BacMap

Definition	Exiguobacterium sp. AT1b, complete genome.
Accession	NC_012673
Length	2,999,895

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The map label for this gene is fadH [H]

Identifier: 229916224

GI number: 229916224

Start: 449863

End: 450627

Strand: Direct

Name: fadH [H]

Synonym: EAT1b_0493

Alternate gene names: 229916224

Gene position: 449863-450627 (Clockwise)

Preceding gene: 229916223

Following gene: 229916233

Centisome position: 15.0

GC content: 52.29

Gene sequence:

>765_bases
ATGAAAACGATTTGGATTACCGGGGGATCGTCCGGTATGGGGAAAGCAATGGCACTAAAATTTAAACAAGAAGGATGGAA
CGTTGCCATCAGTGGTCGAAACGAGGAACGACTACTTGAAGCGATGAGCGAATTGAATGCAATTGAAACAGGTCAAGCGA
TGAGTGTGCAACATGATGTTCGTGATTATGAAGGATGCGCTCAGGCACTCGCTGACATCGTATCTGCTTACGGTCCGGTC
CACGCACTCGTCAACAACGCCGCTGGTAATTTCGTCTGTCCGACGCTCGATTTGTCTCCGAACGGTTGGGCAAGCGTCAT
TGATATCGTCTTGAACGGGACATTCAATTGCACCCATGTTCTCGGGAAACATTGGGAAGCAGATGAAATCCGTGGCGGCT
CCATCATCAACATGGTCGCATCCTATGCGTGGCAGGCTGGTCCCGGTGTCGCACCGAGTGCGGCAGCGAAAGCAGGCGTC
TTGAACTTGACGCGAACACTCGCCGTTGAATGGGGCTACCAATTCGGCGCTCGCGTCAATGCCATCAGTCCCGGACCGAT
CGAACGGACCGGCGGTGCTGAAAAGCTCGTCTCCCATGTGAAGGAAGTGGAGCGCATTCGCCGGAATGTCCCGCTCGGAC
GTTTTGGGACACCTGAAGAAATCGCGGACCTCACTTACTGGATGGCATCAGACGAGATGCGCTATTTGAACGGAGATTGT
ATTTCATTAGACGGTGGACATTGGCTCAACAAACATCCATTCTAA

Upstream 100 bases:

>100_bases
AGAAATGATTCAACATGAATCAATATCTTATTAGAGGATTTTCGCATCGCAAGACGAATACTATAAATGAACGACCATTC
ATTTTCAAGGGGGAATTAAG

Downstream 100 bases:

>100_bases
CCTAGAAAAAGGGACGACCGAAATCAATCGGTCGTCCCTTTCATGTATCCATCCCGTCCCATTCTTCATGAAACTGGTTG
TAGAACCTTTCCATGAAGAC

Product: short chain dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 254; Mature: 254

Protein sequence:

>254_residues
MKTIWITGGSSGMGKAMALKFKQEGWNVAISGRNEERLLEAMSELNAIETGQAMSVQHDVRDYEGCAQALADIVSAYGPV
HALVNNAAGNFVCPTLDLSPNGWASVIDIVLNGTFNCTHVLGKHWEADEIRGGSIINMVASYAWQAGPGVAPSAAAKAGV
LNLTRTLAVEWGYQFGARVNAISPGPIERTGGAEKLVSHVKEVERIRRNVPLGRFGTPEEIADLTYWMASDEMRYLNGDC
ISLDGGHWLNKHPF

Sequences:

>Translated_254_residues
MKTIWITGGSSGMGKAMALKFKQEGWNVAISGRNEERLLEAMSELNAIETGQAMSVQHDVRDYEGCAQALADIVSAYGPV
HALVNNAAGNFVCPTLDLSPNGWASVIDIVLNGTFNCTHVLGKHWEADEIRGGSIINMVASYAWQAGPGVAPSAAAKAGV
LNLTRTLAVEWGYQFGARVNAISPGPIERTGGAEKLVSHVKEVERIRRNVPLGRFGTPEEIADLTYWMASDEMRYLNGDC
ISLDGGHWLNKHPF
>Mature_254_residues
MKTIWITGGSSGMGKAMALKFKQEGWNVAISGRNEERLLEAMSELNAIETGQAMSVQHDVRDYEGCAQALADIVSAYGPV
HALVNNAAGNFVCPTLDLSPNGWASVIDIVLNGTFNCTHVLGKHWEADEIRGGSIINMVASYAWQAGPGVAPSAAAKAGV
LNLTRTLAVEWGYQFGARVNAISPGPIERTGGAEKLVSHVKEVERIRRNVPLGRFGTPEEIADLTYWMASDEMRYLNGDC
ISLDGGHWLNKHPF

Specific function: Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3- enoyl-CoA

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503301, Length=225, Percent_Identity=38.2222222222222, Blast_Score=146, Evalue=2e-35,
Organism=Homo sapiens, GI10190704, Length=249, Percent_Identity=35.3413654618474, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI19923817, Length=255, Percent_Identity=32.156862745098, Blast_Score=134, Evalue=7e-32,
Organism=Homo sapiens, GI15277342, Length=255, Percent_Identity=29.4117647058824, Blast_Score=94, Evalue=9e-20,
Organism=Homo sapiens, GI32483357, Length=250, Percent_Identity=28, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI40254992, Length=249, Percent_Identity=26.5060240963855, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI126723750, Length=251, Percent_Identity=24.7011952191235, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI7705925, Length=247, Percent_Identity=23.4817813765182, Blast_Score=74, Evalue=9e-14,
Organism=Homo sapiens, GI5031737, Length=246, Percent_Identity=28.0487804878049, Blast_Score=69, Evalue=3e-12,
Organism=Escherichia coli, GI1789208, Length=250, Percent_Identity=30.8, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1788459, Length=250, Percent_Identity=29.2, Blast_Score=100, Evalue=8e-23,
Organism=Escherichia coli, GI2367175, Length=257, Percent_Identity=31.9066147859922, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI87082100, Length=255, Percent_Identity=32.156862745098, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1790717, Length=245, Percent_Identity=26.9387755102041, Blast_Score=82, Evalue=2e-17,
Organism=Escherichia coli, GI1787335, Length=251, Percent_Identity=28.6852589641434, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI87082160, Length=259, Percent_Identity=26.2548262548263, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI1786812, Length=255, Percent_Identity=27.0588235294118, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1789378, Length=254, Percent_Identity=28.3464566929134, Blast_Score=77, Evalue=9e-16,
Organism=Escherichia coli, GI1787526, Length=244, Percent_Identity=27.8688524590164, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1787905, Length=246, Percent_Identity=26.4227642276423, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI2367365, Length=246, Percent_Identity=26.0162601626016, Blast_Score=68, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17536651, Length=254, Percent_Identity=40.5511811023622, Blast_Score=175, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17536025, Length=254, Percent_Identity=40.1574803149606, Blast_Score=171, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17561272, Length=241, Percent_Identity=39.8340248962656, Blast_Score=160, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI17562904, Length=263, Percent_Identity=30.7984790874525, Blast_Score=104, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17562910, Length=260, Percent_Identity=30.7692307692308, Blast_Score=100, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17560150, Length=264, Percent_Identity=29.5454545454545, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17562908, Length=261, Percent_Identity=28.735632183908, Blast_Score=94, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17562906, Length=263, Percent_Identity=28.8973384030418, Blast_Score=94, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI17560220, Length=260, Percent_Identity=31.1538461538462, Blast_Score=94, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI72000259, Length=265, Percent_Identity=32.0754716981132, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17531453, Length=261, Percent_Identity=28.735632183908, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17563726, Length=264, Percent_Identity=31.0606060606061, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17561402, Length=255, Percent_Identity=26.6666666666667, Blast_Score=88, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17562990, Length=263, Percent_Identity=30.0380228136882, Blast_Score=87, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17559104, Length=265, Percent_Identity=30.188679245283, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71994604, Length=267, Percent_Identity=26.5917602996255, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI193204405, Length=264, Percent_Identity=28.7878787878788, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71994600, Length=261, Percent_Identity=25.6704980842912, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI25147288, Length=244, Percent_Identity=28.6885245901639, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17538480, Length=263, Percent_Identity=28.1368821292776, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI115534694, Length=245, Percent_Identity=24.8979591836735, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17551412, Length=263, Percent_Identity=26.9961977186312, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17555706, Length=251, Percent_Identity=28.6852589641434, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17560676, Length=247, Percent_Identity=25.5060728744939, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17560332, Length=263, Percent_Identity=26.615969581749, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17538182, Length=254, Percent_Identity=26.3779527559055, Blast_Score=70, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17565030, Length=266, Percent_Identity=28.1954887218045, Blast_Score=68, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6324126, Length=250, Percent_Identity=33.2, Blast_Score=131, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24639444, Length=249, Percent_Identity=31.7269076305221, Blast_Score=100, Evalue=9e-22,
Organism=Drosophila melanogaster, GI24644339, Length=251, Percent_Identity=29.0836653386454, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI21357041, Length=250, Percent_Identity=27.6, Blast_Score=91, Evalue=7e-19,
Organism=Drosophila melanogaster, GI28571526, Length=251, Percent_Identity=27.8884462151394, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24643142, Length=246, Percent_Identity=26.8292682926829, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI21355319, Length=248, Percent_Identity=25.4032258064516, Blast_Score=81, Evalue=8e-16,
Organism=Drosophila melanogaster, GI23397609, Length=252, Percent_Identity=26.984126984127, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI21356301, Length=212, Percent_Identity=28.7735849056604, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI17737361, Length=252, Percent_Identity=26.1904761904762, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.3.1.34 [H]

Molecular weight: Translated: 27425; Mature: 27425

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTIWITGGSSGMGKAMALKFKQEGWNVAISGRNEERLLEAMSELNAIETGQAMSVQHDV
CEEEEEECCCCCCCCCEEEEEECCCCEEEECCCCHHHHHHHHHHHHHHCCCCCHHHHHHH
RDYEGCAQALADIVSAYGPVHALVNNAAGNFVCPTLDLSPNGWASVIDIVLNGTFNCTHV
HHHHHHHHHHHHHHHHHCHHHHHHHCCCCCEECCEECCCCCCHHHHHHHHHCCCCCHHHH
LGKHWEADEIRGGSIINMVASYAWQAGPGVAPSAAAKAGVLNLTRTLAVEWGYQFGARVN
HCCCCCHHHCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHCCCEEC
AISPGPIERTGGAEKLVSHVKEVERIRRNVPLGRFGTPEEIADLTYWMASDEMRYLNGDC
CCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCE
ISLDGGHWLNKHPF
EEECCCCCCCCCCC
>Mature Secondary Structure
MKTIWITGGSSGMGKAMALKFKQEGWNVAISGRNEERLLEAMSELNAIETGQAMSVQHDV
CEEEEEECCCCCCCCCEEEEEECCCCEEEECCCCHHHHHHHHHHHHHHCCCCCHHHHHHH
RDYEGCAQALADIVSAYGPVHALVNNAAGNFVCPTLDLSPNGWASVIDIVLNGTFNCTHV
HHHHHHHHHHHHHHHHHCHHHHHHHCCCCCEECCEECCCCCCHHHHHHHHHCCCCCHHHH
LGKHWEADEIRGGSIINMVASYAWQAGPGVAPSAAAKAGVLNLTRTLAVEWGYQFGARVN
HCCCCCHHHCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHCCCEEC
AISPGPIERTGGAEKLVSHVKEVERIRRNVPLGRFGTPEEIADLTYWMASDEMRYLNGDC
CCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCE
ISLDGGHWLNKHPF
EEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]