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The map label for this gene is gcvPA [H]

Identifier: 229916266

GI number: 229916266

Start: 487146

End: 488492

Strand: Reverse

Name: gcvPA [H]

Synonym: EAT1b_0535

Alternate gene names: 229916266

Gene position: 488492-487146 (Counterclockwise)

Preceding gene: 229916267

Following gene: 229916265

Centisome position: 16.28

GC content: 48.78

Gene sequence:

>1347_bases
ATGAACAGAATGGAATTTCGTTATTTACCGATGACCGAACAAGATGAACGAGACATGTTAGAGACAATCGGCGTCGATTC
AATCGAAGCGCTTCTTTCAGATATTCCAGAAACACTTCGCGAACAAGCATCATTGGCGGCGATTGGGGCTCCGCTTCCGG
AAGTCGATCTCGTTCGTCATATGACGAAGTTGGCTGATAAAAACAAACATACGAAATCATATCCGAGCTTCCTTGGAGCA
GGGATGTACGATCATCTTTCGCCAAGTGTGATGAACCATATGCTTTTGCGTTCTGAATTCTATACGGCGTATACGCCATA
TCAACCTGAGATTTCACAAGGTGAACTTCAGGCGATGTTCGAATTCCAAACAATGATTTGTGAGTTGACAGAAATGGACG
TTGCGAACTCTTCGATGTACGACGGAATCACGGCTCTCGCTGAGGCGACTTACCTAGCGAGCGCGCAGACGAAGAAAAAA
CGTGTCGTCGTCTCTGGTGCAGTGCATCCTGAAGCGAAGGACGTAATCCGTACGTATGCTGACGGACCGGGGCTATCCGT
TGACTACACAGATGTGGTGAACGGGGTGACGGACGTGTCAGACCTTGATTTGACGGATGCGTCGTGTCTTGTCGTACAAT
ATCCAAACTTCTACGGTCGTATTGAAGACTTAGAAACATTGGCAGAATTGGCTCATGAAGCCGGTGCACTCTTCGTCGTT
TCGAGCAACCCGCTCGCCCTCGGAATTCTTGAGTCACCAGGAGCACTCGGTGCGGACATCACGGTCGGAGATGCACAGCC
ATTCGGTATTCCGCAAAGTTTTGGTGGACCGTCATGTGGATACTTCGCGGTCAAAAAATCTTTGATGCGTAAACTACCGG
GACGACTTGTTGGTCAAACGGTCGATGAGGACGGCAAACGCGGATTCGTGTTGACGCTCCAGGCGCGTGAACAGCACATT
CGTCGTGATAAAGCGACATCCAATATCTGTTCGAACCAAGCGCTTAACGCATTGGCTGCTTCGATTACGATGTCCGCTTT
AGGAAAATACGGAATTCGTGATATGGCCGTTCGGAATATTCAAACTGCTCATTATATGAAAGAAGCGTTAAAAGCTGCAG
GATTCAACATCGTGGACGAAGGACCGATGTTCAATGAGTTCGTGGTGGATTTTGGACGTGACGCAGAAGAAGTATCGCGC
CATCTGCTCGAGCATGGCATGATTGGTGGTCTACCGCTTGGTACGTATGAAGGGGAGCGTCAGACACAGATGTTGGTTTG
CGCGACGGAATTGCGCACGAAAGAAGAGATTGATCAGTTTGTCGAAGTGGTTGGGGGGATGAAATAA

Upstream 100 bases:

>100_bases
GAAGAGCGTTTTGTCATCGACATCCGTGGCAAAAAGATTGAAGCCGAACGCGTACCGACACCTTTCTATAAACGAACGAA
ATGAAACAGGGGGATTCAGA

Downstream 100 bases:

>100_bases
TGCAACACGAGCAAACGCTAATTTTTGAAGTATCACGTGAAGGACGGACTGGATATAATTTGCCGACACCGACTGTCCCA
GAGGTTGACCTTGAGACGTT

Product: glycine dehydrogenase subunit 1

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 1; Glycine decarboxylase subunit 1 [H]

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MNRMEFRYLPMTEQDERDMLETIGVDSIEALLSDIPETLREQASLAAIGAPLPEVDLVRHMTKLADKNKHTKSYPSFLGA
GMYDHLSPSVMNHMLLRSEFYTAYTPYQPEISQGELQAMFEFQTMICELTEMDVANSSMYDGITALAEATYLASAQTKKK
RVVVSGAVHPEAKDVIRTYADGPGLSVDYTDVVNGVTDVSDLDLTDASCLVVQYPNFYGRIEDLETLAELAHEAGALFVV
SSNPLALGILESPGALGADITVGDAQPFGIPQSFGGPSCGYFAVKKSLMRKLPGRLVGQTVDEDGKRGFVLTLQAREQHI
RRDKATSNICSNQALNALAASITMSALGKYGIRDMAVRNIQTAHYMKEALKAAGFNIVDEGPMFNEFVVDFGRDAEEVSR
HLLEHGMIGGLPLGTYEGERQTQMLVCATELRTKEEIDQFVEVVGGMK

Sequences:

>Translated_448_residues
MNRMEFRYLPMTEQDERDMLETIGVDSIEALLSDIPETLREQASLAAIGAPLPEVDLVRHMTKLADKNKHTKSYPSFLGA
GMYDHLSPSVMNHMLLRSEFYTAYTPYQPEISQGELQAMFEFQTMICELTEMDVANSSMYDGITALAEATYLASAQTKKK
RVVVSGAVHPEAKDVIRTYADGPGLSVDYTDVVNGVTDVSDLDLTDASCLVVQYPNFYGRIEDLETLAELAHEAGALFVV
SSNPLALGILESPGALGADITVGDAQPFGIPQSFGGPSCGYFAVKKSLMRKLPGRLVGQTVDEDGKRGFVLTLQAREQHI
RRDKATSNICSNQALNALAASITMSALGKYGIRDMAVRNIQTAHYMKEALKAAGFNIVDEGPMFNEFVVDFGRDAEEVSR
HLLEHGMIGGLPLGTYEGERQTQMLVCATELRTKEEIDQFVEVVGGMK
>Mature_448_residues
MNRMEFRYLPMTEQDERDMLETIGVDSIEALLSDIPETLREQASLAAIGAPLPEVDLVRHMTKLADKNKHTKSYPSFLGA
GMYDHLSPSVMNHMLLRSEFYTAYTPYQPEISQGELQAMFEFQTMICELTEMDVANSSMYDGITALAEATYLASAQTKKK
RVVVSGAVHPEAKDVIRTYADGPGLSVDYTDVVNGVTDVSDLDLTDASCLVVQYPNFYGRIEDLETLAELAHEAGALFVV
SSNPLALGILESPGALGADITVGDAQPFGIPQSFGGPSCGYFAVKKSLMRKLPGRLVGQTVDEDGKRGFVLTLQAREQHI
RRDKATSNICSNQALNALAASITMSALGKYGIRDMAVRNIQTAHYMKEALKAAGFNIVDEGPMFNEFVVDFGRDAEEVSR
HLLEHGMIGGLPLGTYEGERQTQMLVCATELRTKEEIDQFVEVVGGMK

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG0403

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. N-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=396, Percent_Identity=37.1212121212121, Blast_Score=263, Evalue=2e-70,
Organism=Escherichia coli, GI1789269, Length=398, Percent_Identity=33.6683417085427, Blast_Score=203, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI17535605, Length=379, Percent_Identity=38.7862796833773, Blast_Score=245, Evalue=4e-65,
Organism=Saccharomyces cerevisiae, GI6323843, Length=361, Percent_Identity=38.5041551246537, Blast_Score=234, Evalue=2e-62,
Organism=Drosophila melanogaster, GI24645648, Length=388, Percent_Identity=36.340206185567, Blast_Score=255, Evalue=5e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023010
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF02347 GDC-P [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 49092; Mature: 49092

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRMEFRYLPMTEQDERDMLETIGVDSIEALLSDIPETLREQASLAAIGAPLPEVDLVRH
CCCCCEEECCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
MTKLADKNKHTKSYPSFLGAGMYDHLSPSVMNHMLLRSEFYTAYTPYQPEISQGELQAMF
HHHHHHCCCCCHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHEECCCCCCCCCHHHHHHH
EFQTMICELTEMDVANSSMYDGITALAEATYLASAQTKKKRVVVSGAVHPEAKDVIRTYA
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHC
DGPGLSVDYTDVVNGVTDVSDLDLTDASCLVVQYPNFYGRIEDLETLAELAHEAGALFVV
CCCCCCEEHHHHHCCCCCCCCCCCCCCCEEEEECCCHHCCHHHHHHHHHHHHHCCEEEEE
SSNPLALGILESPGALGADITVGDAQPFGIPQSFGGPSCGYFAVKKSLMRKLPGRLVGQT
ECCCEEEEEECCCCCCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHCCC
VDEDGKRGFVLTLQAREQHIRRDKATSNICSNQALNALAASITMSALGKYGIRDMAVRNI
CCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
QTAHYMKEALKAAGFNIVDEGPMFNEFVVDFGRDAEEVSRHLLEHGMIGGLPLGTYEGER
HHHHHHHHHHHHCCCCEECCCCCHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCC
QTQMLVCATELRTKEEIDQFVEVVGGMK
HHEEEEHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNRMEFRYLPMTEQDERDMLETIGVDSIEALLSDIPETLREQASLAAIGAPLPEVDLVRH
CCCCCEEECCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
MTKLADKNKHTKSYPSFLGAGMYDHLSPSVMNHMLLRSEFYTAYTPYQPEISQGELQAMF
HHHHHHCCCCCHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHEECCCCCCCCCHHHHHHH
EFQTMICELTEMDVANSSMYDGITALAEATYLASAQTKKKRVVVSGAVHPEAKDVIRTYA
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHC
DGPGLSVDYTDVVNGVTDVSDLDLTDASCLVVQYPNFYGRIEDLETLAELAHEAGALFVV
CCCCCCEEHHHHHCCCCCCCCCCCCCCCEEEEECCCHHCCHHHHHHHHHHHHHCCEEEEE
SSNPLALGILESPGALGADITVGDAQPFGIPQSFGGPSCGYFAVKKSLMRKLPGRLVGQT
ECCCEEEEEECCCCCCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHCCC
VDEDGKRGFVLTLQAREQHIRRDKATSNICSNQALNALAASITMSALGKYGIRDMAVRNI
CCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
QTAHYMKEALKAAGFNIVDEGPMFNEFVVDFGRDAEEVSRHLLEHGMIGGLPLGTYEGER
HHHHHHHHHHHHCCCCEECCCCCHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCC
QTQMLVCATELRTKEEIDQFVEVVGGMK
HHEEEEHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA