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The map label for this gene is accC1 [H]

Identifier: 229916255

GI number: 229916255

Start: 478410

End: 479753

Strand: Reverse

Name: accC1 [H]

Synonym: EAT1b_0524

Alternate gene names: 229916255

Gene position: 479753-478410 (Counterclockwise)

Preceding gene: 229916256

Following gene: 229916254

Centisome position: 15.99

GC content: 50.3

Gene sequence:

>1344_bases
ATGAAATTATTAATTGCTAATCGCGGGGAAATCGCGGTTCGAATCATACGTGCAGCAAAAGAATTGAATATTCCGACGGT
CGCTGTCTTTTCTGAGGCAGATCGTGAAGCGTTACATGTTCATTTGGCTGACGAGGCCTATTGTATCGGTCCGAATCCGT
CGAAGGACTCCTATTTAAATATCCCAAATATCTTATCAGTCGCCTGCGCCGTGGATGCGACGATGGTACATCCGGGTTAC
GGCTTTTTGGCTGAAAATGCCGAGTTCGCCGAGATGTGCGAGGCGTGCGGGATTCAATTTGTCGGCCCGAGCAGCTATGC
GATTCGCAAAATGGGAATCAAGGATGAGGCCAAACGAACGATGATCGAGTCAGGTGTTCCTGTCGTTCCGGGTTCAAGTG
GGGTCGTCACCGACGAAGAAGCCATGGAACTCGCACGTGAAATGGGCTATCCCGTCATCATCAAGGCGACAGCCGGTGGT
GGAGGACGTGGCATTCGCGTCGCTCGAGACGAGGATGAACTCGTTTCAGGGTTGGTCGCGACACGTAAAGAAGCGAAGCA
GGCGTTTGGGAATGGGGACGTGTATCTTGAGAAGTTCATCGAGTCGTTCCGTCACGTCGAAGTGCAGGTTCTTGCTGATC
AATTCGGCAATGTCATTCACTTAGGTGAACGTGATTGTACGATCCAACGACGCATGCAGAAACTAGTCGAAGAGGCGCCA
TCACCTGCCATTGATGAAACGACACGTCAACTGATGGGGGATGCGGCAGTCAAAGCGGCAAAAGCCATTCAGTACTCGGG
AGCGGGGACCATCGAGTTCATTTACGTTCCGGAATCAAACGAGTTCTACTTCATGGAGATGAATACCCGGATTCAAGTCG
AGCATCCCGTCACCGAGATGATCACAGGATTCGATCTCGTTCAAGCGCAGCTCGAAGTGGCGCTCGGCCATCCGCTCGCC
ATCTCACAAGAGGACATTACGTTCTCAGGACATTCCATCGAATGTCGAATCAATGCGGAGGACCCGTTTATGGACTTCCG
TCCGATGGCAGGGAAAATTGACCAATATATCGTTCCAGGCGGCATGGGTGTCCGTGTCGATAGTGGACTCTATGCAGGTG
CCATGATCCCACCGTTCTATGACTCGATGGTTGCGAAATTGATTGTCCATGCACCAACGCGTGATGAGGCCATTCTGAAA
ATGTTGCGTGCTTTAGATGAGTTTACGGTTTCGGGGATTAAAACGACGATTCCATTCCATCAACAAGTCATGGCACATGA
GCAGTTCCGTATTGGAACGTTCGATACGAAATTCGTTGAAAAAGAAATGTCATTGGCAAAATAA

Upstream 100 bases:

>100_bases
GTTGAAGCGGAAATCAGTGGCGAAATCGTAGAAGTGTTAGTCGCCGATGGCGATCTCGTCGAATTCGGTCAACCGCTCTT
CAGCGTGAAGTGAGGTCGTT

Downstream 100 bases:

>100_bases
CATGAACCAGGAAGCCCGAACATTATTTCGGTTTCCTGGTTTTTTGTACTGAATTTATGAGTGCTTTATGCTAAACTATC
ACAATGAAAGCATGTAAAAG

Product: acetyl-CoA carboxylase, biotin carboxylase

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A 1; ACC 1 [H]

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MKLLIANRGEIAVRIIRAAKELNIPTVAVFSEADREALHVHLADEAYCIGPNPSKDSYLNIPNILSVACAVDATMVHPGY
GFLAENAEFAEMCEACGIQFVGPSSYAIRKMGIKDEAKRTMIESGVPVVPGSSGVVTDEEAMELAREMGYPVIIKATAGG
GGRGIRVARDEDELVSGLVATRKEAKQAFGNGDVYLEKFIESFRHVEVQVLADQFGNVIHLGERDCTIQRRMQKLVEEAP
SPAIDETTRQLMGDAAVKAAKAIQYSGAGTIEFIYVPESNEFYFMEMNTRIQVEHPVTEMITGFDLVQAQLEVALGHPLA
ISQEDITFSGHSIECRINAEDPFMDFRPMAGKIDQYIVPGGMGVRVDSGLYAGAMIPPFYDSMVAKLIVHAPTRDEAILK
MLRALDEFTVSGIKTTIPFHQQVMAHEQFRIGTFDTKFVEKEMSLAK

Sequences:

>Translated_447_residues
MKLLIANRGEIAVRIIRAAKELNIPTVAVFSEADREALHVHLADEAYCIGPNPSKDSYLNIPNILSVACAVDATMVHPGY
GFLAENAEFAEMCEACGIQFVGPSSYAIRKMGIKDEAKRTMIESGVPVVPGSSGVVTDEEAMELAREMGYPVIIKATAGG
GGRGIRVARDEDELVSGLVATRKEAKQAFGNGDVYLEKFIESFRHVEVQVLADQFGNVIHLGERDCTIQRRMQKLVEEAP
SPAIDETTRQLMGDAAVKAAKAIQYSGAGTIEFIYVPESNEFYFMEMNTRIQVEHPVTEMITGFDLVQAQLEVALGHPLA
ISQEDITFSGHSIECRINAEDPFMDFRPMAGKIDQYIVPGGMGVRVDSGLYAGAMIPPFYDSMVAKLIVHAPTRDEAILK
MLRALDEFTVSGIKTTIPFHQQVMAHEQFRIGTFDTKFVEKEMSLAK
>Mature_447_residues
MKLLIANRGEIAVRIIRAAKELNIPTVAVFSEADREALHVHLADEAYCIGPNPSKDSYLNIPNILSVACAVDATMVHPGY
GFLAENAEFAEMCEACGIQFVGPSSYAIRKMGIKDEAKRTMIESGVPVVPGSSGVVTDEEAMELAREMGYPVIIKATAGG
GGRGIRVARDEDELVSGLVATRKEAKQAFGNGDVYLEKFIESFRHVEVQVLADQFGNVIHLGERDCTIQRRMQKLVEEAP
SPAIDETTRQLMGDAAVKAAKAIQYSGAGTIEFIYVPESNEFYFMEMNTRIQVEHPVTEMITGFDLVQAQLEVALGHPLA
ISQEDITFSGHSIECRINAEDPFMDFRPMAGKIDQYIVPGGMGVRVDSGLYAGAMIPPFYDSMVAKLIVHAPTRDEAILK
MLRALDEFTVSGIKTTIPFHQQVMAHEQFRIGTFDTKFVEKEMSLAK

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=440, Percent_Identity=49.7727272727273, Blast_Score=443, Evalue=1e-124,
Organism=Homo sapiens, GI189095269, Length=441, Percent_Identity=48.7528344671202, Blast_Score=419, Evalue=1e-117,
Organism=Homo sapiens, GI65506442, Length=441, Percent_Identity=48.7528344671202, Blast_Score=419, Evalue=1e-117,
Organism=Homo sapiens, GI295821183, Length=441, Percent_Identity=48.7528344671202, Blast_Score=418, Evalue=1e-117,
Organism=Homo sapiens, GI106049528, Length=450, Percent_Identity=47.5555555555556, Blast_Score=397, Evalue=1e-110,
Organism=Homo sapiens, GI106049295, Length=450, Percent_Identity=47.5555555555556, Blast_Score=397, Evalue=1e-110,
Organism=Homo sapiens, GI106049292, Length=450, Percent_Identity=47.5555555555556, Blast_Score=397, Evalue=1e-110,
Organism=Homo sapiens, GI38679977, Length=501, Percent_Identity=30.3393213572854, Blast_Score=234, Evalue=2e-61,
Organism=Homo sapiens, GI38679967, Length=501, Percent_Identity=30.3393213572854, Blast_Score=234, Evalue=2e-61,
Organism=Homo sapiens, GI38679971, Length=501, Percent_Identity=30.3393213572854, Blast_Score=234, Evalue=2e-61,
Organism=Homo sapiens, GI38679960, Length=501, Percent_Identity=30.3393213572854, Blast_Score=234, Evalue=2e-61,
Organism=Homo sapiens, GI38679974, Length=501, Percent_Identity=30.3393213572854, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI134142062, Length=501, Percent_Identity=29.940119760479, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI18105007, Length=252, Percent_Identity=25.7936507936508, Blast_Score=80, Evalue=4e-15,
Organism=Escherichia coli, GI1789654, Length=446, Percent_Identity=54.4843049327354, Blast_Score=457, Evalue=1e-130,
Organism=Escherichia coli, GI1786216, Length=279, Percent_Identity=23.2974910394265, Blast_Score=62, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17567343, Length=441, Percent_Identity=45.3514739229025, Blast_Score=400, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI71987519, Length=440, Percent_Identity=47.9545454545455, Blast_Score=398, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17562816, Length=450, Percent_Identity=44.6666666666667, Blast_Score=375, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI71997168, Length=510, Percent_Identity=29.0196078431373, Blast_Score=213, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI71997163, Length=510, Percent_Identity=29.0196078431373, Blast_Score=212, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI133931226, Length=490, Percent_Identity=27.9591836734694, Blast_Score=202, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI193204318, Length=260, Percent_Identity=25, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6319685, Length=427, Percent_Identity=42.8571428571429, Blast_Score=361, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6319695, Length=447, Percent_Identity=45.1901565995526, Blast_Score=358, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6321376, Length=447, Percent_Identity=45.8612975391499, Blast_Score=349, Evalue=6e-97,
Organism=Saccharomyces cerevisiae, GI6323863, Length=457, Percent_Identity=31.0722100656455, Blast_Score=227, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6324343, Length=514, Percent_Identity=29.9610894941634, Blast_Score=223, Evalue=5e-59,
Organism=Saccharomyces cerevisiae, GI6322331, Length=197, Percent_Identity=24.3654822335025, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24651757, Length=444, Percent_Identity=46.3963963963964, Blast_Score=423, Evalue=1e-118,
Organism=Drosophila melanogaster, GI281363050, Length=451, Percent_Identity=47.8935698447894, Blast_Score=398, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24652224, Length=451, Percent_Identity=47.8935698447894, Blast_Score=398, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24652222, Length=451, Percent_Identity=47.8935698447894, Blast_Score=398, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24652220, Length=451, Percent_Identity=47.8935698447894, Blast_Score=398, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24652218, Length=451, Percent_Identity=47.8935698447894, Blast_Score=398, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24652212, Length=451, Percent_Identity=47.8935698447894, Blast_Score=398, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24652210, Length=451, Percent_Identity=47.8935698447894, Blast_Score=398, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24652214, Length=451, Percent_Identity=47.8935698447894, Blast_Score=398, Evalue=1e-111,
Organism=Drosophila melanogaster, GI19921944, Length=451, Percent_Identity=47.8935698447894, Blast_Score=398, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24652216, Length=451, Percent_Identity=47.8935698447894, Blast_Score=398, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24651759, Length=408, Percent_Identity=45.343137254902, Blast_Score=380, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24586458, Length=496, Percent_Identity=29.4354838709677, Blast_Score=210, Evalue=1e-54,
Organism=Drosophila melanogaster, GI161076409, Length=496, Percent_Identity=29.4354838709677, Blast_Score=210, Evalue=2e-54,
Organism=Drosophila melanogaster, GI161076407, Length=496, Percent_Identity=29.4354838709677, Blast_Score=210, Evalue=2e-54,
Organism=Drosophila melanogaster, GI24586460, Length=496, Percent_Identity=29.4354838709677, Blast_Score=210, Evalue=2e-54,
Organism=Drosophila melanogaster, GI45555749, Length=271, Percent_Identity=25.0922509225092, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24642586, Length=271, Percent_Identity=25.0922509225092, Blast_Score=79, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 49074; Mature: 49074

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLIANRGEIAVRIIRAAKELNIPTVAVFSEADREALHVHLADEAYCIGPNPSKDSYLN
CEEEEECCCCHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEECCCEEEECCCCCCCCEEC
IPNILSVACAVDATMVHPGYGFLAENAEFAEMCEACGIQFVGPSSYAIRKMGIKDEAKRT
CCHHHHHHHHHCEEEECCCCCEEECCCHHHHHHHHCCEEEECCCCHHEEECCCHHHHHHH
MIESGVPVVPGSSGVVTDEEAMELAREMGYPVIIKATAGGGGRGIRVARDEDELVSGLVA
HHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCEEEECCHHHHHHHHHH
TRKEAKQAFGNGDVYLEKFIESFRHVEVQVLADQFGNVIHLGERDCTIQRRMQKLVEEAP
HHHHHHHHCCCCCHHHHHHHHHHHHEEEEEEHHHCCCEEEECCCCCHHHHHHHHHHHHCC
SPAIDETTRQLMGDAAVKAAKAIQYSGAGTIEFIYVPESNEFYFMEMNTRIQVEHPVTEM
CCCHHHHHHHHHHHHHHHHHHHHEECCCCEEEEEEEECCCCEEEEEECCEEEECCCHHHH
ITGFDLVQAQLEVALGHPLAISQEDITFSGHSIECRINAEDPFMDFRPMAGKIDQYIVPG
HHHHHHHHHHHHHHCCCCEEECCCCEEECCCEEEEEECCCCCCCCCCCCCCCCCCEEECC
GMGVRVDSGLYAGAMIPPFYDSMVAKLIVHAPTRDEAILKMLRALDEFTVSGIKTTIPFH
CCCEEECCCEEECCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCEEECCCHH
QQVMAHEQFRIGTFDTKFVEKEMSLAK
HHHHHHCCEEECCCCHHHHHHHHHHCC
>Mature Secondary Structure
MKLLIANRGEIAVRIIRAAKELNIPTVAVFSEADREALHVHLADEAYCIGPNPSKDSYLN
CEEEEECCCCHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEECCCEEEECCCCCCCCEEC
IPNILSVACAVDATMVHPGYGFLAENAEFAEMCEACGIQFVGPSSYAIRKMGIKDEAKRT
CCHHHHHHHHHCEEEECCCCCEEECCCHHHHHHHHCCEEEECCCCHHEEECCCHHHHHHH
MIESGVPVVPGSSGVVTDEEAMELAREMGYPVIIKATAGGGGRGIRVARDEDELVSGLVA
HHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCEEEECCHHHHHHHHHH
TRKEAKQAFGNGDVYLEKFIESFRHVEVQVLADQFGNVIHLGERDCTIQRRMQKLVEEAP
HHHHHHHHCCCCCHHHHHHHHHHHHEEEEEEHHHCCCEEEECCCCCHHHHHHHHHHHHCC
SPAIDETTRQLMGDAAVKAAKAIQYSGAGTIEFIYVPESNEFYFMEMNTRIQVEHPVTEM
CCCHHHHHHHHHHHHHHHHHHHHEECCCCEEEEEEEECCCCEEEEEECCEEEECCCHHHH
ITGFDLVQAQLEVALGHPLAISQEDITFSGHSIECRINAEDPFMDFRPMAGKIDQYIVPG
HHHHHHHHHHHHHHCCCCEEECCCCEEECCCEEEEEECCCCCCCCCCCCCCCCCCEEECC
GMGVRVDSGLYAGAMIPPFYDSMVAKLIVHAPTRDEAILKMLRALDEFTVSGIKTTIPFH
CCCEEECCCEEECCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCEEECCCHH
QQVMAHEQFRIGTFDTKFVEKEMSLAK
HHHHHHCCEEECCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7592499; 8969508; 9384377 [H]