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The map label for this gene is bfmBAA [H]

Identifier: 229916238

GI number: 229916238

Start: 460364

End: 461371

Strand: Reverse

Name: bfmBAA [H]

Synonym: EAT1b_0507

Alternate gene names: 229916238

Gene position: 461371-460364 (Counterclockwise)

Preceding gene: 229916239

Following gene: 229916237

Centisome position: 15.38

GC content: 50.6

Gene sequence:

>1008_bases
ATGGAACAGATGACTGTAAACTCATATGAAGAGCTTGGTTTAACAAAACAAGATTTATTGGCGATGTACGAAACGATGGT
ACGTGCCCGCAAAATCGATGAACGGATGTGGAAGTTGAACCGCGCCGGGAAAATCCCATTCGTCGTCTCATGTCAAGGAC
AAGAAGCGGCGCAAGTCGGTGCGGCGTTCGCACTCGAAAAAGGAATCGACTACGTCTTGCCTTATTATCGTGATGTGGCG
GTCGTCCTTCACTTCGGTCAAACGTCAAGAGACTTGATGTTGTCGGCATTCGCGAAAGCGGAAGACCCGAACTCAGGTGG
TCGTCAGATGCCTGGTCACTTCGGATCGAAAGCACATCGCATCGTAACGGGTTCATCTCCGGTCACGACACAAGTACCTC
ATGCAGTCGGGATCGCACTTGCGGCGAAGATGAAAAAAGAAGAACTCGTCACGTTCGTTTCGTTCGGAGAAGGGTCTTCG
AACCAAGGAGACTTCCATGAAGGCGCAAACTTTGCAGGTGTCCACAAGTTGCCGGTCATCTTGTTCTGTGAGAACAACAA
GTATGCGATTTCGGTTCCTCTTACGAAACAGTTGGCATGTGAGCGCGTATCAGACCGTGCAAAAGGTTACGGCATGCCAG
GTGTGACAGTCGACGGGACAGACCCGATCGCCGTCTATGCGGTCGTGAAGGAAGCGCGTGAACGTGCACTTCGCGGAGAA
GGACCGACATTAATCGAAGCAGAAGTTGAACGTCTCGTGCCACACTCATCGGATGACGATGACAAAGCGTACCGTTCAGC
TGAAGAATTGGCGGGGTTAAAAGAGCGGGATGGCATTCAATTGTTCCGTCAACGACTTGTGAACGACGGAATCGCAACGG
CGGAGACACTTGCTGAAATCGATGCACAAATCGATGCTGAAGTGAATGAAGCGACGACATATGCGGACAAAGCACCGTAT
GCATCGCCTGAATCTGCACTAGATTACGTCTATGAGGAGGAAAAATGA

Upstream 100 bases:

>100_bases
GGGACAACTTGTGCACCCGCATCCTGCACTGAGCGAAGCCTTCCAAGAAGCGGCTCTTGCCGTCGATGGATTACCGATTC
ACGCCTAAGGAGGAACAAGG

Downstream 100 bases:

>100_bases
TGAAAACGTTTATCGAAGCGATCAATGAAGCGATTCATGAGGAAATGGAGCGCGACGAAAACGTCTTCGTCGTCGGGGAA
GACGTCGGCGTTCGTGGTGG

Product: 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)

Products: NA

Alternate protein names: Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain; BCKDH E1-alpha [H]

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MEQMTVNSYEELGLTKQDLLAMYETMVRARKIDERMWKLNRAGKIPFVVSCQGQEAAQVGAAFALEKGIDYVLPYYRDVA
VVLHFGQTSRDLMLSAFAKAEDPNSGGRQMPGHFGSKAHRIVTGSSPVTTQVPHAVGIALAAKMKKEELVTFVSFGEGSS
NQGDFHEGANFAGVHKLPVILFCENNKYAISVPLTKQLACERVSDRAKGYGMPGVTVDGTDPIAVYAVVKEARERALRGE
GPTLIEAEVERLVPHSSDDDDKAYRSAEELAGLKERDGIQLFRQRLVNDGIATAETLAEIDAQIDAEVNEATTYADKAPY
ASPESALDYVYEEEK

Sequences:

>Translated_335_residues
MEQMTVNSYEELGLTKQDLLAMYETMVRARKIDERMWKLNRAGKIPFVVSCQGQEAAQVGAAFALEKGIDYVLPYYRDVA
VVLHFGQTSRDLMLSAFAKAEDPNSGGRQMPGHFGSKAHRIVTGSSPVTTQVPHAVGIALAAKMKKEELVTFVSFGEGSS
NQGDFHEGANFAGVHKLPVILFCENNKYAISVPLTKQLACERVSDRAKGYGMPGVTVDGTDPIAVYAVVKEARERALRGE
GPTLIEAEVERLVPHSSDDDDKAYRSAEELAGLKERDGIQLFRQRLVNDGIATAETLAEIDAQIDAEVNEATTYADKAPY
ASPESALDYVYEEEK
>Mature_335_residues
MEQMTVNSYEELGLTKQDLLAMYETMVRARKIDERMWKLNRAGKIPFVVSCQGQEAAQVGAAFALEKGIDYVLPYYRDVA
VVLHFGQTSRDLMLSAFAKAEDPNSGGRQMPGHFGSKAHRIVTGSSPVTTQVPHAVGIALAAKMKKEELVTFVSFGEGSS
NQGDFHEGANFAGVHKLPVILFCENNKYAISVPLTKQLACERVSDRAKGYGMPGVTVDGTDPIAVYAVVKEARERALRGE
GPTLIEAEVERLVPHSSDDDDKAYRSAEELAGLKERDGIQLFRQRLVNDGIATAETLAEIDAQIDAEVNEATTYADKAPY
ASPESALDYVYEEEK

Specific function: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components:branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltran

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the BCKDHA family [H]

Homologues:

Organism=Homo sapiens, GI11386135, Length=329, Percent_Identity=36.7781155015198, Blast_Score=202, Evalue=4e-52,
Organism=Homo sapiens, GI258645172, Length=329, Percent_Identity=36.7781155015198, Blast_Score=198, Evalue=6e-51,
Organism=Homo sapiens, GI4885543, Length=326, Percent_Identity=31.2883435582822, Blast_Score=142, Evalue=4e-34,
Organism=Homo sapiens, GI4505685, Length=326, Percent_Identity=30.9815950920245, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI291084742, Length=326, Percent_Identity=30.9815950920245, Blast_Score=141, Evalue=7e-34,
Organism=Homo sapiens, GI291084744, Length=329, Percent_Identity=29.7872340425532, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI291084757, Length=320, Percent_Identity=28.4375, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI86563355, Length=330, Percent_Identity=36.6666666666667, Blast_Score=204, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI86563357, Length=330, Percent_Identity=36.6666666666667, Blast_Score=204, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI17536047, Length=320, Percent_Identity=30.9375, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI32564172, Length=320, Percent_Identity=30.9375, Blast_Score=136, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6321026, Length=333, Percent_Identity=32.1321321321321, Blast_Score=144, Evalue=2e-35,
Organism=Drosophila melanogaster, GI21355903, Length=259, Percent_Identity=37.8378378378378, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24639748, Length=306, Percent_Identity=31.3725490196078, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24639744, Length=310, Percent_Identity=30, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI28571106, Length=310, Percent_Identity=30, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24639740, Length=310, Percent_Identity=30, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24639746, Length=267, Percent_Identity=30.7116104868914, Blast_Score=114, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.4 [H]

Molecular weight: Translated: 36685; Mature: 36685

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQMTVNSYEELGLTKQDLLAMYETMVRARKIDERMWKLNRAGKIPFVVSCQGQEAAQVG
CCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHH
AAFALEKGIDYVLPYYRDVAVVLHFGQTSRDLMLSAFAKAEDPNSGGRQMPGHFGSKAHR
HHHHHHHCCHHHHHHHHCEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCE
IVTGSSPVTTQVPHAVGIALAAKMKKEELVTFVSFGEGSSNQGDFHEGANFAGVHKLPVI
EEECCCCCCCCCCHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCHHCCCCCCCEECCEEE
LFCENNKYAISVPLTKQLACERVSDRAKGYGMPGVTVDGTDPIAVYAVVKEARERALRGE
EEECCCCEEEECCCHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHHHHHCCC
GPTLIEAEVERLVPHSSDDDDKAYRSAEELAGLKERDGIQLFRQRLVNDGIATAETLAEI
CCEEHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHH
DAQIDAEVNEATTYADKAPYASPESALDYVYEEEK
HHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHCCCC
>Mature Secondary Structure
MEQMTVNSYEELGLTKQDLLAMYETMVRARKIDERMWKLNRAGKIPFVVSCQGQEAAQVG
CCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHH
AAFALEKGIDYVLPYYRDVAVVLHFGQTSRDLMLSAFAKAEDPNSGGRQMPGHFGSKAHR
HHHHHHHCCHHHHHHHHCEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCE
IVTGSSPVTTQVPHAVGIALAAKMKKEELVTFVSFGEGSSNQGDFHEGANFAGVHKLPVI
EEECCCCCCCCCCHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCHHCCCCCCCEECCEEE
LFCENNKYAISVPLTKQLACERVSDRAKGYGMPGVTVDGTDPIAVYAVVKEARERALRGE
EEECCCCEEEECCCHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHHHHHCCC
GPTLIEAEVERLVPHSSDDDDKAYRSAEELAGLKERDGIQLFRQRLVNDGIATAETLAEI
CCEEHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHH
DAQIDAEVNEATTYADKAPYASPESALDYVYEEEK
HHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8504804; 8969508; 9384377 [H]