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The map label for this gene is pdp [H]

Identifier: 229916180

GI number: 229916180

Start: 410546

End: 411847

Strand: Reverse

Name: pdp [H]

Synonym: EAT1b_0449

Alternate gene names: 229916180

Gene position: 411847-410546 (Counterclockwise)

Preceding gene: 229916181

Following gene: 229916179

Centisome position: 13.73

GC content: 50.77

Gene sequence:

>1302_bases
ATGCGTATGGTCGATTTGATTTTAAAGAAACGTAACGGTGGAGAATTGAACGAAGAGGAGATTCGCTTCGTTGTCGAAGG
TTTCACGAACGAATCAATCCCTGACTATCAAATGTCAGCCTTATCGATGGCCATCTATTTTAACGGGATGACTGAAAACG
AGACGGCTGCCTTGACGATGGAAATGGTAAAGTCGGGAGATACGATCGATCTTTCCAATATCGAAGGGAAAAAAGTCGAC
AAGCACTCAACGGGCGGCGTCGGTGACAAGATCAGCTTGATCGTGGCACCACTCGTCGCTTCAATCGGCATCCCTGTCGC
GAAGATGAGTGGTCGCGGTCTCGGTCACACAGGTGGTACGATCGATAAGCTCGAATCATTCCCAGGGTTCAACGTAGAAT
TGACGGAAGAGCAGTTCACGAAACAAGTAAACGATATCAAGATGTCGATCATCGGGCAGACAGGGAACTTGACGCCTGCG
GATAAGCGCTTGTACGCGCTTCGCGACGTCACGGCTACGGTTGAGTCGATTCCGCTCATCGCAAGTTCAATCATGTCGAA
GAAGATTGCAGCTGGAGCGGATAGTATCGTTCTTGACGTCAAGACAGGTTCTGGTGCGTTCATGAAATCGTTTGATGATG
CGAAAGCCCTCGCCGAAGAAATGGTCGCAATCGGGAAAAATGTCGGCCGTAAGACGGTCGCGGTCATCACGGACATGGAC
CAACCACTCGGTTTTGAAATCGGGAACGCGAACGAAGTGAAAGAAGCGATTGAAGTCCTCTCAGGTAAAGAAGTCGAAGA
TTTGAAAACAATCGCGCTCACGATCGCTGGACATATGGCTGTCCTCGGTGAGTTTTATCCGACGTTTGAAGAGGCGTATG
CCGACCTTGAGAAGCGCATTGCCGATGGACACGCCCTCGAGGTGTTCCGCAAGTTCGTCGAAGCACAAGGTGGCGACGCA
TCACTCGTCGATGATGTGACGAAATTACCACAAGCTTCATATGAGACGACATTTGTCGCAAAAGAAGCAGGTTATGTCGA
GTCGATCATCGCAGACGAAGTGGGTGTTGCGGCGATGCTTCTCGGTGCAGGACGCGCGACGAAAGAAGACAAAATCGATT
TCGCGGCAGGCATCACGCTTGAGAAGAAAGTCGGCGACCGTGTCGAGGCAGGCGATGTGATCGCGGTACTCCGTTCGAAC
ATCGAAGACATGTCTTCAGCCATCGAGCGTTTAGACCATGCGTATACGATCGGTGCAACGAAACCAGAGGCACGTCCACT
CGTTCACGCAGTGATTCAATAA

Upstream 100 bases:

>100_bases
GTCATCGAAACGACAGAGCGCGTTCGTCAAGACTTCCTCTCTCTCGTACGTGGCACGATTAAAAGCATGTAAGTAACTTA
ATTTTAGGAGGACGACAGTT

Downstream 100 bases:

>100_bases
GGCAGAACGTCTGTTTCCACAAAAAAGTGGAGACAGACGTGTTTTTTTGATAAGATGGGTAATGTGAGTGTCAAACAGCA
GGATACATATTATGAAAAAG

Product: pyrimidine-nucleoside phosphorylase

Products: NA

Alternate protein names: PYNP [H]

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MRMVDLILKKRNGGELNEEEIRFVVEGFTNESIPDYQMSALSMAIYFNGMTENETAALTMEMVKSGDTIDLSNIEGKKVD
KHSTGGVGDKISLIVAPLVASIGIPVAKMSGRGLGHTGGTIDKLESFPGFNVELTEEQFTKQVNDIKMSIIGQTGNLTPA
DKRLYALRDVTATVESIPLIASSIMSKKIAAGADSIVLDVKTGSGAFMKSFDDAKALAEEMVAIGKNVGRKTVAVITDMD
QPLGFEIGNANEVKEAIEVLSGKEVEDLKTIALTIAGHMAVLGEFYPTFEEAYADLEKRIADGHALEVFRKFVEAQGGDA
SLVDDVTKLPQASYETTFVAKEAGYVESIIADEVGVAAMLLGAGRATKEDKIDFAAGITLEKKVGDRVEAGDVIAVLRSN
IEDMSSAIERLDHAYTIGATKPEARPLVHAVIQ

Sequences:

>Translated_433_residues
MRMVDLILKKRNGGELNEEEIRFVVEGFTNESIPDYQMSALSMAIYFNGMTENETAALTMEMVKSGDTIDLSNIEGKKVD
KHSTGGVGDKISLIVAPLVASIGIPVAKMSGRGLGHTGGTIDKLESFPGFNVELTEEQFTKQVNDIKMSIIGQTGNLTPA
DKRLYALRDVTATVESIPLIASSIMSKKIAAGADSIVLDVKTGSGAFMKSFDDAKALAEEMVAIGKNVGRKTVAVITDMD
QPLGFEIGNANEVKEAIEVLSGKEVEDLKTIALTIAGHMAVLGEFYPTFEEAYADLEKRIADGHALEVFRKFVEAQGGDA
SLVDDVTKLPQASYETTFVAKEAGYVESIIADEVGVAAMLLGAGRATKEDKIDFAAGITLEKKVGDRVEAGDVIAVLRSN
IEDMSSAIERLDHAYTIGATKPEARPLVHAVIQ
>Mature_433_residues
MRMVDLILKKRNGGELNEEEIRFVVEGFTNESIPDYQMSALSMAIYFNGMTENETAALTMEMVKSGDTIDLSNIEGKKVD
KHSTGGVGDKISLIVAPLVASIGIPVAKMSGRGLGHTGGTIDKLESFPGFNVELTEEQFTKQVNDIKMSIIGQTGNLTPA
DKRLYALRDVTATVESIPLIASSIMSKKIAAGADSIVLDVKTGSGAFMKSFDDAKALAEEMVAIGKNVGRKTVAVITDMD
QPLGFEIGNANEVKEAIEVLSGKEVEDLKTIALTIAGHMAVLGEFYPTFEEAYADLEKRIADGHALEVFRKFVEAQGGDA
SLVDDVTKLPQASYETTFVAKEAGYVESIIADEVGVAAMLLGAGRATKEDKIDFAAGITLEKKVGDRVEAGDVIAVLRSN
IEDMSSAIERLDHAYTIGATKPEARPLVHAVIQ

Specific function: The Enzymes Which Catalyze The Reversible Phosphorolysis Of Pyrimidine Nucleosides Are Involved In The Degradation Of These Compounds And In Their Utilization As Carbon And Energy Sources, Or In The Rescue Of Pyrimidine Bases For Nucleotide Synthesis. [C

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI166158925, Length=436, Percent_Identity=37.6146788990826, Blast_Score=269, Evalue=5e-72,
Organism=Homo sapiens, GI4503445, Length=436, Percent_Identity=37.6146788990826, Blast_Score=269, Evalue=5e-72,
Organism=Homo sapiens, GI166158922, Length=436, Percent_Identity=37.6146788990826, Blast_Score=269, Evalue=5e-72,
Organism=Escherichia coli, GI1790842, Length=403, Percent_Identity=42.4317617866005, Blast_Score=317, Evalue=7e-88,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872 [H]

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C [H]

EC number: =2.4.2.2 [H]

Molecular weight: Translated: 46357; Mature: 46357

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRMVDLILKKRNGGELNEEEIRFVVEGFTNESIPDYQMSALSMAIYFNGMTENETAALTM
CCHHHHHHHCCCCCCCCHHHHHHHEECCCCCCCCCHHHHHHEEEEEECCCCCCCHHHHHH
EMVKSGDTIDLSNIEGKKVDKHSTGGVGDKISLIVAPLVASIGIPVAKMSGRGLGHTGGT
HHHHCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCC
IDKLESFPGFNVELTEEQFTKQVNDIKMSIIGQTGNLTPADKRLYALRDVTATVESIPLI
HHHHHCCCCCCEEECHHHHHHHHHHEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHH
ASSIMSKKIAAGADSIVLDVKTGSGAFMKSFDDAKALAEEMVAIGKNVGRKTVAVITDMD
HHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCC
QPLGFEIGNANEVKEAIEVLSGKEVEDLKTIALTIAGHMAVLGEFYPTFEEAYADLEKRI
CCCCEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
ADGHALEVFRKFVEAQGGDASLVDDVTKLPQASYETTFVAKEAGYVESIIADEVGVAAML
CCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCEEEEEHHCCHHHHHHHHHHHHHHHH
LGAGRATKEDKIDFAAGITLEKKVGDRVEAGDVIAVLRSNIEDMSSAIERLDHAYTIGAT
HHCCCCCCCCCCHHHCCCEEHHHCCCCCCCCHHHHHHHHCHHHHHHHHHHHHCEEEECCC
KPEARPLVHAVIQ
CCCHHHHHHHHCC
>Mature Secondary Structure
MRMVDLILKKRNGGELNEEEIRFVVEGFTNESIPDYQMSALSMAIYFNGMTENETAALTM
CCHHHHHHHCCCCCCCCHHHHHHHEECCCCCCCCCHHHHHHEEEEEECCCCCCCHHHHHH
EMVKSGDTIDLSNIEGKKVDKHSTGGVGDKISLIVAPLVASIGIPVAKMSGRGLGHTGGT
HHHHCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCC
IDKLESFPGFNVELTEEQFTKQVNDIKMSIIGQTGNLTPADKRLYALRDVTATVESIPLI
HHHHHCCCCCCEEECHHHHHHHHHHEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHH
ASSIMSKKIAAGADSIVLDVKTGSGAFMKSFDDAKALAEEMVAIGKNVGRKTVAVITDMD
HHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCC
QPLGFEIGNANEVKEAIEVLSGKEVEDLKTIALTIAGHMAVLGEFYPTFEEAYADLEKRI
CCCCEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
ADGHALEVFRKFVEAQGGDASLVDDVTKLPQASYETTFVAKEAGYVESIIADEVGVAAML
CCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCEEEEEHHCCHHHHHHHHHHHHHHHH
LGAGRATKEDKIDFAAGITLEKKVGDRVEAGDVIAVLRSNIEDMSSAIERLDHAYTIGAT
HHCCCCCCCCCCHHHCCCEEHHHCCCCCCCCHHHHHHHHCHHHHHHHHHHHHCEEEECCC
KPEARPLVHAVIQ
CCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8987664; 9817849 [H]