAGAATCGATT

Downstream 100 bases:

>100_bases
CGAGTATCCCTTCGCAATCGCGGAGGGATTTTTTTACGCACAAAAACTCCTTTCGCAATCGAAAGGAGTTTTCTGTTTGA
TGCATCAGAAGAACTGACGC

Product: amino acid permease-associated region

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
METNKLKRELSTRQLTMISLGSAIGTGLFLGSGLAIQTAGPSVLVSYAIGAFIVLLLMGALAEMTVAHPTSGSFGTIAER
YVHPLAGFLVRYSYWVANVLAVGVEVSAIAIYMRYWFPDVNGFVWVALFGGLLIYVNARHVHTFGTTEYWLSFIKVTAII
LFIVLGAATLFGEPGSPIESITTGNEGFFAFGFYGMWVTIFISLFSFLGTELVAVTAGEAKDPDQAVPRALRATVFRLTF
FYVVTLAIMLMLIPWQQAGIDQSPFVLVMEQFDVPFAAGILNFVILIAALSAMNAQLYASTRMMYSLAEAGDAPKAFKKI
SKNGIPMFALLVSTGGIVLAALLQVFMESSYPFLMGISMFGAIFTWFMVFVSHLFFRKKWTGRKLPVRMMGYPFLPLLGA
VLLLSLMITTWFTDFNILLKFGVPWLIGLTIIYYVREQMRKKQDRPSDIEQAN

Sequences:

>Translated_453_residues
METNKLKRELSTRQLTMISLGSAIGTGLFLGSGLAIQTAGPSVLVSYAIGAFIVLLLMGALAEMTVAHPTSGSFGTIAER
YVHPLAGFLVRYSYWVANVLAVGVEVSAIAIYMRYWFPDVNGFVWVALFGGLLIYVNARHVHTFGTTEYWLSFIKVTAII
LFIVLGAATLFGEPGSPIESITTGNEGFFAFGFYGMWVTIFISLFSFLGTELVAVTAGEAKDPDQAVPRALRATVFRLTF
FYVVTLAIMLMLIPWQQAGIDQSPFVLVMEQFDVPFAAGILNFVILIAALSAMNAQLYASTRMMYSLAEAGDAPKAFKKI
SKNGIPMFALLVSTGGIVLAALLQVFMESSYPFLMGISMFGAIFTWFMVFVSHLFFRKKWTGRKLPVRMMGYPFLPLLGA
VLLLSLMITTWFTDFNILLKFGVPWLIGLTIIYYVREQMRKKQDRPSDIEQAN
>Mature_453_residues
METNKLKRELSTRQLTMISLGSAIGTGLFLGSGLAIQTAGPSVLVSYAIGAFIVLLLMGALAEMTVAHPTSGSFGTIAER
YVHPLAGFLVRYSYWVANVLAVGVEVSAIAIYMRYWFPDVNGFVWVALFGGLLIYVNARHVHTFGTTEYWLSFIKVTAII
LFIVLGAATLFGEPGSPIESITTGNEGFFAFGFYGMWVTIFISLFSFLGTELVAVTAGEAKDPDQAVPRALRATVFRLTF
FYVVTLAIMLMLIPWQQAGIDQSPFVLVMEQFDVPFAAGILNFVILIAALSAMNAQLYASTRMMYSLAEAGDAPKAFKKI
SKNGIPMFALLVSTGGIVLAALLQVFMESSYPFLMGISMFGAIFTWFMVFVSHLFFRKKWTGRKLPVRMMGYPFLPLLGA
VLLLSLMITTWFTDFNILLKFGVPWLIGLTIIYYVREQMRKKQDRPSDIEQAN

Specific function: Transporter For The Intake Of S-Methylmethionine. [C]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI258614003, Length=392, Percent_Identity=24.4897959183673, Blast_Score=73, Evalue=7e-13,
Organism=Homo sapiens, GI258614005, Length=392, Percent_Identity=24.4897959183673, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI110347453, Length=336, Percent_Identity=24.702380952381, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI115648063, Length=454, Percent_Identity=24.6696035242291, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI115648022, Length=454, Percent_Identity=24.6696035242291, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI87081708, Length=463, Percent_Identity=38.0129589632829, Blast_Score=297, Evalue=9e-82,
Organism=Escherichia coli, GI1786789, Length=409, Percent_Identity=39.6088019559902, Blast_Score=293, Evalue=2e-80,
Organism=Escherichia coli, GI1786302, Length=444, Percent_Identity=35.8108108108108, Blast_Score=288, Evalue=6e-79,
Organism=Escherichia coli, GI1786602, Length=457, Percent_Identity=36.7614879649891, Blast_Score=273, Evalue=2e-74,
Organism=Escherichia coli, GI1788480, Length=442, Percent_Identity=37.5565610859729, Blast_Score=261, Evalue=6e-71,
Organism=Escherichia coli, GI48994972, Length=461, Percent_Identity=33.1887201735358, Blast_Score=246, Evalue=2e-66,
Organism=Escherichia coli, GI1790653, Length=387, Percent_Identity=34.1085271317829, Blast_Score=229, Evalue=4e-61,
Organism=Escherichia coli, GI1789017, Length=404, Percent_Identity=32.9207920792079, Blast_Score=226, Evalue=3e-60,
Organism=Escherichia coli, GI87081915, Length=400, Percent_Identity=32.75, Blast_Score=216, Evalue=4e-57,
Organism=Saccharomyces cerevisiae, GI6320772, Length=457, Percent_Identity=30.4157549234136, Blast_Score=190, Evalue=4e-49,
Organism=Saccharomyces cerevisiae, GI6324061, Length=422, Percent_Identity=31.042654028436, Blast_Score=188, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6324990, Length=427, Percent_Identity=30.2107728337237, Blast_Score=185, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6324924, Length=433, Percent_Identity=30.2540415704388, Blast_Score=184, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6321629, Length=407, Percent_Identity=28.7469287469287, Blast_Score=184, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6324553, Length=388, Percent_Identity=30.4123711340206, Blast_Score=183, Evalue=5e-47,
Organism=Saccharomyces cerevisiae, GI6322892, Length=400, Percent_Identity=30.5, Blast_Score=173, Evalue=4e-44,
Organism=Saccharomyces cerevisiae, GI6324059, Length=447, Percent_Identity=30.8724832214765, Blast_Score=173, Evalue=6e-44,
Organism=Saccharomyces cerevisiae, GI6320251, Length=405, Percent_Identity=28.8888888888889, Blast_Score=165, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6319824, Length=413, Percent_Identity=28.8135593220339, Blast_Score=164, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6321053, Length=473, Percent_Identity=26.215644820296, Blast_Score=164, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6320717, Length=405, Percent_Identity=28.3950617283951, Blast_Score=164, Evalue=4e-41,
Organism=Saccharomyces cerevisiae, GI6319543, Length=407, Percent_Identity=28.2555282555283, Blast_Score=157, Evalue=4e-39,
Organism=Saccharomyces cerevisiae, GI6322967, Length=393, Percent_Identity=30.2798982188295, Blast_Score=154, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6319608, Length=444, Percent_Identity=25.4504504504505, Blast_Score=149, Evalue=7e-37,
Organism=Saccharomyces cerevisiae, GI6319542, Length=402, Percent_Identity=27.1144278606965, Blast_Score=149, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6324981, Length=389, Percent_Identity=30.3341902313625, Blast_Score=142, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6320364, Length=483, Percent_Identity=24.4306418219462, Blast_Score=100, Evalue=9e-22,
Organism=Drosophila melanogaster, GI24667468, Length=385, Percent_Identity=24.9350649350649, Blast_Score=76, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 50079; Mature: 50079

Theoretical pI: Translated: 9.53; Mature: 9.53

Prosite motif: PS00027 HOMEOBOX_1 ; PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METNKLKRELSTRQLTMISLGSAIGTGLFLGSGLAIQTAGPSVLVSYAIGAFIVLLLMGA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHH
LAEMTVAHPTSGSFGTIAERYVHPLAGFLVRYSYWVANVLAVGVEVSAIAIYMRYWFPDV
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
NGFVWVALFGGLLIYVNARHVHTFGTTEYWLSFIKVTAIILFIVLGAATLFGEPGSPIES
CHHHHHHHHCCHHEEEECCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
ITTGNEGFFAFGFYGMWVTIFISLFSFLGTELVAVTAGEAKDPDQAVPRALRATVFRLTF
HCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHHHHHHH
FYVVTLAIMLMLIPWQQAGIDQSPFVLVMEQFDVPFAAGILNFVILIAALSAMNAQLYAS
HHHHHHHHHHHHHCCHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
TRMMYSLAEAGDAPKAFKKISKNGIPMFALLVSTGGIVLAALLQVFMESSYPFLMGISMF
HHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHH
GAIFTWFMVFVSHLFFRKKWTGRKLPVRMMGYPFLPLLGAVLLLSLMITTWFTDFNILLK
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
FGVPWLIGLTIIYYVREQMRKKQDRPSDIEQAN
HCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
METNKLKRELSTRQLTMISLGSAIGTGLFLGSGLAIQTAGPSVLVSYAIGAFIVLLLMGA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHH
LAEMTVAHPTSGSFGTIAERYVHPLAGFLVRYSYWVANVLAVGVEVSAIAIYMRYWFPDV
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
NGFVWVALFGGLLIYVNARHVHTFGTTEYWLSFIKVTAIILFIVLGAATLFGEPGSPIES
CHHHHHHHHCCHHEEEECCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
ITTGNEGFFAFGFYGMWVTIFISLFSFLGTELVAVTAGEAKDPDQAVPRALRATVFRLTF
HCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHHHHHHH
FYVVTLAIMLMLIPWQQAGIDQSPFVLVMEQFDVPFAAGILNFVILIAALSAMNAQLYAS
HHHHHHHHHHHHHCCHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
TRMMYSLAEAGDAPKAFKKISKNGIPMFALLVSTGGIVLAALLQVFMESSYPFLMGISMF
HHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHH
GAIFTWFMVFVSHLFFRKKWTGRKLPVRMMGYPFLPLLGAVLLLSLMITTWFTDFNILLK
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
FGVPWLIGLTIIYYVREQMRKKQDRPSDIEQAN
HCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7704263; 9384377; 8550462; 8867804 [H]