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The map label for this gene is parC [H]

Identifier: 229916009

GI number: 229916009

Start: 241754

End: 244159

Strand: Reverse

Name: parC [H]

Synonym: EAT1b_0277

Alternate gene names: 229916009

Gene position: 244159-241754 (Counterclockwise)

Preceding gene: 229916010

Following gene: 229916007

Centisome position: 8.14

GC content: 52.74

Gene sequence:

>2406_bases
ATGTCGACGATTCAACACATTTTAAACCTATCTCTCGAACAGGTCGTCGGTGACCGGTTCGGGCGTTACTCAAAATATAT
CATTCAAGACCGTGCCTTACCGGACGCTCGTGACGGACTTAAGCCCGTACAACGCCGGATTCTATATGCAATGCACCATG
AGGGAAATACGAACGATAAGCCTTACCGGAAGTCCGCCAAGACGGTCGGGAACGTCATCGGGAACTATCACCCGCACGGT
GACTCGTCCGTCTATGAGGCGATGGTACGCCTCTCACAAGACTGGAAACTCCGGTATCCGCTCATCGATATGCATGGGAA
CAATGGGTCGATGGACGGTGACCCAGCAGCGGCCATGCGTTATACGGAAGCCCGTCTCTCGAAGATTGCCGGTGTCATGC
TGACGTCGATTGCGAAAAATACGGTCGATTACACGCCGAACTTTGATGATTCTACGGAAGAACCGCTCGTCTTGCCGTCG
CTCCTTCCGAACCTTCTCATGAACGGAACGACAGGGATTTCGGCCGGTTATGCGACGGAAATCCCACCGCATAACTTGAC
AGAAGTCCTCAACCTCGCCATCGCACGCTTGAAGGGCCAGGTCGATATCGCTAAAGATGCGCTCGAGTATGTCACAGGTC
CTGACTTCCCGACCGGGGGGACGGTCATGGGTAAAGACGGTATCCTAAAGGCGTTCGAGACCGGTAAAGGGAAGGTCATC
ATCCGGGCGAAGTCCGAGATTGAGCAATTAAAAGGTGGCCGTGAACAGATCACGATCACAGAACTTCCGTATGAAGTGAA
TAAGGCGAACCTCGTCAAAAAGATGGAAGAGCTCCGCCTCGATAAAAAGGTCGAAGGCGTCGCAGAAGTCCGTGACGAAA
CAGATCGGACGGGACTTCGGGTCGTCATCGAATTGAAGAAAGAGGCCGACGCAGAAGGTGTGCTTCACTTCTTTTTGAAG
CATACGGACTTGCAACTCGCCTATAACTATAATATGGTCTCCATCGTGAACCGGACGCCGAAGCAGATGGGAATCATCCC
GATCATCGATGCTTACTTGAAGCATGTCGAAGAGGTCGTGACGCGCAGGACGACGTTCGAACTCGAGCAGGCGAAGAAAC
GTGCTGAAATCGTCGATGCCTTAGAACAAGCCATCTCGGTCCTCGATGAGACACTCGAATTGATCCGTTCCGCCAAAGAC
AAGGCGGACGCGAAGAAGAAACTGATGGAGCGGTTCTCATTCACGGAACGACAAGCCGAAGCCGTCGTCATGCTCCAATT
GTATCGACTCACGAATACGGACATCGTCGAGTTGCAAAAAGAAGCAAAGGCGCTCCAAAAAGAGATTGCCCGCCTCTCAA
ACATCCTCGATGTGGACGCGACAAAACGGAAGTTGATCGTGAAAGAACTTACGGCATTGCGTGACGAGTTCGGAGATGAC
CGTCGTTCGGTCATCGAGTCGGAAGTTGAGGAATTAAAACTGAAGACGGAAGTTATGATTGCTGTCGAAGAGACGATGGT
ATTCGTCAGCCGTGACGGGTACGTCAAACGTGCCTCGATGCGTTCGTATGGAGCGTCGAGTGACGTTTTACCGGAGATGA
AAGAAAAGGATCGTCCACTCCTTACGACACAAGCCATGACGACGGACCACTTGCTCGTCTGGACGAACAAGGGCAGCTAC
CTCCTCATCCCGGTCCATCAGATTCCAGAATCGAAGTGGAAGGATGCCGGACAACACGTGGCCAACCTCGTTCCGATTGA
AGGGGAACAGGTTATCTCGGCAGACGTCGTCTCGACGTTTGATACGGACGCCCATTGCCTCTTCGTGACGAAAGACGGGA
TGGTCAAACGTACACCGTTGCGCGACTACGACGCGCAGCGGAAATCGAAACCACTCATGGCCTTGAAGCTGAAAGGTGAC
GACGAGGTCGTCTTCGCCGGGATCAGTGACGGTCCAGGGCAGTTGTTCCTTGTTTCAGAGCGTGGATACGGGCTCTGGTT
CAAAGAGGATGATGTCCCTGTCGTCGGACAGCGGGCAGCCGGTGTGAAGGCGATGAACCTGAAAGACGGTGACCTCGTCG
CCGATGCCTTCTCCTTCTTCACGCCACCATTATTCGTTCTCGTGACGCAACGGGGAGCGGTCAAGAAGATGAAGCTCGAG
GACCAGTTCGACTGTACGAACCGCAACCTTCGGGGGACGATGCTCATTCGTGAGGTCAAATCAAAACCGCACCAAATCCG
TCGTGTGCTTCCGGTGCATGGGGATGAGACGCTTCATATCGTCGGAAAAGAAAAAGCAAAACAAGTAAAGACAAAAACCC
TTACGCTACTCGATCGCTATGCCAACGGCTCTTTCGTCTTTGACGAAGACTCGTTCGGTGAAATCGAGGACGTGTATCTC
GATTAA

Upstream 100 bases:

>100_bases
GTGAGTGGATCGAGGAGAACGTCGCCTTCGGACTCCAGGAAGATGATTCGATCATCGCCAATGAACATGTGACTAAAGCG
ATTGAGGAAGTGATGTAACG

Downstream 100 bases:

>100_bases
TCAAAAGACCTGTGATTTGGCTGATTCGCCGTTCACAGGTCTTTTTGTCGTAGCCATGTCTCTAGATCGTGTTGTTGTCG
TCGATGGTGCCGCGTGTGCA

Product: DNA topoisomerase IV, A subunit

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 801; Mature: 800

Protein sequence:

>801_residues
MSTIQHILNLSLEQVVGDRFGRYSKYIIQDRALPDARDGLKPVQRRILYAMHHEGNTNDKPYRKSAKTVGNVIGNYHPHG
DSSVYEAMVRLSQDWKLRYPLIDMHGNNGSMDGDPAAAMRYTEARLSKIAGVMLTSIAKNTVDYTPNFDDSTEEPLVLPS
LLPNLLMNGTTGISAGYATEIPPHNLTEVLNLAIARLKGQVDIAKDALEYVTGPDFPTGGTVMGKDGILKAFETGKGKVI
IRAKSEIEQLKGGREQITITELPYEVNKANLVKKMEELRLDKKVEGVAEVRDETDRTGLRVVIELKKEADAEGVLHFFLK
HTDLQLAYNYNMVSIVNRTPKQMGIIPIIDAYLKHVEEVVTRRTTFELEQAKKRAEIVDALEQAISVLDETLELIRSAKD
KADAKKKLMERFSFTERQAEAVVMLQLYRLTNTDIVELQKEAKALQKEIARLSNILDVDATKRKLIVKELTALRDEFGDD
RRSVIESEVEELKLKTEVMIAVEETMVFVSRDGYVKRASMRSYGASSDVLPEMKEKDRPLLTTQAMTTDHLLVWTNKGSY
LLIPVHQIPESKWKDAGQHVANLVPIEGEQVISADVVSTFDTDAHCLFVTKDGMVKRTPLRDYDAQRKSKPLMALKLKGD
DEVVFAGISDGPGQLFLVSERGYGLWFKEDDVPVVGQRAAGVKAMNLKDGDLVADAFSFFTPPLFVLVTQRGAVKKMKLE
DQFDCTNRNLRGTMLIREVKSKPHQIRRVLPVHGDETLHIVGKEKAKQVKTKTLTLLDRYANGSFVFDEDSFGEIEDVYL
D

Sequences:

>Translated_801_residues
MSTIQHILNLSLEQVVGDRFGRYSKYIIQDRALPDARDGLKPVQRRILYAMHHEGNTNDKPYRKSAKTVGNVIGNYHPHG
DSSVYEAMVRLSQDWKLRYPLIDMHGNNGSMDGDPAAAMRYTEARLSKIAGVMLTSIAKNTVDYTPNFDDSTEEPLVLPS
LLPNLLMNGTTGISAGYATEIPPHNLTEVLNLAIARLKGQVDIAKDALEYVTGPDFPTGGTVMGKDGILKAFETGKGKVI
IRAKSEIEQLKGGREQITITELPYEVNKANLVKKMEELRLDKKVEGVAEVRDETDRTGLRVVIELKKEADAEGVLHFFLK
HTDLQLAYNYNMVSIVNRTPKQMGIIPIIDAYLKHVEEVVTRRTTFELEQAKKRAEIVDALEQAISVLDETLELIRSAKD
KADAKKKLMERFSFTERQAEAVVMLQLYRLTNTDIVELQKEAKALQKEIARLSNILDVDATKRKLIVKELTALRDEFGDD
RRSVIESEVEELKLKTEVMIAVEETMVFVSRDGYVKRASMRSYGASSDVLPEMKEKDRPLLTTQAMTTDHLLVWTNKGSY
LLIPVHQIPESKWKDAGQHVANLVPIEGEQVISADVVSTFDTDAHCLFVTKDGMVKRTPLRDYDAQRKSKPLMALKLKGD
DEVVFAGISDGPGQLFLVSERGYGLWFKEDDVPVVGQRAAGVKAMNLKDGDLVADAFSFFTPPLFVLVTQRGAVKKMKLE
DQFDCTNRNLRGTMLIREVKSKPHQIRRVLPVHGDETLHIVGKEKAKQVKTKTLTLLDRYANGSFVFDEDSFGEIEDVYL
D
>Mature_800_residues
STIQHILNLSLEQVVGDRFGRYSKYIIQDRALPDARDGLKPVQRRILYAMHHEGNTNDKPYRKSAKTVGNVIGNYHPHGD
SSVYEAMVRLSQDWKLRYPLIDMHGNNGSMDGDPAAAMRYTEARLSKIAGVMLTSIAKNTVDYTPNFDDSTEEPLVLPSL
LPNLLMNGTTGISAGYATEIPPHNLTEVLNLAIARLKGQVDIAKDALEYVTGPDFPTGGTVMGKDGILKAFETGKGKVII
RAKSEIEQLKGGREQITITELPYEVNKANLVKKMEELRLDKKVEGVAEVRDETDRTGLRVVIELKKEADAEGVLHFFLKH
TDLQLAYNYNMVSIVNRTPKQMGIIPIIDAYLKHVEEVVTRRTTFELEQAKKRAEIVDALEQAISVLDETLELIRSAKDK
ADAKKKLMERFSFTERQAEAVVMLQLYRLTNTDIVELQKEAKALQKEIARLSNILDVDATKRKLIVKELTALRDEFGDDR
RSVIESEVEELKLKTEVMIAVEETMVFVSRDGYVKRASMRSYGASSDVLPEMKEKDRPLLTTQAMTTDHLLVWTNKGSYL
LIPVHQIPESKWKDAGQHVANLVPIEGEQVISADVVSTFDTDAHCLFVTKDGMVKRTPLRDYDAQRKSKPLMALKLKGDD
EVVFAGISDGPGQLFLVSERGYGLWFKEDDVPVVGQRAAGVKAMNLKDGDLVADAFSFFTPPLFVLVTQRGAVKKMKLED
QFDCTNRNLRGTMLIREVKSKPHQIRRVLPVHGDETLHIVGKEKAKQVKTKTLTLLDRYANGSFVFDEDSFGEIEDVYLD

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm. Note=Bipolarly localized [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=176, Percent_Identity=28.9772727272727, Blast_Score=71, Evalue=4e-12,
Organism=Homo sapiens, GI19913406, Length=181, Percent_Identity=29.8342541436464, Blast_Score=70, Evalue=9e-12,
Organism=Escherichia coli, GI1788562, Length=775, Percent_Identity=38.4516129032258, Blast_Score=509, Evalue=1e-145,
Organism=Escherichia coli, GI1789396, Length=516, Percent_Identity=38.5658914728682, Blast_Score=341, Evalue=1e-94,
Organism=Caenorhabditis elegans, GI212645845, Length=217, Percent_Identity=27.1889400921659, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6324241, Length=164, Percent_Identity=29.8780487804878, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17136538, Length=366, Percent_Identity=25.6830601092896, Blast_Score=70, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013760
- InterPro:   IPR005741 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 89994; Mature: 89862

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTIQHILNLSLEQVVGDRFGRYSKYIIQDRALPDARDGLKPVQRRILYAMHHEGNTNDK
CCHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCHHCCHHHHHHHHHHHHCCCCCCCCC
PYRKSAKTVGNVIGNYHPHGDSSVYEAMVRLSQDWKLRYPLIDMHGNNGSMDGDPAAAMR
CHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEECCEEEEECCCCCCCCCHHHHHH
YTEARLSKIAGVMLTSIAKNTVDYTPNFDDSTEEPLVLPSLLPNLLMNGTTGISAGYATE
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEECHHHHHHHHHCCCCCCCCCCCCC
IPPHNLTEVLNLAIARLKGQVDIAKDALEYVTGPDFPTGGTVMGKDGILKAFETGKGKVI
CCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCEEECCCCCHHHEECCCCEEE
IRAKSEIEQLKGGREQITITELPYEVNKANLVKKMEELRLDKKVEGVAEVRDETDRTGLR
EEEHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
VVIELKKEADAEGVLHFFLKHTDLQLAYNYNMVSIVNRTPKQMGIIPIIDAYLKHVEEVV
EEEEECCCCCHHHHHHHHHHCCCEEEEECCCEEEEECCCHHHCCCHHHHHHHHHHHHHHH
TRRTTFELEQAKKRAEIVDALEQAISVLDETLELIRSAKDKADAKKKLMERFSFTERQAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVVMLQLYRLTNTDIVELQKEAKALQKEIARLSNILDVDATKRKLIVKELTALRDEFGDD
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCH
RRSVIESEVEELKLKTEVMIAVEETMVFVSRDGYVKRASMRSYGASSDVLPEMKEKDRPL
HHHHHHHHHHHHHHHHHEEEEEEEEEEEEECCCCEEEHHHHHCCCCCCCCCCHHHCCCCE
LTTQAMTTDHLLVWTNKGSYLLIPVHQIPESKWKDAGQHVANLVPIEGEQVISADVVSTF
EEEECCCCCEEEEEECCCCEEEEEHHHCCCHHHHHHHHHHHHCCCCCCCCEEEHHHHHHC
DTDAHCLFVTKDGMVKRTPLRDYDAQRKSKPLMALKLKGDDEVVFAGISDGPGQLFLVSE
CCCCEEEEEECCCCEEECCCCCCCHHHCCCCEEEEEECCCCCEEEEECCCCCCCEEEEEC
RGYGLWFKEDDVPVVGQRAAGVKAMNLKDGDLVADAFSFFTPPLFVLVTQRGAVKKMKLE
CCCEEEEECCCCCEECCCCCCEEEECCCCCCHHHHHHHHHCCCEEEEEECCCCCEEECCC
DQFDCTNRNLRGTMLIREVKSKPHQIRRVLPVHGDETLHIVGKEKAKQVKTKTLTLLDRY
CCCCCCCCCCCHHHHHHHHHCCHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHHHC
ANGSFVFDEDSFGEIEDVYLD
CCCCEEECCCCCCCCHHEECC
>Mature Secondary Structure 
STIQHILNLSLEQVVGDRFGRYSKYIIQDRALPDARDGLKPVQRRILYAMHHEGNTNDK
CHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCHHCCHHHHHHHHHHHHCCCCCCCCC
PYRKSAKTVGNVIGNYHPHGDSSVYEAMVRLSQDWKLRYPLIDMHGNNGSMDGDPAAAMR
CHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEECCEEEEECCCCCCCCCHHHHHH
YTEARLSKIAGVMLTSIAKNTVDYTPNFDDSTEEPLVLPSLLPNLLMNGTTGISAGYATE
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEECHHHHHHHHHCCCCCCCCCCCCC
IPPHNLTEVLNLAIARLKGQVDIAKDALEYVTGPDFPTGGTVMGKDGILKAFETGKGKVI
CCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCEEECCCCCHHHEECCCCEEE
IRAKSEIEQLKGGREQITITELPYEVNKANLVKKMEELRLDKKVEGVAEVRDETDRTGLR
EEEHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
VVIELKKEADAEGVLHFFLKHTDLQLAYNYNMVSIVNRTPKQMGIIPIIDAYLKHVEEVV
EEEEECCCCCHHHHHHHHHHCCCEEEEECCCEEEEECCCHHHCCCHHHHHHHHHHHHHHH
TRRTTFELEQAKKRAEIVDALEQAISVLDETLELIRSAKDKADAKKKLMERFSFTERQAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVVMLQLYRLTNTDIVELQKEAKALQKEIARLSNILDVDATKRKLIVKELTALRDEFGDD
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCH
RRSVIESEVEELKLKTEVMIAVEETMVFVSRDGYVKRASMRSYGASSDVLPEMKEKDRPL
HHHHHHHHHHHHHHHHHEEEEEEEEEEEEECCCCEEEHHHHHCCCCCCCCCCHHHCCCCE
LTTQAMTTDHLLVWTNKGSYLLIPVHQIPESKWKDAGQHVANLVPIEGEQVISADVVSTF
EEEECCCCCEEEEEECCCCEEEEEHHHCCCHHHHHHHHHHHHCCCCCCCCEEEHHHHHHC
DTDAHCLFVTKDGMVKRTPLRDYDAQRKSKPLMALKLKGDDEVVFAGISDGPGQLFLVSE
CCCCEEEEEECCCCEEECCCCCCCHHHCCCCEEEEEECCCCCEEEEECCCCCCCEEEEEC
RGYGLWFKEDDVPVVGQRAAGVKAMNLKDGDLVADAFSFFTPPLFVLVTQRGAVKKMKLE
CCCEEEEECCCCCEECCCCCCEEEECCCCCCHHHHHHHHHCCCEEEEEECCCCCEEECCC
DQFDCTNRNLRGTMLIREVKSKPHQIRRVLPVHGDETLHIVGKEKAKQVKTKTLTLLDRY
CCCCCCCCCCCHHHHHHHHHCCHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHHHC
ANGSFVFDEDSFGEIEDVYLD
CCCCEEECCCCCCCCHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969507; 9539793; 9384377 [H]