Click here to switch to the map view.

The map label for this gene is bfmBAB [H]

Identifier: 229916237

GI number: 229916237

Start: 459387

End: 460364

Strand: Reverse

Name: bfmBAB [H]

Synonym: EAT1b_0506

Alternate gene names: 229916237

Gene position: 460364-459387 (Counterclockwise)

Preceding gene: 229916238

Following gene: 229916236

Centisome position: 15.35

GC content: 51.94

Gene sequence:

>978_bases
ATGAAAACGTTTATCGAAGCGATCAATGAAGCGATTCATGAGGAAATGGAGCGCGACGAAAACGTCTTCGTCGTCGGGGA
AGACGTCGGCGTTCGTGGTGGTGTATTCCGAGCCACTCAAGGATTGATTGAAAAGTATGGAGAGGATCGTGTCATCGACG
CACCGCTCGCTGAGAGTGCGATTGCCGGAGTCGGGGTCGGAGCTGCCATGTACGGCATGCGACCGATCGCAGAAATGCAA
TTCGCAGACTTTATCATGCCAGCAGTGAACCAAATCGTTTCTGAAGCGGCAAAAATTCGATACCGTTCAAACAACGATTG
GACATGTCCGATGGTCATCCGAGCTCCTTTCGGTGGCGGTATTCACGGAGCACTCTATCACTCGCAATCGGTCGAGGCGA
TGTTCAGTTCGACGCCAGGTCTAAAAGTCGTCATTCCATCTGACCCAGTCGATGCGAAGGGGTTGTTGAAAGCAGCAATC
CGTTCGAACGACCCTGTCCTCTTCTTCGAGCATAAGCGCGCCTATCGTCTTTTGAAGGCAGACTTGCCGACAGACGAATA
TACGGTTGAAATCGGTAAGGCTGCGGTTAAACGGGAAGGTGACGATATCACGATCATCACGTACGGTCTTTGTGTGCATA
TGGCACAAGAGGCAGCGAAAACGCTCGAAGAAGAAGGGATCAGCACGCACATCCTCGATCTTCGTACCGTCTACCCGCTC
GACCAAGAAGCGATCATCGAGTCAGTCAAGAAGACAGGTAAAGTGCTACTCGTGACAGAGGACAACAAAGAAGGAAGCAT
CATCGGAGAAGTAGCGGCGATTATCGCGGAGAAGGCGCTCTTCGAACTCGATGCGCCGATTGAACGCTTAGCAGGTCCTG
ATGTGCCGGCAATGCCGTATGCACCACCGATGGAAAAATTCTTTATCGTATCCCCAGAAAAAATTGCCGAGCGGGCGCGT
CAGCTCGCGGCGTTTTAA

Upstream 100 bases:

>100_bases
AAATCGATGCTGAAGTGAATGAAGCGACGACATATGCGGACAAAGCACCGTATGCATCGCCTGAATCTGCACTAGATTAC
GTCTATGAGGAGGAAAAATG

Downstream 100 bases:

>100_bases
GGAGGCATCTCCATGGAACAAACGATTACCATGCCCCAACTTGGGGAGAGTGTGACTGAAGGCACGATCACGACCTATCT
CGTCAAACCGGGCGACCGTG

Product: transketolase central region

Products: NA

Alternate protein names: Branched-chain alpha-keto acid dehydrogenase E1 component beta chain; BCKDH E1-beta [H]

Number of amino acids: Translated: 325; Mature: 325

Protein sequence:

>325_residues
MKTFIEAINEAIHEEMERDENVFVVGEDVGVRGGVFRATQGLIEKYGEDRVIDAPLAESAIAGVGVGAAMYGMRPIAEMQ
FADFIMPAVNQIVSEAAKIRYRSNNDWTCPMVIRAPFGGGIHGALYHSQSVEAMFSSTPGLKVVIPSDPVDAKGLLKAAI
RSNDPVLFFEHKRAYRLLKADLPTDEYTVEIGKAAVKREGDDITIITYGLCVHMAQEAAKTLEEEGISTHILDLRTVYPL
DQEAIIESVKKTGKVLLVTEDNKEGSIIGEVAAIIAEKALFELDAPIERLAGPDVPAMPYAPPMEKFFIVSPEKIAERAR
QLAAF

Sequences:

>Translated_325_residues
MKTFIEAINEAIHEEMERDENVFVVGEDVGVRGGVFRATQGLIEKYGEDRVIDAPLAESAIAGVGVGAAMYGMRPIAEMQ
FADFIMPAVNQIVSEAAKIRYRSNNDWTCPMVIRAPFGGGIHGALYHSQSVEAMFSSTPGLKVVIPSDPVDAKGLLKAAI
RSNDPVLFFEHKRAYRLLKADLPTDEYTVEIGKAAVKREGDDITIITYGLCVHMAQEAAKTLEEEGISTHILDLRTVYPL
DQEAIIESVKKTGKVLLVTEDNKEGSIIGEVAAIIAEKALFELDAPIERLAGPDVPAMPYAPPMEKFFIVSPEKIAERAR
QLAAF
>Mature_325_residues
MKTFIEAINEAIHEEMERDENVFVVGEDVGVRGGVFRATQGLIEKYGEDRVIDAPLAESAIAGVGVGAAMYGMRPIAEMQ
FADFIMPAVNQIVSEAAKIRYRSNNDWTCPMVIRAPFGGGIHGALYHSQSVEAMFSSTPGLKVVIPSDPVDAKGLLKAAI
RSNDPVLFFEHKRAYRLLKADLPTDEYTVEIGKAAVKREGDDITIITYGLCVHMAQEAAKTLEEEGISTHILDLRTVYPL
DQEAIIESVKKTGKVLLVTEDNKEGSIIGEVAAIIAEKALFELDAPIERLAGPDVPAMPYAPPMEKFFIVSPEKIAERAR
QLAAF

Specific function: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components:branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltran

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557353, Length=322, Percent_Identity=41.9254658385093, Blast_Score=264, Evalue=7e-71,
Organism=Homo sapiens, GI34101272, Length=322, Percent_Identity=41.9254658385093, Blast_Score=264, Evalue=7e-71,
Organism=Homo sapiens, GI156564403, Length=307, Percent_Identity=40.0651465798046, Blast_Score=228, Evalue=7e-60,
Organism=Homo sapiens, GI291084858, Length=307, Percent_Identity=38.7622149837134, Blast_Score=211, Evalue=6e-55,
Organism=Homo sapiens, GI133778974, Length=186, Percent_Identity=32.258064516129, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI205277463, Length=285, Percent_Identity=27.0175438596491, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI4507521, Length=285, Percent_Identity=27.0175438596491, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17506935, Length=296, Percent_Identity=44.2567567567568, Blast_Score=248, Evalue=4e-66,
Organism=Caenorhabditis elegans, GI17538422, Length=323, Percent_Identity=39.938080495356, Blast_Score=235, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI17539652, Length=290, Percent_Identity=27.2413793103448, Blast_Score=68, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6319698, Length=310, Percent_Identity=40.3225806451613, Blast_Score=236, Evalue=4e-63,
Organism=Drosophila melanogaster, GI160714832, Length=312, Percent_Identity=42.6282051282051, Blast_Score=246, Evalue=2e-65,
Organism=Drosophila melanogaster, GI160714828, Length=312, Percent_Identity=42.6282051282051, Blast_Score=245, Evalue=2e-65,
Organism=Drosophila melanogaster, GI21358145, Length=307, Percent_Identity=40.3908794788274, Blast_Score=232, Evalue=3e-61,
Organism=Drosophila melanogaster, GI24650940, Length=307, Percent_Identity=40.3908794788274, Blast_Score=232, Evalue=3e-61,
Organism=Drosophila melanogaster, GI24650943, Length=89, Percent_Identity=42.6966292134831, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24650945, Length=89, Percent_Identity=42.6966292134831, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI45551847, Length=285, Percent_Identity=26.6666666666667, Blast_Score=71, Evalue=9e-13,
Organism=Drosophila melanogaster, GI45550715, Length=285, Percent_Identity=26.6666666666667, Blast_Score=71, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24645119, Length=255, Percent_Identity=27.843137254902, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.4 [H]

Molecular weight: Translated: 35505; Mature: 35505

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTFIEAINEAIHEEMERDENVFVVGEDVGVRGGVFRATQGLIEKYGEDRVIDAPLAESA
CCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCEECCCHHHHH
IAGVGVGAAMYGMRPIAEMQFADFIMPAVNQIVSEAAKIRYRSNNDWTCPMVIRAPFGGG
HHHCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCEECEEEEECCCCCC
IHGALYHSQSVEAMFSSTPGLKVVIPSDPVDAKGLLKAAIRSNDPVLFFEHKRAYRLLKA
CHHHHCCCHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHCCCCCEEEEECHHHHHHHHC
DLPTDEYTVEIGKAAVKREGDDITIITYGLCVHMAQEAAKTLEEEGISTHILDLRTVYPL
CCCCCCEEEEHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHCCCC
DQEAIIESVKKTGKVLLVTEDNKEGSIIGEVAAIIAEKALFELDAPIERLAGPDVPAMPY
CHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCC
APPMEKFFIVSPEKIAERARQLAAF
CCCCCCEEEECHHHHHHHHHHHCCC
>Mature Secondary Structure
MKTFIEAINEAIHEEMERDENVFVVGEDVGVRGGVFRATQGLIEKYGEDRVIDAPLAESA
CCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCEECCCHHHHH
IAGVGVGAAMYGMRPIAEMQFADFIMPAVNQIVSEAAKIRYRSNNDWTCPMVIRAPFGGG
HHHCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCEECEEEEECCCCCC
IHGALYHSQSVEAMFSSTPGLKVVIPSDPVDAKGLLKAAIRSNDPVLFFEHKRAYRLLKA
CHHHHCCCHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHCCCCCEEEEECHHHHHHHHC
DLPTDEYTVEIGKAAVKREGDDITIITYGLCVHMAQEAAKTLEEEGISTHILDLRTVYPL
CCCCCCEEEEHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHCCCC
DQEAIIESVKKTGKVLLVTEDNKEGSIIGEVAAIIAEKALFELDAPIERLAGPDVPAMPY
CHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCC
APPMEKFFIVSPEKIAERARQLAAF
CCCCCCEEEECHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8504804; 8969508; 9384377 [H]