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The map label for this gene is toxA [H]

Identifier: 229916762

GI number: 229916762

Start: 981350

End: 983107

Strand: Direct

Name: toxA [H]

Synonym: EAT1b_1035

Alternate gene names: 229916762

Gene position: 981350-983107 (Clockwise)

Preceding gene: 229916761

Following gene: 229916763

Centisome position: 32.71

GC content: 52.5

Gene sequence:

>1758_bases
ATGACATGGAAAAGAAGGGTCGGCATCGGTCTGTTAATCGGTGCAGTGTGGACGAGTCCACAGTTCGCATCCGCTGAGGG
TTCATTCCAAAAGACGGAGGATGGCATCGTCTATACGTCGAGTGACGGGACGGTACTGACGGGATGGCAAGAAATCGACG
GCCATACATACTATCTGAATGAAGATGGCACCCTCCTCACAGGTTGGCAGGAAATCGAAGGGGCTACCTATTACTTTGAG
ACAGACGGTCGACTCGTCACGGGTGCTTACGCGATTGACGGTACGACATACACGTTTGACGAGAACGGAAAGCTACTCAC
CGGCTGGCAGGAACGGGACGGTCTCGTCTACTATTACGATGAGACCGGTCAACCCGTCACCGGATTCCAGACGATTGCCG
GCAAGCGATATTACTTCAACGAGGATGGGGTCCGTCTCTCGGGATGGCAGCAGCTTGGTGACGCCAAGCATTATTTCTTC
CCAGACGGCACCATCCGTACAGGGATGTATACGATTGACGGCAAGAAATATTATTTGATGGAGCAAGGGAAGATGGCGAC
CGGATGGCAGACGATTGGCACACGTCGCTATTACTTCGGGGATGACGGGGTACGTCGCCAAGGACTCGCCCGGATTGGTG
ACAAGATGTACGGTTTCCATCCCACTTACGGATACCGTCTCGAAGGACTCTATCGCATCAACAATCGACACTATTTGTTC
GGAAAATACGGCGACCGCAAGTATGGGCTACAGCGAATCGATGGTGTCATGTATGGATTCCATCCGACGTACGGGTACCG
ACTAGAAGGTGTCCATAAACTAAATGCACGCATCTATTCATTCGACTCATACGGACGACGCGAGTATGGGTTCCAAACGG
TCGATGGGAAGAAGGTCGGATTCCACCCGACCTACGGATACCGCCTGCAAGGGAAATTCCGATTGGATGGGAAGACGTAT
CATTTCCACTCGACGGGTGTCCCCGAGAAAGGATGGAAATATACGACCCAGTACGAGTATTACGCTCCCGCGTTGACGAA
GAAGACGGATTGGCAAGCCATCGACGGCAAGTGGTATTACTTTGACACGTATGGAAAGATGTATCAAAACCGTCGTGTCG
GCAATGCCTCGTTCGATGCGCGGGGCGCCTATTCTCAGGCACTGTCCATCTATAAGATGAGCGTCCCACTTTATCGTCAG
TTCCCGATGGGCTATCCGTCCGGCTGCGAGTTCTTCTCCCTCAAGATGGCGCTTGAAGAGAAAGGTCGTGCCGTCAGCGC
CTCGACCTTATATAACGAGATGCCGAAGAGCATGTGGAACGCACGTTATGAGAACCGTCTCTATCGCTGGGTTGACCCGA
ACGTCATGTTCACGGGAGATCCGAAAGGGACGCTCGGCAAGTATAAGAACTACGGGATTTACCCGAAAGGCATGATCGGA
TTTGCCAGCAAGTATCGTCCGGTGAAAGACTTGTCCAACCAAGGCCTCGGCTCGATTGAGCGTGAACTGTCGATGGGTAA
CCCGGTCATCGTCTGGGCGAGCGTCGACTTCAACAAACCGTACGGCTACTTCAACTGGTACACCGCTTCGAACAAGAAGT
TCACCGGCTACGTCAACTATCACGTCATGTTAGCGACCGGATATGACAAATCAAACTTGTATATCAACGACCCATATCGT
GGACGCTTGGTCATCCCGAAATCAAAAGTGAGCGCCGTCATGAGCGCGACAGGATGGAAAGCGCTCGCGGTCAGATAA

Upstream 100 bases:

>100_bases
CGGCGTAAACGTCTGACCTTACAAATGATTCATTTGCCACAGCTTCATCTTGGATAAATATGGGTATCTCTTCTGTATGC
ATACAGAGGAGGTCACATGA

Downstream 100 bases:

>100_bases
GTAAGAAGGAACGTGTCTTTCATCGAAGGGCACGTTTTTTGTGTGCGATTAGGAGAATAGTACGAAATGCAGAAATATAA
ATTCCTATTTTTATGATTAA

Product: cell wall binding repeat-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 585; Mature: 584

Protein sequence:

>585_residues
MTWKRRVGIGLLIGAVWTSPQFASAEGSFQKTEDGIVYTSSDGTVLTGWQEIDGHTYYLNEDGTLLTGWQEIEGATYYFE
TDGRLVTGAYAIDGTTYTFDENGKLLTGWQERDGLVYYYDETGQPVTGFQTIAGKRYYFNEDGVRLSGWQQLGDAKHYFF
PDGTIRTGMYTIDGKKYYLMEQGKMATGWQTIGTRRYYFGDDGVRRQGLARIGDKMYGFHPTYGYRLEGLYRINNRHYLF
GKYGDRKYGLQRIDGVMYGFHPTYGYRLEGVHKLNARIYSFDSYGRREYGFQTVDGKKVGFHPTYGYRLQGKFRLDGKTY
HFHSTGVPEKGWKYTTQYEYYAPALTKKTDWQAIDGKWYYFDTYGKMYQNRRVGNASFDARGAYSQALSIYKMSVPLYRQ
FPMGYPSGCEFFSLKMALEEKGRAVSASTLYNEMPKSMWNARYENRLYRWVDPNVMFTGDPKGTLGKYKNYGIYPKGMIG
FASKYRPVKDLSNQGLGSIERELSMGNPVIVWASVDFNKPYGYFNWYTASNKKFTGYVNYHVMLATGYDKSNLYINDPYR
GRLVIPKSKVSAVMSATGWKALAVR

Sequences:

>Translated_585_residues
MTWKRRVGIGLLIGAVWTSPQFASAEGSFQKTEDGIVYTSSDGTVLTGWQEIDGHTYYLNEDGTLLTGWQEIEGATYYFE
TDGRLVTGAYAIDGTTYTFDENGKLLTGWQERDGLVYYYDETGQPVTGFQTIAGKRYYFNEDGVRLSGWQQLGDAKHYFF
PDGTIRTGMYTIDGKKYYLMEQGKMATGWQTIGTRRYYFGDDGVRRQGLARIGDKMYGFHPTYGYRLEGLYRINNRHYLF
GKYGDRKYGLQRIDGVMYGFHPTYGYRLEGVHKLNARIYSFDSYGRREYGFQTVDGKKVGFHPTYGYRLQGKFRLDGKTY
HFHSTGVPEKGWKYTTQYEYYAPALTKKTDWQAIDGKWYYFDTYGKMYQNRRVGNASFDARGAYSQALSIYKMSVPLYRQ
FPMGYPSGCEFFSLKMALEEKGRAVSASTLYNEMPKSMWNARYENRLYRWVDPNVMFTGDPKGTLGKYKNYGIYPKGMIG
FASKYRPVKDLSNQGLGSIERELSMGNPVIVWASVDFNKPYGYFNWYTASNKKFTGYVNYHVMLATGYDKSNLYINDPYR
GRLVIPKSKVSAVMSATGWKALAVR
>Mature_584_residues
TWKRRVGIGLLIGAVWTSPQFASAEGSFQKTEDGIVYTSSDGTVLTGWQEIDGHTYYLNEDGTLLTGWQEIEGATYYFET
DGRLVTGAYAIDGTTYTFDENGKLLTGWQERDGLVYYYDETGQPVTGFQTIAGKRYYFNEDGVRLSGWQQLGDAKHYFFP
DGTIRTGMYTIDGKKYYLMEQGKMATGWQTIGTRRYYFGDDGVRRQGLARIGDKMYGFHPTYGYRLEGLYRINNRHYLFG
KYGDRKYGLQRIDGVMYGFHPTYGYRLEGVHKLNARIYSFDSYGRREYGFQTVDGKKVGFHPTYGYRLQGKFRLDGKTYH
FHSTGVPEKGWKYTTQYEYYAPALTKKTDWQAIDGKWYYFDTYGKMYQNRRVGNASFDARGAYSQALSIYKMSVPLYRQF
PMGYPSGCEFFSLKMALEEKGRAVSASTLYNEMPKSMWNARYENRLYRWVDPNVMFTGDPKGTLGKYKNYGIYPKGMIGF
ASKYRPVKDLSNQGLGSIERELSMGNPVIVWASVDFNKPYGYFNWYTASNKKFTGYVNYHVMLATGYDKSNLYINDPYRG
RLVIPKSKVSAVMSATGWKALAVR

Specific function: Only after the enteral delivery of the enterotoxin A may the characteristic disease called pseudomembranous colitis be induced [H]

COG id: COG5263

COG function: function code R; FOG: Glucan-binding domain (YG repeat)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 32 cell wall-binding repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018337
- InterPro:   IPR007577
- InterPro:   IPR020974 [H]

Pfam domain/function: PF01473 CW_binding_1; PF04488 Gly_transf_sug; PF11713 Peptidase_C80 [H]

EC number: NA

Molecular weight: Translated: 67396; Mature: 67264

Theoretical pI: Translated: 9.64; Mature: 9.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTWKRRVGIGLLIGAVWTSPQFASAEGSFQKTEDGIVYTSSDGTVLTGWQEIDGHTYYLN
CCCCHHCCEEEEEEEEECCCCCCCCCCCCEECCCCEEEECCCCEEEEEEEECCCEEEEEC
EDGTLLTGWQEIEGATYYFETDGRLVTGAYAIDGTTYTFDENGKLLTGWQERDGLVYYYD
CCCCEEECHHHHCCEEEEEECCCEEEEEEEEECCEEEEECCCCCEEECEECCCCEEEEEC
ETGQPVTGFQTIAGKRYYFNEDGVRLSGWQQLGDAKHYFFPDGTIRTGMYTIDGKKYYLM
CCCCCCCCCHHHCCCEEEECCCCEEEECHHHCCCCCEEECCCCCEEEEEEEECCCEEEEE
EQGKMATGWQTIGTRRYYFGDDGVRRQGLARIGDKMYGFHPTYGYRLEGLYRINNRHYLF
ECCCCCCCEEECCCEEEEECCCCHHHHHHHHHCHHHCCCCCCCCEEEEEEEEECCEEEEE
GKYGDRKYGLQRIDGVMYGFHPTYGYRLEGVHKLNARIYSFDSYGRREYGFQTVDGKKVG
ECCCCCHHCHHHHCCEEEECCCCCCEEECCEEEECEEEEEECCCCCHHCCEEECCCCEEC
FHPTYGYRLQGKFRLDGKTYHFHSTGVPEKGWKYTTQYEYYAPALTKKTDWQAIDGKWYY
CCCCCCEEEEEEEEECCEEEEEECCCCCCCCCEEEEEEEEECCCCCCCCCCEEECCEEEE
FDTYGKMYQNRRVGNASFDARGAYSQALSIYKMSVPLYRQFPMGYPSGCEFFSLKMALEE
EECHHHHHHCCCCCCCCCCCCCCHHHEEEEEEECCCHHHHCCCCCCCCCCEEEEEEEHHH
KGRAVSASTLYNEMPKSMWNARYENRLYRWVDPNVMFTGDPKGTLGKYKNYGIYPKGMIG
CCCEEEHHHHHHHHHHHHHCCHHHCCEEEEECCCEEEECCCCCCCCCCCCCCCCCCCHHH
FASKYRPVKDLSNQGLGSIERELSMGNPVIVWASVDFNKPYGYFNWYTASNKKFTGYVNY
HHHCCCCHHHHCCCCCCHHHHHHCCCCCEEEEEEECCCCCCCEEEEEECCCCEEEEEEEE
HVMLATGYDKSNLYINDPYRGRLVIPKSKVSAVMSATGWKALAVR
EEEEEECCCCCCEEECCCCCCEEEEEHHHHHHHHHCCCCEEEEEC
>Mature Secondary Structure 
TWKRRVGIGLLIGAVWTSPQFASAEGSFQKTEDGIVYTSSDGTVLTGWQEIDGHTYYLN
CCCHHCCEEEEEEEEECCCCCCCCCCCCEECCCCEEEECCCCEEEEEEEECCCEEEEEC
EDGTLLTGWQEIEGATYYFETDGRLVTGAYAIDGTTYTFDENGKLLTGWQERDGLVYYYD
CCCCEEECHHHHCCEEEEEECCCEEEEEEEEECCEEEEECCCCCEEECEECCCCEEEEEC
ETGQPVTGFQTIAGKRYYFNEDGVRLSGWQQLGDAKHYFFPDGTIRTGMYTIDGKKYYLM
CCCCCCCCCHHHCCCEEEECCCCEEEECHHHCCCCCEEECCCCCEEEEEEEECCCEEEEE
EQGKMATGWQTIGTRRYYFGDDGVRRQGLARIGDKMYGFHPTYGYRLEGLYRINNRHYLF
ECCCCCCCEEECCCEEEEECCCCHHHHHHHHHCHHHCCCCCCCCEEEEEEEEECCEEEEE
GKYGDRKYGLQRIDGVMYGFHPTYGYRLEGVHKLNARIYSFDSYGRREYGFQTVDGKKVG
ECCCCCHHCHHHHCCEEEECCCCCCEEECCEEEECEEEEEECCCCCHHCCEEECCCCEEC
FHPTYGYRLQGKFRLDGKTYHFHSTGVPEKGWKYTTQYEYYAPALTKKTDWQAIDGKWYY
CCCCCCEEEEEEEEECCEEEEEECCCCCCCCCEEEEEEEEECCCCCCCCCCEEECCEEEE
FDTYGKMYQNRRVGNASFDARGAYSQALSIYKMSVPLYRQFPMGYPSGCEFFSLKMALEE
EECHHHHHHCCCCCCCCCCCCCCHHHEEEEEEECCCHHHHCCCCCCCCCCEEEEEEEHHH
KGRAVSASTLYNEMPKSMWNARYENRLYRWVDPNVMFTGDPKGTLGKYKNYGIYPKGMIG
CCCEEEHHHHHHHHHHHHHCCHHHCCEEEEECCCEEEECCCCCCCCCCCCCCCCCCCHHH
FASKYRPVKDLSNQGLGSIERELSMGNPVIVWASVDFNKPYGYFNWYTASNKKFTGYVNY
HHHCCCCHHHHCCCCCCHHHHHHCCCCCEEEEEEECCCCCCCEEEEEECCCCEEEEEEEE
HVMLATGYDKSNLYINDPYRGRLVIPKSKVSAVMSATGWKALAVR
EEEEEECCCCCCEEECCCCCCEEEEEHHHHHHHHHCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2109310; 2105276 [H]