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The map label for this gene is hemN [H]

Identifier: 229916350

GI number: 229916350

Start: 572087

End: 573241

Strand: Reverse

Name: hemN [H]

Synonym: EAT1b_0620

Alternate gene names: 229916350

Gene position: 573241-572087 (Counterclockwise)

Preceding gene: 229916351

Following gene: 229916348

Centisome position: 19.11

GC content: 47.88

Gene sequence:

>1155_bases
TTGGCTAAAGCCGTATATCTTCACATTCCATTTTGTGAACATATTTGTTATTACTGTGATTTCAACAAGGTGTTTTTAAA
AAATCAACCTGTTGATGATTATTTAGATGCATTAAAACGAGAGATGGTATTGACGCTCGAGGCGTTTCCGACAGAGCGGA
TTGATACCATCTTTATCGGAGGCGGGACACCGACTGCGCTCAATGAGGAGCAGATGGCGCGCCTGATGGACATGGTCCGC
CAACACCTTCTGCCACTCGCGTCAGACGACTTAGAGTATTCTGTCGAAGCGAACCCGAACTTTGTGAGTGCGGAAAAACT
CGACACGATGAAAGCAGGTGGCGTCAACCGACTTAGTTTCGGTGTCCAGACGTTTGATGATGGTGGACTTGAGCGCATCG
GGCGGACGCATCGGGCGGATGATGTGTTCGAGACGGTAAGCGAAGCGGCAAAACGCTTTGACAATATCTCGATTGACCTG
ATGTTCGGTCTTCCGGAACAAACCCTTGAACAAATTGACCGTGATTTAGCGCTAGCGCTCCAATTACCGATTCAACATGT
ATCCTCTTATTCGTTGATCCTCGAGCCGCATACCGTCTTTGCGATTCAAGATCGAAAAGGGAAGCTCCGTTTACCGGGGG
AAGATGTCGAAGTCGAAATGTACTTGAAAGTGATGGAGACGCTTGAACGCCATGGTCTCAAACAATATGAAATCTCCAAC
TATGGCTTGCCTGGTCGAGAGAGTCGTCACAATCAAGTGTACTGGCGCAATGAAGAGTATTATGGATTCGGAGCCGGAGC
GCATAGTTATTTGAATGGGACACGTCGCGCCAATATCGCTCCAATTCCTCACTATATTAAAGCAGAAGGCATCCCTGTGA
AACGGGTGACCGAACTAGAAGAAGTGGAAAAGATGGAAGAAGAGTTGTTCCTCGGCCTGCGTATGCGTTCCGGGGTCTCG
CTTCAGACGTTTGAACAAAAGTACGGAGTGTCGCTCGATGATGTGTTCGGTCACGTCATCGAAGAGTTGGTGAAGAAGTC
ACTGATTGAACGGACGGACACACATATCCGTCTAACGGCATCCGGTTTGCCACTCGCCAATGAAGCCTTTGCAGCCTTTA
TTGGAGAAGCAAAACTTGAACATGCTGATTCATAA

Upstream 100 bases:

>100_bases
AAGAGTGGATTATTCATTCATCGATTCGATTGATGGCGCAGGCTGGAAAGAACAGACGAAAAGCGTTATAAATGGAATGA
GAAGAAAGGGGTGGCCGAAA

Downstream 100 bases:

>100_bases
AAAAATGGACAAGTCCCTCGTGAGGATTTGTCCATTTTCTTATATTACAAGACGAGATCACGATAGAGCGGTGTAAGCCG
ACCGAACGTGTCTTCGACCA

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 384; Mature: 383

Protein sequence:

>384_residues
MAKAVYLHIPFCEHICYYCDFNKVFLKNQPVDDYLDALKREMVLTLEAFPTERIDTIFIGGGTPTALNEEQMARLMDMVR
QHLLPLASDDLEYSVEANPNFVSAEKLDTMKAGGVNRLSFGVQTFDDGGLERIGRTHRADDVFETVSEAAKRFDNISIDL
MFGLPEQTLEQIDRDLALALQLPIQHVSSYSLILEPHTVFAIQDRKGKLRLPGEDVEVEMYLKVMETLERHGLKQYEISN
YGLPGRESRHNQVYWRNEEYYGFGAGAHSYLNGTRRANIAPIPHYIKAEGIPVKRVTELEEVEKMEEELFLGLRMRSGVS
LQTFEQKYGVSLDDVFGHVIEELVKKSLIERTDTHIRLTASGLPLANEAFAAFIGEAKLEHADS

Sequences:

>Translated_384_residues
MAKAVYLHIPFCEHICYYCDFNKVFLKNQPVDDYLDALKREMVLTLEAFPTERIDTIFIGGGTPTALNEEQMARLMDMVR
QHLLPLASDDLEYSVEANPNFVSAEKLDTMKAGGVNRLSFGVQTFDDGGLERIGRTHRADDVFETVSEAAKRFDNISIDL
MFGLPEQTLEQIDRDLALALQLPIQHVSSYSLILEPHTVFAIQDRKGKLRLPGEDVEVEMYLKVMETLERHGLKQYEISN
YGLPGRESRHNQVYWRNEEYYGFGAGAHSYLNGTRRANIAPIPHYIKAEGIPVKRVTELEEVEKMEEELFLGLRMRSGVS
LQTFEQKYGVSLDDVFGHVIEELVKKSLIERTDTHIRLTASGLPLANEAFAAFIGEAKLEHADS
>Mature_383_residues
AKAVYLHIPFCEHICYYCDFNKVFLKNQPVDDYLDALKREMVLTLEAFPTERIDTIFIGGGTPTALNEEQMARLMDMVRQ
HLLPLASDDLEYSVEANPNFVSAEKLDTMKAGGVNRLSFGVQTFDDGGLERIGRTHRADDVFETVSEAAKRFDNISIDLM
FGLPEQTLEQIDRDLALALQLPIQHVSSYSLILEPHTVFAIQDRKGKLRLPGEDVEVEMYLKVMETLERHGLKQYEISNY
GLPGRESRHNQVYWRNEEYYGFGAGAHSYLNGTRRANIAPIPHYIKAEGIPVKRVTELEEVEKMEEELFLGLRMRSGVSL
QTFEQKYGVSLDDVFGHVIEELVKKSLIERTDTHIRLTASGLPLANEAFAAFIGEAKLEHADS

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=377, Percent_Identity=34.4827586206897, Blast_Score=181, Evalue=1e-45,
Organism=Escherichia coli, GI1789325, Length=268, Percent_Identity=38.8059701492537, Blast_Score=182, Evalue=4e-47,
Organism=Escherichia coli, GI87082341, Length=390, Percent_Identity=26.9230769230769, Blast_Score=139, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 43606; Mature: 43475

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKAVYLHIPFCEHICYYCDFNKVFLKNQPVDDYLDALKREMVLTLEAFPTERIDTIFIG
CCCEEEEECCHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHEEEEECCCCCCCCEEEEC
GGTPTALNEEQMARLMDMVRQHLLPLASDDLEYSVEANPNFVSAEKLDTMKAGGVNRLSF
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCEECHHHHHHHHCCCCCEEEE
GVQTFDDGGLERIGRTHRADDVFETVSEAAKRFDNISIDLMFGLPEQTLEQIDRDLALAL
CCEECCCCCHHHHCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHH
QLPIQHVSSYSLILEPHTVFAIQDRKGKLRLPGEDVEVEMYLKVMETLERHGLKQYEISN
HHHHHHCCCEEEEECCCEEEEEECCCCCEECCCCCCHHHHHHHHHHHHHHCCCCEEEECC
YGLPGRESRHNQVYWRNEEYYGFGAGAHSYLNGTRRANIAPIPHYIKAEGIPVKRVTELE
CCCCCCCCCCCCEEEECCCEEEECCCHHHHHCCCCCCCCCCCCCHHCCCCCCHHHHHHHH
EVEKMEEELFLGLRMRSGVSLQTFEQKYGVSLDDVFGHVIEELVKKSLIERTDTHIRLTA
HHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEE
SGLPLANEAFAAFIGEAKLEHADS
CCCCCCHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AKAVYLHIPFCEHICYYCDFNKVFLKNQPVDDYLDALKREMVLTLEAFPTERIDTIFIG
CCEEEEECCHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHEEEEECCCCCCCCEEEEC
GGTPTALNEEQMARLMDMVRQHLLPLASDDLEYSVEANPNFVSAEKLDTMKAGGVNRLSF
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCEECHHHHHHHHCCCCCEEEE
GVQTFDDGGLERIGRTHRADDVFETVSEAAKRFDNISIDLMFGLPEQTLEQIDRDLALAL
CCEECCCCCHHHHCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHH
QLPIQHVSSYSLILEPHTVFAIQDRKGKLRLPGEDVEVEMYLKVMETLERHGLKQYEISN
HHHHHHCCCEEEEECCCEEEEEECCCCCEECCCCCCHHHHHHHHHHHHHHCCCCEEEECC
YGLPGRESRHNQVYWRNEEYYGFGAGAHSYLNGTRRANIAPIPHYIKAEGIPVKRVTELE
CCCCCCCCCCCCEEEECCCEEEECCCHHHHHCCCCCCCCCCCCCHHCCCCCCHHHHHHHH
EVEKMEEELFLGLRMRSGVSLQTFEQKYGVSLDDVFGHVIEELVKKSLIERTDTHIRLTA
HHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEE
SGLPLANEAFAAFIGEAKLEHADS
CCCCCCHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757728; 8969508; 9384377; 1339421 [H]