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The map label for this gene is murC

Identifier: 229916435

GI number: 229916435

Start: 660656

End: 661963

Strand: Reverse

Name: murC

Synonym: EAT1b_0705

Alternate gene names: 229916435

Gene position: 661963-660656 (Counterclockwise)

Preceding gene: 229916436

Following gene: 229916434

Centisome position: 22.07

GC content: 46.18

Gene sequence:

>1308_bases
ATGAACCGTTATCACTTCGTCGGAATTAAAGGAACGGGCATGAGTCCTTTAGCTCAAATTTTATTTGATATGAACAATGA
GGTCCGTGGATCGGACGTTGAAAAAGCATTTTTTACAGAAGAAGCATTGAACCGTAAAGGGATTGAAATTTTGCCATTCG
ATCCTGAAAATATTTCGGAAGACCAAATCGTTGTGCAAGGAAACGCGTTCAGTGATGATCATCCAGAAATCGTGCGTGCG
CGTGAACTCGGATTGACGATTTATAAGTATTATGAGTTTTTAGGTGAACTCGCGAACCATTACACGAGTGTCGCTATCAC
CGGGTCACACGGGAAGACGTCAACGACGGGATTACTTGCACACGTCATGCGTGGAATCGAACCGACATCGTTCTTAATCG
GCGATGGCACGGGAGAAGGAGTGGCGGATTCGAAAAACTTCGTCTTCGAAGCTTGTGAGTACAAGCGTCATTTCTTATAC
TACCGTCCAGACTACGCGATTATGACGAATATCGACTTTGACCATTCGGACTATTTCTCTGGTCTTGATGACGTCATTGA
CGCTTTCCAAGAAATGGCGAAACAAGTGAAGAAAGGAATCATTGCTTGTGGCGATGACGAAAATCTTCAACAGATTCAAG
CCAACGTGCCGCTCGTCTATTATGGTTTCGGGGCGCACAATGATTTCCGTGCTGAACAGGTCACATCGACAGAAAATGGA
ACGACATTTGATGTCTTTTTACGTGATGACTTCTACGGAACGTTCCGGATTCCTGGATATGGAGACCACAGCGTGTTGAA
CGCGCTCGCTGTCATTGCGACATGCGACTACGAGAACTTGCCGAAAGAATTGGTGAAAGAGCGTCTTGAGACGTTCAATG
GTGTAAAACGCCGATTCAGTGAATCGACGTTAAACGACCAAGTGCTTGTCGATGACTACGCGCATCATCCGCGGGAGATC
AGTGCAACGGTCGAAGCGGCTCGGAAAAAGTATGGCAATCGAGAAGTCGTTGCGATTTTCCAACCACATACGTATACACG
CTTGAAATCATTCATGGACGATTTTGCGACGGCATTGGCCGAAGCGGACACTGTCTATTTATGTGATATTTTCGGTTCAG
CACGTGAGCAGGAAGGAACGGTCACGATCGAAGACCTCCAATCACGAATCGAAGGCGCGCATATTTTAAAACGTGGTGGT
ACAGGCGTGTTACGCAACCATGCCGATGCCGTGCTCTTATTCATGGGTGCCGGTGATATTCAAACGTATCAGCGCGAATA
TGAAGAAGTTGTAAAACTTGAAGCATAA

Upstream 100 bases:

>100_bases
AACAATAATCTGTAATAGCACGACTCTGTGAGTTTTGCTATAATGACAAAGGTTTGTCGCATTTTGACGAGCCGTAATGA
ATTAGGGGGGCTATTTACAG

Downstream 100 bases:

>100_bases
GTGTGAAGGGAGACGAAAGTCTCTCTTTTTTATGTTTAGCCATCCAAAATCTCGGTAATAGTAGTATCGATGAATATGAC
AAAGGAGATGTTAGGAATGG

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MNRYHFVGIKGTGMSPLAQILFDMNNEVRGSDVEKAFFTEEALNRKGIEILPFDPENISEDQIVVQGNAFSDDHPEIVRA
RELGLTIYKYYEFLGELANHYTSVAITGSHGKTSTTGLLAHVMRGIEPTSFLIGDGTGEGVADSKNFVFEACEYKRHFLY
YRPDYAIMTNIDFDHSDYFSGLDDVIDAFQEMAKQVKKGIIACGDDENLQQIQANVPLVYYGFGAHNDFRAEQVTSTENG
TTFDVFLRDDFYGTFRIPGYGDHSVLNALAVIATCDYENLPKELVKERLETFNGVKRRFSESTLNDQVLVDDYAHHPREI
SATVEAARKKYGNREVVAIFQPHTYTRLKSFMDDFATALAEADTVYLCDIFGSAREQEGTVTIEDLQSRIEGAHILKRGG
TGVLRNHADAVLLFMGAGDIQTYQREYEEVVKLEA

Sequences:

>Translated_435_residues
MNRYHFVGIKGTGMSPLAQILFDMNNEVRGSDVEKAFFTEEALNRKGIEILPFDPENISEDQIVVQGNAFSDDHPEIVRA
RELGLTIYKYYEFLGELANHYTSVAITGSHGKTSTTGLLAHVMRGIEPTSFLIGDGTGEGVADSKNFVFEACEYKRHFLY
YRPDYAIMTNIDFDHSDYFSGLDDVIDAFQEMAKQVKKGIIACGDDENLQQIQANVPLVYYGFGAHNDFRAEQVTSTENG
TTFDVFLRDDFYGTFRIPGYGDHSVLNALAVIATCDYENLPKELVKERLETFNGVKRRFSESTLNDQVLVDDYAHHPREI
SATVEAARKKYGNREVVAIFQPHTYTRLKSFMDDFATALAEADTVYLCDIFGSAREQEGTVTIEDLQSRIEGAHILKRGG
TGVLRNHADAVLLFMGAGDIQTYQREYEEVVKLEA
>Mature_435_residues
MNRYHFVGIKGTGMSPLAQILFDMNNEVRGSDVEKAFFTEEALNRKGIEILPFDPENISEDQIVVQGNAFSDDHPEIVRA
RELGLTIYKYYEFLGELANHYTSVAITGSHGKTSTTGLLAHVMRGIEPTSFLIGDGTGEGVADSKNFVFEACEYKRHFLY
YRPDYAIMTNIDFDHSDYFSGLDDVIDAFQEMAKQVKKGIIACGDDENLQQIQANVPLVYYGFGAHNDFRAEQVTSTENG
TTFDVFLRDDFYGTFRIPGYGDHSVLNALAVIATCDYENLPKELVKERLETFNGVKRRFSESTLNDQVLVDDYAHHPREI
SATVEAARKKYGNREVVAIFQPHTYTRLKSFMDDFATALAEADTVYLCDIFGSAREQEGTVTIEDLQSRIEGAHILKRGG
TGVLRNHADAVLLFMGAGDIQTYQREYEEVVKLEA

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=461, Percent_Identity=28.8503253796095, Blast_Score=151, Evalue=8e-38,
Organism=Escherichia coli, GI1790680, Length=389, Percent_Identity=28.0205655526992, Blast_Score=134, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_EXISA (C4L4P1)

Other databases:

- EMBL:   CP001615
- RefSeq:   YP_002885081.1
- ProteinModelPortal:   C4L4P1
- GeneID:   7871477
- GenomeReviews:   CP001615_GR
- KEGG:   eat:EAT1b_0705
- OMA:   YHEFLGD
- ProtClustDB:   PRK00421
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 48911; Mature: 48911

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRYHFVGIKGTGMSPLAQILFDMNNEVRGSDVEKAFFTEEALNRKGIEILPFDPENISE
CCCEEEEEEECCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCEEECCCCCCCCC
DQIVVQGNAFSDDHPEIVRARELGLTIYKYYEFLGELANHYTSVAITGSHGKTSTTGLLA
CEEEEECCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHH
HVMRGIEPTSFLIGDGTGEGVADSKNFVFEACEYKRHFLYYRPDYAIMTNIDFDHSDYFS
HHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHCCEEEEECCCEEEEEECCCCCHHHHC
GLDDVIDAFQEMAKQVKKGIIACGDDENLQQIQANVPLVYYGFGAHNDFRAEQVTSTENG
CHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHCCCCEEEEECCCCCCCCHHHHCCCCCC
TTFDVFLRDDFYGTFRIPGYGDHSVLNALAVIATCDYENLPKELVKERLETFNGVKRRFS
CEEEEEEECCCCEEEECCCCCCHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHHHHHH
ESTLNDQVLVDDYAHHPREISATVEAARKKYGNREVVAIFQPHTYTRLKSFMDDFATALA
HCCCCCCEEECHHCCCCHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHH
EADTVYLCDIFGSAREQEGTVTIEDLQSRIEGAHILKRGGTGVLRNHADAVLLFMGAGDI
CCCEEEEEECCCCCCCCCCCEEHHHHHHHHCHHHHHHCCCCCHHHCCCCEEEEEECCCCH
QTYQREYEEVVKLEA
HHHHHHHHHHHHCCC
>Mature Secondary Structure
MNRYHFVGIKGTGMSPLAQILFDMNNEVRGSDVEKAFFTEEALNRKGIEILPFDPENISE
CCCEEEEEEECCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCEEECCCCCCCCC
DQIVVQGNAFSDDHPEIVRARELGLTIYKYYEFLGELANHYTSVAITGSHGKTSTTGLLA
CEEEEECCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHH
HVMRGIEPTSFLIGDGTGEGVADSKNFVFEACEYKRHFLYYRPDYAIMTNIDFDHSDYFS
HHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHCCEEEEECCCEEEEEECCCCCHHHHC
GLDDVIDAFQEMAKQVKKGIIACGDDENLQQIQANVPLVYYGFGAHNDFRAEQVTSTENG
CHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHCCCCEEEEECCCCCCCCHHHHCCCCCC
TTFDVFLRDDFYGTFRIPGYGDHSVLNALAVIATCDYENLPKELVKERLETFNGVKRRFS
CEEEEEEECCCCEEEECCCCCCHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHHHHHH
ESTLNDQVLVDDYAHHPREISATVEAARKKYGNREVVAIFQPHTYTRLKSFMDDFATALA
HCCCCCCEEECHHCCCCHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHH
EADTVYLCDIFGSAREQEGTVTIEDLQSRIEGAHILKRGGTGVLRNHADAVLLFMGAGDI
CCCEEEEEECCCCCCCCCCCEEHHHHHHHHCHHHHHHCCCCCHHHCCCCEEEEEECCCCH
QTYQREYEEVVKLEA
HHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA