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The map label for this gene is hpt [H]

Identifier: 229916262

GI number: 229916262

Start: 483956

End: 484483

Strand: Reverse

Name: hpt [H]

Synonym: EAT1b_0531

Alternate gene names: 229916262

Gene position: 484483-483956 (Counterclockwise)

Preceding gene: 229916263

Following gene: 229916259

Centisome position: 16.15

GC content: 45.64

Gene sequence:

>528_bases
ATGAAGATTCAAATCAAAGGAAAACTGTTTGATGAACAGCAGATTCAAACACGTGTGAAAGAGTTGGCTGAAGAAATTGA
GAACGATGCAGAAGGAACACCGATCGTGATCGTCGCCGTGTTAAAGGGTTCGATGGTCTTTGCGGCAGACTTGATGCGAT
ACATGAAAGGCAGCGTTCAGCTCGATACGGTCGCGACGTCTTCTTACGGGAAAAAGACGGTCTCGAGTGGGAGTGTGCAG
CTTCGGAAGGACTTGGATTTAGATGTGGAAGGAAAGTATGTCGTCATTATCGAGGACATCATCGACACGGGACAGACGTT
GAAATTCTTGTGTAAACATATGGAACTCCATCAACCGAAACAGTTGAAAATTTGTACGCTTCTCGACAAGCCGGCGCGTC
GACTCGTTCAATTGGACGCAGACTATGTCGGGTTCGAAATTCCTGATGAGTTTGTCATCGGATATGGGATCGATTATGCG
GAGCAATATCGGAATCTTCCATATATCGGATATGTAGAGACGACATAA

Upstream 100 bases:

>100_bases
TTCATATTTATCATAGAATGTATATTTTTTAGTTATTATTATGTTAAGATGAATCGTGGATTGAATAGATAGGGGGTGAC
GGCGAACATTCGCCGGATAA

Downstream 100 bases:

>100_bases
AAAGGAGCGCCGCGGCGCTCCTTTTACATGTTTGCTTTCTTTTTCTTCTTGCCTTTTTTTCCTTCAATCACTGTTAAGTG
TGGAGGATTGCTACGATGTA

Product: hypoxanthine phosphoribosyltransferase

Products: NA

Alternate protein names: HPRT [H]

Number of amino acids: Translated: 175; Mature: 175

Protein sequence:

>175_residues
MKIQIKGKLFDEQQIQTRVKELAEEIENDAEGTPIVIVAVLKGSMVFAADLMRYMKGSVQLDTVATSSYGKKTVSSGSVQ
LRKDLDLDVEGKYVVIIEDIIDTGQTLKFLCKHMELHQPKQLKICTLLDKPARRLVQLDADYVGFEIPDEFVIGYGIDYA
EQYRNLPYIGYVETT

Sequences:

>Translated_175_residues
MKIQIKGKLFDEQQIQTRVKELAEEIENDAEGTPIVIVAVLKGSMVFAADLMRYMKGSVQLDTVATSSYGKKTVSSGSVQ
LRKDLDLDVEGKYVVIIEDIIDTGQTLKFLCKHMELHQPKQLKICTLLDKPARRLVQLDADYVGFEIPDEFVIGYGIDYA
EQYRNLPYIGYVETT
>Mature_175_residues
MKIQIKGKLFDEQQIQTRVKELAEEIENDAEGTPIVIVAVLKGSMVFAADLMRYMKGSVQLDTVATSSYGKKTVSSGSVQ
LRKDLDLDVEGKYVVIIEDIIDTGQTLKFLCKHMELHQPKQLKICTLLDKPARRLVQLDADYVGFEIPDEFVIGYGIDYA
EQYRNLPYIGYVETT

Specific function: This enzyme acts exclusively on hypoxanthine; it does not act on guanine [H]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=171, Percent_Identity=36.8421052631579, Blast_Score=104, Evalue=4e-23,
Organism=Homo sapiens, GI9910262, Length=165, Percent_Identity=36.3636363636364, Blast_Score=102, Evalue=1e-22,
Organism=Escherichia coli, GI87081689, Length=166, Percent_Identity=47.5903614457831, Blast_Score=162, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17510817, Length=173, Percent_Identity=32.3699421965318, Blast_Score=96, Evalue=9e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 19784; Mature: 19784

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIQIKGKLFDEQQIQTRVKELAEEIENDAEGTPIVIVAVLKGSMVFAADLMRYMKGSVQ
CEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCEE
LDTVATSSYGKKTVSSGSVQLRKDLDLDVEGKYVVIIEDIIDTGQTLKFLCKHMELHQPK
EEEEECCCCCCCCCCCCCEEEEECCCCCCCCCEEEEEHHHHCCCHHHHHHHHHHHHCCCC
QLKICTLLDKPARRLVQLDADYVGFEIPDEFVIGYGIDYAEQYRNLPYIGYVETT
CEEEEHHHCHHHHHHHHHCCCCCCCCCCCCEEEECCCCHHHHHCCCCEEEEEECC
>Mature Secondary Structure
MKIQIKGKLFDEQQIQTRVKELAEEIENDAEGTPIVIVAVLKGSMVFAADLMRYMKGSVQ
CEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCEE
LDTVATSSYGKKTVSSGSVQLRKDLDLDVEGKYVVIIEDIIDTGQTLKFLCKHMELHQPK
EEEEECCCCCCCCCCCCCEEEEECCCCCCCCCEEEEEHHHHCCCHHHHHHHHHHHHCCCC
QLKICTLLDKPARRLVQLDADYVGFEIPDEFVIGYGIDYAEQYRNLPYIGYVETT
CEEEEHHHCHHHHHHHHHCCCCCCCCCCCCEEEECCCCHHHHHCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2388850 [H]