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The map label for this gene is mccB [H]

Identifier: 229916338

GI number: 229916338

Start: 557649

End: 558806

Strand: Reverse

Name: mccB [H]

Synonym: EAT1b_0608

Alternate gene names: 229916338

Gene position: 558806-557649 (Counterclockwise)

Preceding gene: 229916339

Following gene: 229916337

Centisome position: 18.63

GC content: 51.04

Gene sequence:

>1158_bases
ATGCGTACAAAGACAGCACTCATTCACGGCGGTAAAACGACGGACCCGTTGACAGGGGCCGTCACGCCACCGATTTATCA
AACGAGCACGTATAAGCAAGACGGGATTGGCAACTTGCGAGAAGGGTACGAGTACTCACGATCAGCAAACCCGACTCGGA
CGGCATTAGAGACATTGATTGCCGACATCGAAGGCGGCGTGCAAGGATTTGCATTCGGATCTGGGATGGCAGCCATCTCG
ACGGTGCTTATGTTATTGAAATCTGGAGACCACGTCATCGTCGGGTCTGATGTATATGGAGGAACGTACCGTGTATTCAA
TCGAGTATTTCAGTCACGAGGCTTGGAAGCAACTTTTGTCGATACATCCGATGAAGCAGCGGTTCGGGATGCGCTTCAAG
CGAACACGAAGATGATTTATGTCGAGACCCCGACAAATCCTCTCTTGAACGTGACGGACATTCGGGCGATGCGTCAGATT
GCCGACGAGGCAGATGTGTTACTCGTCGTGGACAATACGTTTATGACCCCTTACTTCCAAAATCCGATCGATCTTGGTGC
AGACTACGTCCTTCACAGTGCCACGAAGTACTTAGGTGGACATAGTGACGTCGTAGCGGGACTTGTTGTCGCACGTACGG
AAGAGCAGGGCGAGGCTTTGGCGTTCCTGCAAAACTCTGTTGGCGCAGTCCTTGGACCACAAGATAGCTTTCTTGTTGTA
CGGGGAATCAAGACGTTGGCTGTTCGGATGGAAGAGATTGAATCGAATGCACGTGCACTGGTCGAATTCCTTCAGTCGAA
CGAGTCTGTATCACGCGTGCTCCACCCAAGTGTATCGAGTGAGGAAGCGAAACGGATTCATTTATCGCAGGCACGTGGAT
TCGGTGGGATGATCGCATTTGATGTCGGTTCAGCGGAAGCGGCAGAAATGATGGTCGCGAAGACGAAATACTTCACGCTC
GCAGAAAGTTTAGGAGCGGTTGAGAGTTTGATCAGTGTTCCGGCACGCATGACACATGCCTCGATTCCAGCCGAACGCAG
AGCGGAACTTGGCATCACCGATGGGCTCGTCCGTATTTCGGTCGGACTTGAGGACATTGATGACTTGATCGAAGACTTGG
CACAAGCATTAACAGCAATTGAACAAGTGAAACAATAA

Upstream 100 bases:

>100_bases
GTAAAAGAAGCGAGTCAATTGACGGAAGGCACGATTGTCACCATCTTGCCTGATAGTGCAGAACGATATTTAAGTCAAGG
AATTGTCAAGGAGGCAGAAC

Downstream 100 bases:

>100_bases
ACGGTCAGGGCGCGATTTCGCGCCTTTTTTTCATGAAACAAAAGTCTTGTATCGGGAGTCTTTCATCGACTAAACTGTCT
TTAACTTGTAAGAGAGCGGG

Product: Cystathionine gamma-lyase

Products: NA

Alternate protein names: Gamma-cystathionase; Homocysteine gamma-lyase [H]

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MRTKTALIHGGKTTDPLTGAVTPPIYQTSTYKQDGIGNLREGYEYSRSANPTRTALETLIADIEGGVQGFAFGSGMAAIS
TVLMLLKSGDHVIVGSDVYGGTYRVFNRVFQSRGLEATFVDTSDEAAVRDALQANTKMIYVETPTNPLLNVTDIRAMRQI
ADEADVLLVVDNTFMTPYFQNPIDLGADYVLHSATKYLGGHSDVVAGLVVARTEEQGEALAFLQNSVGAVLGPQDSFLVV
RGIKTLAVRMEEIESNARALVEFLQSNESVSRVLHPSVSSEEAKRIHLSQARGFGGMIAFDVGSAEAAEMMVAKTKYFTL
AESLGAVESLISVPARMTHASIPAERRAELGITDGLVRISVGLEDIDDLIEDLAQALTAIEQVKQ

Sequences:

>Translated_385_residues
MRTKTALIHGGKTTDPLTGAVTPPIYQTSTYKQDGIGNLREGYEYSRSANPTRTALETLIADIEGGVQGFAFGSGMAAIS
TVLMLLKSGDHVIVGSDVYGGTYRVFNRVFQSRGLEATFVDTSDEAAVRDALQANTKMIYVETPTNPLLNVTDIRAMRQI
ADEADVLLVVDNTFMTPYFQNPIDLGADYVLHSATKYLGGHSDVVAGLVVARTEEQGEALAFLQNSVGAVLGPQDSFLVV
RGIKTLAVRMEEIESNARALVEFLQSNESVSRVLHPSVSSEEAKRIHLSQARGFGGMIAFDVGSAEAAEMMVAKTKYFTL
AESLGAVESLISVPARMTHASIPAERRAELGITDGLVRISVGLEDIDDLIEDLAQALTAIEQVKQ
>Mature_385_residues
MRTKTALIHGGKTTDPLTGAVTPPIYQTSTYKQDGIGNLREGYEYSRSANPTRTALETLIADIEGGVQGFAFGSGMAAIS
TVLMLLKSGDHVIVGSDVYGGTYRVFNRVFQSRGLEATFVDTSDEAAVRDALQANTKMIYVETPTNPLLNVTDIRAMRQI
ADEADVLLVVDNTFMTPYFQNPIDLGADYVLHSATKYLGGHSDVVAGLVVARTEEQGEALAFLQNSVGAVLGPQDSFLVV
RGIKTLAVRMEEIESNARALVEFLQSNESVSRVLHPSVSSEEAKRIHLSQARGFGGMIAFDVGSAEAAEMMVAKTKYFTL
AESLGAVESLISVPARMTHASIPAERRAELGITDGLVRISVGLEDIDDLIEDLAQALTAIEQVKQ

Specific function: Catalyzes the conversion of cystathionine to cysteine, and homocysteine to sulfide [H]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=378, Percent_Identity=48.1481481481481, Blast_Score=323, Evalue=2e-88,
Organism=Homo sapiens, GI299473759, Length=378, Percent_Identity=43.3862433862434, Blast_Score=270, Evalue=1e-72,
Organism=Homo sapiens, GI25453487, Length=377, Percent_Identity=42.1750663129974, Blast_Score=250, Evalue=1e-66,
Organism=Escherichia coli, GI1790375, Length=383, Percent_Identity=42.8198433420365, Blast_Score=310, Evalue=1e-85,
Organism=Escherichia coli, GI1789383, Length=391, Percent_Identity=27.1099744245524, Blast_Score=149, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17538055, Length=385, Percent_Identity=48.3116883116883, Blast_Score=334, Evalue=5e-92,
Organism=Caenorhabditis elegans, GI17560056, Length=361, Percent_Identity=47.3684210526316, Blast_Score=326, Evalue=1e-89,
Organism=Caenorhabditis elegans, GI71980708, Length=374, Percent_Identity=39.572192513369, Blast_Score=260, Evalue=9e-70,
Organism=Saccharomyces cerevisiae, GI6319307, Length=383, Percent_Identity=45.4308093994778, Blast_Score=319, Evalue=6e-88,
Organism=Saccharomyces cerevisiae, GI6321254, Length=401, Percent_Identity=36.1596009975062, Blast_Score=233, Evalue=5e-62,
Organism=Saccharomyces cerevisiae, GI6321904, Length=395, Percent_Identity=30.6329113924051, Blast_Score=168, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6323333, Length=422, Percent_Identity=31.7535545023697, Blast_Score=162, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6321170, Length=322, Percent_Identity=30.7453416149068, Blast_Score=151, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6322590, Length=375, Percent_Identity=25.3333333333333, Blast_Score=83, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6322970, Length=261, Percent_Identity=26.8199233716475, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323557, Length=338, Percent_Identity=23.9644970414201, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI19922554, Length=377, Percent_Identity=48.5411140583554, Blast_Score=365, Evalue=1e-101,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.1; =4.4.1.2 [H]

Molecular weight: Translated: 41406; Mature: 41406

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTKTALIHGGKTTDPLTGAVTPPIYQTSTYKQDGIGNLREGYEYSRSANPTRTALETLI
CCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHH
ADIEGGVQGFAFGSGMAAISTVLMLLKSGDHVIVGSDVYGGTYRVFNRVFQSRGLEATFV
HHHCCCCCEEECCCCHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHCCCEEEEE
DTSDEAAVRDALQANTKMIYVETPTNPLLNVTDIRAMRQIADEADVLLVVDNTFMTPYFQ
CCCCHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCC
NPIDLGADYVLHSATKYLGGHSDVVAGLVVARTEEQGEALAFLQNSVGAVLGPQDSFLVV
CCHHCCHHHHHHHHHHHHCCCHHHHHHHHHEECCCCCHHHHHHHHCCCCEECCCCCEEEE
RGIKTLAVRMEEIESNARALVEFLQSNESVSRVLHPSVSSEEAKRIHLSQARGFGGMIAF
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHHCCCCCCEEEE
DVGSAEAAEMMVAKTKYFTLAESLGAVESLISVPARMTHASIPAERRAELGITDGLVRIS
ECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCHHHHHHCCCCCCEEEEE
VGLEDIDDLIEDLAQALTAIEQVKQ
ECHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRTKTALIHGGKTTDPLTGAVTPPIYQTSTYKQDGIGNLREGYEYSRSANPTRTALETLI
CCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHH
ADIEGGVQGFAFGSGMAAISTVLMLLKSGDHVIVGSDVYGGTYRVFNRVFQSRGLEATFV
HHHCCCCCEEECCCCHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHCCCEEEEE
DTSDEAAVRDALQANTKMIYVETPTNPLLNVTDIRAMRQIADEADVLLVVDNTFMTPYFQ
CCCCHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCC
NPIDLGADYVLHSATKYLGGHSDVVAGLVVARTEEQGEALAFLQNSVGAVLGPQDSFLVV
CCHHCCHHHHHHHHHHHHCCCHHHHHHHHHEECCCCCHHHHHHHHCCCCEECCCCCEEEE
RGIKTLAVRMEEIESNARALVEFLQSNESVSRVLHPSVSSEEAKRIHLSQARGFGGMIAF
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHHCCCCCCEEEE
DVGSAEAAEMMVAKTKYFTLAESLGAVESLISVPARMTHASIPAERRAELGITDGLVRIS
ECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCHHHHHHCCCCCCEEEEE
VGLEDIDDLIEDLAQALTAIEQVKQ
ECHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377 [H]